Review
Oncology
Zoi Piperigkou, Konstantina Kyriakopoulou, Christos Koutsakis, Stylianos Mastronikolis, Nikos K. Karamanos
Summary: Proteolytic enzymes and non-proteolytic enzymatic partners play crucial roles in cancer cell propagation and metastatic potential. This article revisits the functions of major matrix remodeling molecules and discusses their epigenetic regulation mechanisms, pharmacological targeting, and ongoing clinical trials. The importance of targeting matrix remodeling partners for cancer management is explored in relation to tissue homeostasis and ECM turnover.
Review
Biochemistry & Molecular Biology
Nikos K. Karamanos, Achilleas D. Theocharis, Zoi Piperigkou, Dimitra Manou, Alberto Passi, Spyros S. Skandalis, Demitrios H. Vynios, Veronique Orian-Rousseau, Sylvie Ricard-Blum, Christian E. H. Schmelzer, Laurent Duca, Madeleine Durbee, Nikolaos A. Afratis, Linda Troeberg, Marco Franchi, Valentina Masola, Maurizio Onisto
Summary: Extracellular matrix (ECM) is a dynamic 3-dimensional network of macromolecules providing structural support for cells and tissues. It plays key regulatory roles in cell signaling, functions, and morphology. Different ECM components affect cell processes such as proliferation, migration, differentiation, angiogenesis, and immunity regulation, with structural alterations associated with disease progression.
Article
Cell Biology
Katharina Joechle, Huda Jumaa, Kerstin Thriene, Claus Hellerbrand, Birte Kulemann, Stefan Fichtner-Feigl, Sven A. Lang, Jessica Guenzle
Summary: The study showed that OSI-027, a dual kinase inhibitor targeting mTOR complexes, can significantly impact the migratory and metastatic capacity of cholangiocarcinoma cells by reducing cell mobility and migration, decreasing colony-forming ability, and downregulating MMP2 and MMP9 expression. Additionally, OSI-027 impaired survival and anti-apoptotic signaling as determined by AKT and MAPK blotting, suggesting that dual targeting of mTORC1/2 may be a viable option for anti-neoplastic therapy in CCA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Chang Liu, Xiao Guo, Yutong Chen, Meijun Zhao, Shuai Shi, Zheng Luo, Jian Song, Zhihong Zhang, Wenchuang Yang, Keyi Liu
Summary: This study utilized the technology of flexible liposomes to co-load apigenin and doxycycline, which showed good encapsulation efficiency, drug loading, in vitro release, and transdermal efficiency. The A/D-FLip liposome exhibited anti-photoaging effects by combating oxidative stress, reducing inflammation, inhibiting MMPs activation, and preventing collagen loss. Cellular and animal experiments demonstrated that A/D-FLip could inhibit oxidative stress damage, decrease inflammatory factors, and prevent skin collagen loss, making it a promising skin care product or drug against UV damage and skin photoaging.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Tarik Issad, Hasanain Al-Mukh, Abdelouhab Bouaboud, Patrick Pagesy
Summary: O-GlcNAcylation is a crucial protein modification that regulates protein functions and cell signaling, and is associated with numerous physiological and pathological processes.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Bartosz Pilecki, Paulo V. S. D. de Carvalho, Katrine L. Kirketerp-Moller, Anders Schlosser, Karin Kejling, Magdalena Dubik, Nicklas P. Madsen, Jane Stubbe, Pernille B. L. Hansen, Thomas L. Andersen, Jesper B. Moeller, Niels Marcussen, Vasco Azevedo, Svend Hvidsten, Christina Baun, Guo-Ping Shi, Jes S. Lindholt, Grith L. Sorensen
Summary: MFAP4 plays a crucial role in promoting the development of AAA by inducing macrophage-rich inflammation and MMP activity within the vessel wall. Its deficiency leads to reduced AAA incidence and ameliorates pathological changes in AAA, implicating regulation of monocyte influx and MMP production as key mechanisms.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Immunology
Arpana Verma, Maninder Kaur, Princy Luthra, Lakshyaveer Singh, Divya Aggarwal, Indu Verma, Bishan D. D. Radotra, Sanjay Kumar Bhadada, Sadhna Sharma
Summary: Diabetes is a significant risk factor for latent tuberculosis activation and worsens tuberculosis treatment outcomes. The study focuses on understanding the interaction between M. tuberculosis and its host during latent tuberculosis infection under hyperglycemic conditions or diabetes. An animal model was used to study the relationship, and various host factors such as cytokines and MMPs were analyzed. The results showed that diabetes worsens the containment of mycobacterial infection and affects granuloma formation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Neurosciences
Susanne Wiemann, Aisha Yousf, Stephanie C. Joachim, Carolin Peters, Ana M. Mueller-Buehl, Natalie Wagner, Jacqueline Reinhard
Summary: This study aimed to investigate the functional role of the glycoprotein tenascin-C (Tnc) in retinal ischemia, finding increased Tnc levels after ischemia accompanied by diminished rod-photoreceptor degeneration and retinal dysfunction in KO mice. Additionally, KO mice showed lower levels of activated caspase 3(+) cells, suggesting a potential role of Tnc in synaptic remodeling during ischemic retinal degeneration. Increased vesicular glutamate transporter 1 (vGlut1) levels in both ischemic groups indicated impaired glutamatergic signaling and excitotoxicity after ischemia.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Bagher Pourheydar, Mahrokh Samadi, Parisa Habibi, Ahmad Ali Nikibakhsh, Roya Naderi
Summary: Treatment with tropisetron in diabetic rats led to significant improvements in blood glucose, serum cystatin C, and urinary total protein levels, indicating enhanced kidney function and reduced renal fibrosis. The expression of TGF-beta 1, p53, MMP-9, and MMP-2 in the kidneys of diabetic rats was regulated by tropisetron, suggesting its potential as a therapeutic agent for diabetic nephropathy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Biochemistry & Molecular Biology
Katerina Strouhalova, Ondrej Tolde, Daniel Rosel, Jan Brabek
Summary: MT1-MMP (MMP-14) is a versatile protease involved in regulating extracellular matrix degradation, activation of other proteases, as well as various cellular processes such as migration and viability in both physiological and pathological conditions. The cytoplasmic tail of MT1-MMP, consisting of the final 20 C-terminal amino acids, plays a crucial role in determining its localization, signal transduction capabilities, and interaction with other proteins. This review summarizes the involvement of the cytoplasmic tail in regulating and executing the functions of MT1-MMP, providing insights into cellular adhesion and invasion mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Youjia Zhang, Maomao Song, Yingwen Bi, Yuan Lei, Xinghuai Sun, Yuhong Chen
Summary: In this study, TIPARP was identified as a regulator of intraocular pressure by modulating extracellular matrix and cell cytoskeleton proteins. TIPARP was significantly upregulated in the blood and trabecular meshwork of patients with primary open angle glaucoma.
COMMUNICATIONS BIOLOGY
(2022)
Article
Clinical Neurology
Taylor E. Branyan, Amutha Selvamani, Min Jung Park, Kriti E. Korula, Kelby F. Kosel, Rahul Srinivasan, Farida Sohrabji
Summary: The study identifies miR-20a-3p as a potential therapeutic for stroke and reveals different expression levels of this microRNA in astrocytes of different genders and age groups. Results show that miR-20a-3p has more neuroprotective effects when expressed in neurons, and intravenous injections of miR-20a-3p mimic significantly improve stroke outcomes.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Behpour Yousefi, Vahid Semnani, Tahmineh Mokhtari, Sam Zarbakhsh, Mohammad Hasan Tabrizi Amjad, Mehdi Barati, Hoda Doustmohammadi
Summary: This study aimed to evaluate the effects of aluminum sulfate with propolis on uterine leiomyoma in rat model. The results showed that the combination of propolis and aluminum sulfate significantly decreased myometrium collagen contents and reduced the gene expression of MMP-2 and 9.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Multidisciplinary Sciences
Braxton Noll, Farah Bahrani Mougeot, Michael T. Brennan, Jean-Luc C. Mougeot
Summary: This study found that the degradation of salivary epithelium in primary Sjogren's syndrome (pSS) patients is initially caused by overexpression of MMP9. The expression of MMP9 and its associated transcription factor ETS1 was assessed in primary salivary gland epithelial cells (SGECs) and potential regulatory mechanisms were investigated in immortalized SGECs. It was found that ETS1 and MMP9 were overexpressed in SGECs of pSS patients. Knocking down ETS1 resulted in reduced mRNA and protein levels of MMP9. ETS1 overexpression affected the expression of markers associated with epithelial-mesenchymal transition (EMT) and progenitor cells.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Qichen Yang, Samantha Antonio Leong, Kwok Ping Chan, Xiang-Ling Yuan, Tsz Kin Ng
Summary: This study found that continuous exposure to curcumin had complex effects on human bone marrow-derived mesenchymal stem cells, impacting cell maintenance, proliferation, migration, differentiation, and gene expression. The dosage of curcumin played a crucial role in determining the outcomes, suggesting that careful consideration of treatment length and dosage is important when using curcumin for biomedical purposes.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)