标题
Flip the coin: IL-7 and IL-7R in health and disease
作者
关键词
-
出版物
NATURE IMMUNOLOGY
Volume 20, Issue 12, Pages 1584-1593
出版商
Springer Science and Business Media LLC
发表日期
2019-11-20
DOI
10.1038/s41590-019-0479-x
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Glucocorticoids and selumetinib are highly synergistic in RAS pathway mutated childhood acute lymphoblastic leukemia through upregulation of BIM.
- (2019) Elizabeth C. Matheson et al. HAEMATOLOGICA
- PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia
- (2019) Zhaohui Gu et al. NATURE GENETICS
- A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia
- (2019) Padma Akkapeddi et al. LEUKEMIA
- Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB
- (2019) Louise V. Webb et al. IMMUNITY
- Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity
- (2019) Livia Weijenborg Campos et al. BLOOD
- IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease
- (2019) Lyssia Belarif et al. JOURNAL OF CLINICAL INVESTIGATION
- The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development
- (2019) Gabriel A. Leung et al. DEVELOPMENT
- IL ‐7‐dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti‐tumour response
- (2019) Hung‐Chang Chen et al. EMBO REPORTS
- Interleukin-7 Contributes to the Invasiveness of Prostate Cancer Cells by Promoting Epithelial–Mesenchymal Transition
- (2019) Min A. Seol et al. Scientific Reports
- New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models
- (2019) Julie A. Hixon et al. LEUKEMIA
- IL-7 treatment supports CD8+ mucosa-associated invariant T-cell restoration in HIV-1-infected patients on antiretroviral therapy
- (2018) Ornella Sortino et al. AIDS
- IL-7–dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes
- (2018) Jie Yang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia
- (2018) Sarah D. Cramer et al. LEUKEMIA
- Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration
- (2018) Lukose K. Thampy et al. PLoS One
- Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations
- (2018) Emilee Senkevitch et al. Oncotarget
- Interleukin 7-expressing fibroblasts promote breast cancer growth through sustenance of tumor cell stemness
- (2018) Maximilian Boesch et al. OncoImmunology
- IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia
- (2018) Ameera Alsadeq et al. BLOOD
- Cell circuits between B cell progenitors and IL-7+mesenchymal progenitor cells control B cell development
- (2018) Chris Fistonich et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates
- (2018) Lyssia Belarif et al. Nature Communications
- Interleukin-7 Availability Is Maintained by a Hematopoietic Cytokine Sink Comprising Innate Lymphoid Cells and T Cells
- (2017) Christopher E. Martin et al. IMMUNITY
- JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias
- (2017) C Delgado-Martin et al. LEUKEMIA
- The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling
- (2017) T Girardi et al. LEUKEMIA
- The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
- (2017) Yu Liu et al. NATURE GENETICS
- Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia
- (2017) P Richter-Pechańska et al. Blood Cancer Journal
- IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis
- (2016) Eric Gracey et al. ANNALS OF THE RHEUMATIC DISEASES
- Therapeutic targeting of IL-7R signaling pathways in ALL treatment
- (2016) S. D. Cramer et al. BLOOD
- Elevated systemic interleukin-7 in patients with colorectal cancer and individuals at high risk of cancer: association with lymph node involvement and tumor location in the right colon
- (2016) Malgorzata Krzystek-Korpacka et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Adjuvant Immunotherapy to Improve Outcome in High-Risk Pediatric Sarcomas
- (2016) M. S. Merchant et al. CLINICAL CANCER RESEARCH
- IL-7/IL-7 receptor axis stimulates prostate cancer cell invasion and migration via AKT/NF-κB pathway
- (2016) Hu Qu et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors
- (2016) Ying Cheng et al. JOURNAL OF CLINICAL INVESTIGATION
- Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2in Newly Formed Tertiary Lymphoid Structures
- (2016) Saba Nayar et al. JOURNAL OF IMMUNOLOGY
- Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling
- (2016) C S Tremblay et al. LEUKEMIA
- MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia
- (2016) K Canté-Barrett et al. LEUKEMIA
- Thy1+IL-7+lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation
- (2016) Kenta Shinoda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR
- (2016) Nneha Sakre et al. Oncotarget
- IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study
- (2016) Yunlei Li et al. PLOS MEDICINE
- Sepsis and septic shock
- (2016) Richard S. Hotchkiss et al. Nature Reviews Disease Primers
- ELYPSE-7: a randomized placebo-controlled phase IIa trial with CYT107 exploring the restoration of CD4+ lymphocyte count in lymphopenic metastatic breast cancer patients
- (2015) O. Trédan et al. ANNALS OF ONCOLOGY
- Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia
- (2015) V. Sheikh et al. BLOOD
- Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia
- (2015) S. L. Maude et al. BLOOD
- Receptor occupancy and blocking of STAT5 signaling by an anti-IL-7 receptor α antibody in cynomolgus monkeys
- (2015) Brent Kern et al. CYTOMETRY PART B-CLINICAL CYTOMETRY
- Interleukin-7 Produced by Intestinal Epithelial Cells in Response to Citrobacter rodentium Infection Plays a Major Role in Innate Immunity against This Pathogen
- (2015) Wei Zhang et al. INFECTION AND IMMUNITY
- Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia
- (2015) Srividya Swaminathan et al. NATURE IMMUNOLOGY
- IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection
- (2015) Amine Boudil et al. NATURE IMMUNOLOGY
- Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma
- (2015) Takeya Adachi et al. NATURE MEDICINE
- ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling
- (2015) Steven Goossens et al. Nature Communications
- Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility
- (2015) A. Martin-Lorenzo et al. Cancer Discovery
- Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia
- (2014) C. Shochat et al. BLOOD
- IL-7 splicing variant IL-7δ5 induces EMT and metastasis of human breast cancer cell lines MCF-7 and BT-20 through activation of PI3K/Akt pathway
- (2014) Jie Yang et al. HISTOCHEMISTRY AND CELL BIOLOGY
- IL-7 Receptor Blockade Inhibits IL-17-Producing γδ Cells and Suppresses Melanoma Development
- (2014) Jun Li et al. INFLAMMATION
- Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential
- (2014) Louise M. Treanor et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Genomic and molecular characterization of esophageal squamous cell carcinoma
- (2014) De-Chen Lin et al. NATURE GENETICS
- A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia
- (2014) Daniel Herranz et al. NATURE MEDICINE
- Treatment of Progressive Multifocal Leukoencephalopathy With Interleukin 7
- (2014) Karl B. Alstadhaug et al. JAMA Neurology
- Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage
- (2013) M. Iolyeva et al. BLOOD
- In vivo leukemogenic potential of an interleukin 7 receptor chain mutant in hematopoietic stem and progenitor cells
- (2013) K. Yokoyama et al. BLOOD
- MYC fails to efficiently shape malignant transformation in T-cell acute lymphoblastic leukemia
- (2013) Marie Loosveld et al. GENES CHROMOSOMES & CANCER
- Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals
- (2013) Beate Heizmann et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-7 Produced by Thymic Epithelial Cells Plays a Major Role in the Development of Thymocytes and TCR + Intraepithelial Lymphocytes
- (2013) S. Shitara et al. JOURNAL OF IMMUNOLOGY
- IL-7-producing stromal cells are critical for lymph node remodeling
- (2012) L. Onder et al. BLOOD
- Overexpression of IL-7 enhances cisplatin resistance in glioma
- (2012) Lei Cui et al. CANCER BIOLOGY & THERAPY
- Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia
- (2012) Kathryn G. Roberts et al. CANCER CELL
- IL-7Rα deficiency in p53 null mice exacerbates thymocyte telomere erosion and lymphomagenesis
- (2012) R Kibe et al. CELL DEATH AND DIFFERENTIATION
- Clinical Impact of Immune Microenvironment in Stage I Lung Adenocarcinoma: Tumor Interleukin-12 Receptor β2 (IL-12Rβ2), IL-7R, and Stromal FoxP3/CD3 Ratio Are Independent Predictors of Recurrence
- (2012) Kei Suzuki et al. JOURNAL OF CLINICAL ONCOLOGY
- The clonal and mutational evolution spectrum of primary triple-negative breast cancers
- (2012) Sohrab P. Shah et al. NATURE
- The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
- (2012) Jinghui Zhang et al. NATURE
- Exogenous Amino Acids Are Essential for Interleukin-7 Induced CD8 T Cell Gowth
- (2012) Claire Pearson et al. PLoS One
- Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing
- (2012) Winnie S. Liang et al. PLoS One
- Anti-IL-7 receptor- reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function
- (2012) L.-F. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interleukin-7 up-regulates cyclin D1 via activator protein-1 to promote proliferation of cell in lung cancer
- (2011) Jian Ming et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias
- (2011) A. Silva et al. CANCER RESEARCH
- IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology
- (2011) Marc Pellegrini et al. CELL
- Cutaneous immunosurveillance by self-renewing dermal γδ T cells
- (2011) Nital Sumaria et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Gain-of-function mutations ininterleukin-7 receptor-α(IL7R) in childhood acute lymphoblastic leukemias
- (2011) Chen Shochat et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Ebf1orPax5haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia
- (2011) Lynn M. Heltemes-Harris et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer
- (2011) Chantal Mengus et al. Journal of Translational Medicine
- Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells
- (2011) A Silva et al. LEUKEMIA
- Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
- (2011) Priscila P Zenatti et al. NATURE GENETICS
- Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
- (2011) Carl A Anderson et al. NATURE GENETICS
- The Long-Term Survival Potential of Mature T Lymphocytes Is Programmed During Development in the Thymus
- (2011) C. Sinclair et al. Science Signaling
- Seeing Is Believing: Illuminating the Source ofIn VivoInterleukin-7
- (2011) Grace Yoonhee Kim et al. Immune Network
- Bone invading NSCLC cells produce IL-7: mice model and human histologic data
- (2010) Ilaria Roato et al. BMC CANCER
- A case of progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia
- (2010) A. Patel et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Kit Ligand and Il7 Differentially Regulate Peyer's Patch and Lymph Node Development
- (2010) S. Chappaz et al. JOURNAL OF IMMUNOLOGY
- Ets-1 Maintains IL-7 Receptor Expression in Peripheral T Cells
- (2010) R. Grenningloh et al. JOURNAL OF IMMUNOLOGY
- IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection
- (2009) I. Sereti et al. BLOOD
- Interleukin 7/interleukin 7 receptor induce c-Fos/c-Jun-dependent vascular endothelial growth factor-D up-regulation: A mechanism of lymphangiogenesis in lung cancer
- (2009) Jian Ming et al. EUROPEAN JOURNAL OF CANCER
- Interleukin-7 (IL-7) and IL-7 splice variants affect differentiation of human neural progenitor cells
- (2009) M Moors et al. GENES AND IMMUNITY
- Hepatic Interleukin-7 Expression Regulates T Cell Responses
- (2009) Yukihisa Sawa et al. IMMUNITY
- Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma
- (2009) Lara Cattaruzza et al. INTERNATIONAL JOURNAL OF CANCER
- CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia
- (2009) Sara González-García et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
- (2009) Yann M Kerdiles et al. NATURE IMMUNOLOGY
- AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines
- (2008) D. S. Levy et al. BLOOD
- BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3
- (2008) J. Nakayama et al. BLOOD
- Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
- (2008) Claude Sportès et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Interleukin-7 in rheumatoid arthritis
- (2008) S. M. Churchman et al. RHEUMATOLOGY
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