Article
Multidisciplinary Sciences
Shivesh Kumar, Raul Zavaliev, Qinglin Wu, Ye Zhou, Jie Cheng, Lucas Dillard, Jordan Powers, John Withers, Jinshi Zhao, Ziqiang Guan, Mario J. Borgnia, Alberto Bartesaghi, Xinnian Dong, Pei Zhou
Summary: NPR1 is a key regulator of the defence transcriptome induced by the plant immune signal salicylic acid. Structural analysis reveals the unique features of NPR1 and its interaction with salicylic acid, providing insights into its regulatory mechanisms. Moreover, the formation of the NPR1-TGA complex and its role in transcription activation shed light on how NPR1 reprograms the defence transcriptome.
Article
Multidisciplinary Sciences
Tao-Tao Chen, Yanling Lin, Shijun Zhang, Shuxin Liu, Lei Song, Wenhong Zhong, Zhao-Qing Luo, Aidong Han
Summary: The intracellular bacterial pathogen Legionella pneumophila hijacks host vesicular transport factor p115 to localize its effector protein LegA15 in host lipid droplets (LDs) and causes fragmentation of host Golgi apparatus. LegA15 is an atypical GTPase that modulates host LD homeostasis through its GTPase activity.
Article
Oncology
Ying Zhang, Wei Zhang, Qiyou Yuan, Wenqing Hong, Ping Yin, Tingting Shen, Lutong Fang, Junlan Jiang, Fangxiao Shi, Weiwei Chen
Summary: This study aims to investigate the role of transmembrane protein-related genes in the development and prognosis of glioma and provide new insights into the pathogenesis of the disease. Prognostic transmembrane protein-related genes were identified and a prognostic model was constructed to predict the survival rate of glioma patients. The study found that transmembrane protein-related genes may influence the development and prognosis of glioma by regulating the immune microenvironment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Renjie Chen, Pengwei Sun, Guitao Zhong, Wei Wang, Dingzhong Tang
Summary: This study reveals the role of RLP53 in positively regulating immune signaling in Arabidopsis thaliana. A point mutation in RLP53 fully suppresses disease resistance and cell death in edr1 mutants. RLP53 interacts with the LRR receptor-like kinase SOBIR1 and the co-receptor BAK1 to regulate plant immunity. Additionally, the GPI-anchored protein LLG1 interacts with RLP53 and mediates its accumulation in the plasma membrane.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Plant Sciences
Jiawei Xiong, Xiaoping Wan, Maolin Ran, Xiumei Xu, Lezhang Chen, Feng Yang
Summary: Plant hormone brassinosteroids (BRs) play crucial roles in plant immunity by regulating the expression of callose synthase gene GLUCAN SYNTHASE-LIKE 8 (GSL8) and promoting callose accumulation, which enhances the resistance to pathogen infection. The molecular mechanism and key components of BR-induced pathogen resistance remain to be fully elucidated.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Broto Chakrabarty, Nita Parekh
Summary: This study classifies and analyzes human ANKYRIN proteins to understand their diversity and their significance in disease association.
Article
Biochemistry & Molecular Biology
Yuerong Cai, Gang Liang
Summary: This study reveals the crucial roles of CITF1 in the copper homeostasis signaling network, showing that CITF1 enhances tolerance to copper deficiency and promotes the expression of copper uptake genes. SPL7 directly activates the CITF1 promoter to regulate the copper uptake system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jieru Zhao, Zhixiang Yuan, Xixi Han, Tingting Bao, Tingmi Yang, Zhuang Liu, Hongxia Liu
Summary: In this study, the researchers found that β-Carbonic anhydrase (βCA) is crucial for both plant growth and immunity. They observed that the expression of Solanum lycopersicum βCA1 (Sl βCA1) was significantly increased in response to Xanthomonas euvesicatoria 85-10 treatment. Silencing of Sl βCA1 in tomato plants confirmed its active role in plant disease resistance. Furthermore, the study showed that the interaction between the elicitor PopW and Sl βCA1 plays a role in immune response. This research highlights the importance of Sl βCA1 in plant immunity and its recognition by the elicitor protein PopW.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Na Zhang, Feiming Ye, Yu Zhou, Wei Zhu, Cuiping Xie, Haiqiong Zheng, Han Chen, Jinghai Chen, Xiaojie Xie
Summary: CARP, a cardiac-specific stress-response protein, plays a crucial role in regulating cardiac remodeling and function. Overexpression of CARP in mice resulted in dilated cardiomyopathy, impaired heart function, and reduced survival rate in response to ischemic acute myocardial infarction. The overexpression of CARP was associated with the suppression of calcium-handling proteins and decreased cell contraction.
Article
Biochemistry & Molecular Biology
Zhen Wu, Tao Hu, Andres Merits, Yu He, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Yunya Liu, Ling Zhang, Yanling Yu, Anchun Cheng, Shun Chen
Summary: Unlike most arthropod-transmitted flaviviruses, the Tembusu virus (TMUV) remains active during winter and can be transmitted through the digestive tract. The study shows that intestinal bacteria play a crucial role in TMUV infection, with lipopolysaccharide (LPS) from Gram-negative bacteria enhancing TMUV proliferation via the Toll-like receptor 4 (TLR4) pathway.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Fei Qin, Baoshan Cai, Jian Zhao, Lei Zhang, Yi Zheng, Bingyu Liu, Chengjiang Gao
Summary: MAVS mRNA undergoes m(6)A modification through METTL14, affecting its stability and immune response to RNA viruses. Deficiency of METTL14 increases MAVS mRNA stability, leading to enhanced response to RNA virus infection.
Article
Biochemistry & Molecular Biology
Liying He, Jiaqi Liang, Chaonan Chen, Jijun Chen, Yihui Shen, Shuangshuang Sun, Lei Li
Summary: Deficiency of C9orf72 exacerbates neurodegeneration induced by poly-GR by impairing NHEJ repair, resulting in the accumulation of DNA damage and overactivation of PARP-1.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Genetics & Heredity
Juan Mao, Wenxin Li, Jing Liu, Jianming Li
Summary: Plant GSK3-like kinases are highly conserved protein serine/threonine kinases that become inactivated in response to developmental and environmental signals, playing important roles in plant growth, development, and stress responses.
Article
Biology
Yoshifumi Takahata, Hiromasa Hagino, Ayaka Kimura, Mitsuki Urushizaki, Sachi Kobayashi, Kanta Wakamori, Chika Fujiwara, Eriko Nakamura, Kayon Yu, Hiroshi Kiyonari, Kana Bando, Tomohiko Murakami, Toshihisa Komori, Kenji Hata, Riko Nishimura
Summary: Scientists identify Smoc1 and Smoc2 as novel targets for Runx2, playing important roles in bone formation. Double knockout mice for Smoc1 and Smoc2 show skeletal developmental abnormalities, indicating their involvement in intramembranous and endochondral bone formation. Their findings may lead to novel therapeutic strategies for various bone and cartilage diseases.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Amit Kumar, Jochen Balbach
Summary: Ankyrin repeat proteins, found across all three domains of life, play a crucial role in protein-protein interactions to regulate biological processes. With a basic architecture of repeating modules forming elongated structures and lacking long-range interactions, these proteins exhibit graded stability, impacting both folding and biological functions. The conformational changes of these repeats act as molecular switches for biological regulation, making them versatile for modern drug discovery.
Article
Plant Sciences
Tongjun Sun, Lucas Busta, Qian Zhang, Pingtao Ding, Reinhard Jetter, Yuelin Zhang
Article
Plant Sciences
Baptiste Castel, Pok-Man Ngou, Volkan Cevik, Amey Redkar, Dae-Sung Kim, Ying Yang, Pingtao Ding, Jonathan D. G. Jones
Article
Plant Sciences
Bruno Pok Man Ngou, Hee Kyung Ahn, Pingtao Ding, Amey Redkar, Hannah Brown, Yan Ma, Mark Youles, Laurence Tomlinson, Jonathan D. G. Jones
JOURNAL OF EXPERIMENTAL BOTANY
(2020)
Article
Biotechnology & Applied Microbiology
Pingtao Ding, Bruno Pok Man Ngou, Oliver J. Furzer, Toshiyuki Sakai, Ram Krishna Shrestha, Dan MacLean, Jonathan D. G. Jones
PLANT BIOTECHNOLOGY JOURNAL
(2020)
Review
Plant Sciences
Pingtao Ding, Yuli Ding
TRENDS IN PLANT SCIENCE
(2020)
Article
Multidisciplinary Sciences
Zane Duxbury, Shanshan Wang, Craig MacKenzie, Jeannette L. Tenthorey, Xiaoxiao Zhang, Sung Un Huh, Lanxi Hu, Lionel Hill, Pok N. Ngou, Pingtao Ding, Jian Chen, Yan Ma, Hailong Guo, Baptiste Castel, Panagiotis N. Moschou, Maud Bernoux, Peter N. Dodds, Russell E. Vance, Jonathan D. G. Jones
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Bruno Pok Man Ngou, Hee-Kyung Ahn, Pingtao Ding, Jonathan D. G. Jones
Summary: Research shows that intracellular receptors and cell-surface receptors in plant immunity interact and enhance each other to activate strong defense mechanisms against pathogens. The immune system of plant cells plays a crucial role in pathogen recognition and the activation of proteins.
Review
Plant Sciences
Minhang Yuan, Bruno Pok Man Ngou, Pingtao Ding, Xin Xiu-Fan
Summary: Plants have innate immune responses to resist pathogen attacks, involving pattern-recognition receptors (PRRs) and nucleotide-binding domain leucine-rich repeat containing receptors (NLRs) that lead to pattern-triggered immunity (PTI) and effector-triggered immunity (ETI). Despite different activation mechanisms, PTI and ETI converge into similar downstream responses, with evidence of interactions and shared components between PRR-mediated and NLR-mediated signaling cascades. Future research on signal collaboration between PRR-initiated and NLR-initiated immunity will provide a more comprehensive understanding of the plant immune system.
CURRENT OPINION IN PLANT BIOLOGY
(2021)
Article
Plant Sciences
Pingtao Ding, Toshiyuki Sakai, Ram Krishna Shrestha, Nicolas Manosalva Perez, Wenbin Guo, Bruno Pok Man Ngou, Shengbo He, Chang Liu, Xiaoqi Feng, Runxuan Zhang, Klaas Vandepoele, Dan MacLean, Jonathan D. G. Jones
Summary: This study combines RNA-seq and ATAC-seq to investigate the effects of cell-surface and intracellular receptor-mediated immunity activation on gene expression and chromatin accessibility. The results reveal overlapping and conserved transcriptional regulatory mechanisms between the two immune systems.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Plant Sciences
Bruno Pok Man Ngou, Jonathan D. G. Jones, Pingtao Ding
Summary: Plants have cell-surface and intracellular receptors to recognize pathogen effectors. These receptors, along with their coreceptors, form networks to mediate downstream immune responses. The cell-surface and intracellular immune systems are interdependent and function synergistically to provide robust resistance against pathogens.
TRENDS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Nitika Mukhi, Hannah Brown, Danylo Gorenkin, Pingtao Ding, Adam R. Bentham, Clare E. M. Stevenson, Jonathan D. G. Jones, Mark J. Banfield
Summary: Plants use NLRs to detect pathogen-derived effector proteins, with RRS1-R/RPS4 providing disease resistance against different bacterial pathogens. The WRKY domain of RRS1 is involved in perceiving different classes of effectors to initiate immune responses, but the exact mechanism is not fully understood.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Bruno Pok Man Ngou, Pingtao Ding, Jonathan D. G. Jones
Summary: Understanding the plant immune system is crucial for protecting crops from diseases. Plants have a two-tiered innate immune system to resist pathogens. Over the last 30 years, significant progress has been made in identifying immune receptors and understanding the signaling pathways and interactions between different components of the immune system.
Review
Biochemistry & Molecular Biology
Niels Aerts, Himanshu Chhillar, Pingtao Ding, Saskia C. M. Van Wees
Summary: This article discusses the importance and regulation mechanisms of transcriptional reprogramming in plant immunity. The tight regulation of transcriptional regulators and other mechanisms allows plants to properly respond to different types of pathogens. The article also highlights emerging technologies that promise to enhance our understanding of the regulation of the plant immune transcriptome.
ESSAYS IN BIOCHEMISTRY
(2022)
Review
Plant Sciences
Yuxiang Jiang, Pingtao Ding
Summary: This article reviews the important roles of calcium ions in plant immunity, including their activation, signal decoding, and termination. Despite recent progress, there are still many unanswered questions that can be addressed with existing tools and new technologies.
TRENDS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Yulu Zhou, Ruixia Niu, Zhijuan Tang, Rui Mou, Zhao Wang, Sitao Zhu, Hongchun Yang, Pingtao Ding, Guoyong Xu
Summary: This study identifies Arabidopsis HEM1 as a global translational regulator of plant immunity that controls cell death and bacterial growth during effector-triggered immunity. HEM1 utilizes a plant-specific condensation domain to interact with the translation machinery and suppress immune gene translation, thereby preventing immunopathology-associated tissue damage. These findings provide important insights into the regulatory mechanisms of immune activation in plants.