期刊
ORGANIC LETTERS
卷 15, 期 16, 页码 4050-4053出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol401396u
关键词
-
资金
- National Institutes of Health [P41GM086210, R01CA172310]
Novel bioactive lipids were identified from a Guamanian cyanobacterium, the Pseudomonas aeruginosa quorum sensing inhibitor pitinoic acid A (1) and the anti-inflammatory pitinoic acids B (2) and C. The structure of 2 was confirmed by synthesis, which also allowed for biological evaluation. Since 2 is an ester of pitinoic acids A and C, it represents a prodrug strategy to liberate dual biological activity for the management of P. aeruginosa infections and their associated inflammation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据