OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer

OTUB1 modulates c-IAP1 stability to regulate signalling pathways

(2013) Tatiana Goncharov et al.   EMBO JOURNAL

Genetic and Epigenetic Down-regulation of MicroRNA-212 Promotes Colorectal Tumor Metastasis via Dysregulation of MnSOD

(2013) Xiangqi Meng et al.   GASTROENTEROLOGY

A Survival Analysis of the Liver-First Reversed Management of Advanced Simultaneous Colorectal Liver Metastases

(2012) Axel Andres et al.   ANNALS OF SURGERY

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Genetic disruption of USP9X sensitizes colorectal cancer cells to 5-fluorouracil

(2012) Dennis R. Harris et al.   CANCER BIOLOGY & THERAPY

E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions

(2012) Patrícia Carneiro et al.   FEBS LETTERS

Molecular Basis of Lys-63-linked Polyubiquitination Inhibition by the Interaction between Human Deubiquitinating Enzyme OTUB1 and Ubiquitin-conjugating Enzyme UBC13

(2012) Yusuke Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

(2012) Yu-Chi Juang et al.   MOLECULAR CELL

The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer

(2012) X Li et al.   ONCOGENE

Overexpression of ZEB2 in Peritumoral Liver Tissue Correlates with Favorable Survival after Curative Resection of Hepatocellular Carcinoma

(2012) Mu-Yan Cai et al.   PLoS One

MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1

(2011) Hui Wang et al.   CARCINOGENESIS

E-Cadherin and the Cytoskeletal Network in Colorectal Cancer Development and Metastasis

(2011) Andrea Buda et al.   CELL COMMUNICATION AND ADHESION

Vimentin in cancer and its potential as a molecular target for cancer therapy

(2011) Arun Satelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

(2011) Xiao-Xin Sun et al.   EMBO JOURNAL

Role of the recently identified dysadherin in E-cadherin adhesion molecule downregulation in head and neck cancer

(2011) Alexandros Georgolios et al.   MEDICAL ONCOLOGY

Shifting trends in liver-directed management of patients with colorectal liver metastasis: A population-based analysis

(2011) Skye C. Mayo et al.   SURGERY

When cleavage is not attractive: Non-catalytic inhibition of ubiquitin chains at DNA double-strand breaks by OTUB1

(2010) Andrew N. Blackford et al.   DNA REPAIR

Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer

(2010) Yan-Long Liu et al.   JOURNAL OF SURGICAL ONCOLOGY

Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci

(2010) Marianne Berg et al.   Molecular Cancer

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

(2010) Shinichiro Nakada et al.   NATURE

NF-ĸB and Bcl-3 Activation Are Prognostic in Metastatic Colorectal Cancer

(2010) Soham D. Puvvada et al.   ONCOLOGY

Molecular mechanisms controlling E-cadherin expression in breast cancer

(2009) Somesh Baranwal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer

(2009) Otto Schmalhofer et al.   CANCER AND METASTASIS REVIEWS

Evidence for Bidentate Substrate Binding as the Basis for the K48 Linkage Specificity of Otubain 1

(2009) Tao Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

PIK3CA alterations in Middle Eastern ovarian cancers

(2009) Jehad Abubaker et al.   Molecular Cancer

Structural basis and specificity of human otubain 1-mediated deubiquitination

(2008) Mariola J. Edelmann et al.   BIOCHEMICAL JOURNAL