Article
Nutrition & Dietetics
Sinju Sundaresan, Connor Johnson, Kala B. Dixon, Michael Dole, Donna Kilkelly, Joseph Antoun, Charles Robb Flynn, Naji N. Abumrad, Robyn Tamboli
Summary: The study found that there are differences in duodenal nutrient sensing between obese and non-obese individuals, with obese individuals having a blunted response to nutrient infusion. Blocking vagal transmission affects nutrient sensing, hunger, and appetite in non-obese individuals, but has no additional effects in obese individuals.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Judit Companys, Maria Jose Gosalbes, Laura Pla-Paga, Lorena Calderon-Perez, Elisabet Llaurado, Anna Pedret, Rosa Maria Valls, Nuria Jimenez-Hernandez, Berner Andree Sandoval-Ramirez, Josep Maria del Bas, Antoni Caimari, Laura Rubio, Rosa Sola
Summary: The study identified specific gut microbiota composition associated with clinical variables and dietary intake in overweight/obese and lean subjects. Certain bacteria were found to be biomarkers for obesity, and the association between saturated fatty acids and different bacterial genera varied based on BMI, indicating potential tools for managing obesity through diet-microbiota interactions.
Article
Nutrition & Dietetics
Todd C. Rideout, Gabriella A. Andreani, Jillian Pembroke, Divya Choudhary, Richard W. Browne, Saleh Mahmood, Mulchand S. Patel
Summary: Increased consumption of dietary pulse protein can regulate body weight and improve metabolic health outcomes. Exchanging casein for yellow pea protein in a maternal diet during pregnancy and lactation can protect against obesity and dyslipidemia in offspring.
Article
Microbiology
Manal Ali Ahmad, Mirey Karavetian, Carole Ayoub Moubareck, Gabi Wazz, Tarek Mahdy, Koen Venema
Summary: This study found differences in gut microbiota composition between obese and lean adult Emiratis, as well as associations between certain microbial genera and obesity. These findings highlight the potential relationship between gut microbiota and obesity, and further research is warranted.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Debora Romualdo Lacerda, Albena Nunes-Silva, Ana Leticia Malheiros Silveira, Katia Anunciacao Costa, Debora Fernandes Rodrigues, Michele Macedo Moraes, Vanessa Pinho, Gustavo Batista Menezes, Mauro Martins Teixeira, Samuel Penna Wanner, Danusa Dias Soares, Adaliene Versiani Matos Ferreira
Summary: This study investigated the effect of acute exercise on the inflammatory response in adipose tissue of lean and obese mice. Acute exercise enhanced the levels of IL-6 and tumor necrosis factor-a in the adipose tissue of lean mice, while no changes were observed in proinflammatory cytokines in obese mice. However, the levels of IL-13, IL-4, and IL-10 were increased in obese mice after exercise. These findings suggest that acute exercise promotes an inflammatory response in adipose tissue of lean mice, but elicits an anti-inflammatory response in adipose tissue of obese mice.
Article
Nutrition & Dietetics
Daniela Fangmann, Corinna Geisler, Kristina Schlicht, Katharina Hartmann, Jana Koepke, Anika Tiede, Ute Settgast, Kathrin Tuerk, Dominik M. Schulte, Karina Altmann, Ingrid Clawin-Raedecker, Peter Ch Lorenzen, Stefan Schreiber, Karin Schwarz, Matthias Laudes
Summary: The study found that total nutritional protein intake is inversely associated with FGF-21 serum levels, while a purified and well-characterised oligopeptide is able to induce an increase in FGF-21 serum levels in humans. These findings indicate a differential role of various components of protein metabolism on FGF-21, rather than this factor solely being a sensor of total nutritional protein intake.
CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Christine Henke, Sven Haufe, Doreen Ziehl, Stefan R. Bornstein, Jeanette Schulz-Menger, Martin Heni, Stefan Engeli, Jens Jordan, Andreas L. Birkenfeld
Summary: This study identified weight loss through a low-fat diet as the first physiological intervention in humans to reduce NEP levels in plasma and adipose tissue, contributing to improved cardiac function in patients with heart failure.
Article
Endocrinology & Metabolism
Patricia Arroyo Tardio, Gabriela Baldini, Eleonora Seelig
Summary: High-calorie food intake causes an immediate and substantial cortisol response in both lean and obese subjects, independent of body weight. Contrary to the current literature, this study shows that obese individuals have a normal physiological cortisol response to food. The significant and prolonged increase in cortisol further supports the hypothesis that frequent high-calorie meals contribute to hypercortisolism and worsen weight gain.
ENDOCRINE CONNECTIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hannah Mulhall, Jeanne M. DiChiara, Olivier Huck, Salomon Amar
Summary: This study demonstrates that pasteurized A. muciniphila can counteract P. gingivalis-induced periodontal destruction and reduce inflammatory infiltrate.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Nutrition & Dietetics
Fernanda Duarte Moreira, Caio Eduardo Goncalves Reis, Alexis Fonseca Welker, Andrea Donatti Gallassi
Summary: This study found that consumption of 15g of ground raw golden flaxseed can reduce the 2-hour postprandial glycemic response in men with T2DM. Although flaxseed does not affect peak glucose time, palatability, and taste parameters, it effectively lowers the rise in peak glucose levels and the AUC glycemic response within two hours.
Article
Food Science & Technology
Gaelle Boudry, Ilario Mennella, Olivia Menard, Regis Janvier, Isabelle Nogret, Ashkan Madadlou, Armelle Cahu, Laurence Le Normand, Eric Bobillier-Chaumont, Rosalia Ferracane, Paola Vitaglione, Didier Dupont, David Val-Laillet
Summary: This study investigated the effect of OEA delivery kinetics on appetite suppression using different forms of dairy snacks. The results showed that liquid snacks containing OEA significantly reduced the amount of food consumed by minipigs, while semi-solid snacks did not have the same effect. Further experiments suggested that enhanced release of OEA in liquid snacks may affect endocannabinoid and other related metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Behavioral Sciences
Antonietta Robino, Natalia Rosso, Martina Guerra, Pio Corleone, Biagio Casagranda, Pablo J. Giraudi, Claudio Tiribelli, Catrin Simeth, Fabio Monica, Martina La Bianca, Paolo Gasparini, Nicolo de Manzini, Silvia Palmisano
Summary: The study found that obese patients perceive sweet and bitter tastes more intensely compared to normal-weight subjects, and there is a significant increase in the expression of TAS2R38 gene in the stomach of obese individuals.
Article
Biochemistry & Molecular Biology
Oscar J. Lara-Guzman, Diego A. Rivera, Vanessa Corrales-Agudelo, Laura Salazar-Jaramillo, Angel Gil-Izquierdo, Sonia Medina, Camille Oger, Thierry Durand, Jean-Marie Galano, Juan S. Escobar, Katalina Munoz-Durango, Jelver A. Sierra
Summary: Cardiometabolic disease risk factors are associated with elevated oxidative stress biomarkers. Gut microbiota dysbiosis may be linked to the intensity of oxidative metabolism. Urinary oxylipins could be specific biomarkers associated with BMI and are sensitive to be regulated by dietary antioxidants.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Yanqi Lan, Ying Lu, Jinfeng Li, Shiqi Hu, Shuohua Chen, Yanhong Wang, Xiaojie Yuan, Hongmin Liu, Xiaomo Wang, Shouling Wu, Li Wang
Summary: This study aimed to investigate the prognosis of lean nonalcoholic fatty liver disease (NAFLD) and found that individuals with this phenotype had a higher risk of all-cause death, digestive system cancers, and obesity-related cancers than other groups, but a lower risk of cardiovascular disease (CVD) than overweight/obese NAFLD subjects. LN subjects with hypertension may be a high-risk phenotype.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Biology
G. A. Ferreira, L. Wagner, R. Maziero, T. Ataide-Silva, N. A. Silva, R. Bertuzzi, A. E. Lima-Silva
Summary: Caffeine intake reduced sedentary time and increased light physical activity time among obese police officers, as well as improved their disposition towards physical activity.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Review
Urology & Nephrology
Carsten Leue, Joanna Kruimel, Desiree Vrijens, Adrian Masclee, Jim van Os, Gommert van Koeveringe
NATURE REVIEWS UROLOGY
(2017)
Article
Gastroenterology & Hepatology
Zlatan Mujagic, Daisy M. A. E. Jonkers, A. Pali S. Hungin, Niek J. de Wit, Knut-Arne Wensaas, Margaret Palka, Vico Leeters, Joanna W. Kruimel, Carsten Leue, Ad A. M. Masclee, Jean W. M. Muris
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2017)
Meeting Abstract
Gastroenterology & Hepatology
Marten H. Otten, Yvon Holierhoek, Fien Stellingwerf, Marieke Welters, Joanna W. Kruimel
Article
Gastroenterology & Hepatology
L. Vork, D. Keszthelyi, Z. Mujagic, J. W. Kruimel, C. Leue, I. Ponten, H. Tornblom, M. Simren, A. Albu-Soda, Q. Aziz, M. Corsetti, L. Holvoet, J. Tack, S. S. Rao, J. van Os, E. G. Quetglas, D. A. Drossman, A. A. M. Masclee
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Article
Gastroenterology & Hepatology
L. Vork, Z. Z. R. M. Weerts, Z. Mujagic, J. W. Kruimel, M. A. M. Hesselink, J. W. M. Muris, D. Keszthelyi, D. M. A. E. Jonkers, A. A. M. Masclee
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Article
Gastroenterology & Hepatology
Tim Klaassen, Fabienne G. M. Smeets, Lisa Vork, Jan Tack, Nicholas J. Talley, Magnus Simren, Qasim Aziz, Alexander C. Ford, Joanna W. Kruimel, Jose M. Conchillo, Carsten Leue, Adrian A. M. Masclee, Daniel Keszthelyi
Summary: This study demonstrated the good validity and reliability of a novel ESM-based PROM for assessing gastrointestinal symptoms in FD patients. The novel PROM allows evaluation of individual symptom patterns and interactions between symptoms and environmental/contextual factors. ESM has the potential to increase patients' disease insight, provide tools for self-management, and improve shared decision making, aiding in the transition toward personalized health care for FD patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Surgery
Gwen M. C. Masclee, Daniel Keszthelyi, Jose M. Conchillo, Joanna W. Kruimel, Nicole D. Bouvy, Ad A. M. Masclee
Summary: The efficacy and safety of sleeve gastrectomy and Roux-en-Y gastric bypass surgery were systematically evaluated in patients with refractory gastroparesis. Studies showed that both surgeries improved symptoms and gastric emptying in patients with refractory gastroparesis. These surgical interventions may be considered as an effective treatment option for a small group of patients when other therapies have failed.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Health Care Sciences & Services
Esther van Barneveld, Arianne Lim, Nehalennia van Hanegem, Frits van Osch, Lisa Vork, Joanna Kruimel, Marlies Bongers, Carsten Leue
Summary: This study aimed to evaluate the psychometric properties of an endometriosis-specific ESM tool. The results showed that the ESM tool had high validity and reliability for assessing symptoms in women with endometriosis.
JMIR FORMATIVE RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Fabienne G. M. Smeets, Denise Strijbos, Daniel Keszthelyi, Chantal Hoge, Joanna W. Kruimel, Jose M. Conchillo, Ad A. M. Masclee
GASTROINTESTINAL DISORDERS
(2019)
Meeting Abstract
Gastroenterology & Hepatology
E. Wilms, D. Jonkers, D. Keszthelyi, Z. Mujagic, L. Vork, Z. Z. Weerts, J. Kruimel, F. Troost, A. Masclee
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
F. Smeets, D. Keszthelyi, L. Vork, J. Tack, N. Talley, M. Simren, Q. Aziz, A. Ford, J. Conchillo, J. Kruimel, J. van Os, A. Masclee
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
L. Vork, Z. Mujagic, M. Drukker, D. Keszthelyi, J. Conchillo, M. Hesselink, J. van Os, A. Masclee, C. Leue, J. Kruimel
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
L. Vork, A. Masclee, B. Beckers, J. Conchillo, J. Kruimel, Q. Aziz, D. Keszthelyi
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Meeting Abstract
Urology & Nephrology
A. Herrewegh, D. Vrijens, J. Kruimel, C. Leue, G. van Koeveringe
NEUROUROLOGY AND URODYNAMICS
(2018)
Meeting Abstract
Urology & Nephrology
A. Herrewegh, L. Vork, C. Leue, J. Kruimel, G. van Koeveringe, D. Vrijens
NEUROUROLOGY AND URODYNAMICS
(2018)