Article
Plant Sciences
Jonathan Przybyla-Toscano, Andrew E. Maclean, Marina Franceschetti, Daniela Liebsch, Florence Vignols, Olivier Keech, Nicolas Rouhier, Janneke Balk
Summary: NFU4 and NFU5 proteins in plants have a housekeeping function and are involved in the lipoylation process of mitochondrial dehydrogenases, providing Fe-S clusters to lipoyl synthase.
Article
Microbiology
Mathieu Sourice, Isabel Askenasy, Pierre Simon Garcia, Yann Denis, Gael Brasseur, Patricia J. J. Kiley, Beatrice Py, Corinne Aubert
Summary: Fe-S proteins play a crucial role in various biological processes, making it essential for organisms to maintain Fe-S cluster homeostasis. This study presents the coordination of two Fe-S cluster biogenesis machineries in a bacterium from the Deltaproteobacteria branch. The findings highlight the diversity and commonalities in the regulation of Fe-S cluster homeostasis in response to environmental changes.
Review
Biochemistry & Molecular Biology
Leszek Rydz, Maria Wrobel, Halina Jurkowska
Summary: Mitochondria are crucial organelles for the synthesis of Fe-S clusters, with sulfurtransferases playing a key role. Fe-S clusters are essential for Fe-S proteins, susceptible to oxidative stress but capable of being resynthesized or repaired. Sulfurtransferases are involved in the formation, maturation, and reconstitution of Fe-S clusters.
Review
Biochemistry & Molecular Biology
Courtney J. Campbell, Ashley E. Pall, Akshata R. Naik, Lindsey N. Thompson, Timothy L. Stemmler
Summary: Iron-sulfur clusters are crucial for cellular activities and the ISC pathway serves as the central mechanism for providing 2Fe-2S clusters in eukaryotes. Study of the NIAUF complex reveals insights into the coordinated mechanism of Fe-S cluster assembly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jordan D. Pritts, Sarah L. J. Michel
Summary: Metal ions are commonly found as protein co-factors in biology. The distribution and utilization of metals in biology has evolved over time. Zinc finger proteins are a common class of metal co-factored proteins, but there have been cases where proteins annotated as zinc finger proteins actually contain Fe-S clusters. Researchers can differentiate the metal co-factors using bioinformatics and specific methods.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qin Li, Yongbing Li, Xiaohan Li, Sanfeng Chen
Summary: This study identified a number of genes related to nitrogenase Fe-S cluster biosynthesis in Paenibacillus polymyxa WLY78, with nifS-like, SufC, SufD, SufB, and YutI being key genes involved in the formation of the Fe-S cluster of nitrogenase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Nidhi Kirtikumar Bub, Sakshi Anand, Swati Garg, Vishal Saxena, Dhanabala Subhiksha Rajesh Khanna, Deeptanshu Agarwal, Sanjay Kumar Kochar, Shailja Singh, Shilpi Garg
Summary: This study identifies Dre2 as a potential target for artemisinin drugs and demonstrates that artemisinin derivatives can interact with Dre2, altering its activity and inducing cell death.
Article
Chemistry, Inorganic & Nuclear
Juan He, Jia Wei, Gan Xu, Xu-Dong Chen
Summary: The rational construction of versatile Mo-Fe-S cubane clusters was achieved using a LEGO strategy, providing a controlled synthesis method for biomimetic chemistry.
INORGANIC CHEMISTRY
(2022)
Article
Plant Sciences
Saradia Kar, Hans-Joerg Mai, Hadeel Khalouf, Heithem Ben Abdallah, Samantha Flachbart, Claudia Fink-Straube, Andrea Braeutigam, Guosheng Xiong, Lianguang Shang, Sanjib Kumar Panda, Petra Bauer
Summary: Iron (Fe) toxicity is a major challenge for plant cultivation in acidic waterlogged soil environments, particularly for lowland rice, a staple food crop. A study identified genes related to excess Fe tolerance in rice, which could be crucial for targeted breeding of rice crops for increased Fe tolerance during domestication.
PLANT AND CELL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Parool Gupta, Rani Mansuri, Priya Priydarshni, Sachidananda Behera, Amir Zaidi, Shamshun Nehar, Ganesh Chandra Sahoo, Krishna Pandey, Vahab Ali
Summary: This study revealed the interaction between two proteins, Cfd1 and Nbp35, in L. donovani, forming a stable complex involved in the cellular process of Fe-S cluster biogenesis and transfer. The upregulation of Cfd1 and Nbp35 proteins in drug-resistant parasites leads to increased Fe-S protein levels, promoting parasite survival under drug pressure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Nunziata Maio, Bernard A. P. Lafont, Debangsu Sil, Yan Li, J. Martin Bollinger, Carsten Krebs, Theodore C. Pierson, W. Marston Linehan, Tracey A. Rouault
Summary: Research has shown that the catalytic subunit nsp12 of the SARS-CoV-2 RdRp complex ligates two iron-sulfur metal cofactors which are essential for viral replication and interaction with the viral helicase. Oxidation of these clusters by TEMPOL inhibits RdRp activity and blocks SARS-CoV-2 replication in cell culture, indicating that these iron-sulfur clusters could be targeted for therapy of COVID-19.
Article
Biochemistry & Molecular Biology
Jing Du, Zhaoyang Huang, Yanchun Li, Xueying Ren, Chaoting Zhou, Ruolan Liu, Ping Zhang, Guojie Lei, Jianxin Lyu, Jianghui Li, Guoqiang Tan
Summary: Copper is a necessary mineral nutrient but excess copper is cytotoxic. Wilson's disease is an autosomal recessive hereditary disease characterized by pathological copper accumulation in organs. The molecular mechanism of Wilson's disease is not fully understood and further research is needed to develop therapeutic strategies.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Hayley N. Brawley, Alexia C. Kreinbrink, Justin D. Hierholzer, Shaik Waseem Vali, Paul A. Lindahl
Summary: The composition and characteristics of labile iron pools (LFePs) in cytosol from Escherichia coli were investigated. The LFeP was found to be primarily composed of high-spin Fe(II) species and showed a tighter binding to ATP. This study provides insight into the chemical composition and properties of LFePs in biological systems.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Microscopy
Tiara V. Hinton, Sharon Batelu, Noah Gleason, Timothy L. Stemmler
Summary: Fe-S clusters play crucial roles in biochemical pathways in living organisms, synthesizing through mitochondrial and cytosolic pathways in eukaryotes. Deficiency in Fe-S clusters can be detrimental to cell and organism viability.
Article
Microbiology
Ashutosh S. Tripathi, Kushi Anand, Mayashree Das, Ruchika Annie O'Niel, Chandrani Thakur, Raghunatha Reddy R. L., Raju Rajmani, Nagasuma Chandra, Sunil Laxman, Amit Singh
Summary: This study identifies a novel critical protein, SufT, in Mtb that plays an important role in the maturation of Fe-S clusters. SufT interacts with other proteins to regulate Fe-S cluster biogenesis in Mtb and affects the survival, metabolism, and infectivity of Mtb.
Review
Cell Biology
Karl F. Lechtreck, Julie C. Van De Weghe, James Aaron Harris, Peiwei Liu
Article
Multidisciplinary Sciences
Peiwei Liu, Karl F. Lechtreck
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Review
Multidisciplinary Sciences
Liu PeiWei, Qi Ming, Xue XiuHua, Ren HaiYun
CHINESE SCIENCE BULLETIN
(2011)
Article
Biochemistry & Molecular Biology
Peiwei Liu, Ming Qi, Yuqian Wang, Mingqin Chang, Chang Liu, Mengxiang Sun, Weicai Yang, Haiyun Ren
Article
Cell Biology
Peiwei Liu, Xiaochu Lou, Jenna L. Wingfield, Jianfeng Lin, Daniela Nicastro, Karl Lechtreck
JOURNAL OF CELL BIOLOGY
(2020)
Article
Cell Biology
Jenna L. Wingfield, Betlehem Mekonnen, Ilaria Mengoni, Peiwei Liu, Mareike Jordan, Dennis Diener, Gaia Pigino, Karl Lechtreck
Summary: The study utilized two-color imaging of fluorescent protein-tagged IFT components to show that IFT-A and IFT-B proteins from a given anterograde train usually return in the same set of retrograde trains. Additionally, concurrent turnaround was typical for IFT-B proteins and the IFT dynein subunit D1 bLIC-GFP, but severance was also observed.
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Jin Dai, Gui Zhang, Rama A. Alkhofash, Betlehem Mekonnen, Sahana Saravanan, Bin Xue, Zhen-Chuan Fan, Ewelina Betleja, Douglas G. Cole, Peiwei Liu, Karl Lechtreck
Summary: The loss of Chlamydomonas ARL13 impedes BBSome-dependent protein transport, resulting in overlapping biochemical defects in arl13 and bbs mutant cilia.
JOURNAL OF CELL BIOLOGY
(2022)
Review
Cell Biology
Peiwei Liu, Ying Liu, Jun Zhou
Summary: Cilia are surface-exposed organelles that provide motility and sensory functions for cells, and it is widely believed that mechanosensation can be mediated through cilia. Polycystin-1 and -2 (PC-1 and PC-2, respectively) are transmembrane proteins that can localize to cilia; however, the molecular mechanisms by which polycystins contribute to mechanosensation are still controversial.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Shuang Sun, Zhaoyang Xu, Haijie Hu, Manxi Zheng, Liang Zhang, Wei Xie, Lei Sun, Peiwei Liu, Tianliang Li, Liangran Zhang, Min Chen, Xueliang Zhu, Min Liu, Yunfan Yang, Jun Zhou
Summary: This study identified a toxin called alveolysin produced by Bacillus cereus that can disrupt cell junctions in intestinal epithelium by increasing CD59 and CFAP100 proteins. These findings reveal the mechanism by which B. cereus causes intestinal diseases and systemic infections, and propose new strategies for prevention and treatment.
