Article
Biochemistry & Molecular Biology
Wenqin Xu, Xiaocui Ma, Qing Wang, Jingjing Ye, Nengqian Wang, Zhenzhen Ye, Tianbing Chen
Summary: This study identified GCN5L1 as a new regulator of pulmonary surfactant, playing a role in the biogenesis and positioning/trafficking of surfactant-containing lamellar bodies.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Agronomy
Yingying Zhao, Deng Yan, Jinjing Liu, Shuzhen Yang, Dongmei Li, Litao Peng
Summary: In this study, the function of the vacuolar ATPase subunit H (VmaH) in Penicillium digitatum was characterized. The results showed that silencing the VmaH gene reduced cell growth and pathogenicity of P. digitatum, increased vacuolar pH and decreased extracellular pH. Furthermore, VmaH gene silencing inhibited the expression of transport genes and interfered with nutrient metabolic processing, leading to altered cell morphology and weakened pathogenicity.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Cell Biology
Soon C. Heo, Jae C. You, Suhan Jung, Yu N. Kim, Sang-Hun Shin, Jae-Yeol Lee, Hyung J. Kim
Summary: This study reveals the important regulatory roles of Pim kinases in periodontal disease, particularly in osteoclastogenesis and bone resorption activity. Pim-2 acts as a major modulator by regulating the expression of the a3 isoform.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Environmental Sciences
Chia-Hao Lin, Sian-Tai Liu, Yu-Chun Wang, Yi-Ling Tsou, Huei-Jyun Hu
Summary: Maintenance of an acid-base balance is crucial for vertebrates, and fishes secrete more acid in response to acidity. This study using zebrafish as a model revealed the involvement of vitamin D in acid secretion in fishes.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Immunology
Maylin Merino-Wong, Barbara A. Niemeyer, Dalia Alansary
Summary: The study shows that PMCA4 expression varies in different human CD4(+) T cell compartments, with modulation of PMCA4 leading to different increases in SOCE, suggesting an important role for PMCA4 in regulating compartment stoichiometry.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoman Li, Liang Wang, Jialin Hao, Qingfeng Zhu, Min Guo, Changjing Wu, Sihui Li, Qiqiang Guo, Qiuhong Ren, Ning Bai, Fei Yi, Bo Jiang, Wenyu Zhang, Yanling Feng, Hongde Xu, Han Jiang, Xiaoyue Zhai, Guohua Zhang, Hong-Long Ji, Xuesong Yang, Dan Zhang, Jianhua Fu, Jianjun Chang, Xiaoyu Song, Liu Cao
Summary: This study found that autophagy is involved in the maturation of lamellar bodies (LB) and regulates the production of surfactant proteins in alveolar epithelial cells. Changes in autophagic activity affect LB formation and function.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Linlin Tian, Xiaodong Li, Yi Ding, Minli Li, Yunzhao Tang, Daiqing Li
Summary: The study showed that CLOCK is abundantly expressed in rat pancreatic beta cells, and its knockdown significantly affects insulin secretion. The potential pathway of CLOCK mediating Cav1.2 expression may play a crucial role in regulating insulin secretion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biology
Qianqian Pang, Chunyi Liu, Yulong Qiao, Jian Zhao, Sin Man Lam, Mei Mei, Guanghou Shui, Shilai Bao, Qiuling Li
Summary: Deletion of the GM130 gene disrupts the Golgi structure, impairing the secretion of lung surfactant proteins and lipids. This leads to an enlargement of alveolar airspace and increased alveolar epithelial autophagy, which can be partially rescued by surfactant repletion in GM130-deficient mice.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Salome Rognant, Samuel N. Baldwin, Harry A. T. Pritchard, Adam Greenstein, Kirstine Calloe, Christian Aalkjaer, Thomas A. Jepps
Summary: Prorenin enhances arterial contractility by inhibiting BKCa and increasing intracellular Ca2+ release, which is likely mediated through a local shift in pH upon activation of (P)RR and stimulation of V-ATPase.
Article
Microbiology
Congcong Sun, Xingyue Li, Yuanwei Zhang, Ling Lu
Summary: The study identified a crucial role of VmaC gene in Aspergillus fumigatus, involving in maintaining cellular homeostasis and cell wall integration pathway regulation. Compared to model yeasts, VmaC in A. fumigatus is essential for hyphal growth and conidiation.
Article
Biochemistry & Molecular Biology
Andrew J. Nickerson, Vazhaikkurichi M. Rajendran
Summary: The corticosteroid hormone aldosterone enhances K+ secretion in the colon and plays a critical role in maintaining K+ balance. Previous studies showed that aldosterone up-regulates basolateral NKCC1 specifically in the distal colon to support K+ secretion, but its effects on the proximal colon are unclear. Understanding these region-specific effects is important for managing gastrointestinal pathologies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Toxicology
Julie Harney, Piyush Bajaj, James E. Finley, Anna K. Kopec, Petra H. Koza-Taylor, Germaine G. Boucher, Thomas A. Lanz, Colleen M. Doshna, Christopher J. Somps, Karissa Adkins, Christopher Houle
Summary: This study established an in vitro AEC model that replicated abnormal lung findings observed in animals with LRRK2 perturbations, demonstrating that LRRK2 inhibition can significantly increase LB size. This research has the potential to expand current understanding of LRRK2 function in the lung.
TOXICOLOGY IN VITRO
(2021)
Article
Biochemistry & Molecular Biology
Ting- Lee, Nguyen Ngoc Trang, Ting-Wei Lee, Satoshi Higa, Yu-Hsun Kao, Yao-Chang Chen, Yi-Jen Chen
Summary: A ketogenic diet may attenuate the effects of diabetic cardiomyopathy by regulating sodium and calcium homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Rasaq Olajide Akinsola, Choon Weng Lee, Edmund Ui Hang Sim, Kumaran Narayanan
Summary: Inhibition of lysosomal V-ATPase enhances the efficiency of E. coli for gene delivery into mammalian cells, as shown by the increase in green fluorescent protein expression in various cell lines.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Cell Biology
Elena Senis, Miriam Esgleas, Sonia Najas, Veronica Jimenez-Sabado, Camilla Bertani, Marta Gimenez-Alejandre, Alba Escriche, Jorge Ruiz-Orera, Marta Hergueta-Redondo, Mireia Jimenez, Albert Giralt, Paolo Nuciforo, M. Mar Alba, Hector Peinado, Daniel del Toro, Leif Hove-Madsen, Magdalena Goetz, Maria Abad
Summary: Recent research has identified a new essential microprotein, pTUNAR, encoded by lncRNA, which plays a key role in neural differentiation and neurite formation. Deficiency of pTUNAR enhances the differentiation potential of mouse embryonic stem cells towards neural lineage, while overexpression impairs neuronal differentiation by reducing neurite formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Hematology
Yujie Guo, Amarjit Mishra, Emily Howland, Chunling Zhao, Dhananjay Shukla, Tingting Weng, Lin Liu
Article
Multidisciplinary Sciences
Amarjit Mishra, Alexandra L. Brown, Xianglan Yao, Shutong Yang, Sung-Jun Park, Chengyu Liu, Pradeep K. Dagur, J. Philip McCoy, Karen J. Keeran, Gayle Z. Nugent, Kenneth R. Jeffries, Xuan Qu, Zu-Xi Yu, Stewart J. Levine, Jay H. Chung
NATURE COMMUNICATIONS
(2015)
Article
Immunology
Amarjit Mishra, Yujie Guo, Li Zhang, Sunil More, Tingting Weng, Narendranath Reddy Chintagari, Chaoqun Huang, Yurong Liang, Samuel Pushparaj, Deming Gou, Melanie Breshears, Lin Liu
JOURNAL OF IMMUNOLOGY
(2016)
Article
Allergy
Amarjit Mishra, Xianglan Yao, Ankit Saxena, Elizabeth M. Gordon, Maryann Kaler, Rosemarie A. Cuento, Amisha V. Barochia, Pradeep K. Dagur, J. Philip McCoy, Karen J. Keeran, Kenneth R. Jeffries, Xuan Qu, Zu-Xi Yu, Stewart J. Levine
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Review
Immunology
Amarjit Mishra
JOURNAL OF IMMUNOLOGY RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Honghao Zhang, Yujie Guo, Amarjit Mishra, Deming Guo, Narendranath Reddy Chintagari, Lin Liu
Article
Immunology
Karin Fredriksson, Amarjit Mishra, Jonathan K. Lam, Elizabeth M. Mushaben, Rosemarie A. Cuento, Katharine S. Meyer, Xianglan Yao, Karen J. Keeran, Gayle Z. Nugent, Xuan Qu, Zu-Xi Yu, Yanqin Yang, Nalini Raghavachari, Pradeep K. Dagur, J. Philip McCoy, Stewart J. Levine
JOURNAL OF IMMUNOLOGY
(2014)
Article
Cell Biology
Y. Guo, A. Mishra, T. Weng, N. R. Chintagari, Y. Wang, C. Zhao, C. Huang, L. Liu
CELL DEATH & DISEASE
(2014)
Article
Immunology
Anil Kumar Jaiswal, Sangeet Makhija, Natalie Stahr, Maninder Sandey, Amol Suryawanshi, Ankit Saxena, Pradeep K. Dagur, J. Philip McCoy, Stewart J. Levine, Amarjit Mishra
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Anil Kumar Jaiswal, Sangeet Makhija, Natalie Stahr, Maninder Sandey, Amol Suryawanshi, Amarjit Mishra
Article
Physiology
Anil Kumar Jaiswal, Jyoti Yadav, Sangeet Makhija, Maninder Sandey, Amol Suryawanshi, Amit Kumar Mitra, Amarjit Mishra
Summary: The study found that aged mice exhibit increased airway hyperresponsiveness, mixed granulomatous airway inflammation, and changes in immune response, suggesting that the development of airway inflammation may be age-related. Additionally, the age-dependent decline in SPLUNC1 levels may be involved in developing steroid-resistant airway inflammation and asthma heterogeneity.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Immunology
Anil Kumar Jaiswal, Jyoti Yadav, Sangeet Makhija, Suman Mazumder, Amit Kumar Mitra, Amol Suryawanshi, Maninder Sandey, Amarjit Mishra
Summary: The study revealed a direct regulatory role of the Irg1/itaconate pathway in dendritic cells for the development of airway inflammation, suggesting a possible therapeutic target in modulating allergic asthma.
MUCOSAL IMMUNOLOGY
(2022)
Article
Immunology
Anil K. Jaiswal, Maninder Sandey, Amol Suryawanshi, Russell C. Cattley, Amarjit Mishra
IMMUNITY INFLAMMATION AND DISEASE
(2019)
Review
Cell Biology
Amarjit Mishra
JOURNAL OF BIOMEDICAL SCIENCE
(2013)