标题
An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
作者
关键词
kinase, metabolic signaling, phosphorylation, AMPK, mTORC1, lysosome, energy homeostasis
出版物
Cell Reports
Volume 38, Issue 7, Pages 110365
出版商
Elsevier BV
发表日期
2022-02-16
DOI
10.1016/j.celrep.2022.110365
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy
- (2020) Pietri Puustinen et al. Autophagy
- In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds
- (2020) Sean N. O’Byrne et al. MOLECULES
- The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?
- (2019) Diana Vara-Ciruelos et al. Open Biology
- Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1
- (2019) Ina Yoon et al. SCIENCE
- AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965
- (2018) Toby A. Dite et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms
- (2018) Chinwendu Nwadike et al. MOLECULAR AND CELLULAR BIOLOGY
- 1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors
- (2018) Christopher Asquith et al. MOLECULES
- A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase–Ragulator lysosomal scaffold
- (2018) Rosalie E. Lawrence et al. NATURE CELL BIOLOGY
- AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
- (2017) Daniel Garcia et al. MOLECULAR CELL
- Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
- (2017) Chen-Song Zhang et al. NATURE
- Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes
- (2017) Monther Abu-Remaileh et al. SCIENCE
- The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
- (2017) Toby A. Dite et al. Nature Communications
- Protein kinase C phosphorylates AMP-activated protein kinase 1 Ser487
- (2016) H. R. Heathcote et al. BIOCHEMICAL JOURNAL
- PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells
- (2016) Kimberly A. Coughlan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A systems study reveals concurrent activation of AMPK and mTOR by amino acids
- (2016) Piero Dalle Pezze et al. Nature Communications
- Dynamics of mTORC1 activation in response to amino acids
- (2016) Maria Manifava et al. eLife
- Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
- (2015) Daniel F. Egan et al. MOLECULAR CELL
- Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance
- (2015) Jiyong Liang et al. Nature Communications
- mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells
- (2015) Serguei A. Gordeev et al. Oncotarget
- Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells
- (2014) Simon A. Hawley et al. BIOCHEMICAL JOURNAL
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism
- (2014) Chen-Song Zhang et al. Cell Metabolism
- Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
- (2014) John W. Scott et al. CHEMISTRY & BIOLOGY
- PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
- (2014) Peter V. Hornbeck et al. NUCLEIC ACIDS RESEARCH
- Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy
- (2013) Haibin Xi et al. BIOCHEMICAL PHARMACOLOGY
- Glucose-starved Cells Do Not Engage in Prosurvival Autophagy
- (2013) Silvia Ramírez-Peinado et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of AMPK Catabolic Action by GSK3
- (2013) Tsukasa Suzuki et al. MOLECULAR CELL
- Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1
- (2013) S Shin et al. ONCOGENE
- mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
- (2013) S. A. Kang et al. SCIENCE
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake
- (2012) Yossi Dagon et al. Cell Metabolism
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics
- (2012) Qingsong Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK functions as an adenylate charge-regulated protein kinase
- (2012) Jonathan S. Oakhill et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation
- (2011) S. Shin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
- (2011) L. Shang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)
- (2010) J. S. Oakhill et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
- (2010) D. F. Egan et al. SCIENCE
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
- (2009) Carson C. Thoreen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes
- (2008) John W. Scott et al. CHEMISTRY & BIOLOGY
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now