Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior

Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism

(2021) Chelsea L Faber et al.   eLife

A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia

(2021) Shengjie Fan et al.   Nature Communications

Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus

(2021) Matthew K. H. Wong et al.   Frontiers in Endocrinology

Mouse Spexin: (I) NMR Solution Structure, Docking Models for Receptor Binding, and Histological Expression at Tissue Level

(2021) Matthew K. H. Wong et al.   Frontiers in Endocrinology

Peripheral Spexin Inhibited Food Intake in Mice

(2020) Shuangyu Lv et al.   International Journal of Endocrinology

Leptin receptor-expressing neurons in the ventromedial nucleus of the hypothalamus contribute to weight loss caused by fourth ventricle leptin infusions

(2019) Marissa Seamon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Different Spexin level in Obese vs Normal Weight Children and Its Relationship with Obesity Related Risk Factors

(2019) Maryam Behrooz et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

(2018) Alexandre Caron et al.   eLife

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

(2018) Silvia S. Kang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Presynaptic Regulation of Leptin in a Defined Lateral Hypothalamus–Ventral Tegmental Area Neurocircuitry Depends on Energy State

(2017) Jing-Jing Liu et al.   JOURNAL OF NEUROSCIENCE

Spexin Suppress Food Intake in Zebrafish: Evidence from Gene Knockout Study

(2017) Binbin Zheng et al.   Scientific Reports

Fourth-ventricle leptin infusions dose-dependently activate hypothalamic signal transducer and activator of transcription 3

(2016) Ruth B. S. Harris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Molecular cloning and functional characterization of spexin in orange-spotted grouper ( Epinephelus coioides )

(2016) Shuisheng Li et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Decreased Circulating Levels of Spexin in Obese Children

(2016) Seema Kumar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus

(2015) Bhavna N. Desai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ya-fish (Schizothorax prenanti) spexin: identification, tissue distribution and mRNA expression responses to periprandial and fasting

(2015) Hongwei Wu et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes

(2015) Liping Gu et al.   PEPTIDES

Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III

(2014) Dong-Kyu Kim et al.   ENDOCRINOLOGY

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

(2014) Jae Geun Kim et al.   NATURE NEUROSCIENCE

Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity

(2014) José L. Walewski et al.   Obesity

Goldfish spexin: solution structure and novel function as a satiety factor in feeding control

(2013) Matthew K. H. Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus

(2013) Yun Liu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Functional Heterogeneity of Arcuate Nucleus Pro-Opiomelanocortin Neurons: Implications for Diverging Melanocortin Pathways

(2012) Jong-Woo Sohn et al.   MOLECULAR NEUROBIOLOGY

Thyroid Transcription Factor‐1 Regulates Feeding Behavior via Melanocortin Pathway in the Hypothalamus

(2011) Jae Geun Kim et al.   DIABETES

Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception

(2011) Lawrence Toll et al.   FASEB JOURNAL

Visfatin Induces Sickness Responses in the Brain

(2011) Byong Seo Park et al.   PLoS One

Spexin Expression in Normal Rat Tissues

(2010) Andrea Porzionato et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Hypothalamic Sites of Leptin Action Linking Metabolism and Reproduction

(2010) José Donato et al.   NEUROENDOCRINOLOGY

Expression of the spexin gene in the rat adrenal gland and evidences suggesting that spexin inhibits adrenocortical cell proliferation

(2010) Marcin Rucinski et al.   PEPTIDES

Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

(2009) Gina M. Leinninger et al.   Cell Metabolism

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

(2009) M. B. Ernst et al.   JOURNAL OF NEUROSCIENCE

Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

(2009) E. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary Sequence Modeling for Discovery of Peptide Hormones

(2009) Kemal Sonmez et al.   PLoS Computational Biology

Activation of Stat3 Signaling in AgRP Neurons Promotes Locomotor Activity

(2008) Andrea Mesaros et al.   Cell Metabolism

Molecular and neural mediators of leptin action

(2008) Scott A. Robertson et al.   PHYSIOLOGY & BEHAVIOR