Article
Public, Environmental & Occupational Health
Vittorio Gattini, Marco Napoletano, Alessandra Bonotti, Aldo Mignani, Francesca Cosentino, Giovanni Guglielmi, Poupak Fallahi, Alfonso Cristaudo, Rudy Foddis
Summary: In response to a meningococcal epidemic outbreak, there was a significant increase in demand for antimeningococcal vaccination among healthcare workers at the University Hospital of Pisa. A total of 41.1% of the population received the vaccine, with better compliance observed among women, older healthcare workers, those with lower educational qualifications, doctors, and healthcare workers in specific departments.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Immunology
Abigail Norris Turner, Alexandria Carter, Yih-Ling Tzeng, David S. Stephens, Morgan Brown, Brandon Snyder, Adam C. Retchless, Xin Wang, Jose A. Bazan
Summary: The study showed that urethral infection with the US_NmUC did not offer protection against gonorrhea despite high sequence similarity in shared protein antigens.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Biochemical Research Methods
Dmitry Ershov, Minh-Son Phan, Joanna W. Pylvanainen, Stephane U. Rigaud, Laure Le Blanc, Arthur Charles-Orszag, James R. W. Conway, Romain F. Laine, Nathan H. Roy, Daria Bonazzi, Guillaume Dumenil, Guillaume Jacquemet, Jean-Yves Tinevez
Summary: TrackMate is an automated tracking software that is used for analyzing bioimages. The new version, TrackMate 7, addresses modern research challenges by integrating advanced segmentation algorithms into tracking pipelines. This new version demonstrates its effectiveness across a wide range of bio-imaging experiments, combining machine and deep learning-based image segmentation with accurate object tracking for improved 2D and 3D tracking in biological research.
Article
Immunology
Lene Fogt Lundbo, Zitta Barrella Harboe, Hakon Sandholdt, Lars Smith-Hansen, Palle Valentiner-Branth, Steen Hoffmann, Thomas Benfield
Summary: A Danish case-control study found that certain comorbidities increased the risk of invasive meningococcal disease ranging from 2- to 40-fold. These comorbidities included renal disease, immunological disorders, liver disease, cancer, and solid organ transplantation. Vaccination and appropriate medical care may be necessary for these populations with increased risk.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Kathryn A. Matthias, Kristie L. Connolly, Afrin A. Begum, Ann E. Jerse, Andrew N. Macintyre, Gregory D. Sempowski, Margaret C. Bash
Summary: Recent studies have found that Neisseria meningitidis vaccines lacking specific proteins can provide protection against Neisseria gonorrhoeae infections in mice, and the antibodies produced can cross-react with N. gonorrhoeae. This finding supports the development of a cross-protective vaccine against Neisseria infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Eve Bernet, Marthe Lebughe, Antony T. Vincent, Mohammad Mehdi Haghdoost, Golara Golbaghi, Steven Laplante, Annie Castonguay, Frederic J. Veyrier
Summary: The study suggests that a boron-based salt, sodium tetraphenylborate (NaBPh4), displays high bactericidal activity against Neisseria meningitidis and Neisseria gonorrhoeae, with limited impact on closely related commensal species. The drug candidate's target(s) are likely located intracellularly or within the cell envelope, and mutants with decreased susceptibility show reduced virulence. This narrow selectivity of NaBPh4 is observed to have potential therapeutic importance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Chung Pham Van, The Trong Nguyen, Sy Tien Bui, Trong Van Nguyen, Huyen Thi Thanh Tran, Dong Trac Pham, Long Phi Trieu, Manh Dang Nguyen
Summary: This study described the prevalence, clinical features, and treatment outcomes of IMD among young soldiers of the Vietnam People's Army, and identified ceftriaxone resistance in Neisseria meningitidis. New recruits were found to be at higher risk of IMD, with prognostic factors for severity including petechial rash, septicemia, and meningococcemia.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Cell Biology
Simon Peters, Ingo Fohmann, Thomas Rudel, Alexandra Schubert-Unkmeir
Summary: Sphingolipids play crucial roles in cellular processes such as cell growth, apoptosis, inflammation, and migration, as well as in the occurrence of infectious diseases. Pathogens can manipulate sphingolipid metabolism to facilitate invasion and establish a favorable environment in the host. Additionally, certain sphingolipid metabolites can act as the first line of defense against microbes.
Article
Immunology
Sara Morselli, Valeria Gaspari, Alessia Cantiani, Melissa Salvo, Claudio Foschi, Tiziana Lazzarotto, Antonella Marangoni
Summary: The study found a negative association between Neisseria meningitidis and Neisseria gonorrhoeae in a cohort of men having sex with men, with meningococcal carriage being more common in younger individuals.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Freda E-C Jen, Jennifer L. Edwards, Ibrahim M. El-Deeb, Mark J. Walker, Mark von Itzstein, Michael P. Jennings
Summary: The ionophore PBT2, when used alone, has shown potential in killing both N.meningitidis and MDR N. gonorrhoeae, making it a candidate therapy for MDR N. gonorrhoeae infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Randa H. Ali, Mohamed E. Ali, Reham Samir
Summary: This study developed a novel chemical protocol to produce Neisseria meningitidis ghost vaccine. The vaccine candidate showed both safety and immunogenicity. In animal model, it induced a significantly higher humoral immune response and better serum bactericidal assay values compared to the commercial vaccine. However, clinical studies are needed to further evaluate its effectiveness.
Article
Microbiology
Elvis Achondou Akomoneh, Jolein Gyonne Elise Laumen, Said Abdellati, Christophe Van Dijck, Thibau Vanbaelen, Xavier Basil Britto, Sheeba S. Manoharan-Basil, Chris Kenyon
Summary: This study investigated the inhibitory effect of oropharyngeal microbiota and Listerine mouthwash on the growth of Neisseria gonorrhoeae and Neisseria meningitidis. It found that certain bacteria had inhibitory activity against these pathogens, but daily use of Listerine did not decrease their prevalence.
Review
Microbiology
Bethany L. Burns, Daniel D. Rhoads
Summary: Neisseria meningitidis is a common commensal bacterium that can also cause severe disease. The emergence of nonencapsulated N. meningitidis urethritis Glade (US_NmUC) in the United States has led to the challenge of diagnosing and distinguishing it from Neisseria gonorrhoeae. This review explores the history, emergence, diagnosis, and treatment of meningococcal urethritis.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Microbiology
Francesca Necchi, Giuseppe Stefanetti, Renzo Alfini, Elena Palmieri, Martina Carducci, Roberta Di Benedetto, Fabiola Schiavo, Maria Grazia Aruta, Fabiola Giusti, Ilaria Ferlenghi, Yun Shan Goh, Simona Rondini, Francesca Micoli
Summary: This study investigated the immune response differences in heterologous expression of Neisseria meningitidis factor H binding protein (fHbp) in the lumen of Salmonella Typhimurium GMMA. The results showed that formulating fHbp in O-antigen negative GMMA on Alum induced a weak anti-fHbp IgG response in mice. However, chemically conjugating fHbp on the surface of GMMA resulted in a stronger functional response.
Article
Infectious Diseases
Nichlas Hovmand, Lene Fogt Lundbo, Gitte Kronborg, Sidsel Skou Voss, Hakon Sandholdt, Steen Hoffmann, Palle Valentiner-Branth, Thomas Ben
Summary: In Denmark, the incidence of Neisseria meningitidis serogroup W has increased, with higher mortality compared to other serogroups. Age and manifestation are associated with increased risk of infection and death.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Maria C. Herrera, Pierre Chymkowitch, Joseph M. Robertson, Jens Eriksson, Stig Ove Boe, Ingrun Alseth, Jorrit M. Enserink
NUCLEIC ACIDS RESEARCH
(2018)
Article
Microbiology
Maria Letizia Di Martino, Viktor Ek, Wolf-Dietrich Hardt, Jens Eriksson, Mikael E. Sellin
Article
Cell Biology
Christopher von Beek, Ida Waern, Jens Eriksson, Fabio Rabelo Melo, Carl Robinson, Andrew S. Waller, Mikael E. Sellin, Bengt Guss, Gunnar Pejler
CELLULAR MICROBIOLOGY
(2019)
Article
Microbiology
Petra Geiser, Maria Letizia Di Martino, Pilar Samperio Ventayol, Jens Eriksson, Eduardo Sima, Anas Kh. Al-Saffar, David Ahl, Mia Phillipson, Dominic-Luc Webb, Magnus Sundbom, Per M. Hellstrom, Mikael E. Sellin
Summary: This study reveals the complete infection cycle of Salmonella enterica serovar Typhimurium within human and mouse enteroids, and demonstrates how bacterial invasion of the epithelium strongly fuels expansion in the luminal compartment through a mechanism involving the death and expulsion of bacterium-infected epithelial cells.
Article
Multidisciplinary Sciences
Pilar Samperio Ventayol, Petra Geiser, Maria Letizia Di Martino, Alexandra Florbrant, Stefan A. Fattinger, Naemi Walder, Eduardo Sima, Feng Shao, Nelson O. Gekara, Magnus Sundbom, Wolf-Dietrich Hardt, Dominic-Luc Webb, Per M. Hellstrom, Jens Eriksson, Mikael E. Sellin
Summary: The study found that infection with Salmonella Typhimurium triggers focal contractions in intestinal epithelial cells, which are initiated by the NAIP/NLRC4 inflammasome and can prevent infected cell death and expulsion, thereby protecting the integrity of the intestinal epithelium.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Allergy
Erika Mendez-Enriquez, Maya Salomonsson, Jens Eriksson, Christer Janson, Andrei Malinovschi, Mikael E. Sellin, Jenny Hallgren
Summary: It has been found that mast cell progenitors can be activated by IgE cross-linking, which may contribute to the development of acute allergic airway inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biology
Sabeen Survery, Fredrik Hurtig, Syed Razaul Haq, Jens Eriksson, Lionel Guy, K. Johan Rosengren, Ann-Christin Lindas, Celestine N. Chi
Summary: The study characterizes proteins of Heimdallarchaeeota LC3, a member of the Asgard superphylum, and specifically investigates heim-Profilin and heim-Actin, and their interactions with polyproline and phospholipids. The 3D-structure of Heimdallarchaeota LC3 profilin is determined. The results suggest the existence of a complex cytoskeleton in the last eukaryotic common ancestor, indicating an origin predating the rise of the eukaryotes.
COMMUNICATIONS BIOLOGY
(2021)
Article
Microbiology
Jorik M. van Rijn, Jens Eriksson, Jana Gruttner, Magnus Sundbom, Dominic-Luc Webb, Per M. Hellstrom, Staffan G. Svard, Mikael E. Sellin
Summary: Understanding the dynamic interactions between individual microbes and host cells is crucial for infectious disease research. A new method for live-cell imaging of microbial infection dynamics on human intestinal epithelial cell layers has been developed, providing insights into the behavior of Salmonella and Giardia pathogens.
Article
Cell Biology
Ignacio Garcia, Sara Orellana-Munoz, Lucia Ramos-Alonso, Aram N. Andersen, Christine Zimmermann, Jens Eriksson, Stig Ove Boe, Petra Kaferle, Manolis Papamichos-Chronakis, Pierre Chymkowitch, Jorrit M. Enserink
Summary: Cells use mechanisms to detect signals and respond, with Kel1 serving as a noise suppressor in the yeast pheromone pathway, preventing cell death by inhibiting membrane protein recruitment to prevent spontaneous activation of the pathway.
Article
Biochemistry & Molecular Biology
Viktor Ek, Stefan A. Fattinger, Alexandra Florbrant, Wolf-Dietrich Hardt, Maria Letizia Di Martino, Jens Eriksson, Mikael E. Sellin
Summary: This study utilized microscopy to investigate single-bacterium characteristics in Salmonella enterica serovar Typhimurium, revealing a gradual transition from fast planktonic growth to a host cell-invasive phenotype within the bacterial population and establishing a transient subpopulation of hyperinvasive doublet bacteria.
MOLECULAR MICROBIOLOGY
(2022)
Article
Cell Biology
Aida Paivandy, Jens Eriksson, Fabio Rabelo Melo, Mikael E. Sellin, Gunnar Pejler
CELL DEATH DISCOVERY
(2019)
Article
Biology
Sara Sigurlasdottir, Sunil D. Saroj, Olaspers Sara Eriksson, Jens Eriksson, Ann-Beth Jonsson
Article
Biology
Sara Sigurlasdottir, Olaspers Sara Eriksson, Jens Eriksson, Ann-Beth Jonsson
Article
Microbiology
Jorik M. van Rijn, Jens Eriksson, Jana Gruttner, Magnus Sundbom, Dominic-Luc Webb, Per M. Hellstrom, Staffan G. Svard, Mikael E. Sellin
Summary: The study focuses on dynamic interactions between pathogenic microbes and host tissues, utilizing live-cell microscopy to visualize microbe behavior on intestinal epithelial cell (IEC) layers. By imaging without fluorescent labels, the method provides high-resolution observation of Salmonella and Giardia interactions on the epithelial surface, revealing pathogen-specific swimming patterns and stages of infection cycles previously unrecognized. This relatively inexpensive approach bridges the divide between technical requirements for live-cell imaging and physiological infection niche parameters.
Article
Genetics & Heredity
Kristian Alfsnes, Stephan A. Frye, Jens Eriksson, Vegard Eldholm, Ola Bronstad Brynildsrud, Jon Bohlin, Odile B. Harrison, Derek W. Hood, Martin C. J. Maiden, Tone Tonjum, Ole Herman Ambur
MICROBIAL GENOMICS
(2018)