Article
Multidisciplinary Sciences
Patrick Sweeney, Can Chen, Indika Rajapakse, Roger D. Cone
Summary: Mutations in MC4R gene can lead to hyperphagia and obesity, with the activity of PVN MC4R neurons being influenced by changes in energy state and pharmacological intervention. Utilizing endomicroscopic and mathematical methods, it is possible to determine the quantitative and qualitative changes in PVN MC4R neurons during fasting and refeeding, as well as the encoding of different energy states by distinct neuronal ensembles.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Xin Wang, Joan B. Escobar, David Mendelowitz
Summary: This study explores the potential involvement of atypical activity in the locus coeruleus in autism spectrum disorder (ASD) and investigates the neurotransmission from hypothalamic paraventricular (PVN) oxytocin (OXT) neurons to LC NA neurons. The research demonstrates the release of oxytocin from PVN OXT fibers in the LC and shows that optogenetic excitation of PVN OXT fibers excites LC NA neurons through co-release of oxytocin and glutamate, with a greater effect observed in males. Additionally, chemogenetic activation of PVN OXT neurons increases attention to novel objects specifically in male animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Amelia M. Douglass, Jon M. Resch, Joseph C. Madara, Hakan Kucukdereli, Ofer Yizhar, Abhinav Grama, Masahito Yamagata, Zongfang Yang, Bradford B. Lowell
Summary: Fasting activates the HPA axis through the inhibition of GABAergic afferents by AgRP neurons in the PVH. This study reveals the neural basis for fasting-induced HPA axis activation and provides insights into the mechanisms underlying stress-induced HPA axis activation.
Article
Anatomy & Morphology
Maria G. Bilbao, Daniel Garrigos, Marta Martinez-Morga, Angel Toval, Yevheniy Kutsenko, Rosario Bautista, Alberto Barreda, Bruno Ribeiro Do-Couto, Luis Puelles, Jose Luis Ferran
Summary: In this study, a prosomeric immunohistochemical mapping of hypothalamic cells expressing tyrosine hydroxylase (TH) in rats was conducted. The results showed that TH-positive cells were predominantly located in the periventricular stratum of the paraventricular and subparaventricular alar domains, as well as in the acroterminal arcuate nucleus and the terminal periventricular stratum in the tuberal region. The prosomeric model proved useful for determining the precise location of TH-positive cells relative to morphogenetic signals and provided potential causal explanation for the specification of this hypothalamic cell type.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Teresa A. Milner, Natalina H. Contoreggi, Fangmin Yu, Megan A. Johnson, Gang Wang, Clara Woods, Sanoara Mazid, Tracey A. Van Kempen, Elizabeth M. Waters, Bruce S. McEwen, Kenneth S. Korach, Michael J. Glass
Summary: The study found that administering ER beta agonists in peri-AOF female mice can suppress neurogenic hypertension, but it has no effect on age-matched male mice. Additionally, ER beta signaling in the PVN of female mice plays an important role in blood pressure regulation and contributes to hypertension susceptibility in females at an early stage of ovarian failure.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Liufang Yin, Lijun Zhang, Lingling Luo, Yalei Liu, Fei Wang, Yaru Feng, Hongqing Wang, Yongli Han, Yingxuan Yan, Cheng Huang, Shengjie Fan
Summary: It has been discovered that berbamine (BBM) can improve obesity by inhibiting the activity of Rab8a GTPase and activating anorexigenic neurons in the paraventricular nucleus of the hypothalamus (PVH), leading to weight loss and improved metabolic balance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Changlin Chen, Yichen Lin, Feng Cai, Jinsui Li, Haixun Li, Xiantao Li
Summary: Adenosine promotes sleep by inhibiting glutamatergic neurons in the paraventricular hypothalamic nucleus, which reduces their excitability.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Xu Wang, Haohong Li
Summary: This study found that synaptic remodeling, lipid droplet accumulation, and synaptic dysfunction occur in feeding-related brain regions of obese mice induced by high-fat diet. These impairments are associated with energy homeostasis and reward regulation, which may contribute to overeating in obesity.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Caroline L. Wee, Erin Song, Maxim Nikitchenko, Kristian J. Herrera, Sandy Wong, Florian Engert, Samuel Kunes
Summary: This study reveals the impact of social isolation on the oxytocinergic circuit in the zebrafish brain and how chemical signals from conspecific animals modulate this circuit. The results provide a model for understanding how social stimuli mediate adaptive behaviors through neural circuits.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Connor M. Aitken, Janine C. M. Jaramillo, Warren Davis, Liam Brennan-Xie, Stuart J. Mcdougall, Andrew J. Lawrence, Philip J. Ryan
Summary: Chemogenetic activation of oxytocin receptor-expressing neurons in the parabrachial nucleus acts as a satiation signal for water intake. This research investigates the effect of activating these neurons on satiation for different types of fluids. The results show that activation of these neurons predominantly controls initial fluid-satiation responses after rehydration, but not longer-term intake of highly caloric, palatable solutions.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Kuldeep Shrivastava, Thaarini Swaminathan, Alessandro Barlotta, Vikshar Athreya, Hassan Choudhry, Mark A. Rossi
Summary: Maternal overnutrition during gestation and lactation leads to increased body weight in offspring, which normalizes after weaning but predisposes them to diet-induced obesity in adulthood. This is associated with altered synaptic strength in an extended amygdala-lateral hypothalamic pathway, which is influenced by developmental growth rate.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Bora Jeong, Kwang-Kon Kim, Tae-Hwan Lee, Han-Rae Kim, Byong-Seo Park, Jeong-Woo Park, Jin-Kwon Jeong, Jae-Young Seong, Byung-Ju Lee
Summary: This study found that SPX mediates the effect of leptin on energy homeostasis in the hypothalamus. Administration of SPX reduced food intake and body weight gain, and SPX expression was found in leptin receptor ObRb-positive cells in the hypothalamus. Leptin increased SPX expression and this effect was mediated by the STAT3 pathway.
Article
Biology
Kazuaki Nishimura, Kiyoshi Yoshino, Naofumi Ikeda, Kazuhiko Baba, Kenya Sanada, Yasuki Akiyama, Haruki Nishimura, Kentaro Tanaka, Satomi Sonoda, Hiromichi Ueno, Mitsuhiro Yoshimura, Takashi Maruyama, Toru Hachisuga, Yoichi Ueta
Summary: This study provides the first evidence that estrogen regulates the dynamic changes in oxytocin levels in the hypothalamus. The study also shows that these changes vary between sexes. Additionally, estrogen has significant effects on oxytocin expression and gene expression levels.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biology
Fan Wang, Yuge Chen, Yuxin Lin, Xuze Wang, Kaiyuan Li, Yong Han, Jintao Wu, Xingyi Shi, Zhenggang Zhu, Chaoying Long, Xiaojun Hu, Shumin Duan, Zhihua Gao
Summary: The CCK-expressing neurons in the LPBCCK directly project to the PVN and play a role in controlling defensive behaviors. Activation of LPBCCK neurons promotes aversion and defensive behaviors, while inhibition of LPBCCK neurons attenuates flight responses. Optogenetic experiments reveal that LPBCCK neurons control defensive behaviors by projecting axon terminals to the PVN.
Article
Neurosciences
Hao-Hua Wei, Xiang-Shan Yuan, Ze-Ka Chen, Pei-Pei Chen, Zhe Xiang, Wei-Min Qu, Rui-Xi Li, Guo-Min Zhou, Zhi-Li Huang
Summary: The AVP neurons in SON and PVN receive similar input patterns from multiple brain regions, with PVNAVP neurons having broader and denser inputs compared to SONAVP neurons. Additionally, differentiated input sources were found, with SONAVP neurons receiving more projections from thermoregulatory nuclei and PVNAVP neurons receiving more afferent inputs from circadian rhythm-regulating nuclei. The study provides insights into the distinct afferent framework of AVP neurons in SON and PVN, laying the foundation for further research on their diverse roles.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Psychology, Biological
Lynda Whiting, James E. McCutcheon, Christina N. Boyle, Mitchell F. Roitman, Thomas A. Lutz
PHYSIOLOGY & BEHAVIOR
(2017)
Article
Endocrinology & Metabolism
Thomas A. Lutz, Bernd Coester, Lynda Whiting, Ambrose A. Dunn-Meynell, Christina N. Boyle, Sebastien G. Bouret, Barry E. Levin, Christelle Le Foll
Article
Biochemical Research Methods
Philippe J. Eugster, Christina N. Boyle, Sylvain Prod'hom, Erika Tarasco, Thierry Buclin, Thomas A. Lutz, Alan G. Harris, Eric Grouzmann
DRUG TESTING AND ANALYSIS
(2018)
Review
Endocrinology & Metabolism
Christina Neuner Boyle, Thomas Alexander Lutz, Christelle Le Foll
MOLECULAR METABOLISM
(2018)
Article
Physiology
Sonya Duffy, Thomas A. Lutz, Christina N. Boyle
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2018)
Article
Physiology
Seraina S. Senn, Christelle Le Foll, Lynda Whiting, Erika Tarasco, Sonya Duffy, Thomas A. Lutz, Christina Neuner Boyle
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Erika Tarasco, Christina N. Boyle, Giovanni Pellegrini, Myrtha Arnold, Regula Steiner, Thorsten Hornemann, Dimitris Nasias, Dimitris Kardassis, Lynda Whiting, Thomas A. Lutz
INTERNATIONAL JOURNAL OF OBESITY
(2019)
Review
Neurosciences
Christina N. Boyle, Christelle Le Foll
Article
Neurosciences
Bernd Coester, Sydney W. Pence, Soraya Arrigoni, Christina N. Boyle, Christelle Le Foll, Thomas A. Lutz
Article
Immunology
Elisa S. Roesti, Christina N. Boyle, Daniel T. Zeman, Marcos Sande-Melon, Federico Storni, Gustavo Cabral-Miranda, Alexander Knuth, Thomas A. Lutz, Monique Vogel, Martin F. Bachmann
Article
Endocrinology & Metabolism
Simone Carneiro-Nascimento, Jolanta Opacka-Juffry, Adele Costabile, Christina N. Boyle, Adrienne Mueller Herde, Simon M. Ametamey, Hannes Sigrist, Christopher R. Pryce, Michael Patterson
PSYCHONEUROENDOCRINOLOGY
(2020)
Article
Psychology, Biological
Miriam Honegger, Thomas A. Lutz, Christina N. Boyle
Summary: The ability of amylin to inhibit food intake is reduced under hypoglycemic conditions, possibly due to the co-sensitivity of AP neurons to amylin and glucose. Amylin can also buffer meal-induced glucose appearance at EU and HYPO levels.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Amalia Ruiz-Serrano, Christina N. Boyle, Josep M. Monne Rodriguez, Julia Guenter, Agnieszka E. Jucht, Svende Pfundstein, Andreas M. Bapst, Thomas A. Lutz, Roland H. Wenger, Carsten C. Scholz
Summary: Dysregulated energy metabolism is a major cause of various diseases. OTUB1 plays an important regulatory role in energy metabolism. Deletion of OTUB1 in mice leads to increased energy expenditure and improved glucose metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Christina N. Boyle, Yi Zheng, Thomas A. Lutz
Summary: Amylin, a pancreatic beta-cell hormone, plays important physiological roles in metabolic control, such as regulating satiation, gastric emptying, and glucagon secretion. Amylin analogs have emerged as promising approaches for obesity and diabetes treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Erika Tarasco, Petra Seebeck, Svende Pfundstein, Adrian F. Daly, Philippe J. Eugster, Alan G. Harris, Eric Grouzmann, Thomas A. Lutz, Christina N. Boyle
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)