Article
Rheumatology
Cristiana Sieiro Santos, Ruben Rego Salgueiro, Clara Moriano Morales, Carolina Alvarez Castro, Elvira Diez Alvarez
Summary: This study aimed to determine the clinical significance of cardiovascular disease in patients with primary Sjogren's syndrome (pSS) and analyze the risk factors associated with it. The results showed that patients with extraglandular involvement had a higher prevalence of arterial hypertension, dyslipidemia, hyperuricemia, and coronary artery disease. Furthermore, patients with positive anti-Ro/SSA and anti-La/SSB antibodies had a higher risk of cardiac rhythm abnormalities, hyperuricemia, venous thrombosis, coronary artery disease, and cerebrovascular disease.
CLINICAL RHEUMATOLOGY
(2023)
Article
Clinical Neurology
Maija Orjatsalo, Eemil Partinen, Gerd Wallukat, Anniina Alakuijala, Markku Partinen
Summary: The study found that patients with narcolepsy type 1 carry autoimmune antibodies that may be related to symptoms such as cataplexy, hallucinations, pain, and autonomic dysfunction. Positive autoantibodies against M2 muscarinic receptors, nociception receptors, and beta 2 adrenergic receptors may exacerbate the progression of the disease.
Review
Immunology
Gabriela Guzman-Martinez, Concepcion Maranon
Summary: Patients with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease (CVD), which is becoming one of the most relevant complications and a significant factor causing morbidity and mortality in SLE. Immune constituents, including specific circulating cell populations, autoantibodies, and inflammatory mediators, play a role in the pathogenesis of atherosclerosis and endothelial damage in SLE patients. This review summarizes the presentation of CVD in SLE, the role of autoimmune responses in inducing atherogenesis, endothelial impairment, and cardiac disease, and discusses the utility of immune mediators as early CVD biomarkers and targets for clinical intervention in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Felix S. Mueller, Zouhair Aherrahrou, Hanna Grasshoff, Marc W. Heidorn, Jens Y. Humrich, Laurence Johanson, Redouane Aherrahrou, Tobias Reinberger, Andreas Schulz, Vincent ten Cate, Alejandro Pallares Robles, Thomas Koeck, Steffen Rapp, Tanja Lange, Lukas Brachaczek, Finn Luebber, Jeanette Erdmann, Harald Heidecke, Kai Schulze-Forster, Ralf Dechend, Karl J. Lackner, Norbert Pfeiffer, Jasmin Ghaemi Kerahrodi, Oliver Tuescher, Andreas Schwarting, Konstantin Strauch, Thomas Muenzel, Juergen H. Prochaska, Gabriela Riemekasten, Philipp S. Wild
Summary: This study found that anti-CXCR3 aAbs were abundant in individuals without autoimmune diseases, and were closely associated with cardiovascular end-organ damage, all-cause mortality, and cardiac morbidity and mortality.
EUROPEAN HEART JOURNAL
(2023)
Article
Rheumatology
Markus Mueller, Michael E. Gschwandtner, Wolfgang Emminger, Hans Kiener, Sebastian Schnaubelt, Georgiana-Aura Giurgea, Robin Ristl, Thomas Perkmann, Renate Koppensteiner, Oliver Schlager
Summary: The objective of this study was to characterize the associations between individual nailfold capillary aberrations and autoantibodies in children and adults with Raynaud's phenomenon (RP). Nailfold capillaroscopy and laboratory tests were conducted on consecutive RP patients without previously known connective tissue disease. The prevalence of nailfold capillary aberrations and antinuclear antibodies (ANA) was assessed and analyzed separately for children and adults, revealing a less pronounced association between nailfold capillary aberrations and ANA in children. Further studies are needed to validate these observations in children with RP.
Article
Food Science & Technology
Chengkai Wu, Bosai He, Xiao Wang, Yang Zou, Ruixin Ma, Yanting Gu, Jian Huang, Songping Li, Jinhui Wang, Jiahong Wang
Summary: This study demonstrated that Salvianolic acid A (Sal A) effectively attenuates vascular injury caused by chronic kidney disease. Its mechanisms of action involve activation of the PI3K/Akt/Nrf2/HO-1 signaling pathway for antioxidant effects and suppression of the SIRT1/TLR4/NF-kappa B/P38 signaling pathway for anti-inflammatory effects.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Shaowei Kang, Bin Wang, Yanan Xie, Xu Cao, Mei Wang
Summary: M1 and M2 macrophages are crucial for cardiac healing post-MI, with M1 macrophages playing a critical role in promoting remodeling through activation of the EMT pathway.
Article
Immunology
Anna-Maria Herzner, Zia Khan, Eric L. Van Nostrand, Sara Chan, Trinna Cuellar, Ronald Chen, Ximo Pechuan-Jorge, Laszlo Komuves, Margaret Solon, Zora Modrusan, Benjamin Haley, Gene W. Yeo, Timothy W. Behrens, Matthew L. Albert
Summary: The study identified a synergistic induction of MDA5-dependent IFN responses with hnRNPC and ADAR deficiency, leading to dysregulation of Alu-containing introns in cells. Furthermore, some putative MDA5 ligands showed reduced editing in the absence of ADAR.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jing Yang, Hongxia Li, Chi Zhang, Yafeng Zhou
Summary: There is a high prevalence of ventricular arrhythmias related to sudden cardiac death in patients with chronic kidney disease (CKD). The study found that indoxyl sulfate (IS) reduces Ito,f-related proteins and Ito,f density by activating ROS/MAPK and NF-KB signaling pathways, leading to prolonged action potential duration and QT interval, which increases the susceptibility to arrhythmia in CKD patients.
Article
Oncology
Weicheng Xu, Shiyi Liang, Yuxiang Huang, Shili Zhao, Yunfang Zhang, Yongqiang Li, Yunfang Zhang
Summary: The study found that in patients with stages 3-5 CKD, autoimmune thyroid disease (AITD) may increase the risk of cardiovascular disease, especially by affecting triglyceride levels, increasing the risk of anemia, and promoting micro-inflammation. Attention should be paid to female patients with high TPOAb and TGAb titers. Women with TPOAb positive may be more likely to develop diastolic heart failure.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jung Hee Koh, Sang Jun Yoon, Mina Kim, Seonghun Cho, Johan Lim, Youngjae Park, Hyun-Sook Kim, Sung Won Kwon, Wan-Uk Kim
Summary: Changes in lipid profile in rheumatoid arthritis can serve as potential biomarkers for tracking and treating the disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Eva Prescott, Oskar Angeras, David Erlinge, Erik L. Grove, Marja Hedman, Lisette O. Jensen, John Pernow, Antti Saraste, Axel Akerblom, Sara Svedlund, Anna Rudvik, Jane Knochel, Eva-Lotte Lindstedt, Pavlo Garkaviy, Li-Ming Gan, Anders Gabrielsen
Summary: In patients with recent myocardial infarction, AZD5718 exhibited a dose-dependent inhibition of leukotriene biosynthesis and was well tolerated. However, it did not have a significant impact on coronary microvascular function.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Christian Lundtoft, Daniel Eriksson, Matteo Bianchi, Maribel Aranda-Guillen, Nils Landegren, Solbritt Rantapaa-Dahlqvist, Peter Soderkvist, Jeniffer R. S. Meadows, DISSECT Consortium, Immunoarray Consortium, Swedish Addison Registry Study Grp, Gerli Rosengren Pielberg, Sophie Bensing, Gerli Rosengren Pielberg, Kerstin Lindblad-Toh, Lars Ronnblom, Olle Kampe
Summary: Autoantibodies against the adrenal enzyme 21-hydroxylase are a hallmark manifestation in autoimmune Addison's disease (AAD). This study identified strong associations between copy number variants in the CYP21 region and the risk of AAD, most likely due to linkage disequilibrium with disease-associated HLA class II alleles.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Rheumatology
Yubin Luo, Yanli Tong, Liang Wu, Haitao Niu, Yanhong Li, Lin Chong Su, Yuxi Wu, Aline Bozec, Mario M. Zaiss, Pingying Qing, Hua Zhao, Chunyu Tan, Qiuping Zhang, Yi Zhao, Huairong Tang, Yi Liu
Summary: This study aims to investigate the gut microbiome and serum metabolic characteristics of individuals at high risk for rheumatoid arthritis (RA) and the causative effect of gut microbiome on the mucosal immune system and its involvement in the pathogenesis of arthritis. The results showed that the gut microbial composition differed between healthy controls and high-risk RA individuals, and there were significant differences in serum metabolites between the two groups. Fecal microbiota transplantation (FMT) from high-risk RA individuals triggered intestinal barrier dysfunction and changes in mucosal immunity, contributing to the development of arthritis.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Immunology
Daniela Giordano, Runa Kuley, Kevin E. Draves, Keith B. Elkon, Natalia V. Giltiay, Edward A. Clark
Summary: The BAFF-producing cells, including neutrophils, monocytes, dendritic cells, T cells, and B cells, were found to be expanded in lupus models. BAFF expression in monocytes and dendritic cells was crucial for maintaining systemic BAFF levels and mature B cell pools.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Friedrich C. Luft
AMERICAN JOURNAL OF NEPHROLOGY
(2014)
Article
Cardiac & Cardiovascular Systems
Jens Titze, Dominik N. Mueller, Friedrich C. Luft
CANADIAN JOURNAL OF CARDIOLOGY
(2014)
Article
Pharmacology & Pharmacy
C. Schroeder, K. Heusser, A. A. Zoerner, A. Grosshennig, D. Wenzel, M. May, F. C. G. J. Sweep, H. Mehling, F. C. Luft, J. Tank, J. Jordan
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2014)
Editorial Material
Peripheral Vascular Disease
Friedrich C. Luft
Article
Biochemistry & Molecular Biology
Robert Fischer, Anne Konkel, Heidrun Mehling, Katrin Blossey, Andrej Gapelyuk, Niels Wessel, Clemens von Schacky, Ralf Dechend, Dominik N. Muller, Michael Rothe, Friedrich C. Luft, Karsten Weylandt, Wolf-Hagen Schunck
JOURNAL OF LIPID RESEARCH
(2014)
Editorial Material
Genetics & Heredity
Friedrich C. Luft
JOURNAL OF MOLECULAR MEDICINE-JMM
(2014)
Editorial Material
Physiology
Friedrich C. Luft
Review
Physiology
Friedrich C. Luft
Summary: This article discusses the conversion of biomarkers into reliable laboratory tests, examining both early and recently propagated biomarkers. It also proposes the need for faster and better tests that can reflect decreased renal function and predict increased AKI risk.
Editorial Material
Physiology
Jan-Hendrik B. Hardenberg, Friedrich C. Luft
Article
Biochemistry & Molecular Biology
Birgit Meusser, Bettina Purfuerst, Friedrich C. Luft
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Editorial Material
Physiology
Friedrich C. Luft
Editorial Material
Physiology
Qing Ye, En Yin Lai, Friedrich C. Luft, Pontus B. Persson, Jianhua Mao
Editorial Material
Peripheral Vascular Disease
Friedrich C. Luft
Editorial Material
Cardiac & Cardiovascular Systems
Friedrich C. Luft
EUROPEAN HEART JOURNAL
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Friedrich C. Luft
