Article
Plant Sciences
Ma Yadanar Phyo, Jun Xian Goh, Lik Tong Tan
Summary: In this study, a new cyclic depsipeptide, triproamide, was isolated from a marine cyanobacterium along with known and new analogues. Triproamide and the analogues showed potential anti-tumor activity.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Zijun Chen, Na Chen, Peng Fu, Weiping Wang, Shilin Bian, Huihui Zhang, Sicheng Shen, Bingnan Han
Summary: Two new derivatives of aplysiatoxin, named neo-debromoaplysiatoxin I and neo-debromoaplysiatoxin J, were isolated from marine cyanobacterium Lyngbya sp. collected from the South China Sea. Their structures and absolute configurations were determined. Both compounds exhibited inhibitory activity against Kv1.5 K+ channel, but showed differential cytotoxic effects.
Article
Microbiology
Ethan C. Cissell, Sophie J. McCoy
Summary: This study characterized viral-host trophic structure within coral reef benthic cyanobacterial mats and revealed that viruses are active members of mat communities, with higher abundance and activity compared to hosts, indicating a top-heavy intra-mat trophic structure.
ENVIRONMENTAL MICROBIOLOGY
(2023)
Review
Chemistry, Medicinal
Diaa T. A. Youssef, Shatha J. Mufti, Abeer A. Badiab, Lamiaa A. Shaala
Summary: Cyanobacteria of the Lyngbya genus are a valuable source of chemically diverse natural products with significant pharmaceutical potential. This comprehensive review summarizes the anti-infective compounds isolated from various species within the Lyngbya morphotype, showcasing their antibacterial, antiparasitic, antifungal, antiviral, and molluscicidal activities.
Review
Pharmacology & Pharmacy
Surendra Swain, Shuvasree Bej, Ajit Kumar Bishoyi, Chinmayee Priyadarsani Mandhata, Chita Ranjan Sahoo, Rabindra Nath Padhy
Summary: This study focuses on the distribution and phytochemistry of the non-nitrogen fixing, filamentous cyanobacterium Lyngbya sp., and the antimicrobial and anticancer activities of its phycochemicals as well as the biosynthesized nanoparticles. Various phycocompounds with pharmaceutical potential, such as curio, apramide, flavonoids, and proteins, were isolated from Lyngbya sp. The nanoparticles biosynthesized with Lyngbya sp. have multiple applications in biofuel, agriculture, cosmetics, and industry, and have shown promising antimicrobial and anticancer properties.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Kasey E. Clark, Angela Capper, Wei-Ting Liu, Amanda M. Fenner, Alejandro Almanza, Gina Della Togna, Liuris Herrera, Timothy Johns, Valerie J. Paul, Pieter C. Dorrestein, Todd L. Capson, Marcy J. Balunas
Summary: A multidisciplinary approach was used to evaluate chemical ecological dietary interactions among marine organisms in order to isolate novel ecologically relevant compounds with biotechnological potential. The sea hare Dolabrifera nicaraguana exhibited a preference for consuming Lyngbya sp., leading to the discovery of two new depsipeptide compounds. These compounds showed activity against tropical parasites, suggesting that further studies involving sea hares and cyanobacteria may yield bioactive compounds with biotechnological applications.
FRONTIERS IN MARINE SCIENCE
(2021)
Letter
Public, Environmental & Occupational Health
Yves-Marie Ducrot, Mael Nicolas, Claude Payri, Antoine Bertolotti
Summary: Toxic seaweed dermatitis is a rare irritant dermatitis caused by toxins of the marine cyanobacterium Lyngbya majuscula after sea bathing in tropical areas, resulting in papular and bullous lesions mainly in the genital area, but severe ocular lesions can also occur.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Chemistry, Analytical
P. Ramesh, A. Rajendran
Summary: The present study reports the green synthesis of MnO2 nanoparticles using Lyngbya Majuscula through a single-step co-precipitation method. The green synthesized MnO2 nanoparticles were characterized using a combination of microscopy and spectroscopic techniques, including X-Ray diffraction analysis, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, and high-resolution transmission electron microscopy. The study showed that the green synthesized MnO2 nanoparticles exhibited high photocatalytic degradation of methylene blue dye under different light sources such as LED, UV, and sunlight irradiation. Additionally, the nanoparticles demonstrated significant antibacterial activity against various microorganisms and effective elimination of dangerous microorganisms through the agar well diffusion method.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Laurine Darcel, Louis Bornancin, Delphine Raviglione, Isabelle Bonnard, Suzanne C. Mills, Julio Saez-Vasquez, Bernard Banaigs, Nicolas Inguimbert
Summary: In the marine environment, sessile cyanobacteria have developed chemical strategies to protect themselves from grazers, while herbivores have evolved to bypass these defenses and sometimes even benefit from them. The sea hare Stylocheilus striatus feeds on a toxic cyanobacterium as a food source and uses it as a camouflage against predators, demonstrating a unique symbiotic relationship. Through research, an enzyme in the mollusk's digestive gland has been found capable of transforming toxic cyanobacterial compounds, shedding light on potential antibiotic resistance mechanisms in marine organisms.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Sofia Kokkaliari, Danmeng Luo, Valerie J. Paul, Hendrik Luesch
Summary: The marine cyanobacteria contain bioactive natural products, including two compounds iezoside and iezoside B with unique structures and cytotoxic activity.
Article
Multidisciplinary Sciences
Christophe Six, Morgane Ratin, Dominique Marie, Erwan Corre
Summary: This study found that tropical Synechococcus and those adapted to subpolar habitats have evolved different growth strategies and photosynthetic characteristics in response to different temperature environments. In low-temperature conditions, Synechococcus adapts to growth by increasing photoprotection capacity, while in high-temperature conditions, it achieves rapid growth by strengthening the photosynthetic machinery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Fisheries
B. K. Diggles, L. Barnes, M. Landos, M. M. Dennis, J. P. J. O'Carroll
Summary: The study reviewed ectoparasites of queenfish in northern Australia and found that queenfish near Gladstone Harbour predominantly suffered from infections of the parasite L. spinifer, leading to skin lesions, while queenfish from the Northern Territory and other areas in Queensland had lower infection rates and intensities. The presence of heavy L. spinifer infections, combined with poor water quality and direct exposure to contaminated dredge spoil and blooms of cyanobacterium Lyngbya majuscula, can be associated with cutaneous disease in wild-caught queenfish.
DISEASES OF AQUATIC ORGANISMS
(2021)
Article
Chemistry, Medicinal
Daria Elzbieta Nawrot, Ghada Bouz, Ondrsi Jandourek, Klara Konecna, Pavla Paterova, Pavel Barta, Martin Novak, Radim Kucera, Julia Zemanova, Martin Forbak, Jana Kordulakova, Oto Pavlis, Pavla Kubickova, Martin Dolezal, Jan Zitko
Summary: Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death among infectious diseases caused by a single microbe. With the emergence of antimicrobial resistance, the success rate of treating this infection is decreasing, and there is an urgent need for novel treatments. In this study, a novel series of compounds inspired by combining fragments from first-line and second-line agents for tuberculosis were synthesized and evaluated. Compound 10c from the second series showed selective and potent antimycobacterial activity against both drug-sensitive and drug-resistant Mtb strains, with no cytotoxicity. The compound targeted methionine metabolism rather than the folate pathway and had a long half-life, overcoming the limitations of current drugs for tuberculosis.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Plant Sciences
Frederikke D. Andersen, Katja D. Pedersen, Dennis Wilkens Juhl, Tobias Mygind, Paul Chopin, Esben B. Svenningsen, Thomas B. Poulsen, Marie Braad Lund, Andreas Schramm, Charlotte H. Gotfredsen, Thomas Torring
Summary: This study reveals that triculamin and alboverticillin, two natural products with potent and specific activity against mycobacteria, are actually the same lasso peptide. By determining the structure using 2D NMR spectroscopy and exploring the bioactivity, we found that their precursor peptides have a follower instead of a leader peptide, which is different from known lasso peptides.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Microbiology
Uday S. Ganapathy, Ruben Gonzalez del Rio, Monica Cacho-Izquierdo, Fatima Ortega, Joel Lelievre, David Barros-Aguirre, Marissa Lindman, Veronique Dartois, Martin Gengenbacher, Thomas Dick
Summary: This study identified benzoxaborole EC/11770 as a potential treatment for NTM lung disease, showing activity against M. abscessus and M. avium complexes, including drug-tolerant biofilms. The compound was effective in a mouse model, with low resistance frequency, confirming leucyl-tRNA synthetase as the target for antimycobacterial development.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Rana Montaser, Valerie J. Paul, Hendrik Luesch
Article
Chemistry, Medicinal
Rana Montaser, Hendrik Luesch
FUTURE MEDICINAL CHEMISTRY
(2011)
Article
Plant Sciences
Rana Montaser, Khalil A. Abboud, Valerie J. Paul, Hendrik Luesch
JOURNAL OF NATURAL PRODUCTS
(2011)
Article
Plant Sciences
Sarath P. Gunasekera, Chivas S. Owle, Rana Montaser, Hendrik Luesch, Valerie J. Paul
JOURNAL OF NATURAL PRODUCTS
(2011)
Article
Chemistry, Organic
Rana Montaser, Valerie J. Paul, Hendrik Luesch
Article
Biochemistry & Molecular Biology
Rana Montaser, Neil L. Kelleher
ACS CHEMICAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yun Ji Park, Gerri M. Roberts, Rana Montaser, Grace E. Kenney, Paul M. Thomas, Neil L. Kelleher, Amy C. Rosenzweig
Summary: Methanobactins are ribosomally produced peptidic natural products that bind copper with high affinity, originating from methanotrophic bacteria to acquire copper needed for enzymatic methane oxidation. They have unique structures and provide support for the proposed role of unknown biosynthetic enzymes.
Article
Multidisciplinary Sciences
Yun Ji Park, Richard J. Jodts, Jeffrey W. Slater, Reyvin M. Reyes, Valerie J. Winton, Rana A. Montaser, Paul M. Thomas, William B. Dowdle, Anahi Ruiz, Neil L. Kelleher, J. Martin Bollinger, Carsten Krebs, Brian M. Hoffman, Amy C. Rosenzweig
Summary: The iron-containing heterodimeric MbnBC enzyme complex plays a central role in the biosynthesis of methanobactins (Mbns) and its active species is a mixed-valent, antiferromagnetically coupled Fe(II)Fe(III) center. MbnC is also involved in recognition of the MbnA leader peptide.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Lindsay K. Caesar, Rana Montaser, Nancy P. Keller, Neil L. Kelleher
Summary: Organisms in nature have evolved specialized enzymatic machinery to biosynthesize a variety of secondary metabolites, which has profound impacts on human health. Recent advancements in metabolomics and genomics have allowed for efficient exploration of new chemical spaces in natural product discovery. Integrated strategies now enable researchers to simultaneously identify expressed secondary metabolites and their biosynthetic machinery.
NATURAL PRODUCT REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Armando Moreno-Velasco, Mabel Fragoso-Serrano, Pedro de Jesus Flores-Tafoya, Sebastian Carrillo-Rojas, Elihu Bautista, Suzana Guimara Leitao, Jhon F. Castaneda-Gomez, Rogelio Pereda-Miranda
Summary: This study investigated the roots of Operculina hamiltonii, a traditional medicinal plant in Brazil. Three new acyl sugars or resin glycosides were identified and their structures elucidated. The combination of these compounds with other drugs showed enhanced cytotoxic effects on breast cancer cells.
Article
Biochemistry & Molecular Biology
Qian-Qing Liu, Lin-An Xiong, Jia-Yu Qian, Ting-Ting Gong, Lie-Feng Ma, Luo Fang, Zha-Jun Zhan
Summary: A new naturally occurring compound, Linderagatins C-F (1-4), with the structures of diaryltetrahydrofuran-type 7,9'-dinorlignans, was discovered in the roots of Lindera aggregata. The neuroprotective effects of compounds 2 and 3 on erastin-induced ferroptosis in HT-22 cells were found to be significant.