Review
Immunology
Yanpeng Feng, Zhiyuan Chen, Yi Xu, Yuxuan Han, Xiujuan Jia, Zixuan Wang, Nannan Zhang, Wenjing Lv
Summary: NFKBIZ, encoded by NFKBIZ, is a recently identified IkappaB family protein that has been the focus of studies due to its role in inflammation. It is a key gene in the regulation of inflammatory factors in the NF-KB pathway, affecting the progression of related diseases. The investigation of NFKBIZ has led to a better understanding of its functions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Thomas C. J. Tan, Van Kelly, Xiaoyan Zou, David Wright, Tony Ly, Rose Zamoyska
Summary: This study reveals that the elongation factor eIF5a in naive CD8(+) T cells is dynamically regulated upon activation through post-translational modification, and it facilitates the translation of specific proteins. It is essential for long-term survival of effector CD8(+) T cells, and controls the production of proteins important for proliferation and effector functions.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Long-Feng Lu, Can Zhang, Zhuo-Cong Li, Xiao-Yu Zhou, Jing-Yu Jiang, Dan-Dan Chen, Yong-An Zhang, Feng Xiong, Fang Zhou, Shun Li
Summary: Zebrafish transmembrane protein 33 (TMEM33) negatively regulates interferon (IFN) production through two distinct mechanisms: interacting with and degrading MAVS via K48-linked ubiquitination, and acting as a decoy substrate for cellular TBK1 to reduce phosphorylation of MITA/IRF3. These findings reveal the role for TMEM33 in regulating cellular immune responses and expand our understanding of negative regulatory mechanisms of IFN.
Article
Multidisciplinary Sciences
Robert G. Schaut, Mitchell V. Palmer, Paola M. Boggiatto, Indira T. Kudva, Crystal L. Loving, Vijay K. Sharma
Summary: The study shows that vaccines based on Shiga-toxin producing Escherichia coli O157:H7 (O157) can provide a potential intervention strategy to limit foodborne zoonotic transmission of O157. While vaccines may offer protection, local cellular immune responses also play a role, with increased lymphoid follicles and specific cell production seen in vaccinated/challenged animals. Enhancing mucosal immunity is critical in controlling O157 in ruminants and limiting transmission to humans.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Cell Biology
Howard C. Crawford
Summary: PDAC, one of the deadliest cancers, is characterized by oncogenic mutations in the KRAS gene. Targeting KRAS directly has been challenging, but recent success in certain mutants indicates a promising new era in therapy. Understanding resistance mechanisms to KRAS inhibitors is crucial for improving PDAC treatment outcomes.
GENES & DEVELOPMENT
(2021)
Article
Neurosciences
Lukas B. Krone, Tomoko Yamagata, Cristina Blanco-Duque, Mathilde C. C. Guillaumin, Martin C. Kahn, Vincent van der Vinne, Laura E. McKillop, Shu K. E. Tam, Stuart N. Peirson, Colin J. Akerman, Anna Hoerder-Suabedissen, Zoltan Molnar, Vladyslav V. Vyazovskiy
Summary: The cortex is shown to play a significant role in both global state control and sleep homeostasis, particularly in vigilance state control and recovery after sleep deprivation.
NATURE NEUROSCIENCE
(2021)
Article
Immunology
Ruoyu Chao, Mikako Nishida, Nahoko Yamashita, Miho Tokumasu, Weiyang Zhao, Ikuru Kudo, Heiichiro Udono
Summary: Metformin enhances IFNγ production by CD8(+) T cells through differential metabolic pathways and nutrient conditions, suggesting its potential application in cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Noriyasu Shikura, Emmanuelle Darbon, Catherine Esnault, Ariane Deniset-Besseau, Delin Xu, Clara Lejeune, Eric Jacquet, Naima Nhiri, Laila Sago, David Cornu, Sebastiaan Werten, Cecile Martel, Marie-Joelle Virolle
Summary: In Streptomyces, antibiotic biosynthesis is triggered in phosphate limitation and energetic stress. A gene encoding polyphosphate kinase is co-transcribed with two downstream genes, one encoding a CHAD domain-containing phosin and the other encoding a nudix hydrolase. The expression of this operon is under the control of the two-component system PhoR/PhoP and is mainly activated in condition of phosphate limitation.
Article
Biochemistry & Molecular Biology
Johannes Hoefle, Timo Trenkner, Nadja Kleist, Vera Schwane, Sarah Vollmers, Bryan Barcelona, Annika Niehrs, Pia Fittje, Van Hung Huynh-Tran, Juergen Sauter, Alexander H. Schmidt, Sven Peine, Angelique Hoelzemer, Laura Richert, Marcus Altfeld, Christian Koerner
Summary: TRAIL is identified to be involved in the recognition and activation of NK cells against HIV-1-infected cells. It induces degranulation and IFN-γ production, and its activation is not limited to its cognate death receptors but also involves decoy receptor I.
Article
Cell Biology
Diana Schuhmacher, Jean-Marie Sontag, Estelle Sontag
Summary: The study reveals the crucial roles of LCMT1, PME1, and PP2A methylation/demethylation in modulating TJ assembly and functional integrity, positioning PP2A at the interface of one-carbon metabolism and the regulation of key TJ and polarity proteins that are deregulated in many human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Lihi Gershon, Martin Kupiec
Summary: During DNA replication, histone acetylation plays a crucial role in maintaining genomic stability. The protein kinase Dun1 is shown to have an essential role in counteracting the effects of hyper-acetylated histones, independent of its known function in regulating dNTPs. This highlights the importance of proper temporal and replication program regulation in cells with hyper-acetylated histones.
Article
Engineering, Environmental
Muhammad Asad Javed, Abdul Mannan Zafar, Ashraf Aly Hassan, Asad A. Zaidi, Muhammad Farooq, Amro El Badawy, Tryg Lundquist, Mohamad Mostafa Ahmed Mohamed, Sulaiman Al-Zuhair
Summary: One of the main challenges in hydrogen production via biophotolysis is the sensitivity of the hydrogenase enzyme to oxygen. This study reviews methods to enhance H-2 production by regulating oxygen concentration and utilizing antioxidants, with techniques such as co-culturing with bacteria and using antioxidants/nanoparticles appearing most significant for environmental sustainability and green energy production.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Cell Biology
Rajakumar Anbazhagan, Raghuveer Kavarthapu, Maria L. Dufau
Summary: Post-transcriptional and translational control of specialized genes are crucial in spermatogenesis. CBs serve as storage and processing centers for mRNA, playing an important role in protein expression timing. GRTH and phospho-GRTH regulate mRNA transport, ensuring proper protein expression during different stages of sperm development.
Article
Oncology
Radhika P. Gogoi, Sandra Galoforo, Alexandra Fox, Colton Morris, Harry Ramos, Vir K. Gogoi, Hussein Chehade, Nicholas K. Adzibolosu, Chenjun Shi, Jitao Zhang, Roslyn Tedja, Robert Morris, Ayesha B. Alvero, Gil Mor
Summary: The study identified CTGF as a crucial gene for maintaining the epithelial phenotype and inhibiting EMT. Its loss is associated with early cellular modifications required for EMT.
Article
Immunology
Lena Michaelis, Marcel Tress, Hanna-Christine Loew, Johanna Klees, Christian Klameth, Anna Lange, Anne Griesshammer, Andrea Schaefer, Sarah Menz, Alex Steimle, Klaus Schulze-Osthoff, Julia-Stefanie Frick
Summary: Intestinal commensal bacteria play a significant role in regulating the development of Th17 cells, with potential implications for autoimmune diseases. The atypical nuclear I kappa B protein I kappa B zeta may be involved in this process. Different gut commensals with varying immunogenicity levels can affect the expression of I kappa B zeta in dendritic cells and influence the immune response, indicating potential therapeutic implications for autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Jiajian Zhou, Yile Huang, Yingzhe Ding, Jie Yuan, Huating Wang, Hao Sun
Article
Biochemical Research Methods
Kun Sun, Jiguang Wang, Huating Wang, Hao Sun
Article
Biochemical Research Methods
Jie Yuan, Jiajian Zhou, Huating Wang, Hao Sun
Article
Cell Biology
Hee-Kyung Hong, Eleonore Maury, Kathryn Moynihan Ramsey, Mark Perelis, Biliana Marcheva, Chiaki Omura, Yumiko Kobayashi, Denis C. Guttridge, Grant D. Barish, Joseph Bass
GENES & DEVELOPMENT
(2018)
Article
Gastroenterology & Hepatology
Mitchell L. Ramsey, Erin Talbert, Daniel Ahn, Tanios Bekaii-Saab, Niharika Badi, P. Mark Bloomston, Darwin L. Conwell, Zobeida Cruz-Monserrate, Mary Dillhoff, Matthew R. Farren, Alice Hinton, Somashekar G. Krishna, Gregory B. Lesinski, Thomas Mace, Andrei Manilchuk, Anne Noonan, Timothy M. Pawlik, Priyani Rajasekera, Carl Schmidt, Denis Guttridge, Phil A. Hart
Article
Biochemistry & Molecular Biology
Fengyuan Chen, Jiajian Zhou, Yuying Li, Yu Zhao, Jie Yuan, Yang Cao, Lijun Wang, Zongkang Zhang, Baoting Zhang, Chi Chiu Wang, Tom H. Cheung, Zhenguo Wu, Carmen Chak-Lui Wong, Hao Sun, Huating Wang
Article
Cell Biology
Jiajian Zhou, Karl K. So, Yuying Li, Yang Li, Jie Yuan, Yingzhe Ding, Fengyuan Chen, Yile Huang, Jin Liu, Wayne Lee, Gang Li, Zhenyu Ju, Hao Sun, Huating Wang
Article
Multidisciplinary Sciences
Qian Zhang, Ryan C. Riddle, Qian Yang, Clifford R. Rosen, Denis C. Guttridge, Naomi Dirckx, Marie-Claude Faugere, Charles R. Farber, Thomas L. Clemens
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Cell Biology
Erin E. Talbert, Maria C. Cuitino, Katherine J. Ladner, Priyani V. Rajasekerea, Melissa Siebert, Reena Shakya, Gustavo W. Leone, Michael C. Ostrowski, Brian Paleo, Noah Weisleder, Peter J. Reiser, Amy Webb, Cynthia D. Timmers, Daniel S. Eiferman, David C. Evans, Mary E. Dillhoff, Carl R. Schmidt, Denis C. Guttridge
Article
Multidisciplinary Sciences
Vikas Malik, Laura Glaser, Dennis Zimmer, Sergiy Velychko, Mingxi Weng, Markus Holzner, Marius Arend, Yanpu Chen, Yogesh Srivastava, Veeramohan Veerapandian, Zahir Shah, Miguel A. Esteban, Huating Wang, Jiekai Chen, Hans R. Schoeler, Andrew P. Hutchins, Sebastiaan H. Meijsing, Sebastian Pott, Ralf Jauch
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Yu Zhao, Jiajian Zhou, Liangqiang He, Yuying Li, Jie Yuan, Kun Sun, Xiaona Chen, Xichen Bao, Miguel A. Esteban, Hao Sun, Huating Wang
NATURE COMMUNICATIONS
(2019)
Editorial Material
Health Care Sciences & Services
Marie Fallon, Imed E. Gallouzi, Denis C. Guttridge, Teresa A. Zimmers
CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE
(2021)
Correction
Cell Biology
Zongbing You, Daniel Saims, Shaoqiong Chen, Zhaocheng Zhang, Denis C. Guttridge, Kun-liang Guan, Ormond A. MacDougald, Anthony M. C. Brown, Gerard Evan, Jan Kitajewski, Cun-Yu Wang
JOURNAL OF CELL BIOLOGY
(2021)
Article
Allergy
Masafumi Sakashita, Tetsuji Takabayashi, Yoshimasa Imoto, Tetsuya Homma, Kanako Yoshida, Kazuhiro Ogi, Yukihiro Kimura, Atsushi Kato, Whitney W. Stevens, Stephanie S. Smith, Kevin C. Welch, James E. Norton, Lydia A. Suh, Roderick G. Carter, Kathryn E. Hulse, Sudarshan Seshadri, Jin-Young Min, Kathryn L. Pothoven, David B. Conley, Bruce K. Tan, Kathleen E. Harris, Robert C. Kern, Shinichi Haruna, Yoshinori Matsuwaki, Ryosuke Ochiai, Shigeharu Fujieda, Robert P. Schleimer
Summary: This study found that patients with AERD have lower levels of retinoids, which may contribute to decreased tPA and fibrinolysis. In vitro experiments showed that retinoic acid can induce tPA production in epithelial cells and reverse the inhibitory effect of IL-13 on tPA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
Xiaona Chen, Guang Xue, Jieyu Zhao, Yuwei Zhang, Suyang Zhang, Wen Wang, Yang Li, Jie Yuan, Liangqiang He, Chun Yin Chan, Yan Liu, Wei Chen, Yu Zhao, Ping Hu, Hao Sun, Chun Kit Kwok, Huating Wang
Summary: This study identifies a lncRNA called Lockd, which is induced in activated muscle stem cells (SCs) upon acute muscle injury. Lockd interacts with RNA helicase DHX36 and stabilizes its interaction with EIF3B proteins, promoting the translation of Anp32e mRNA and ultimately facilitating myoblast proliferation and acute-injury-induced muscle regeneration.