Article
Cell Biology
Crissy Dudgeon, Anthony Casabianca, Chris Harris, Charline Ogier, Melanie Bellina, Stephany Fiore, Agnes Bernet, Benjamin Ducarouge, David Goldschneider, Xiaoyang Su, Jason Pitarresi, Aram Hezel, Subhajyoti De, Wade Narrow, Fady Soliman, Cory Shields, Debora Barbosa Vendramini-Costa, Orjola Prela, Lan Wang, Igor Astsaturov, Patrick Mehlen, Darren R. Carpizo
Summary: The biology of metastatic PDAC differs from the primary tumor, and Netrin-1 plays a crucial role in liver metastasis of PDAC. Inhibiting Netrin-1 may be an effective therapeutic strategy for preventing metastasis.
Review
Oncology
Xiaojia Li, Jie He, Keping Xie
Summary: Pancreatic ductal metaplasia (PDM) is the transformation of cells in the pancreas into ductal or ductal-like cells, and it is associated with the development of pancreatic diseases. Recent studies have uncovered the molecular mechanisms of PDM formation and evolution, and identified biomarkers that can be used for early detection and treatment of pancreatic cancer.
Review
Cell Biology
Colin E. Evans
Summary: Inflammatory lung injury is characterized by cell death, leukocyte infiltration, and disruption of nutrient and oxygen transport. Pulmonary hypoxia is a characteristic feature of inflammatory lung conditions. Hypoxia-inducible transcription factors HIF-1 and HIF-2 control the vascular response to hypoxia. HIF signaling regulates inflammatory lung injury and repair in different cell types.
Article
Cell Biology
Chen Yang, Yanchun Li, Wanye Hu, Xu Wang, Jiayu Hu, Chen Yuan, Chaoting Zhou, Hairui Wang, Jing Du, Ying Wang, Xiangmin Tong
Summary: TEOA inhibits proliferation and migration of pancreatic cancer cells by inducing mitochondrial dysfunction and ROS-dependent autophagic cell death, suggesting its potential as a promising therapeutic agent for pancreatic cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Juanjuan Dai, Yan He, Mingjie Jiang, Mengya Niu, Bin Li, Zengkai Wu, Jingpiao Bao, Li Wen, Xingpeng Wang, Guoyong Hu
Summary: This study revealed that Regenerating Family Member 4 (Reg4) plays a crucial role in pancreatic regeneration by regulating Notch activation, influencing acinar-to-ductal metaplasia and resolution of pancreatitis. Reg4 is identified as a new regulator and potential therapeutic target for pancreatic regeneration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Patrik Simmler, Cedric Cortijo, Lisa Maria Koch, Patricia Galliker, Silvia Angori, Hella Anna Bolck, Christina Mueller, Ana Vukolic, Peter Mirtschink, Yann Christinat, Natalie R. Davidson, Kjong-Van Lehmann, Giovanni Pellegrini, Chantal Pauli, Daniela Lenggenhager, Ilaria Guccini, Till Ringel, Christian Hirt, Kim Fabiano Marquart, Moritz Schaefer, Gunnar Ratsch, Matthias Peter, Holger Moch, Markus Stoffel, Gerald Schwank
Summary: Mutations in the splicing factor SF3B1 are frequently occurring in various cancers and drive tumor progression. This study demonstrates that SF3B1 is a target gene of HIF1 and positively regulates HIF1 pathway activity by facilitating the binding of HIF1 complex to HREs. The reduction in SF3B1 levels impede tumor formation and progression via impaired HIF signaling in a mouse model for pancreatic cancer.
Article
Oncology
Akira Hirota, Jean-Emmanuel Clement, Satoshi Tanikawa, Takayuki Nonoyama, Tamiki Komatsuzaki, Jian Ping Gong, Shinya Tanaka, Masamichi Imajo
Summary: This study revealed that activation of ERK MAP kinase signaling is a novel mechanism for retinoid resistance in breast cancer cells. It also demonstrated that suppression of RAR signaling and activation of ERK signaling are associated with specific subtypes of breast cancers and poor patient prognosis.
Review
Pharmacology & Pharmacy
Ziba Lotfi, Shiva Najjary, Fariba Lotfi, Mohammad Amini, Amir Baghbanzadeh, Darya Javad Rashid, Elmira Roshani Asl, Behzad Baradaran, Ahad Mokhtarzadeh
Summary: Pancreatic cancer is a deadly cancer with low survival rates, mainly due to relapse and resistance to treatment. Tumors have a high desmoplastic stroma, affecting growth and spread. Genetic studies show common molecular features and mutations in key genes in PC development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiao-hui Li, Gui-zhong Huang, Zi-lan Xu, Chong-yu Zhao, Xiao-yuan Dong, Bo-kang Cui, Xiao-jun Lin
Summary: This study found that Interleukin-20 receptor subunit beta (IL20RB) is upregulated in pancreatic cancer and is associated with poor prognosis. IL20RB enhances stemness and chemoresistance in pancreatic cancer by promoting STAT3 phosphorylation. IL20RB may serve as a potential therapeutic target for pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Xian-Yang Qin, Yutaka Furutani, Kento Yonezawa, Nobutaka Shimizu, Miyuki Kato-Murayama, Mikako Shirouzu, Yali Xu, Yumiko Yamano, Akimori Wada, Luc Gailhouste, Rajan Shrestha, Masataka Takahashi, Jeffrey W. W. Keillor, Ting Su, Wenkui Yu, Shinya Fujii, Hiroyuki Kagechika, Naoshi Dohmae, Yohei Shirakami, Masahito Shimizu, Takahiro Masaki, Tomokazu Matsuura, Harukazu Suzuki, Soichi Kojima
Summary: This study examined the effects of ACR on TG2 activity at a structural level and its role in depleting liver cancer stem cells (CSCs). It was found that ACR directly binds to TG2, induces oligomer formation, and inhibits the transamidase activity of cytoplasmic TG2. The loss of TG2 function suppressed stemness-related genes, spheroid proliferation, and induced cell death in a liver CSC subpopulation. Proteome analysis revealed that TG2 inhibition suppressed the expression of EXT1 and heparan sulfate biosynthesis. ACR could act as a novel TG2 inhibitor and TG2-mediated EXT1 signaling is a promising therapeutic target.
CELL DEATH & DISEASE
(2023)
Article
Neurosciences
Kanagaraj Palsamy, Jessica Y. Chen, Kaia Skaggs, Yusuf Qadeer, Meghan Connors, Noah Cutler, Joshua Richmond, Vineeth Kommidi, Allison Poles, Danielle Affrunti, Curtis Powell, Daniel Goldman, Jack M. Parent
Summary: The adult zebrafish brain has the ability to regenerate, while mammals do not. In this study, the role of microglia in brain repair was explored. It was found that inhibition or loss of microglia impaired the regeneration process and prolonged the inflammatory phase.
Article
Cell Biology
Emily E. Fink, Surbhi Sona, Uyen Tran, Pierre-Emmanuel Desprez, Matthew Bradley, Hong Qiu, Mohamed Eltemamy, Alvin Wee, Madison Wolkov, Marlo Nicolas, Booki Min, Georges-Pascal Haber, Oliver Wessely, Byron H. Lee, Angela H. Ting
Summary: This study analyzed the cell populations within the human ureter and inferred potential cell-cell communication networks. It also identified the importance of the sonic hedgehog signaling pathway in adult progenitor cell maintenance and provided a blueprint for guiding ureter tissue engineering.
DEVELOPMENTAL CELL
(2022)
Article
Oncology
Nina G. Steele, Giulia Biffi, Samantha B. Kemp, Yaqing Zhang, Donovan Drouillard, LiJyun Syu, Yuan Hao, Tobiloba E. Oni, Erin Brosnan, Ela Elyada, Abhishek Doshi, Christa Hansma, Carlos Espinoza, Ahmed Abbas, Stephanie The, Valerie Irizarry-Negron, Christopher J. Halbrook, Nicole E. Franks, Megan T. Hoffman, Kristee Brown, Eileen S. Carpenter, Zeribe C. Nwosu, Craig Johnson, Fatima Lima, Michelle A. Anderson, Youngkyu Park, Howard C. Crawford, Costas A. Lyssiotis, Timothy L. Frankel, Arvind Rao, Filip Bednar, Andrzej A. Dlugosz, Jonathan B. Preall, David A. Tuveson, Benjamin L. Allen, Marina Pasca di Magliano
Summary: The study reveals that Hedgehog signaling is uniquely activated in fibroblasts in PDAC, with varying levels of elevation in myofibroblastic CAFs compared to inflammatory CAFs. Inhibition of the Hedgehog pathway slows tumor growth, alters the composition of CAF subtypes, and impacts immune cell infiltration, leading to increased immunosuppression.
CLINICAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Wanglong Qiu, Chia-Yu Kuo, Yu Tian, Gloria H. Su
Summary: Activin, a member of the TGF-beta superfamily, is involved in various physiological processes and human diseases, particularly in tumorigenesis where it plays both tumor-suppressor and tumor-promoter roles. Understanding the mechanisms of activin signaling in tumorigenesis could lead to potential therapeutic targets for human cancers and other diseases.
Article
Multidisciplinary Sciences
Anja Tursch, Natascha Bartsch, Moritz Mercker, Jana Schlueter, Mark Lommel, Anna Marciniak-Czochra, Suat Oezbek, Thomas W. Holstein
Summary: In Hydra regeneration, the interaction between MAPKs and Wnt signaling determines the fate of regenerating tissue by integrating different injury response patterns. This mechanism plays a crucial role in Hydra's regeneration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Letter
Gastroenterology & Hepatology
Stephan B. Dreyer, Rosie Upstill-Goddard, Assya Legrini, Andrew V. Biankin, Nigel B. Jamieson, David K. Chang, Sarah Allison, Andrew V. Biankin, Dario Beraldi, Euan Cameron, David K. Chang
Article
Gastroenterology & Hepatology
Sandrina Martens, Katarina Coolens, Mathias Van Bulck, Tatjana Arsenijevic, Joan Casamitjana, Angel Fernandez Ruiz, Abdessamad El Kaoutari, Jaime Martinez de Villareal, Hediel Madhloum, Farzad Esni, Yves Heremans, Gunter Leuckx, Harry Heimberg, Luc Bouwens, Patrick Jacquemin, Diedert Luc De Paep, Peter in't Veld, Nicky D'Haene, Christelle Bouchart, Nelson Dusetti, Jean-Luc Van Laethem, Wim Waelput, Pierre Lefesvre, Francisco X. Real, Meritxell Rovira, Ilse Rooman
Summary: In larger human pancreatic ducts, basal cells exist. Delta Np63 suppresses duct cell identity. These cells may play an important role in pancreatic disease, including PDAC ontogeny, but are not present in mouse models.
Article
Oncology
Meera Patel, Kathryn A. F. Pennel, Jean A. Quinn, Hannah Hood, David K. Chang, Andrew Biankin, Selma Rebus, Antonia K. Roseweir, James H. Park, Paul G. Horgan, Donald C. McMillan, Joanne Edwards
Summary: Spatial expression of IKK alpha could serve as a potential biomarker in colorectal cancer, with its association with different mutational profiles highlighting possible distinct signaling roles for IKK alpha in the context of colorectal cancer.
BRITISH JOURNAL OF CANCER
(2022)
Review
Gastroenterology & Hepatology
Elyne Backx, Katarina Coolens, Jan-Lars van den Bossche, Isabelle Houbracken, Elisa Espinet, Ilse Rooman
Summary: This review focuses on the pathobiology of pancreatic ductal adenocarcinoma (PDAC) and highlights studies using human cells. The review reveals the remarkable exocrine cell plasticity in adult pancreatic tissue and explores the relationships between these cell states and PDAC molecular subtypes. These findings provide valuable insights into the origins and biology of PDAC.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lily M. Channon, Victoria M. Tyma, Zhihong Xu, David W. Greening, Jeremy S. Wilson, Chamini J. Perera, Minoti V. Apte
Summary: This review provides an overview of the role of extracellular vesicles (EVs) in the pathobiology of pancreatic cancer, as well as the molecular mechanisms mediated by EVs and their cargo in pancreatic cancer progression. EVs offer stability and act as a form of intercellular communication to regulate the function and phenotype of recipient cells.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Biochemistry & Molecular Biology
Sarah K. Hakuno, Ellis Michiels, Eleonore B. Kuhlemaijer, Ilse Rooman, Lukas J. A. C. Hawinkels, Marije Slingerland
Summary: Gastric and pancreatic cancers are difficult-to-treat cancers with a poor prognosis. Developing novel therapeutic targets and personalized therapies is crucial. Well-established preclinical research models, such as patient-derived organoids and patient-derived xenografts, play an important role in identifying targets and testing interventions. These models provide patient-specific avatars and offer new directions for therapy. Future opportunities include co-cultures with immune or stromal cells, organoid-on-a-chip models, and humanized xenografts, which can facilitate a better understanding of cancer heterogeneity and the development of tumor-specific therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bekesho R. Geleta, Faten Tout, Syer Choon Lim, Sumit Sahni, Patric J. Jansson, Minoti V. Apte, Des R. Richardson, Zaklina Kovacevic
Summary: A major obstacle to successful pancreatic cancer treatment is the stroma surrounding the tumor, which secretes growth factors and cytokines that promote cancer progression. This study demonstrates that targeting the metastasis suppressor NDRG1 can inhibit the interaction between pancreatic cancer cells and pancreatic stellate cells mediated by Wnt and TnC, thereby inhibiting tumor progression.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Oncology
Adam S. Bryce, Stephan B. Dreyer, Fieke E. M. Froeling, David K. Chang
Summary: This article discusses the heterogeneity of cancer-associated fibroblasts (CAFs) and their role in the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Molecular profiling allows for a better understanding of the characteristics of CAFs in the PDAC tumor microenvironment. The article also explores the complex relationship between CAFs and other cell types within the PDAC microenvironment, as well as the potential for therapeutic targeting of CAFs.
Review
Oncology
Cosmos Ifeanyi Onyiba, Christopher J. Scarlett, Judith Weidenhofer
Summary: This review discusses the role of SIRT1-7 genes and proteins in breast and prostate cancers, highlighting their involvement in various processes such as proliferation, apoptosis, and metastasis. The review also presents evidence of the regulation of SIRT1-7 by miRNAs and emphasizes the potential value of SIRT1-7 as biomarkers and targets for improved treatment of breast and prostate cancers.
Article
Food Science & Technology
Philip Davy, Timothy Kirkman, Christopher J. J. Scarlett, Quan Vuong
Summary: The study found that flour milled from dried soybean by-product (SMB100) has high levels of dietary fiber, protein, saponins, and isoflavones. Substituting wheat flour with SMB100 negatively impacted the physical properties of white bread, but substituting with 5% of SMB100 significantly improved the dietary fiber content without affecting the physical properties.
Article
Biochemical Research Methods
Tingting Zhao, Lihua Cao, Jiafu Ji, David K. Chang, Jianmin Wu
Summary: Adequate reporting is crucial for evaluating the performance and clinical utility of prognostic prediction models. Previous studies have found incomplete or suboptimal reporting in translational and clinical studies involving multivariable prediction models, limiting their applications. ReProMSig is a web-based integrative platform that provides a structured reporting framework for the development, validation, and application of multivariable prediction models for cancer prognosis. It supports transparent reporting by presenting methodology details and analysis results, requiring minimal manual input. ReProMSig is a valuable resource for healthcare professionals and biomedical researchers, offering a transparent and reproducible approach for the development and evaluation of prognostic biomarkers.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Behavioral Sciences
Celeste Ferraris, Christopher J. Scarlett, Tamara Bucher, Emma L. Beckett
Summary: Early research has shown that there are variations in salt taste qualities in cases of depression, anxiety, and stress. This Australian population survey found that individuals with higher scores indicating severe depression and anxiety had a greater liking for salty foods. These findings suggest a positive correlation between liking salty foods and scores of depression, anxiety, and stress.
Article
Developmental Biology
Lila Gannoun, Catalina De Schrevel, Morgane Belle, Nicolas Dauguet, Younes Achouri, Axelle Loriot, Christophe Vanderaa, Sabine Cordi, Alexandra Dili, Yves Heremans, Ilse Rooman, Isabelle A. Leclercq, Patrick Jacquemin, Laurent Gatto, Frederic P. Lemaigre
Summary: This study identifies new regulators in liver development and explores their functions in both health and liver regeneration. Experimental evidence demonstrates the significance of specific signaling pathways in portal area development and maturation of vascular smooth muscle cells in the hepatic artery.
Article
Oncology
Ellis Michiels, Hediel Madhloum, Silke Van Lint, Nouredin Messaoudi, Rastislav Kunda, Sandrina Martens, Philippe Giron, Catharina Olsen, Pierre Lefesvre, Nelson Dusetti, Leila EL Mohajer, Richard Tomasini, Lukas J. A. C. Hawinkels, Farah Ahsayni, Remy Nicolle, Tatjana Arsenijevic, Christelle Bouchart, Jean-Luc Van Laethem, Ilse Rooman
Summary: This study identifies two subtypes of pancreatic cancer and reveals spatial phenotypes within tumors through analysis of mRNA panels. These findings are important for understanding tumor heterogeneity and guiding therapeutic approaches.
JOURNAL OF PATHOLOGY
(2023)
Article
Biology
P. Janssen, L. De Pauw, M. Mambretti, O. Lara, J. Walckiers, L. Mackens, I. Rooman, B. Guillaume, M. De Ridder, G. Ates, A. Massie
Summary: TBI followed by BMT had long-term impact on weight and locomotion but minimal effect on anxiety and depressive behavior. Impaired neurogenesis and cortical microglia activation were observed after TBI/BMT, and increased BBB permeability potentially contributed to the memory deficit.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)