Review
Medicine, General & Internal
Nazanin Ershadinia, Nicholas A. Tritos
Summary: Acromegaly is a condition caused by a pituitary adenoma that secretes growth hormone, resulting in various complications. Early diagnosis and appropriate treatment are crucial. Diagnosis is confirmed through biochemical tests and MRI. Pituitary surgery is usually the first-line treatment, while medical therapy and radiation therapy can be used as adjunct options.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Endocrinology & Metabolism
Andrea Giustina, Nienke Biermasz, Felipe F. Casanueva, Maria Fleseriu, Pietro Mortini, Christian Strasburger, A. J. van der Lely, John Wass, Shlomo Melmed, Acromegaly Consensus Grp
Summary: The 14th Acromegaly Consensus Conference discussed and reviewed biochemical criteria for acromegaly diagnosis and therapeutic evaluation. The conference emphasized the importance of expert management for this rare disease.
Review
Medicine, General & Internal
Amit Akirov, Hiba Masri-Iraqi, Idit Dotan, Ilan Shimon
Summary: The diagnosis, management, and treatment of acromegaly heavily rely on the levels of serum IGF-1, basal GH, and nadir GH following OGTT. However, these hormone concentrations can be influenced by various factors, leading to discordant levels that may require additional monitoring and data. New standards for GH and IGF-1 provide more accurate tools, but limitations should be considered along with clinical history and imaging studies when evaluating patients with acromegaly.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Geriatrics & Gerontology
Avan Aihie Sayer, Alfonso Cruz-Jentoft
Summary: Sarcopenia is a skeletal muscle disorder that commonly occurs with advancing age and long-term conditions. It is associated with adverse health effects and its recognition in clinical practice is relatively recent. Progress in the future may include the use of routine health data, prescription of resistance exercise, and the translation of biology and epidemiology into new treatment research.
Review
Endocrinology & Metabolism
Maria Fleseriu, Fabienne Langlois, Dawn Shao Ting Lim, Elena V. Varlamov, Shlomo Melmed
Summary: Acromegaly, caused by growth hormone-secreting pituitary adenomas, is usually benign but can be locally invasive and progressive. It leads to a wide range of comorbidities and the normalization of growth hormone and insulin-like growth factor 1 is the primary therapeutic goal. A multimodal approach with surgery, medical therapy, and radiation therapy is required for optimal outcomes.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Jill Sisco, A. J. van der Lely
Summary: Earlier diagnosis of acromegaly is crucial to improve patient's quality of life, reduce disease burden, and minimize economic costs associated with the rare disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, Research & Experimental
Jacobo Kerbel, Amayrani Cano-Zaragoza, Rodrigo Espinosa-Dorado, Keren-Enid Garcia de la Torre, Moises Mercado
Summary: National registries are valuable tools to investigate rare conditions like acromegaly, providing insights into epidemiology, clinical presentation, diagnosis, treatment outcomes, and mortality. While single-center studies are more homogeneous, they are often limited by small sample sizes and lack statistical power.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Michal Elbaum, Marcin Kaluzny, Aleksandra Jawiarczyk-Przybylowska, Beata Wojtczak, Grzegorz Zielinski, Marek Bolanowski
Summary: Uncontrolled acromegaly is associated with increased morbidity and mortality. The incidence of comorbidities and complications in acromegaly patients is high, with the most common being arterial hypertension, multinodular goiter, lipid disorders, hypopituitarism, and degenerative changes. Active acromegaly has a higher incidence of complications compared to treated groups. Successfully cured patients have significantly fewer complications than pharmacologically controlled patients and patients with active acromegaly.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Manel Puig-Domingo, Ignacio Bernabeu, Antonio Pico, Betina Biagetti, Joan Gil, Cristina Alvarez-Escola, Mireia Jorda, Montserrat Marques-Pamies, Berta Soldevila, Maria-Angeles Galvez, Rosa Camara, Javier Aller, Cristina Lamas, Monica Marazuela
Summary: This paper proposes including the clinico-pathologic phenotype in the therapeutic algorithm for acromegaly, utilizing biomarkers for personalized medicine to accelerate the implementation of precision medicine. Additionally, the development, validation, and clinical use of a pasireotide acute test is suggested to identify patients responsive to pasireotide LAR.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Jing-Chun Song, Li-Kun Yang, Wei Zhao, Feng Zhu, Gang Wang, Yao-Peng Chen, Wei-Qin Li
Summary: Trauma-induced hypercoagulopathy, caused by post-traumatic tissue injury, is a common condition in trauma patients and can significantly increase the risk of thrombotic events and mortality. The Chinese Expert Consensus provides 15 recommendations for the definition, pathophysiological mechanism, assessment, prevention, and treatment of trauma-induced hypercoagulopathy, aiming to guide clinical practice for this condition.
MILITARY MEDICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Sajjad Ali Khan, Nanik Ram, Muhammad Qamar Masood, Najmul Islam
Summary: The study found that patients with acromegaly have a high prevalence of cardiovascular and endocrine disorders. Screening and managing these conditions early can lead to better outcomes and decreased mortality.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Oncology
Lorenza Rimassa, Giovanni Brandi, Monica Niger, Nicola Normanno, Delphi Panel Members
Summary: Clinical practice guidelines in Italy recommend genomic profiling for the management of cholangiocarcinoma. However, many Italian oncologists are unfamiliar with genetic testing and targeted treatments. This study provides recommendations based on evidence for molecular testing in diagnosing and treating cholangiocarcinoma, aiming to aid Italian clinicians in selecting appropriate treatment options.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Eva C. Coopmans, Aart J. van der Lely, Sebastian J. C. M. M. Neggers
Summary: Acromegaly is a chronic disorder caused by GH-producing pituitary adenoma. While surgery and medical therapy are standard treatments, some tumors behave aggressively and are resistant to these therapies. In such cases, multimodal therapeutic strategies should be considered.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Agnieszka Jurek, Pawel Krzesinski, Grzegorz Gielerak, Przemyslaw Witek, Grzegorz Zielinski, Anna Kazimierczak, Robert Wierzbowski, Malgorzata Banak, Beata Uzieblo-Zyczkowska
Summary: This study found that even with well-controlled hypertension, patients with acromegaly (AC) exhibit hemodynamic changes in the cardiovascular system, including increased thoracic fluid content (TFC), elevated heart rate, and decreased cardiac contractility indices. These alterations can be detected using impedance cardiography (ICG) as a noninvasive diagnostic tool.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Takehiro Sugiyama, Ayako Yanagisawa-Sugita, Hirokazu Tanaka, Noriko Ihana-Sugiyama, Kenjiro Imai, Mitsuru Ohsugi, Kohjiro Ueki, Nanako Tamiya, Yasuki Kobayashi
Summary: In this retrospective cohort study, using Japan's medical claims and health checkup data, we estimated the cumulative incidence of treatment-requiring diabetic retinopathy after clinical diagnosis of diabetes. Patients diagnosed with diabetes at medical facilities were included and grouped based on their health checkup participation, results, and prompt use of antidiabetic medication after diagnosis. Patients who started antidiabetic medication promptly without recent health checkup faced the highest risk of treatment-requiring diabetic retinopathy. This increased risk was consistently observed across various analyses.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Abdallah Al-Salameh, Guillaume Cadiot, Alain Calender, Pierre Goudet, Philippe Chanson
Summary: Multiple endocrine neoplasia type 1 (MEN1) is a rare syndrome characterized by the co-occurrence of primary hyperparathyroidism, duodenopancreatic neuroendocrine tumours (NETs) and/or pituitary adenomas. Patients with MEN1 should undergo tailored biochemical and imaging screening. Knowledge about the clinical phenotype of these tumours has progressed over the past 10 years, particularly in France and the Netherlands.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Letter
Endocrinology & Metabolism
Marc Diedisheim, Etienne Dancoisne, Jean-Francois Gautier, Etienne Larger, Emmanuel Cosson, Bruno Feve, Philippe Chanson, Sebastien Czernichow, Sopio Tatulashvili, Marie-Laure Raffin-Sanson, Kankoe Sallah, Muriel Bourgeon, Christiane Ajzenberg, Agnes Hartemann, Christel Daniel, Thomas Moreau, Ronan Roussel, Louis Potier
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Andrea Giustina, Marcello D. Bronstein, Philippe Chanson, Stephan Petersenn, Felipe F. Casanueva, Caroline Sert, Aude Houchard, Shlomo Melmed
Summary: The SAGIT instrument has been proven to be a valid and sensitive tool for comprehensively and accurately assessing the severity of acromegaly. Certain components of SAGIT were found to help differentiate between controlled and non-controlled acromegaly patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Marc Diedisheim, Etienne Dancoisne, Jean-Francois Gautier, Etienne Larger, Emmanuel Cosson, Bruno Feve, Philippe Chanson, Sebastien Czernichow, Sopio Tatulashvili, Marie-Laure Raffin-Sanson, Kankoe Sallah, Muriel Bourgeon, Christiane Ajzenberg, Agnes Hartemann, Christel Daniel, Thomas Moreau, Ronan Roussel, Louis Potier
Summary: The study suggests that diabetes is an independent risk factor for the severity of COVID-19, particularly in young adults more so than in older adults, especially for individuals younger than 70 years. Patients with diabetes had higher main outcomes, which were inversely proportional to age, and higher mortality rates, especially significant in patients under 50 years old.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Peter Wolf, Sylvie Salenave, Emmanuel Durand, Jacques Young, Peter Kamenicky, Philippe Chanson, Luigi Maione
Summary: The treatment of acromegaly strongly affects body composition until biochemical disease remission, characterized by an increase in fat mass and a decrease in lean mass. These changes are closely associated with the normalization of IGF-I and are independent of individual therapy.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Maelle Le Bras, Helene Leclerc, Olivia Rousseau, Pierre Goudet, Thomas Cuny, Frederic Castinetti, Catherine Bauters, Philippe Chanson, Antoine Tabarin, Sebastien Gaujoux, Sophie Christin-Maitre, Philippe Ruszniewski, Francoise Borson-Chazot, Isabelle Guilhem, Philippe Caron, Bernard Goichot, Albert Beckers, Brigitte Delemer, Isabelle Raingeard, Bruno Verges, Sarra Smati, Matthieu Wargny, Bertrand Cariou, Samy Hadjadj
Summary: Pituitary adenomas (PAs) in patients with MEN1 are less aggressive than previously estimated, with rare tumor progression under standard monitoring and treatment.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Philippe Chanson, Peter Wolf
Summary: Clinically non functioning pituitary adenomas (NFPAs) are pituitary adenomas that are not hormonally active and are diagnosed based on signs and symptoms related to mass effect. Surgery is the main treatment option, preferably performed by a neurosurgeon with experience in pituitary surgery.
Article
Endocrinology & Metabolism
Luigi Maione, Julie Sarfati, Celine Gonfroy-Leymarie, Sylvie Salenave, Sylvie Brailly-Tabard, Philippe Chanson, Severine Trabado, Ursula B. Kaiser, Jacques Young
Summary: This study compared the natural history and reproductive status of CHH and lesional AHH patients, and found that CHH patients were younger at diagnosis, with smaller testicular volume, while AHH patients had a later onset and higher fertility.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Iulia Potorac, Jean-Francois Bonneville, Adrian F. Daly, Wouter de Herder, Patricia Fainstein-Day, Philippe Chanson, Marta Korbonits, Fernando Cordido, Elisa Baranski Lamback, Mohamed Abid, Veronique Raverot, Gerald Raverot, Emma Anda Apinaniz, Philippe Caron, Helene Du Boullay, Martin Bildingmaier, Marek Bolanowski, Marie Laloi-Michelin, Francoise Borson-Chazot, Olivier Chabre, Sophie Christin-Maitre, Claire Briet, Gonzalo Diaz-Soto, Fabrice Bonneville, Frederic Castinetti, Monica R. Gadelha, Nathalie Oliveira Santana, Maria Stelmachowska-Banas, Tomas Gudbjartsson, Rocio Villar-Taibo, Taiba Zornitzki, Luaba Tshibanda, Patrick Petrossians, Albert Beckers
Summary: This study provides a comprehensive analysis of pituitary MRI characteristics in patients with ectopic acromegaly, highlighting the utility of T2-weighted sequences as an additional tool for establishing the correct diagnosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Luigi Maione, Cristina Albrici, Solange Grunenwald, Celine Mouly, Vincenzo Cimino, Anne-Lise Lecoq, Jean Claude Souberbielle, Philippe Caron, Philippe Chanson
Summary: This study compared the serum IGF-I dynamics and variability in patients treated with SRLs, surgically cured patients, and healthy controls. The results showed that IGF-I decreased significantly at Day 7 and Day 14 after injection in SRL-treated patients, but remained stable in cured patients and healthy controls. In addition, SRL-treated patients had higher IGF-I variability, especially in nonoptimally controlled patients. The measurement at the farthest distance from SRL injection was the best predictor of optimal disease control.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Veronique Raverot, Pauline Perrin, Philippe Chanson, Emmanuel Jouanneau, Thierry Brue, Gerald Raverot
Summary: The high-dose hook effect still exists in a very small minority of prolactin assays, as demonstrated in a study evaluating different assays in France in 2020. One assay tested was sensitive to the effect, leading to falsely lower prolactin concentration when measuring native serum compared to after dilution. The study suggests that the hook effect should still be considered in prolactin assay recommendations.
Article
Endocrinology & Metabolism
Peter Wolf, Alexandre Dormoy, Luigi Maione, Sylvie Salenave, Jacques Young, Peter Kamenicky, Philippe Chanson
Summary: Pasireotide, a second-generation somatostatin receptor ligand (SRL) used for treating acromegaly, may be associated with glucose metabolism impairment. In a retrospective study of 33 patients, we observed that treatment with pasireotide was associated with normalization of serum IGF-1 in almost 60% of patients, but one-third of patients developed diabetes. In the patients who stopped pasireotide because of hyperglycemia, HbA1c promptly decreased. Longitudinal data in 14 patients show that diabetes is mediated by impaired insulin secretion, which occurred shortly and then remained stable on long term, while no significant changes in insulin sensitivity were observed, despite a marked reduction of GH/IGF-1 concentrations. Older age and a worse glycemic control at baseline were the strongest predictors for hyperglycemia.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Kamel Mohammedi, Jerome Bertherat, Gerald Raverot, Delphine Drui, Yves Reznik, Frederic Castinetti, Philippe Chanson, Manon Fafin, Julie Brossaud, Antoine Tabarin
Summary: This study assessed the long-term cortisol exposure in medically treated Cushing disease (CD) patients by measuring the levels of hair cortisol and hair cortisone. Despite normalized urinary free cortisol levels, a subset of patients still displayed altered circadian rhythm of cortisol secretion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Obstetrics & Gynecology
Georgios E. Papadakis, Benedicte de Kalbermatten, Alexandre Dormoy, Sylvie Salenave, Severine Trabado, Oceana Vieira-Pinto, Carine Richa, Peter Kamenicky, Philippe Chanson, Luigi Maione, Nelly Pitteloud, Jacques Young
Summary: Cushing's syndrome (CS) affects the gonadotrope axis and testicular functions differently depending on the intensity of hypercortisolism and underlying etiology. Excess cortisol caused by CS leads to varying degrees of hypogonadotropic hypogonadism (HH), with more severe impairment in men with intense hypercortisolism associated with paraneoplastic/ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS).
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Marc Diedisheim, Etienne Dancoisne, Jean-Francois Gautier, Etienne Larger, Emmanuel Cosson, Bruno Feve, Philippe Chanson, Sebastien Czernichow, Sopio Tatulashvili, Marie-Laure Raffin-Sanson, Kankoe Sallah, Muriel Bourgeon, Christiane Ajzenberg, Agnes Hartemann, Christel Daniel, Thomas Moreau, Ronan Roussel, Louis Potier
Summary: Diabetes is an independent risk factor for severe COVID-19 outcomes, with the risk being higher in younger adults, especially those under 70 years old. The risk of severe outcomes in patients with diabetes increases with age, but reaches a plateau after 70 years old.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
