Article
Biochemistry & Molecular Biology
Jing Zhang, Maarten van Dinther, Midory Thorikay, Babak Mousavi Gourabi, Boudewijn P. T. Kruithof, Peter ten Dijke
Summary: Ubiquitin-specific protease (USP)19 is a deubiquitinating enzyme that regulates protein stability and function, with its alternative splicing resulting in two major variants localized to the endoplasmic reticulum and cytoplasm. USP19-CY promotes TGF-beta signaling by interacting with the TGF-beta type I receptor and preventing its degradation at the plasma membrane, while USP19-ER sequesters the receptor in the ER and inhibits TGF-beta/SMAD signaling. Increased USP19-CY expression is associated with poor prognosis and higher levels in breast cancer tissues, where it enhances epithelial-mesenchymal transition and cell migration. Modulating USP19 splicing or deubiquitinating activity may hold therapeutic potential for breast cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Roland Abi Nahed, Maya Elkhoury Mikhael, Deborah Reynaud, Constance Collet, Nicolas Lemaitre, Thierry Michy, Pascale Hoffmann, Frederic Sergent, Christel Marquette, Padma Murthi, Tiphaine Raia-Barjat, Nadia Alfaidy, Mohamed Benharouga
Summary: NLRP7 gene is overexpressed in gestational choriocarcinoma (CC) and may contribute to cancer cells' tolerance to the maternal immune system through regulating immune tolerance-related factors and promoting cell proliferation while inhibiting differentiation.
Article
Obstetrics & Gynecology
Yiran Zhao, Yajie Zhu, Xi Chen, Hui Lin, Ningxin Qin, Zhiyang Zhou, Han Liu, Yanhui Hao, Chengliang Zhou, Xinmei Liu, Li Jin, Jianzhong Sheng, Hefeng Huang
Summary: The investigation of innate lymphoid cells (ILCs) has revealed their significance in successful pregnancy. This study showed that the proportion and distribution of circulating ILC subsets in peripheral blood changed dynamically during pregnancy. Late-pregnant women displayed a significantly higher proportion of circulating ILCs, mainly ILC2s, while ILC3s were decreased. Plasma progesterone and estradiol levels increased as pregnancy proceeded and were consistent with the expression of their receptors in ILC2s.
REPRODUCTIVE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Benjamin Edginton-White, Constanze Bonifer
Summary: The development of multicellular organisms involves differential usage of genetic information to generate various cell types that form specialized tissues. A shift from studying single genes to a global view of gene expression control has revolutionized our understanding of gene functions and cell communication. The paradigm of blood cell development highlights how transcription factors and chromatin components work together in shaping gene regulatory networks and driving differentiation, as well as how this process is altered in blood cancers. Emerging concepts place these processes within subnuclear structures, adding another layer of control to differential gene expression.
Article
Biochemistry & Molecular Biology
Kinga Wilkus, Klaudia Brodaczewska, Arkadiusz Kajdasz, Claudine Kieda
Summary: The study found significant differences in protein expression, differentiation status, adhesion properties, and barrier formation of endothelial cells derived from tumors compared to normal tissues. Functional assays revealed impaired angiogenesis and increased permeability in tumor-derived endothelial cells, along with enhanced VEGF production in response to hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Zhenya Tan, Chen Kan, Mandy Wong, Minqiong Sun, Yakun Liu, Fan Yang, Siying Wang, Hong Zheng
Summary: The bone marrow microenvironment plays a crucial role in both normal hematopoietic stem cells and pathological leukemic stem cells. Mesenchymal stem cells (MSCs) are particularly involved in leukemia progression, chemoresistance, and relapse. The abnormal behavior of MSCs can contribute to the initiation and development of leukemia. This article summarizes the detailed relationship between MSCs and leukemia, including how MSCs actively and passively regulate leukemia progression through various mechanisms. The recent advances in therapy targeting MSCs are also discussed, aiming to provide new perspectives and therapeutic strategies for leukemia treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Philip S. Robinson, Laura E. Thomas, Federico Abascal, Hyunchul Jung, Luke M. R. Harvey, Hannah D. West, Sigurgeir Olafsson, Bernard C. H. Lee, Tim H. H. Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A. Sanders, Stefanie Lensing, Simon J. A. Buczacki, Rogier Ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J. Campbell, Inigo Martincorena, Julian R. Sampson, Michael R. Stratton
Summary: Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic MUTYH mutations cause predisposition to colorectal adenomas and carcinoma. The authors sequenced normal tissue DNAs from patients with MUTYH-Associated Polyposis (MAP) and found elevated somatic base substitution mutation rates in intestinal epithelial cells, leading to an increased cancer risk.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Lashanale Wallace, Esther A. Obeng
Summary: Hematopoiesis is a crucial process for organismal development and homeostasis, and epigenetic regulation plays a critical role in normal hematopoiesis. Imbalance between self-renewal and cell fate decisions can lead to hematologic diseases, and targeted therapies against epigenetic regulators have shown promising outcomes in hematological malignancy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Immunology
Chih-Hang Anthony Tang, Avery C. Lee, Shiun Chang, Qin Xu, Andong Shao, Yun Lo, Walker T. Spalek, Javier A. Pinilla-Ibarz, Juan R. Del Valle, Chih-Chi Andrew Hu
Summary: STING plays a role in negatively regulating BCR signaling in B cells, leading to reduced response to BCR activation; both expression level and deficiency of STING can impact B cell function and antigen response.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Young Yeon Kim, Jee-Hyun Um, Dong Jin Shin, Dae Jin Jeong, Young Bin Hong, Jeanho Yun
Summary: The tumor suppressor p53 regulates mitochondrial dynamics through the PKA-Drp1 pathway, inducing cellular senescence in various cancer and normal cells. It plays an essential role in H-Ras-induced cellular senescence and replicative senescence in normal human cells. Inhibition of PKA activity reduces mitochondrial elongation and cellular senescence in late-passage normal cells, highlighting the importance of the p53-PKA pathway in maintaining the senescence phenotype.
Article
Oncology
Chaoqun Ma, Dingyuan Tu, Qiang Xu, Yan Wu, Xiaowei Song, Zhifu Guo, Xianxian Zhao
Summary: This study reveals a close correlation between m(7)G RNA modification and immune microenvironment in the development of heart failure. It identifies a five-gene m(7)G regulator diagnostic signature and three m(7)G methylation-associated hub genes, providing new insights into the mechanisms and treatments of heart failure.
CLINICAL EPIGENETICS
(2023)
Article
Multidisciplinary Sciences
Mara Fornasarig, Alessandra Capuano, Stefania Maiero, Eliana Pivetta, Giovanni Guarnieri, Vincenzo Canzonieri, Antonella Zucchetto, Maurizio Mongiat, Renato Cannizzaro, Paola Spessotto
Summary: This study utilized pCLE technique to analyze the vascular features in patients with autoimmune gastritis and early gastric cancer, identifying distinct patterns and suggesting that vascular alterations may contribute to carcinogenesis. The report indicates that pCLE is an effective endoscopic approach for assessing vascular changes in patients with malignant lesions or at high risk for gastric cancer.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Selvakumar Anbalagan, Cecilia Stroem, Jessica A. Downs, Penny A. Jeggo, David McBay, Anna Wilkins, Kai Rothkamm, Kevin J. Harrington, John R. Yarnold, Navita Somaiah
Summary: The study suggests that sensitivity to radiotherapy fraction size is dependent on the presence of wild-type p53 and intact non-homologous end-joining. Cells with WT p53 demonstrate split-dose recovery, while NHEJ-deficient cells lack this recovery ability.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Alessandra Gentilini, Giulia Lori, Alessandra Caligiuri, Chiara Raggi, Giovanni Di Maira, Mirella Pastore, Benedetta Piombanti, Tiziano Lottini, Annarosa Arcangeli, Stefania Madiai, Nadia Navari, Jesus M. Banales, Sabina Di Matteo, Domenico Alvaro, Lea Duwe, Jesper B. Andersen, Alessandro Tubita, Ignazia Tusa, Luca Di Tommaso, Claudia Campani, Elisabetta Rovida, Fabio Marra
Summary: This study revealed the important role of ERK5 in the growth and migration of CCA cells, as well as its involvement in the protumorigenic crosstalk between the tumor and the microenvironment.
Review
Biochemistry & Molecular Biology
Hadia Farrukh, Nader El-Sayes, Karen Mossman
Summary: PD-1/PD-L1 axis is a key focus in cancer research, with research revealing its role in suppressing cytotoxic T-cell killing. While ICB therapy is effective in some patients, lack of immunogenicity in the TME renders it ineffective in many.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Philippe A. Bilodeau, Erin S. Coyne, Simon S. Wing
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2016)
Article
Medicine, Research & Experimental
Derek T. Hall, Takla Griss, Jennifer F. Ma, Brenda Janice Sanchez, Jason Sadek, Anne Marie K. Tremblay, Souad Mubaid, Amr Omer, Rebecca J. Ford, Nathalie Bedard, Arnim Pause, Simon S. Wing, Sergio Di Marco, Gregory R. Steinberg, Russell G. Jones, Imed-Eddine Gallouzi
EMBO MOLECULAR MEDICINE
(2018)
Article
Multidisciplinary Sciences
Ken-ichiro Tanaka, Yingben Xue, Loan Nguyen-Yamamoto, John A. Morris, Ippei Kanazawa, Toshitsugu Sugimoto, Simon S. Wing, J. Brent Richards, David Goltzman
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biochemistry & Molecular Biology
Thomas M. Kitzler, Joan Papillon, Julie Guillemette, Simon S. Wing, Andrey V. Cybulsky
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2012)
Article
Reproductive Biology
Nathalie Bedard, Yaoming Yang, Mary Gregory, Daniel G. Cyr, Joao Suzuki, Xiaomin Yu, Ri-Cheng Chian, Louis Hermo, Cristian O'Flaherty, Charles E. Smith, Hugh J. Clarke, Simon S. Wing
BIOLOGY OF REPRODUCTION
(2011)
Article
Oncology
Francis Robert, John R. Mills, Aouod Agenor, Dantong Wang, Sergio DiMarco, Regina Cencic, Michel L. Tremblay, Imed Eddine Gallouzi, Siegfried Hekimi, Simon S. Wing, Jerry Pelletier
Review
Medical Laboratory Technology
Simon S. Wing, Stewart H. Lecker, R. Thomas Jagoe
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2011)
Review
Biochemistry & Molecular Biology
Simon S. Wing
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Thomas M. Durcan, Maria Kontogiannea, Nathalie Bedard, Simon S. Wing, Edward A. Fon
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Yu Lu, Olasunkanmi A. J. Adegoke, Alain Nepveu, Keiichi I. Nakayama, Nathalie Bedard, Dongmei Cheng, Junmin Peng, Simon S. Wing
MOLECULAR AND CELLULAR BIOLOGY
(2009)
Article
Multidisciplinary Sciences
Rohini Bose, Kai Sheng, Adel R. Moawad, Gurpreet Manku, Cristian O'Flaherty, Teruko Taketo, Martine Culty, Kin Lam Fok, Simon S. Wing
SCIENTIFIC REPORTS
(2017)
Article
Endocrinology & Metabolism
Erin S. Coyne, Nathalie Bedard, Ying Jia Gong, May Faraj, Andre Tchernof, Simon S. Wing
Article
Geriatrics & Gerontology
Anne-Julie Tessier, Simon S. Wing, Elham Rahme, Jose A. Morais, Stephanie Chevalier
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2019)
Review
Biochemistry & Molecular Biology
Olasunkanmi A. J. Adegoke, Brendan E. Beatty, Scot R. Kimball, Simon S. Wing
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2019)