Article
Multidisciplinary Sciences
Linda F. Boeswald, Jasmin Wenderlein, Wolfgang Siegert, Reinhard K. Straubinger, Ellen Kienzle
Summary: Data on mineral digestibility is essential for understanding mineral homeostasis and improving dietary recommendations. While there is ample information on mineral digestibility in farm animals and pets, there is a lack of data in laboratory mice under maintenance conditions, which is crucial for studying mineral homeostasis. This study analyzed data on intake, faecal excretion, and apparent digestibility of various minerals in C57BL/6J mice fed different maintenance diets.
Article
Nutrition & Dietetics
Tsun-Li Cheng, Zi-Yun Lin, Keng-Ying Liao, Wei-Chi Huang, Cian-Fen Jhuo, Pin-Ho Pan, Chun-Jung Chen, Yu-Hsiang Kuan, Wen-Ying Chen
Summary: This study investigated the potential of Magnesium lithospermate B (MLB) in combating muscle atrophy in mice with high-fat diet (HFD)-induced obesity. The results showed that MLB supplementation alleviated metabolic abnormalities and prevented muscle loss caused by obesity, likely through inhibiting muscle degradation pathways. This study also revealed changes in inflammatory markers and signaling pathways associated with muscle atrophy.
Article
Pharmacology & Pharmacy
Kenneth Alper, Janelle Cange, Ria Sah, Deanna Schreiber-Gregory, Henry Sershen, K. Yaragudri Vinod
Summary: This study investigated the effects of psilocybin on voluntary ethanol consumption in adult male and female C57BL/6J mice. The results showed that psilocybin reduced ethanol consumption and preference in male mice, but had no significant effect in female mice.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Chenxiao Zhang, Tengfei Ma, Chang Liu, Ding Ma, Jian Wang, Meng Liu, Jinjun Ran, Xueting Wang, Xiaobei Deng
Summary: PM2.5 exposure can lead to extensive metabolic disturbances, particularly in lipid and amino acid metabolism. It is associated with the enrichment of disease pathways and signaling pathways related to non-alcoholic fatty liver disease, type II diabetes mellitus, TGF-beta, AMPK, and mTOR. Accumulation of acylcarnitine in liver tissue restricts lipid consumption and contributes to hepatic steatosis. The aberrant expression of key transcription factors, such as PPARs and SREBP1, may play a regulatory role in lipid metabolic disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min Shin, Madhavi Pandya, Kristan Espinosa, Ravindra Telang, Jordi Boix, Peter R. Thorne, Srdjan M. Vlajkovic
Summary: The study found that weekly injections of istradefylline in middle-aged C57BL/6 mice can attenuate the progression of ARHL and improve cochlear development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Brenda Kick, Laura Anderson, Rosalinda Doty, Christine Wooley, Meaghan Dyer, Torrian Green, Veronica Knickerbocker, Zoe Brown, Samantha Loeber, Janine Wotton, Bonnie Lyons, Linda Waterman, Zoe Bichler
Summary: Tarsal joint abnormalities, including calcaneal displacement, inflammation, and proliferation of cartilage and connective tissue, have been observed in aged male mice of the C57BL/6J lineage. These abnormalities lead to decreased body weight, increased frailty, heightened touch sensitivity, and reduced running ability. This study emphasizes the importance of further characterizing inbred mouse mutations.
Article
Food Science & Technology
Zhengyuan Chai, Yehua Yan, Shengyue Zan, Xianghong Meng, Fang Zhang
Summary: This study investigated the effect of fermented blueberry pomace on hyperlipidemia in obese mice. The results showed that fermented blueberry pomace significantly reduced weight gain, liver and fat indexes, and hyperlipidemia in the mice. It also improved lipid metabolism and reduced inflammation by upregulating PPAR-alpha and down-regulating SREBP-1 and FAS.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Oncology
Dan Shi, Jingjing Wu, Youqile Wu, Xiaojing Lin, Cai Xu, Xuemei Lian
Summary: Obesity induced by high-fat diet was found to promote lung tumorigenesis in C57BL/6J mice, with leptin-mediated activation of the PI3K/Akt/mTOR/STAT3 pathway likely playing a key role in this mechanism.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xuexia Li, Linfeng Le, Qingqing Shi, Hao Xu, Chao Wang, Yufang Xiong, Xun Wang, Guoli Wu, Qiong Liu, Xiubo Du
Summary: The pathogenesis of Alzheimer's disease (AD) is complex and multifactorial. Tau pathology is more related to clinical symptoms and severity of AD compared to A beta. The interaction between Zn2+ and tau plays a role in tau toxicity, but the mechanism is not fully understood.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Karin Pernold, Eric Rullman, Brun Ulfhake
Summary: The objective was to characterize the pattern of rest and physical activity (PA) of C57BL/6J mice using the raw data output from a scalable home cage monitoring system. The analysis showed that mice spend most of their time in bouts of long rest and engage in physical activity, with a significant preference for the peripheral floor area. The extraction of electrode activations density (EAD) from the raw data can serve as a proxy for PA and rest, enabling monitoring of group housed mice.
Article
Pharmacology & Pharmacy
Moriah Carper, Katherine M. Contreras, D. Matthew Walentiny, Patrick M. Beardsley, M. Imad Damaj
Summary: This study established a mouse model of oxycodone dependence to investigate withdrawal effects, with pretreatment with oxycodone or clonidine preventing emergence of withdrawal signs. Mice treated with oxycodone exhibited more withdrawal signs 24 hours post-injection, while naloxone challenges showed peak withdrawal signs at 6 hours. The model is validated and provides a means to examine novel therapeutics for opioid withdrawal.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Beatriz Ferrer, Lisa M. Prince, Alexey A. Tinkov, Abel Santamaria, Aaron B. Bowman, Michael Aschner
Summary: MeHg disrupts the physiological functions of ghrelin differently in males and females, enhancing ghrelin-induced body weight gain in males by activating the AMPK/UCP2 signaling pathway and mitigating ghrelin-induced weight gain in females by inhibiting mTOR signaling and decreasing Npy mRNA expression.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Sowmya Shree Gopal, Shinde Vijay Sukhdeo, Baskaran Vallikannan, Ganesan Ponesakki
Summary: Lutein has antiobesity effects in a high-fat diet-induced obese mouse model, reducing adipose tissue weight, serum cholesterol, triglycerides, and blood glucose levels, as well as downregulating genes and proteins associated with obesity.
PHYTOTHERAPY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Marina Padua-Reis, Diana Aline Noga, Adriano B. L. Tort, Martina Blunder
Summary: The study found that diazepam had no anxiolytic effect on mouse behavior in the elevated plus maze task, and at the highest dose it impaired locomotor activity, likely due to sedation. In contrast, paroxetine significantly reduced anxiety-like behavior without inducing sedative effects. Therefore, preclinical studies screening new anxiolytic drugs should be cautious with the use of diazepam as a potential positive control.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Victoria Acosta-Rodriguez, Filipa Rijo-Ferreira, Mariko Izumo, Pin Xu, Mary Wight-Carter, Carla B. Green, Joseph S. Takahashi
Summary: Research shows that the interval of fasting and circadian alignment of feeding are important factors in extending lifespan under CR; nighttime CR can alleviate inflammation and metabolic pathway damage caused by aging; circadian interventions promote longevity.
Article
Endocrinology & Metabolism
Edward O. List, Darlene E. Berryman, Reetobrata Basu, Mathew Buchman, Kevin Funk, Prateek Kulkarni, Silvana Duran-Ortiz, Yanrong Qian, Elizabeth A. Jensen, Jonathan A. Young, Gozde Yildirim, Shoshana Yakar, John J. Kopchick
Article
Endocrinology & Metabolism
Andre Sarmento-Cabral, Mercedes del Rio-Moreno, Mari C. Vazquez-Borrego, Mariyah Mahmood, Elena Gutierrez-Casado, Natalie Pelke, Grace Guzman, Papasani Subbaiah, Jose Cordoba-Chacon, Shoshana Yakar, Rhonda D. Kineman
Summary: The study found that knocking down GHR in adult hepatocytes leads to non-alcoholic fatty liver disease, with no significant changes observed in female mice but with symptoms of steatosis, hepatocyte ballooning, and inflammation present in male mice.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Cell Biology
Manisha Dixit, Sher Bahadur Poudel, Shoshana Yakar
Summary: Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) play crucial roles in regulating body growth and skeletal acquisition, with their activity declining with age and leading to detrimental effects on the musculoskeletal system.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Cell Biology
Heather A. Baldwin, Chunxin Wang, Gil Kanfer, Hetal Shah, Antonio Velayos-Baeza, Marija Dulovic-Mahlow, Norbert Brueggemann, Allyson Anding, Eric H. Baehrecke, Dragan Maric, William A. Prinz, Richard J. Youle
Summary: The VPS13 gene family in mammals consists of VPS13A-D, with VPS13D playing a crucial role in regulating peroxisome biogenesis.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Sher Bahadur Poudel, Manisha Dixit, Gozde Yildirim, Jose Cordoba-Chacon, Manuel D. Gahete, Ikeno Yuji, Thorsten Kirsch, Rhonda D. Kineman, Shoshana Yakar
Summary: The study found that adult-onset isolated GH deficiency can lead to increased severity of OA and extended lifespan in female mice. However, high levels of lymphomas were observed in both sexes with AOiGHD. Additionally, males with AOiGHD showed increased cell senescence and significantly decreased health span.
Article
Endocrinology & Metabolism
Laris Achlaug, Lina Somri-Gannam, Shilhav Meisel-Sharon, Rive Sarfstein, Manisha Dixit, Shoshana Yakar, Mordechai Hallak, Zvi Laron, Haim Werner, Ilan Bruchim
Summary: This study evaluated the expression of ZYG11A in EOC patients and found reduced ZYG11A expression in high grade tumors, suggesting a potential tumor suppressor role. The study also identified an inverse correlation between ZYG11A and p53 levels in individual tumors. Further exploration of ZYG11A as a novel biomarker in EOC is warranted based on these findings.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Rand Shibel, Rive Sarfstein, Karthik Nagaraj, Lena Lapkina-Gendler, Zvi Laron, Manisha Dixit, Shoshana Yakar, Haim Werner
Summary: Endometrial cancer is commonly linked to the insulin-like growth factor-1 (IGF1) axis, while individuals with Laron syndrome (LS) are protected from cancer development due to IGF1 deficiency. The downregulation of OR5H2 gene in LS-derived cells suggests a potential role in endometrial cancer as a target for positive regulation by IGF1.
Article
Cell Biology
Manisha Dixit, Silvana Duran-Ortiz, Godze Yildirim, Sher Bahadur Poudel, Leeann D. Louis, Andrzej Bartke, Mitchell B. Schaffler, John J. Kopchick, Shoshana Yakar
Summary: The study investigated the effects of induced somatopause on skeletal integrity using an iGHRKO mouse model, finding that induced somatopause resulted in thinner bones and compromised bone strength. There were progressive declines in osteocyte lacunar number and increases in lacunar volume, along with reductions in canalicular connectivity. Despite compromised bone morphology, osteocyte senescence was reduced in iGHRKO mice. Overall, induced somatopause compromised bone morphology and the bone marrow environment in aging mice.
Article
Cell Biology
Silvana Duran-Ortiz, Edward O. List, Yuji Ikeno, Jonathan Young, Reetobrata Basu, Stephen Bell, Todd McHugh, Kevin Funk, Samuel Mathes, Yanrong Qian, Prateek Kulkarni, Shoshana Yakar, Darlene E. Berryman, John J. Kopchick
Summary: Studies suggest that reducing growth hormone action can enhance healthy lifespan. In adult mice, disrupted GH action resulted in sexual dimorphic effects, with males showing enhanced insulin sensitivity and reduced tumors, while females exhibited increased lifespan and reduced glucose and oxidative stress.
Article
Endocrinology & Metabolism
Mark Slayton, Bijinu Balakrishnan, Abhishek Gupta, Scott Jobe, Ishika Puri, Savannah Neely, Yoshikazu Tamori, David W. Russ, Gozde Yildirim, Shoshana Yakar, Vishva M. Sharma, Vishwajeet Puri
Summary: This study identifies Fsp27 as a novel protein associated with muscle metabolism. The Fsp27-knockout model reveals that Fsp27 plays a role in muscular-fat storage, muscle endurance, and muscle strength, ultimately impacting limb movement. Additionally, the study suggests a potential metabolic paradox in which Fsp27-knockout mice, presumed to be metabolically healthy based on glucose utilization and oxidative metabolism, exhibit impaired exercise capacity and muscular performance.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Cell Biology
Vicente Barrios, Julie A. Chowen, Alvaro Martin-Rivada, Santiago Guerra-Cantera, Jesus Pozo, Shoshana Yakar, Ron G. Rosenfeld, Luis A. Perez-Jurado, Juan Suarez, Jesus Argente
Summary: The GH/IGF axis is crucial in human growth, with recent research focusing on the role of the PAPP-A2 gene mutations in affecting physiology. Understanding the implications of PAPP-A2 can provide insights for controlling growth processes.
Article
Endocrinology & Metabolism
Manisha Dixit, Leeann D. Louis, Jelena Basta-Pljakic, Gozde Yildirim, Sher-Bahadur Poudel, Fancy Kumararaja, Edward O. List, Silvana Ortiz Duran, John J. Kopchick, Ryan R. Ruff, Mitchell B. Schaffler, Shoshana Yakar
Summary: Excess in growth hormone levels can have different effects on bone depending on the gender. Male mice experience bone enlargement, marrow cavity expansion, and thin cortices, while female mice have smaller bone diameter but thicker cortices and better bone quality. Excess growth hormone also leads to increased bone remodeling. In conclusion, excess growth hormone results in sexually dimorphic changes in bone structure and mass.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Pathology
Sher B. Poudel, Ryan R. Ruff, Gozde Yildirim, Manisha Dixit, Benoit Michot, Jennifer L. Gibbs, Silvana D. Ortiz, John J. Kopchick, Thorsten Kirsch, Shoshana Yakar
Summary: This study investigated the effects of long-term excess GH on the knee joint tissues. The results showed that excess GH leads to loss of articular cartilage, osteoporosis, synovitis, and chondrogenesis. The findings suggest that treatment of acromegalic arthropathy should involve inhibition of ectopic chondrogenesis and chondrocyte hypertrophy.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Geriatrics & Gerontology
Gozde Yildirim, Edmara T. P. Bergamo, Sher Bahadur Poudel, Ryan R. R. Ruff, Manisha Dixit, Bin Hu, Dindo Q. Q. Mijares, Lukasz Witek, Carolyn Chlebek, David E. E. Harrison, Randy Strong, Richard A. A. Miller, Warren Ladiges, Timothy G. G. Bromage, Clifford J. J. Rosen, Shoshana Yakar
Summary: SGLT2 inhibitors like CANA can reduce blood glucose levels, but long-term use may increase the risk of osteoporosis and cortical fractures.
Review
Endocrinology & Metabolism
Lauren Battle, Shoshana Yakar, Alessandra Carriero
Summary: Currently, there is no cure for osteogenesis imperfecta (OI) and stem cell therapy shows promise in reducing fractures in mouse models of OI. However, the efficacy of the therapy is influenced by various factors and further research is needed to establish standardized assessment criteria.