Article
Multidisciplinary Sciences
Wenjing Dong, Erqun Song, Yang Song
Summary: The study found that co-treatment of LPS/D-GalN exhibited genotoxic effects on liver and brain cells in mice, but not on sperm and bone marrow cells. This indicates the potential genotoxicity of LPS/D-GalN administered together, suggesting it as an in vivo experimental model for genotoxic studies.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Hiroshi Hamamoto, Suresh Panthee, Atmika Paudel, Suguru Ohgi, Yutaka Suzuki, Koichi Makimura, Kazuhisa Sekimizu
Summary: In this study, we performed in vivo RNA-sequencing analysis to investigate the gene expression of Staphylococcus aureus during infection in mouse liver. Our results showed that the gene expression of S. aureus was affected by changes in the host environment, such as the upregulation of hypoxia response genes and immune response genes. Genes related to anaerobic respiration and metal transporters exhibited different expression patterns at different time points post-infection.
COMMUNICATIONS BIOLOGY
(2022)
Article
Nutrition & Dietetics
Qi Fu, Warren A. Cheung, Amber V. Majnik, Xingrao Ke, Tomi Pastinen, Robert H. Lane
Summary: This study examined the impact of exposure to adverse early-life environments on the development of non-alcoholic fatty liver disease (NAFLD) and the connection between hepatic DNA methylation and late-onset diseases. The findings suggest that exposure to adverse environments leads to changes in hepatic DNA methylation before the onset of NAFLD, indicating that DNA methylation plays a role in the development of this disease.
Article
Multidisciplinary Sciences
Ho Man Tang, C. Conover Talbot, Ming Chiu Fung, Ho Lam Tang
Summary: Researchers described a comprehensive dataset containing time-course mRNA expression profiles for the reversal of ethanol-induced apoptosis in mouse liver cells. By comparing this dataset with others, key regulators governing reversal of apoptosis and other reversible cell death processes can be identified.
Article
Biochemistry & Molecular Biology
Carlos A. Garcia-Prieto, Damiana Alvarez-Errico, Eva Musulen, Alberto Bueno-Costa, Berta N. Vazquez, Alejandro Vaquero, Manel Esteller
Summary: Mouse has been extensively used as a model organism for studying biological pathways and drug effects. However, the knowledge about the mouse epigenome, particularly DNA methylation, is limited. In this study, a newly developed DNA methylation microarray was validated for profiling the mouse genome. The microarray provided reliable results, detected methylation changes, and accurately classified different mouse tissues and organs.
Article
Environmental Sciences
Hai Jia, Ning Liu, Yunchang Zhang, Chao Wang, Ying Yang, Zhenlong Wu
Summary: This study demonstrated that exposure to 3-acetyldeoxynivalenol (3-Ac-DON) resulted in oxidative damage, cell death, and immune cell infiltration in the liver, with activation of endoplasmic reticulum stress. Inhibiting endoplasmic reticulum stress may be a preventive strategy to mitigate the detrimental effects of 3-Ac-DON on liver health.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Tomoe Seki, Hirotaka Yamagata, Shusaku Uchida, Ayumi Kobayashi, Yoshifumi Watanabe, Shin Nakagawa
Summary: Postpartum depression is a significant mental health issue that impacts not only mothers but also children's development, family members, and society at large. The development of an appropriate animal model to study the pathogenesis of postpartum depression is crucial. The new mouse model using a psychological stress method showed significant effects on postpartum depression-like behaviors.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Seiichiro Aoe, Chiemi Yamanaka, Kento Mio
Summary: The study demonstrated that supplementation of a high fat diet with paramylon improved lipid metabolism by suppressing the digestion and absorption pathway in the ileum and activating the hepatic PPAR signaling pathway. This led to reduced abdominal fat accumulation and serum LDL cholesterol concentrations. Additionally, paramylon intake may enhance serum secretory immunoglobulin A concentrations through the promotion of the immunoglobulin production pathway in the ileum.
Article
Gastroenterology & Hepatology
Takeshi Katsuda, Hector Cure, Jonathan Sussman, Kamen P. Simeonov, Christopher Krapp, Zoltan Arany, Markus Grompe, Ben Z. Stanger
Summary: This study introduces a rapid in vivo multiplexed editing (RIME) method that enables the efficient inactivation of one or more genes in the mouse liver. The method is quick, efficient, and cost-effective, making it a valuable tool for analyzing multiple genes in vivo.
Article
Chemistry, Analytical
Yingchun Wu, Caixia Yin, Weijie Zhang, Yongbin Zhang, Fangjun Huo
Summary: This study presents a chemical toolbox, MI-BP-CC, for monitoring viscosity in living cells and fatter liver mice. The toolbox utilizes N,N-diethyl and double bonds as sensitive sites based on the TICT mechanism. The MI-BP-CC probe shows ultra-sensitivity in detecting viscosity and has successfully visualized increased viscosity in pathological models of Parkinson's disease and fatty liver mice.
ANALYTICAL CHEMISTRY
(2022)
Article
Psychiatry
Aki Takahashi
Summary: Significant sex differences exist in psychiatric disorders, with women being more vulnerable to stress-related disorders such as depression and anxiety. Recent research has focused on female mice in the study of repeated social defeat stress models, highlighting the importance of considering various factors in using this model.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Tim Kaden, Katja Graf, Knut Rennert, Ruoya Li, Alexander S. S. Mosig, Martin Raasch
Summary: Drug-induced liver injury is a major threat to patients and the pharmaceutical industry. A study used a three-dimensional microphysiological model of the human liver to investigate the hepatotoxicity of a fluoroquinolone antibiotic, trovafloxacin. The model successfully detected the drug's toxicity, which had not been detected in preclinical testing. This model shows potential for reliably detecting drug-related cytotoxicity.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Kaku Maekawa, Shintaro Yamada, Rahul Sharma, Jayanta Chaudhuri, Scott Keeney
Summary: This study demonstrates that the triplex-forming potential of H-DNA motifs in the mouse genome can be evaluated using S1-seq method. Prominent clusters of S1-seq reads that coincide with H-DNA motifs and correlate strongly with the triplex-forming potential were observed in genomic DNA isolated from mouse testis cells and splenic B cells. The study further explores how the structure of H-DNA is modified by polypyrimidine repeat length and the presence of repeat-interrupting substitutions using naturally occurring H-DNA motifs across the mouse genome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Yuqi Wang, Xiaojing Liu, Hongyuan Jing, Haoran Ren, Shiwen Xu, Mengyao Guo
Summary: TMT triggers YAP phosphorylation to induce oxidative stress and promote apoptosis and necroptosis in mouse liver tissues.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Yuta Yoshida, Yuhei Yajima, Kina Kawakami, Shin-ichi Nakamura, Takamitsu Tsukahara, Katsutaka Oishi, Atsushi Toyoda
Summary: Identifying early stress biomarkers is crucial in preventing mood and anxiety disorders. This study found changes in salivary miRNAs and metabolites in mice subjected to subchronic and mild social defeat stress, with one miRNA, miR-208b-3p, upregulated, possibly linked to myocardial infarction. Pathway analyses suggested that energy metabolism pathways were significantly related to the miRNAs affected by sCSDS in saliva.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Huyen Thi Minh Nguyen, Genki Akanuma, Tu Thi Minh Hoa, Yuji Nakai, Keitarou Kimura, Kazutaka Yamamoto, Takashi Inaoka
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Nutrition & Dietetics
Tsudoi Toyoda, Kota Iida, Tomoko Ishijima, Keiko Abe, Shinji Okada, Yuji Nakai
NUTRITION RESEARCH
(2020)
Article
Biology
Masaru Yamaguchi, Teruki Nishida, Yoshiaki Sato, Yuji Nakai, Ikuo Kashiwakura
RADIATION RESEARCH
(2020)
Article
Food Science & Technology
Issei Yokoyama, Yuji Nakai, Yoshihiro Suzuki, Motoko Ohata, Yusuke Komiya, Jun Nagasao, Keizo Arihara
JOURNAL OF FOOD SCIENCE
(2020)
Letter
Hematology
Michiko T. Yasuda, Yuto Watanabe, Takashi Hosono, Taiichiro Seki, Taka-aki Suzuki, Hiroyuki Sakakibara, Kayoko Shimoi
THROMBOSIS RESEARCH
(2020)
Article
Nutrition & Dietetics
Tomohisa Takagi, Ryotaro Hayashi, Yuji Nakai, Shinji Okada, Rumiko Miyashita, Mayumi Yamada, Yoichi Mihara, Katsura Mizushima, Mayuko Morita, Kazuhiko Uchiyama, Yuji Naito, Yoshito Itoh
Article
Cell Biology
Min Zhang, Kaz Nagaosa, Yuji Nakai, Tetsuo Yasugi, Masako Kushihiki, Dini Rahmatika, Makoto Sato, Akiko Shiratsuchi, Yoshinobu Nakanishi
Article
Food Science & Technology
Wataru Tanaka, Hiroki Matsuyama, Daigo Yokoyama, Yoko Yamashita, Hitoshi Ashida, Masanobu Sakono, Hiroyuki Sakakibara
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Medicine, General & Internal
Satoshi Nagase, Shigehiro Karashima, Hiromasa Tsujiguchi, Hirohito Tsuboi, Sakae Miyagi, Mitsuhiro Kometani, Daisuke Aono, Takuya Higashitani, Masashi Demura, Hiroyuki Sakakibara, Akihiro Yoshida, Akinori Hara, Hiroyuki Nakamura, Yoshiyu Takeda, Hidetaka Nambo, Takashi Yoneda, Shigefumi Okamoto
FRONTIERS IN MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Jun-Song Li, Nobuo Suzui, Yuji Nakai, Yon-Gen Yin, Satomi Ishii, Shu Fujimaki, Naoki Kawachi, Hiroki Rai, Takashi Matsumoto, Kanna Sato-Izawa, Naoko Ohkama-Ohtsu, Shin-ichi Nakamura
Summary: The study found that glutathione can inhibit the translocation of cadmium from plant roots to shoots, and by activating the inward return process of cadmium, it promotes this inhibitory effect. Experimental results demonstrate the important role of the shoot base in distributing cadmium throughout the plant body. Microarray analysis revealed that about 400 genes in the roots responded to root-applied glutathione.
Article
Nutrition & Dietetics
Hirohito Tsuboi, Hiroyuki Sakakibara, Masahiro Matsunaga, Asami Tatsumi, Kimiko Yamakawa-Kobayashi, Naoko Yoshida, Kayoko Shimoi
Review
Biochemistry & Molecular Biology
Hiroyuki Sakakibara, Kayoko Shimoi
Article
Toxicology
Keiichi Itoh, Shoji Masumori, Daisuke Mukai, Hiroyuki Sakakibara, Michiko Yasuda, Kayoko Shimoi
JOURNAL OF TOXICOLOGICAL SCIENCES
(2019)
Article
Toxicology
Wataru Tanaka, Daigo Yokoyama, Yasushi Matsuura, Masahiko Nozaki, Naoya Hirozawa, Hisato Kunitake, Masanobu Sakono, Hiroyuki Sakakibara
TOXICOLOGY REPORTS
(2019)
Article
Agriculture, Dairy & Animal Science
Tomonori Nakanishi, Kazuhiro Kagamizono, Sayaka Yokoyama, Ryoji Suzuki, Hiroyuki Sakakibara, Laurie Erickson, Satoshi Kawahara
ANIMAL SCIENCE JOURNAL
(2020)