Review
Immunology
Wenting Li, Xiaobing Duan, Xingxing Chen, Meixiao Zhan, Haichuan Peng, Ya Meng, Xiaobin Li, Xian-Yang Li, Guofu Pang, Xiaohui Dou
Summary: Epstein-Barr virus (EBV) is the first tumor virus in humans, and nasopharyngeal carcinoma (NPC) accounts for 60% of new tumor cases caused by EBV worldwide annually. Over 90% of patients with undifferentiated NPC are infected with EBV. Immunotherapy has shown significant breakthroughs in the treatment of recurrent or metastatic NPC, providing a broad prospect for NPC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiao Guan, Dan Yu, Mengjie HuangFu, Zhiyi Huang, Tong Dou, Yisa Liu, Luwei Zhou, Xumei Li, Lin Wang, Haiping Liu, Juan Wang, Xu Chen
Summary: The study demonstrated that curcumol inhibits invasion and metastasis of EBV-positive NPC cells by targeting NCL, which further regulates related signaling pathways, providing a new pharmacological basis for clinical treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Otorhinolaryngology
Yue Yuan, Fei Ye, Jian-Hui Wu, Xiao-Yan Fu, Zhong-Xi Huang, Tao Zhang
Summary: This paper reviews recent advances in early screening for nasopharyngeal carcinoma (NPC) and cell-free DNA (cfDNA) methylation, highlighting the low positive predictive value (PPV) of current screening methods and the potential of combining cfDNA methylation analysis with Epstein-Barr virus (EBV) serological testing to improve PPV.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Kelly J. Yu, Wan-Lun Hsu, Chun-Ju Chiang, Tseng-Cheng Chen, Zhiwei Liu, Pei-Jen Lou, Scott Diehl, Alisa M. Goldstein, Chien-Jen Chen, Cheng-Ping Wang, Allan Hildesheim
Summary: This study reassessed familial aggregation of cancer in high-risk Taiwanese multiplex families with NPC cases and found evidence of NPC coaggregation within families, but not a broader familial syndrome involving NPC and other tumors. The study also observed elevated rates of secondary cancers among NPC cases, mostly head and neck and hematopoietic cancers, suggesting radiation treatment effects on subsequent cancer risk.
Review
Microbiology
Ana Banko, Danijela Miljanovic, Ivana Lazarevic, Andja Cirkovic
Summary: This study investigated the connection between LMP1 gene variability and NPC development, finding an association between 30bp deletion and Xhol loss with NPC susceptibility, but 30bp deletion could not distinguish NPC from EBV-associated non-NPC tumors. Certain EBV variants were rare in NPC individuals, signaling the need for further research to verify the biological significance of these differences.
Article
Oncology
Jin-Hao Yang, Xue-Song Sun, Bei-Bei Xiao, Li-Ting Liu, Shan-Shan Guo, Jia-Dong Liang, Guo-Dong Jia, Lin-Quan Tang, Qiu-Yan Chen, Hai-Qiang Mai
Summary: Risk stratification of dmNPC may serve as a new prognostic factor for individualized LRRT treatment, potentially improving survival outcomes of patients. Through multivariate analysis, three independent prognostic factors were identified, with LRRT showing ability to improve OS in low- and intermediate-risk subgroups.
Review
Oncology
Oscar Emanuel, Jacklyn Liu, Volker H. Schartinger, Wen Long Nei, Yuk Yu Chan, Chi Man Tsang, Herbert Riechelmann, Liam Masterson, Johannes Haybaeck, Udo Oppermann, Stefan M. Willems, Marc L. Ooft, Guido Wollmann, David Howard, Bart Vanhaesebroeck, Valerie J. Lund, Gary Royle, Melvin L. K. Chua, Kwok Wai Lo, Pierre Busson, Matt Lechner
Summary: Nasopharyngeal carcinoma is a malignant epithelial tumor primarily found in Asia and associated with poor outcomes when detected at a late stage. Treatment options mainly include radiotherapy and chemotherapy, which can have significant side effects. Recent advances in understanding the molecular biology of the disease have highlighted the potential of somatostatin receptor 2 as a key tumor biomarker and target for improved diagnosis and therapy.
Article
Oncology
Hirotomo Dochi, Satoru Kondo, Shigetaka Komura, Makiko Moriyama-Kita, Takeshi Komori, Asuka Nanbo, Miako Sakaguchi, Masaki Fukuyo, Toshihide Hamabe-Horiike, Mariko Tanaka, Harue Mizokami, Makoto Kano, Yuki Kitagawa, Eiji Kobayashi, Nobuyuki Hirai, Takayoshi Ueno, Yosuke Nakanishi, Kazuhira Endo, Hisashi Sugimoto, Rikinari Hanayama, Atsushi Kaneda, Tomokazu Yoshizaki
Summary: This study reveals a mechanism by which EBV upregulates SPARC expression in NPC cells, creating a pro-metastatic microenvironment. The study also demonstrates the prognostic value of SPARC expression in the adjacent tissues of NPC. Furthermore, the study shows that EBV-positive NPC cells induce SPARC expression in normal nasopharyngeal cells via exosomes, promoting tumor cell invasion and metastasis.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Cell Biology
Panagiota Economopoulou, Anastasios Pantazopoulos, Aris Spathis, Ioannis Kotsantis, Anastasios Kyriazoglou, George Kavourakis, Roubini Zakopoulou, Ioannis Chatzidakis, Maria Anastasiou, Maria Prevezanou, Carlo Resteghini, Lisa Licitra, Cristiana Bergamini, Elena Colombo, Francesca Caspani, Nerina Denaro, Stefania Vecchio, Pierluigi Bonomo, Maria Cossu Rocca, Federica Bertolini, Daris Ferrari, Amanda Psyrri, Paolo Bossi
Summary: The study collected data from Greece and Italy to investigate the efficacy and safety of immunotherapy in patients with recurrent/metastatic NPC in two nonendemic regions. The results showed an overall response rate of 26.2% and highlighted the association between low disease burden and favorable response to treatment.
Article
Otorhinolaryngology
Ronald Lai, David Chun Man Yeung, Zenon Wing Chi Yeung, Thomas Sin Chun Hui, Wai Kei Jacky Lam, Kwan Chee Allen Chan, Cherrie Wing Kei Ng, Zion Wing Hei To, Ryan Hung Wai Cho, Catherine Po Ling Chan, Calvin Chee Fung Lai, Natalie Moon Wah Leung, Eddy Wai Yeung Wong, Joseph Chun Kit Chung, Raymond King Yin Tsang, Kenneth Wing Sum Li, James Chung Hang Chow, Ken Ka Man Cheung, Jason Y. K. Chan
Summary: This study evaluated the sensitivities and specificities of Epstein-Barr virus (EBV) DNA in detecting locally recurrent or persistent nasopharyngeal carcinoma (NPC) through nasopharyngeal (NP) brush biopsy and plasma, and investigated whether a combination of both tests would yield better results. The combined modalities had a sensitivity of 84.62%, specificity of 85.19%, positive predictive value of 73.33%, and negative predictive value of 92.0%. In conclusion, the combination of NP brush biopsy and plasma EBV DNA could be an additional surveillance method for detecting local recurrence of NPC.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Microbiology
Kina Kase, Satoru Kondo, Naohiro Wakisaka, Hirotomo Dochi, Harue Mizokami, Eiji Kobayashi, Makoto Kano, Takeshi Komori, Nobuyuki Hirai, Takayoshi Ueno, Yosuke Nakanishi, Miyako Hatano, Kazuhira Endo, Makiko Moriyama-Kita, Hisashi Sugimoto, Tomokazu Yoshizaki
Summary: The study found that LMP1 can induce the expression of sPD-L1 and PD-L1 in vitro and that the expression of LMP1 is significantly correlated with PD-L1 in NPC patients. Additionally, the serum level of sPD-L1 in NPC patients was higher than in controls, particularly in advanced stage patients. However, the expression of LMP1, PD-L1, and sPD-L1 levels were not associated with prognosis.
Article
Cell Biology
Xiandong Lin, Steven Wang, Keyu Lin, Jingfeng Zong, Qianlan Zheng, Ying Su, Tao Huang
Summary: This study investigated the roles of microRNAs and circular RNAs in Nasopharyngeal Carcinoma (NPC) by constructing a circRNA-miRNA-mRNA co-expression network and performing differential expression analysis. The Epstein-Barr virus (EBV) infection was found to be an important risk factor for NPC, with potential pathological differences between EBV+ and EBV- subtypes. The study identified differentially expressed coding and non-coding RNAs across different comparison groups, helping to elucidate genetic and epigenetic changes central to NPC progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Tingting Yang, Chanping You, Shuhui Meng, Zhengquan Lai, Weipeng Ai, Jun Zhang
Summary: Viral oncogenes can modulate cellular metabolic reprogramming to drive malignant transformation of normal epithelia cells. Understanding the dysregulation of viral oncogene-mediated signaling transduction in metabolic reprogramming may offer new therapeutic targets for virus-associated cancer treatment. This review focuses on elucidating how EBV infection and its encoded oncoproteins alter metabolic reprogramming to promote malignancy, and provides a new perspective on the interplay between EBV infection and metabolic pathways, offering a potential therapeutic intervention strategy for EBV-associated malignant diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Xiao-Hui Zheng, Xi-Zhao Li, Ting Zhou, Cheng-Tao Jiang, Cao-Li Tang, Chang-Mi Deng, Ying Liao, Yong-Qiao He, Tong-Min Wang, Wei-Hua Jia
Summary: Detecting EBV DNA load in nasopharyngeal brushing samples has attracted attention for the diagnosis of nasopharyngeal carcinoma. The diagnostic performance of EBV DNA methylation is less affected by brush sampling methods, showing great potential for the diagnosis of NPC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Xue-Song Sun, Jian-Wei Wang, Feng Han, Ru-Hai Zou, Zhen-Chong Yang, Shan-Shan Guo, Li-Ting Liu, Qiu-Yan Chen, Lin-Quan Tang, Hai-Qiang Mai
Summary: The stiffness of metastatic cervical lymph nodes is closely associated with the prognosis of patients with nasopharyngeal carcinoma. High CLN stiffness is linked to lower distant metastasis-free survival and progression-free survival. CLN stiffness and pretreatment EBV DNA are identified as independent prognostic factors for NPC patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
X. Meng, A. Vander Ark, P. Lee, G. Hostetter, N. A. Bhowmick, L. M. Matrisian, B. O. Williams, C. K. Miranti, X. Li
Article
Oncology
Xiangqi Meng, Alexandra Vander Ark, Paul Daft, Erica Woodford, Jie Wang, Zachary Madaj, Xiaohong Li
Article
Oncology
Wen Ye, Shaoping Ling, Ran-Yi Liu, Zhi-Zhong Pan, Gaoyuan Wang, Shijuan Gao, Jiangxue Wu, Lihua Cao, Lili Dong, Yingchang Li, Yi Zhou, Wuying Du, Xiangqi Meng, Jinna Chen, Xinyuan Guan, Yulong He, Changchuan Pan, X. F. Steven Zheng, Xuemei Lu, Shuai Chen, Wenlin Huang
JOURNAL OF PATHOLOGY
(2018)
Article
Oncology
Hui Wang, Jiangxue Wu, Xiangqi Meng, Xiaofang Ying, Yufang Zuo, Ranyi Liu, Zhizhong Pan, Tiebang Kang, Wenlin Huang
Article
Oncology
Hongyan Yu, Wen Ye, Jiangxue Wu, Xiangqi Meng, Ran-Yi Liu, Xiaofang Ying, Yi Zhou, Hui Wang, Changchuan Pan, Wenlin Huang
CLINICAL CANCER RESEARCH
(2014)
Article
Gastroenterology & Hepatology
Xiangqi Meng, Jiangxue Wu, Changchuan Pan, Hui Wang, Xiaofang Ying, Yi Zhou, Hongyan Yu, Yufang Zuo, Zhizhong Pan, Ran-Yi Liu, Wenlin Huang
Article
Oncology
Xiaofang Ying, Jiangxue Wu, Xiangqi Meng, Yufang Zuo, Qing Xia, Jinou Chen, Yanfen Feng, Ranyi Liu, Liren Li, Wenlin Huang
Article
Biochemistry & Molecular Biology
Yi Zhou, Jiangxue Wu, Xiang Fu, Wuying Du, Ling Zhou, Xiangqi Meng, Hongyan Yu, Jiaxin Lin, Wen Ye, Jiani Liu, Hui Peng, Ran-Yi Liu, Changchuan Pan, Wenlin Huang
Article
Multidisciplinary Sciences
Hongyan Yu, Xiangqi Meng, Jiangxue Wu, Changchuan Pan, Xiaofang Ying, Yi Zhou, Ranyi Liu, Wenlin Huang
Article
Oncology
Sourik S. Ganguly, Paul G. Daft, Jingchen Cao, Xiangqi Meng, Zhendong A. Zhong, Alexandra Vander Ark, Austin Meadows, Zach Madaj, Bart Williams, Xiaohong Li
Article
Oncology
Hongyan Yu, Mingxu Xie, Zhaoyue Meng, Chun-Yin Lo, Franky Leung Chan, Liwen Jiang, Xiangqi Meng, Xiaoqiang Yao
Summary: Prostate cancer (Pca) is the most common cancer type among males worldwide, with dysregulation of Ca2+ signaling playing important roles during Pca progression. In this study, it was found that MCOLN2 expression is significantly elevated in Pca tissues, promoting Pca development through the IL-1 beta/NF-kappa B pathway. Targeting MCOLN2 could be a potential therapeutic strategy in Pca treatment.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Xiangqi Meng, Jingxuan Peng, Xiaoshan Xie, Fenghai Yu, Wencong Wang, Qihao Pan, Huilin Jin, Xiaoling Huang, Hongyan Yu, Shengrong Li, Dianying Feng, Qingxin Liu, Lekun Fang, Mong-Hong Lee
Summary: This study reveals that the highly expressed long non-coding RNA LVBU in colorectal cancer cells promotes tumor growth and development by regulating the BCL6-p53 signaling pathway, which in turn affects urea cycle and polyamine synthesis.