Article
Cell Biology
Wenhua Su, Liwen Liang, Liang Zhou, Yu Cao, Xiuli Zhou, Shiqi Liu, Qian Wang, Hong Zhang
Summary: This study identified a crucial gene, LILRB2, associated with the progression of peripheral atherosclerotic disease (PAD) through bioinformatics analysis. The role of this gene in PAD was validated using a mouse model.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Felecia M. Marottoli, Troy N. Trevino, Xue Geng, Zarema Arbieva, Pinal Kanabar, Mark Maienschein-Cline, James C. Lee, Sarah E. Lutz, Leon M. Tai
Summary: The study focused on how the APOE genotype of brain endothelial cells affects their phenotype, revealing that APOE4 cells produce less apoE, have altered gene expression profiles, and prefer oxidative phosphorylation. APOE4 cells also showed higher mitochondrial activity, leading to increased reactive oxygen species, inflammation, and oxidative damage. Treatment with a Rev-Erb agonist improved metabolic markers, lowered inflammation, and modulated permeability in APOE4 cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Juan Ma, Hui-Min Ma, Meng-Qi Shen, Yuan Yuan Wang, Yu-Xin Bao, Yong Liu, Ya Ke, Zhong-Ming Qian
Summary: The role of iron in atherosclerosis remains controversial, but this study suggests that an increase in iron content in aortic tissues may contribute to ApoE deficiency-induced atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Baranca Buijsers, Marjolein Garsen, Mark de Graaf, Marinka Bakker-van Bebber, Chunming Guo, Xue Li, Johan van der Vlag
Summary: The study explores the therapeutic potential of inhibiting the endothelial glycocalyx degrading enzyme HPSE1 in kidney diseases. It suggests that HPSE2, a structural homolog of HPSE1 without enzymatic activity, could be a promising HPSE1 inhibitor. The downregulation of HPSE2 under inflammatory and diabetic conditions, and the protective effect of HPSE2 in experimental glomerular diseases support the notion that HPSE2 could be used as a therapeutic strategy for glomerular diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Ying-Shu Liu, Qin Yang, Shen Li, Lan Luo, Hong-Yang Liu, Xin-Yu Li, Zheng-Nan Gao
Summary: The study showed that Lut can alleviate AngII-induced renal damage, including inhibiting fibrosis and inflammation, and promoting autophagy.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Peripheral Vascular Disease
Jessica L. Faulkner, Derrian Wright, Galina Antonova, Iris Z. Jaffe, Simone Kennard, Eric J. Belin de Chantemele
Summary: This study found that leptin infusion in midgestation induces endothelial dysfunction, hypertension, and fetal growth restriction in pregnant mice, which can be prevented by ECMR deletion.
Article
Biochemistry & Molecular Biology
Ping-Hsuan Tsai, Li-Zhen Chen, Kuo-Feng Tseng, Fang-Yu Chen, Ming-Yi Shen
Summary: In this study, the effects of ApoC3rich low-density lipoprotein (AC3RL) and the role of FBXO31 in endothelial cell (EC) senescence and atherosclerosis were investigated, as well as the inhibitory effects of sesamol. The results showed that AC3RL induced EC senescence through DNA damage, but silencing FBXO31 attenuated this effect. Moreover, sesamol was found to significantly reduce atherosclerotic lesions in hamsters fed a high-fat diet.
Article
Medicine, Research & Experimental
Jingjing Xu, Yujie Guo, Xiaochen Huang, Xiaojun Ma, Pengfei Li, Ying Wang, Xixiang Wang, Linhong Yuan
Summary: Deletion of ApoE gene results in lipid metabolic disorder in mouse liver. DHA intervention effectively ameliorates lipid metabolism caused by ApoE deficiency through regulating gene and protein expressions of molecules involved in liver fatty acids transport and lipid metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Agriculture, Multidisciplinary
Wenjing Huang, Zhujun Zeng, Yan Lang, Xia Xiang, Gaofu Qi, Gan Lu, Xiangliang Yang
Summary: The study found that Cannabis seed oil can exert anti-atherosclerotic effects by improving lipid profiles and inflammatory responses, protecting endothelial cell integrity, and reducing arterial lipid deposition.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yuwen Shi, Mengcheng Jiang, Yuhang Zhang, Yuanyuan Diao, Na Li, Weipeng Liu, Zhidong Qiu, Ye Qiu, Ailing Jia
Summary: This study prepared hybrid nanomicelles containing hyperoside and evaluated their effects on atherosclerosis. The results showed that these nanomicelles reduced the aortic plaque area, lowered lipid levels, decreased inflammatory factors, and improved gut bacteria. The nanomicelles also regulated gut flora and lipid metabolism, and inhibited inflammatory responses. These beneficial effects may be mediated by inhibiting NF-κB signal activation and improving gut microflora and dyslipidemia.
Article
Pharmacology & Pharmacy
Chunping Liu, Guiling Chen, Yanfen Chen, Yue Dang, Guangning Nie, Dinghong Wu, Jinhua Li, Zide Chen, Hailong Yang, Dongyue He, Xiong Li, Jingbo Sun, Jiahong Lu, Lei Wang
Summary: Atherosclerosis is a chronic vascular disease characterized by lipid deposition and plaque formation. Danlou tablets showed potential in reducing aortic atherosclerotic plaques and promoting macrophage autophagy, possibly through inhibiting the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Wanasiri Srevarit, Somporn Moonmangmee, Pongsathon Phapugrangkul, Sanchai Kuboon, Annop Klamchuen, Nobuo Saito, Chatchai Ponchio
Summary: This research aims to improve the cathode electrode fabrication for high-efficiency hydrogen (H-2) evolution and promote Escherichia coli (E. coli) degradation at the anode electrode. By synthesizing a heterojunction of TiO2/CuO photocathode and optimizing calcination temperatures, the photoelectrocatalytic (PEC) activity and charge transfer process were enhanced, leading to efficient H-2 production and E. coli degradation. The developed TiO2/CuO cathode electrode demonstrated high effectiveness in H-2 production and promoting the E. coli degradation process, indicating potential for energy and environmental applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Pharmacology & Pharmacy
He Yang, Zuodong Liu, Xiangka Hu, Xiaojuan Liu, Liuming Gui, Zengxiaorui Cai, Chunmei Dai
Summary: This study demonstrates that Panax notoginseng saponins (PNS) may inhibit the progression of atherosclerotic lesions through their anti-inflammatory effect. PNS can suppress the NF-kappa B signaling pathway and inhibit the expression of pro-inflammatory factors such as NF-kappa B p65, IL-6, IL-1 beta, TNF-alpha, and Calpain1.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Pharmacology & Pharmacy
D. Nakladal, J. W. A. Sijbesma, L. M. Visser, U. J. F. Tietge, R. H. J. A. Slart, L. E. Deelman, R. H. Henning, J. L. Hillebrands, H. Buikema
Summary: In this study using a rat ApoE-/- model of early atherosclerosis, it was found that perivascular adipose tissue (PVAT) can modulate aortic relaxation by compensating severe endothelial dysfunction with the release of NO upon cholinergic stimulation.
VASCULAR PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Daniela Impellizzeri, Ramona D'Amico, Roberta Fusco, Alessio Filippo Peritore, Davide Di Paola, Livia Interdonato, Enrico Gugliandolo, Rosalia Crupi, Rosanna Di Paola, Salvatore Cuzzocrea, Marika Cordaro, Rosalba Siracusa
Summary: This study evaluated the effects of bevacizumab on ApoE(-/-) mice undergoing TBI, and found that bevacizumab improved motor deficits, reduced VEGF levels and brain edema, preserved BBB integrity, and mitigated neuroinflammation induced by TBI. Additionally, it was observed for the first time that bevacizumab prevented the acceleration of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Transplantation
Roel Bijkerk, Marije H. Kallenberg, Laurien E. Zijlstra, Bernard M. van den Berg, Jeroen de Bresser, Sebastiaan Hammer, Esther E. Bron, Hakim Achterberg, Mark A. van Buchem, Noeleen C. Berkhout-Byrne, Willem Jan W. Bos, Diana van Heemst, Ton J. Rabelink, Anton Jan van Zonneveld, Marjolijn van Buren, Simon Mooijaart
Summary: This study focused on the association between levels of angiopoietin and cognitive impairment in ESRD patients, revealing an unfavorable angiogenic profile in these patients and identifying certain miRNAs associated with different cognitive domains. These novel angiogenic markers may help to identify cognitive decline in older ESRD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Huayu Zhang, Dianne Vreeken, Danielle G. Leuning, Caroline S. Bruikman, Abidemi Junaid, Wendy Stam, Ruben G. de Bruin, Wendy M. P. J. Sol, Ton J. Rabelink, Bernard M. van den Berg, Anton Jan van Zonneveld, Janine M. van Gils
Summary: Netrin-4 plays a crucial role in endothelial cell function and is essential for maintaining endothelial cell health. Reduced levels of netrin-4 can lead to abnormal endothelial cell function, including senescence, inflammation, and impaired barrier function. Additionally, netrin-4 also enhances endothelial cell adherence to the extracellular matrix, exhibiting a pro-survival effect on endothelial cells.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Review
Medicine, General & Internal
C. A. Bonfiglio, C. Weber, D. Atzler, E. Lutgens
Summary: Current therapies for cardiovascular disease primarily focus on lipid lowering and face residual risk. Inflammation, along with lipids, plays a significant role in atherosclerosis. Clinical trials targeting the interleukin-1 beta-inflammasome pathway have successfully reduced cardiovascular events but not overall CVD mortality. Novel and improved immunotherapeutics for CVD are eagerly anticipated.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Cell Biology
Amber B. Ouweneel, Myrthe E. Reiche, Olga S. C. Snip, Robbert Wever, Ezra J. van der Wel, Frank H. Schaftenaar, Sona Kauerova, Esther Lutgens, Miranda Van Eck, Menno Hoekstra
Summary: This study found that HDL deficiency is associated with an increase in bone marrow stem cells and T cell production. However, HDL deficiency does not significantly affect the size of atherosclerotic lesions and collagen content.
JOURNAL OF CELL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ramzi Khalil, Margien G. S. Boels, Palga Group, Bernard M. van den Berg, Jan A. Bruijn, Ton J. Rabelink, Pancras C. W. Hogendoorn, Hans J. Baelde
Summary: This study investigates the effect of heterozygous germline mutations in the EXT1 and EXT2 genes on the glomerular barrier function and the endothelial glycocalyx in humans. The results show that these mutations do not lead to (micro)albuminuria, specific renal phenotype or changes to the endothelial glycocalyx in humans. These findings contribute to the understanding of the role of EXT1 and EXT2 genes in pathophysiology.
MOLECULAR GENETICS AND GENOMICS
(2022)
Article
Immunology
Anna H. E. Roukens, Cilia R. Pothast, Marion Koenig, Wesley Huisman, Tim Dalebout, Tamar Tak, Shohreh Azimi, Yvonne Kruize, Renate S. Hagedoorn, Mihaela Zlei, Frank J. T. Staal, Fenna J. de Bie, Jacques J. M. van Dongen, Sesmu M. Arbous, Jaimie L. H. Zhang, Maaike Verheij, Corine Prins, Anne M. van der Does, Pieter S. Hiemstra, Jutte J. C. de Vries, Jacqueline J. Janse, Meta Roestenberg, Sebenzile K. Myeni, Marjolein Kikkert, Maria Yazdanbakhsh, Mirjam H. M. Heemskerk, Hermelijn H. Smits, Simon P. Jochems
Summary: Systemic immune cell dynamics during COVID-19 have been well-documented, but less is known about immune cells in the respiratory tract. This study characterized nasal and systemic immune cells in COVID-19 patients, showing increased inflammatory cells in the nasal mucosa during acute infection. After recovery, nasal immune cells mostly normalized, but SARS-CoV-2-specific CD8(+) T cells could persist for at least 2 months.
Article
Medicine, General & Internal
Tamas Pongracz, Jan Nouta, Wenjun Wang, Krista E. van Meijgaarden, Federica Linty, Gestur Vidarsson, Simone A. Joosten, Tom H. M. Ottenhoff, Cornelis H. Hokke, Jutte J. C. de Vries, Sesmu M. Arbous, Anna H. E. Roukens, Manfred Wuhrer
Summary: Low galactosylation, sialylation, and high bisection of anti-S IgG1 were associated with disease severity and inflammatory markers, suggesting the need for further studies to understand the contributions of anti-S IgG1 glycosylation to COVID-19 pathogenesis and its potential as a biomarker.
Article
Cell & Tissue Engineering
Marije Koning, Sebastien J. Dumas, M. Cristina Avramut, Roman Koning, Elda Meta, Ellen Lievers, Loes E. Wiersma, Mila Borri, Xue Liang, Lin Xie, Ping Liu, Fang Chen, Lin Lin, Yonglun Luo, Jaap Mulder, H. Siebe Spijker, Thierry Jaffredo, Bernard M. van den Berg, Peter Carmeliet, Cathelijne W. van den Berg, Ton J. Rabelink
Summary: Intracoelomic transplantation in chicken embryos can induce and study vasculogenesis in kidney organoids, leading to improved maturation and applicability.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Cell & Tissue Engineering
Gangqi Wang, Bram Heijs, Sarantos Kostidis, Rosalie G. J. Rietjens, Marije Koning, Lushun Yuan, Gesa L. Tiemeier, Ahmed Mahfouz, Sebastien J. Dumas, Martin Giera, Jesper Kers, Susana M. Chuva de Sousa Lopes, Cathelijne W. van den Berg, Bernard M. van den Berg, Ton J. Rabelink
Summary: Accumulating evidence demonstrates the importance of metabolism in cell fate determination. This study uses a multi-omics platform to study cell-type-specific dynamics in metabolism during nephrogenesis and highlights the relevance of understanding metabolic trajectories for guiding stem cell differentiation.
Review
Cardiac & Cardiovascular Systems
Menno P. J. de Winther, Magnus Back, Paul Evans, Delphine Gomez, Isabel Goncalves, Helle F. Jorgensen, Rory R. Koenen, Esther Lutgens, Giuseppe Danilo Norata, Elena Osto, Lea Dib, Michael Simons, Konstantinos Stellos, Seppo Yla-Herttuala, Holger Winkels, Marie-Luce Bochaton-Piallat, Claudia Monaco
Summary: The advent of single-cell biology has opened up new possibilities for understanding human biological processes and diagnosing, monitoring, and treating diseases, including cardiovascular disease (CVD). By analyzing CVD samples at the single-cell level, new cell communities that play a role in disease development can be identified, leading to new therapeutic strategies. This review focuses on the single-cell analysis of atherosclerotic plaques, highlighting the current understanding of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. The clinical impact of single-cell technologies in CVD patient care is emphasized, calling for multidisciplinary and international collaborative efforts.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Esther Lutgens, Willem J. M. Mulder, Claudia Monaco, Isabel Goncalves, Coleen McNamera, Johan Kuiper, Randolph Noelle, CHECKPOINT ATHERO Consortium
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jeanine E. Roeters van Lennep, Lale S. Tokgozoglu, Lina Badimon, Sandra M. Dumanski, Martha Gulati, Connie N. Hess, Kirsten B. Holven, Maryam Kavousi, Meral Kayikcioglu, Esther Lutgens, Erin D. Michos, Eva Prescott, Jane K. Stock, Anne Tybjaerg-Hansen, Marieke J. H. Wermer, Marianne Benn
Summary: Cardiovascular disease is the leading cause of death globally, with atherosclerotic cardiovascular disease (ASCVD) being the main contributor. ASCVD mortality is currently increasing, especially in middle-aged women. Sex-specific factors, such as hypertensive disorders of pregnancy, premature menopause, and polycystic ovary syndrome, are associated with higher cardiovascular risk.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jeanine E. Roeters van Lennep, Lale S. Tokgozoglu, Lina Badimon, Sandra M. Dumanski, Martha Gulati, Connie N. Hess, Kirsten B. Holven, Maryam Kavousi, Meral Kayikcioglu, Esther Lutgens, Erin D. Michos, Eva Prescott, Jane K. Stock, Anne Tybjaerg-Hansen, Marieke J. H. Wermer, Marianne Benn
Summary: Cardiovascular disease is the leading cause of death globally, with women experiencing the fastest relative increase in middle-aged mortality. In addition to missed or delayed diagnosis and undertreatment, sex-specific factors contribute to increased cardiovascular risk in women. The European Atherosclerosis Society's position statement focuses on the impact of gender-specific factors and the effects of these factors on women's lifelong lipid profiles, including lipoprotein(a). Sociocultural components further compound these effects. Early identification and treatment of modifiable cardiovascular risk factors in women, especially those related to sex-specific conditions, are necessary to reduce the high burden of cardiovascular disease in women.
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Gangqi Wang, Bram Heijs, Sarantos Kostidis, Ahmed Mahfouz, Rosalie G. J. Rietjens, Roel Bijkerk, Angela Koudijs, Lois A. K. van der Pluijm, Cathelijne W. van den Berg, Sebastien J. Dumas, Peter Carmeliet, Martin Giera, Bernard M. van den Berg, Ton J. Rabelink
Summary: In this study, the authors used mass spectrometry imaging, isotope tracing, and multiplexed immunofluorescence microscopy to study metabolic dynamics in the kidney during ischemia-reperfusion. They developed a high-spatial-resolution metabolomics approach that allows mapping of cell-type-specific changes in central carbon metabolism. This method, combined with immunofluorescence staining, can detect metabolic changes and nutrient partitioning in targeted cell types. The authors identified region-specific metabolic perturbations associated with the lesion and throughout recovery, providing insights into the homeostatic capacity of the kidney microenvironment.
Article
Respiratory System
Lushun Yuan, Shuzhen Cheng, Wendy M. P. J. Sol, Anouk I. M. van der Velden, Hans Vink, Ton J. Rabelink, Bernard M. van den Berg
Summary: Accumulating evidence suggests that endothelial dysfunction is involved in the progression of COVID-19. This study found that serum factors of severe COVID-19 patients may affect the glycocalyx and lead to endothelial dysfunction. The study also demonstrated that certain substances circulating in the plasma of COVID-19 patients in intensive care units are associated with endothelial glycocalyx degradation, barrier disruption, inflammation, and increased coagulation.