Article
Environmental Sciences
Yunxiu Wang, Zhiwei Cao, He Zhao, Zhaowei Gu
Summary: This study found that Nonylphenol (NP) can exacerbate the inflammatory response of ovalbumin (OVA)-induced allergic rhinitis (AR). This exacerbating effect may be related to the TSLP-TSLPR/IL-7R and JAK1/2-STAT3 signaling pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Oncology
Ruby Lieshout, Eline J. C. A. Kamp, Monique M. A. Verstegen, Michail Doukas, Winand N. M. Dinjens, Kubra Koten, Jan N. M. IJzermans, Marco J. Bruno, Maikel P. Peppelenbosch, Luc J. W. van der Laan, Annemarie C. de Vries
Summary: This study reveals that primary sclerosing cholangitis (PSC)-related cholangiocarcinoma (CCA) cells have a higher proliferation rate compared to sporadic CCA cells. The cytokine IL-17A, which is related to inflammation, stimulates the proliferation of CCA cells and may contribute to the high proliferation rate in PSC-CCA. IL-17A represents a potential therapeutic target for (PSC-)CCA.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Wei Liao, Yong Liu, Chaoyu Ma, Liwen Wang, Guo Li, Shruti Mishra, Saranya Srinivasan, Kenneth Ka-Ho Fan, Haijing Wu, Qianwen Li, Ming Zhao, Xun Liu, Erika L. Demel, Xin Zhang, Yuanzheng Qiu, Qianjin Lu, Nu Zhang
Summary: The stepwise induction of CD69 and CD103 distinguishes different differentiation stages of mucosal Trms, while the majority of non-mucosal Trm do not have CD103 expression. CD69 expression alone is not sufficient to accurately define Trm cells in highly vascularized non-mucosal tissues, such as the kidney. The downregulation of IL-18 receptor (IL-18R) is associated with tissue residency, with IL-18R(lo) exclusively identifying tissue-resident cells and IL-18R(hi) population containing both tissue-resident and migratory cells. Additionally, local cytokines and transcription factors play essential roles in regulating the downregulation of IL-18R during kidney Trm differentiation, allowing for the identification of kidney-resident CD8(+) T cells and the underlying molecular mechanisms.
Article
Immunology
Angelo Ferreira Chora, Sofia Marques, Joana Lisboa Goncalves, Priscila Lima, Daniel Gomes da Costa, Daniel Fernandez-Ruiz, Maria Ines Marreiros, Pedro Ruivo, Tania Carvalho, Ruy M. Ribeiro, Karine Serre, William R. Heath, Bruno Silva-Santos, Ann T. Tate, Maria M. Mota
Summary: During malaria infection, Plasmodium replicates in the liver and later infects red blood cells. It has been commonly believed that liver infection does not affect disease pathology as clinical manifestations only occur during the blood stage. However, a study using a mouse model uncoupling liver and blood stages of infection revealed that signals from both stages determine mortality outcomes. This finding was mediated by the activation of Vy4+ y8 T cells during the liver stage, which subsequently influenced cytokine profiles during the blood stage. The study also suggested that IL-17 produced by y8 T cells played a role in protecting mice from lethal cerebral malaria.
Article
Immunology
Adebimpe Fasanya, Nurat Mohammed, Bandar Hasan Saleh, Muyideen Kolapo Tijani, Alexandra Teleka, Maria del Pilar Quintana, Lars Hviid, Kristina E. M. Persson
Summary: Anemia is a common complication in pregnant women with malaria in endemic regions. Antibodies against Phosphatidylserine (PS) may contribute to anemia through destruction of uninfected red blood cells. Levels of anti-PS IgG antibodies were measured in pregnant women in Nigeria and correlated with anemia and immune parameters. The study suggests that lower levels of anti-PS in multigravidae may be beneficial in avoiding anemia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Cell Biology
Guanxi Xiao, Rosie Kumar, Yutaro Komuro, Jasmine Burguet, Visesha Kakarla, Ida Azizkhanian, Sunil A. Sheth, Christopher K. Williams, Xinhai R. Zhang, Michal Macknicki, Andrew Brumm, Riki Kawaguchi, Phu Mai, Naoki Kaneko, Harry V. Vinters, S. Thomas Carmichael, Leif A. Havton, Charles DeCarli, Jason D. Hinman
Summary: Cardiovascular risk factors including obesity worsen cerebral small vessel disease and brain white matter injury. Chronic cerebrovascular risk factors activate molecular pathways in cerebral endothelial cells that alter cell-cell signaling, blocking endogenous and post-ischemic white matter repair. Using cell-specific translating ribosome affinity purification (RiboTag), a coordinated interleukin-chemokine signaling cascade is identified within the oligovascular niche of subcortical white matter triggered by diet-induced obesity (DIO). DIO induces interleukin-17B (IL-17B) signaling, which acts on cerebral endothelial cells through IL-17Rb, increasing both circulating and local endothelial expression of CXCL5. In white matter endothelia, CXCL5 promotes the association of oligodendrocyte progenitor cells (OPCs) with the vasculature and triggers OPC gene expression programs regulating cell migration through chemokine signaling. Targeted blockade of IL-17B reduces vessel-associated OPCs by reducing endothelial CXCL5 expression. CXCL5 blood levels serve as diagnostic and prognostic biomarkers of vascular cognitive impairment in multiple human cohorts.
Article
Immunology
Andres Noe, Mehreen S. Datoo, Amy Flaxman, Mohammad Ali Husainy, Daniel Jenkin, Duncan Bellamy, Rebecca A. Makinson, Richard Morter, Fernando Ramos Lopez, Jonathan Sheridan, Dimitrios Voukantsis, Naveen Prasad, Adrian V. S. Hill, Katie J. Ewer, Alexandra J. Spencer
Summary: This study provides valuable insights into the characteristics and potential of liver CD8+ tissue-resident memory (TRM) cells for protection against liver-stage malaria. It also suggests the possibility of using TRM-like cells as a correlate of protection in malaria vaccine trials. The findings contribute to the development and evaluation of liver-stage malaria vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Orthopedics
Dao-Fang Ding, Yan Xue, Jun-Peng Zhang, Zeng-Qiao Zhang, Wen-Yao Li, Yue-Long Cao, Jian-Guang Xu
Summary: The rat chondrocyte inflammation model may be valuable for studying the early pathological mechanisms of osteoarthritis (OA) based on similarities and differences in gene expression with mouse chondrocytes. The study showed that rat chondrocytes exhibited significant upregulation of proliferation-related genes compared to mouse chondrocytes.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Endocrinology & Metabolism
Hongyu Li, Sirui Liu, Congcong Miao, Yan Lv, Ying Hu
Summary: Gnathodiaphyseal dysplasia (GDD) is a rare genetic disorder characterized by bone sclerosis and cemento-osseous lesions. This study found that mutations in the ANO5 gene can affect the metabolism of osteoblasts, leading to abnormal calcium homeostasis and cellular proliferation, which may contribute to the underlying pathogenesis of GDD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Tejram Sahu, Ella J. Gehrke, Yevel Flores-Garcia, Godfree Mlambo, Julia D. Romano, Isabelle Coppens
Summary: The liver stage-specific autophagy mutant of Plasmodium berghei (ATG8 overexpressor) used as a live vaccine under a Chemoprophylaxis vaccination (CVac) regimen provides superior long-lasting protection compared to WT-CVac, predominantly dependent on a CD8(+) T-cell response through an IFN-gamma-independent mechanism. This vaccination strategy is also a powerful model for studying protective immunity mechanisms and discovering new protective antigens.
Article
Environmental Sciences
Marie Collard, Louise Camenzuli, Delina Lyon, David Saunders, Nathalie Vallotton, Pippa Curtis-Jackson
Summary: The Chemical Strategy for Sustainability (CSS) aims to protect drinking water resources from chemical pollution. The German Environment Agency (UBA) proposed the Persistent and Mobile (PM) concept to identify potential pollutants based on their degradation potential and transport velocity. However, the reassessment of experimental data showed that the PM concept does not accurately predict the presence or level of contamination in surface or groundwater. Regulations based on the PM concept may not effectively identify substances of concern for drinking water sources. The development of specific exposure models would be more beneficial for the protection of drinking water resources and consumers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cell Biology
Gemma L. Johnson, Morgan B. Glasser, Julia F. Charles, Jeffrey Duryea, Jessica A. Lehoczky
Summary: En1 and Lmx1b are re-expressed during mouse digit tip regeneration, but do not affect dorsal-ventral patterning. Genetic deletion of En1 or Lmx1b has a modest impact on bone regeneration in the digit tip.
Article
Multidisciplinary Sciences
Naoko Iwata-Yoshikawa, Nozomi Shiwa, Tsuyoshi Sekizuka, Kaori Sano, Akira Ainai, Takuya Hemmi, Michiyo Kataoka, Makoto Kuroda, Hideki Hasegawa, Tadaki Suzuki, Noriyo Nagata
Summary: This study established a lethal animal model using BALB/c mice and a mouse-passaged isolate from a European lineage of SARS-CoV-2. The model demonstrated the characteristics of vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection, including eosinophilic immunopathology and insufficient neutralizing antibodies. Immunization with recombinant spike protein without appropriate adjuvant caused T(H)2-shifted immune response and lack of neutralizing antibodies in adult BALB/c mice.
Article
Immunology
Naoko Fuji, Michael Pichichero, Ravinder Kaur
Summary: Current licensed pneumococcal conjugate vaccines (PCVs) show decreased effectiveness against serotype-3 pneumococcal diseases, possibly due to the release of capsule polysaccharide (CPS-3) as an immune evasion mechanism. Clinical isolates of serotype-3 strains release more capsule than the WU2 strain and 19A strains. Higher levels of CPS-3 are found in middle-ear fluid (MEF) during acute otitis media (AOM) compared to CPS-19A. Unbound anti-CPS-3 IgG levels negatively correlate with free CPS-3 and a certain level of anti-CPS-3 antibody can protect mice from AOM and pneumonia.
Article
Cell Biology
Zuohua Xie, Bing Lin, Xinju Jia, Ting Su, Ying Wei, Jiping Tang, Chengzhi Yang, Chuanbao Cui, Jinxiang Liu
Summary: The study revealed an increased expression of IL-10 in the peripheral blood of sepsis patients, which inhibited HUVEC proliferation and promoted apoptosis through the STAT3 signaling pathway.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Infectious Diseases
Deirdre A. Cunningham, Jing-wen Lin, Thibaut Brugat, William Jarra, Irene Tumwine, Garikai Kushinga, Jai Ramesar, Blandine Franke-Fayard, Jean Langhorne
Article
Microbiology
Thibaut Brugat, Adam James Reid, Jing-wen Lin, Deirdre Cunningham, Irene Tumwine, Garikai Kushinga, Sarah McLaughlin, Philip Spence, Ulrike Boehme, Mandy Sanders, Solomon Conteh, Ellen Bushell, Tom Metcalf, Oliver Billker, Patrick E. Duffy, Chris Newbold, Matthew Berriman, Jean Langhorne
NATURE MICROBIOLOGY
(2017)
Article
Medicine, General & Internal
Damian Perez-Mazliah, Minh Phuong Nguyen, Caroline Hosking, Sarah McLaughlin, Matthew D. Lewis, Irene Tumwine, Prisca Levy, Jean Langhorne
Article
Immunology
Jie Yang, Ferry Cornelissen, Natalie Papazian, Rogier M. Reijmers, Miriam Llorian, Tom Cupedo, Mark Coles, Benedict Seddon
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Sanket Rane, Thea Hogan, Benedict Seddon, Andrew J. Yates
Review
Immunology
Benedict Seddon, Andrew J. Yates
IMMUNOLOGICAL REVIEWS
(2018)
Article
Multidisciplinary Sciences
Jing-wen Lin, Jan Sodenkamp, Deirdre Cunningham, Katrien Deroost, Tshibuayi Christine Tshitenge, Sarah McLaughlin, Tracey J. Lamb, Bradley Spencer-Dene, Caroline Hosking, Jai Ramesar, Chris J. Janse, Christine Graham, Anne O'Garra, Jean Langhorne
SCIENTIFIC REPORTS
(2017)
Article
Biology
Damian Perez-Mazliah, Peter J. Gardner, Edina Schweighoffer, Sarah McLaughlin, Caroline Hosking, Irene Tumwine, Randall S. Davis, Alexandre J. Potocnik, Victor L. J. Tybulewicz, Jean Langhorne
Article
Immunology
Louise Webb, Alessandro Barbarulo, Jelle Huysentruyt, Tom Vanden Berghe, Nozomi Takahashi, Steven Ley, Peter Vandenabeele, Benedict Seddon
Review
Immunology
Damian Perez-Mazliah, Francis M. Ndungu, Racheal Aye, Jean Langhorne
IMMUNOLOGICAL REVIEWS
(2020)
Review
Immunology
Joao T. Barata, Scott K. Durum, Benedict Seddon
Article
Biology
Thea Hogan, Maria Nowicka, Daniel Cownden, Claire F. Pearson, Andrew J. Yates, Benedict Seddon
Biographical-Item
Immunology
Benedict Seddon, Fiona Powrie, Neil Barclay
Article
Biology
Sanket Rane, Thea Hogan, Edward Lee, Benedict Seddon, Andrew J. Yates
Summary: In this study, a unified model of naive CD4 and CD8 T cell population dynamics in mice was identified using multiple modelling and experimental approaches. It was found that both subsets divide rarely and progressively increase their survival capacity with cell age. Newly generated naive CD8 T cells were found to be lost more rapidly during the first 3-4 weeks of life. No evidence for elevated division rates in neonates or feedback regulation of naive T cell numbers at any age was found.
Correction
Biology
Carlos Talavera-Lopez, Barbara Capuccini, Richard Mitter, Jing-wen Lin, Jean Langhorne
BMC RESEARCH NOTES
(2019)