Article
Plant Sciences
Yinghui Li, Rajib Roychowdhury, Liubov Govta, Samidha Jaiwar, Zhen-Zhen Wei, Imad Shams, Tzion Fahima
Summary: Reactive oxygen species (ROS) and hypersensitive response (HR) play important roles in plant immunity against pathogens. In this study, we quantitatively analyzed the accumulation of apoplastic ROS (apoROS) and intracellular ROS (intraROS) in wheat cells infected with Blumeria graminis f. sp. tritici (Bgt). We found that apoROS accumulation accounted for 70 to 80% of infected wheat cells in both compatible and incompatible host-pathogen interactions. IntraROS accumulation and localized cell death responses were mainly observed in wheat lines carrying nucleotide-binding leucine-rich repeat R genes. Our results provide new insights into the immune responses against wheat powdery mildew.
Article
Biochemistry & Molecular Biology
Xue-Hui Wang, Tian-Zhang Song, Hong-Yi Zheng, Yi-Hui Li, Yong-Tang Zheng
Summary: The destruction of intestinal epithelial barrier appears earlier than mucosal immune dysfunction in early stages of HIV and SIV infections, primarily due to oxidative stress-induced DNA damage and apoptosis. Mitochondrial dysfunction and oxidative stress are identified as key contributors to gut epithelial barrier disruption in early SIV-infected rhesus macaques.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Immunology
Weiyao Jing, Cui Liu, Chenghong Su, Limei Liu, Ping Chen, Xiangjun Li, Xinghua Zhang, Bo Yuan, Haidong Wang, Xiaozheng Du
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation, pannus formation, and bone and cartilage damage. The hypoxic microenvironment of RA joints can cause reactive oxygen species (ROS) accumulation and mitochondrial damage, which upregulate inflammatory pathways and contribute to angiogenesis and bone destruction, thereby accelerating RA progression. This review highlights the effects of ROS accumulation and mitochondrial damage on inflammation, angiogenesis, and bone and cartilage damage in RA, as well as discusses therapeutic approaches targeting ROS or mitochondria to alleviate symptoms and the current gaps and controversies in research.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yingjun Liu, Huajian Zhang
Summary: Nitric oxide (NO) and reactive oxygen species (ROS) play important roles in plant defense by regulating stomatal closure and hypersensitive response (HR). Research reveals that H2O2 is involved in HR-mediated cell death.
PLANT SIGNALING & BEHAVIOR
(2021)
Article
Chemistry, Multidisciplinary
Yuxuan Ma, Zhangwei Lu, Bin Jia, Ye Shi, Jun Dong, Shuoxing Jiang, Zhe Li
Summary: This study introduces a targeted treatment for rheumatoid arthritis (RA) using folic acid-modified triangular DNA origami nanostructures (FA-tDONs). The FA-tDONs can efficiently scavenge reactive oxygen species (ROS) and nitric oxide (NO), leading to the transition of pro-inflammatory macrophages to an anti-inflammatory phenotype. In an RA mouse model, FA-tDONs treatment effectively alleviates synovial inflammation and cartilage damage, attenuating disease progression.
Article
Biochemistry & Molecular Biology
Seong-Won Yang, Young-Il Jeong, Min-Suk Kook, Byung-Hoon Kim
Summary: Folic acid-conjugated nanophotosensitizers showed ROS-sensitive properties and could be delivered to cancer cells via a folate receptor-mediated pathway, making them promising candidates for targeted photodynamic therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Yunxiu Zhang, Qingyan Jia, Fuchun Nan, Jian Wang, Ke Liang, Jian Li, Xiaokuang Xue, Haohui Ren, Weimin Liu, Jiechao Ge, Pengfei Wang
Summary: In this study, three types of red-emissive carbon dots (RCDs) were successfully prepared with maximum emission at approximately 680 nm. The RCDs exhibited adjustable generation of reactive oxygen species (ROS) through type I and type II photodynamic therapy (PDT). The unique ROS formation of RCDs was determined by their core sizes and surface states, and they were able to induce cell programmed death via activating mitochondrion-mediated apoptotic pathways. This work provides a new prospect for RCDs as nanophotosensitizers to overcome the limitations of single type PDT.
Article
Plant Sciences
Li Tian, Junjiao Li, Caimin Huang, Dandan Zhang, Yan Xu, Xingyong Yang, Jian Song, Dan Wang, Nianwei Qiu, Dylan P. G. Short, Patrik Inderbitzin, Krishna Subbarao, Jieyin Chen, Xiaofeng Dai
Summary: The accumulation of ROS is a common defense mechanism in higher plants against pathogen attack. Previous studies showed that Cu/Zn-SOD1 (VdSOD1) in plants is upregulated following infection, indicating its role in pathogen virulence. Deletion of VdSOD1 leads to increased sensitivity to ROS generator menadione and relies on Golgi reassembly stacking protein for secretion. Overall, VdSOD1 plays a significant role in scavenging ROS and promoting virulence in V. dahliae.
MOLECULAR PLANT PATHOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Jialuo Ding, Yanhui Du, Xinying Hu, Mengyuan Zhao, Yeying Li, Le Li, Yu Su, Zhenkun Lin
Summary: Excessive reactive oxygen species (ROS) can cause oxidative stress and dysfunction of white adipocytes and white fat. Nanozymes, specifically aptamer-modified atomically precise gold Au-25 nanoclusters (Apt-Au-25 NCs), have shown potential in scavenging ROS and treating ROS-related diseases. The study demonstrates that Apt-Au-25 NCs have high targeting capability towards white adipocytes, exhibit SOD-like and CAT-like activity, and are efficient in scavenging ROS in white adipocytes, suggesting their potential for obesity and related disease treatment.
Article
Automation & Control Systems
Yongzheng Zhao, Hao Xiong, Yanhong Li, Wei Gao, Chen Hua, Jianrong Wu, Cunyi Fan, Xiaojun Cai, Yuanyi Zheng
Summary: This study introduces ROSrobots with magnetically actuated reactive oxygen species (ROS) scavenging capabilities by generating Prussian blue on the surfaces of MagRobots. Under a magnetic field, ROSrobots demonstrate multimodal transformation, locomotion, and manipulation in complex environments, and can be controlled to move in three-dimensional geometries using a simple method.
ADVANCED INTELLIGENT SYSTEMS
(2022)
Article
Chemistry, Multidisciplinary
Zunjing Liu, Zihao Liu, Yi Shan, Chen Xu, Bingran Yu, Fu-Jian Xu
Summary: This study introduced a ROS scavenger and a targeted peptide to construct a nucleic acid delivery system for treating atherosclerosis. The system effectively reduced inflammation and reactive oxygen species production, alleviating the progression of atherosclerosis, and displayed good biosafety.
Article
Engineering, Biomedical
Jianhua He, Wenli Zhang, Xiaoju Zhou, Fengfei Xu, Jiahui Zou, Qiqi Zhang, Yi Zhao, Hongliang He, Hu Yang, Jianping Liu
Summary: Nanoparticle-based therapeutics show potential for treating atherosclerosis, but the complex plaque microenvironment hinders their targeting ability. In this study, we developed reactive oxygen species (ROS)-responsive and size-reducible nanoassemblies to overcome this barrier. These nanoassemblies specifically accumulated in atherosclerotic plaque, rapidly disassembled in response to excess ROS, and released smaller nanoparticles for deeper penetration and targeted drug delivery. In vivo studies demonstrated that the nanoassemblies reduced plaque size, lipid deposition, macrophage content, and local inflammatory factor levels, while also alleviating systemic inflammation. Overall, the ROS-responsive and size-reducible nanoassemblies exhibit enhanced targeting ability and provide an effective approach for atherosclerosis therapy.
BIOACTIVE MATERIALS
(2023)
Review
Microbiology
Hao Li, Xuedong Zhou, Yuyao Huang, Binyou Liao, Lei Cheng, Biao Ren
Summary: Reactive oxygen species (ROS) play key roles in antibiotic-mediated killing and host-mediated killing, but their involvement presents challenges and complexities. Certain bacterial pathogens thriving under ROS conditions suggest the need to focus on pathogen evolution to adapt to ROS.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Sandra Vols, Naomi Kaisar-Iluz, Merav E. Shaul, Arik Ryvkin, Haim Ashkenazy, Avishag Yehuda, Ronza Atamneh, Adina Heinberg, Meital Ben-David-Naim, Menucha Nadav, Shira Hirsch, Vera Mitesser, Seth J. Salpeter, Ron Dzikowski, Zvi Hayouka, Jonathan M. Gershoni, Zvi G. Fridlender, Zvi Granot
Summary: This article describes the discovery of peptides that specifically bind to neutrophils and the development of nanoparticles decorated with these peptides for neutrophil-specific targeting. The study also demonstrates the specific modulation of neutrophil function and longevity by encapsulating neutrophil modifying small molecules within these nanoparticles.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Minh Phuong Nguyen, Yuna Kim, Dongryeol Ryu, Dukjoon Kim
Summary: This study presents an innovative chemotherapy mechanism using reactive oxygen species (ROS) and doxorubicin-loaded polyaspartamide-encapsulated superparamagnetic iron oxide nanoparticles. The nanocarriers showed high efficacy in inhibiting tumor growth and inducing cell death in cancer cells, which opens the door for future advancements in cancer-targeted chemotherapy.
ACS APPLIED NANO MATERIALS
(2022)
Article
Infectious Diseases
Wen-Han Chang, Shen-Huan Liang, Fu-Sheng Deng, Ching-Hsuan Lin
Article
Infectious Diseases
Fu-Sheng Deng, Ching-Hsuan Lin
Article
Immunology
Fu-Sheng Deng, Ching-Hsuan Lin
Article
Microbiology
Shen-Huan Liang, Jen-Hua Cheng, Fu-Sheng Deng, Pei-An Tsai, Ching-Hsuan Lin
Article
Infectious Diseases
Chih-Ting Chien, Yu-Chia Chen, Yun-Chun Liu, Shen-Huan Liang, Hsien-Hen Lin, Ching-Hsuan Lin
Article
Plant Sciences
Li-Hung Chen, Ching-Hsuan Lin, Kuang-Ren Chung
MOLECULAR PLANT PATHOLOGY
(2013)
Article
Microbiology
Ching-Hsuan Lin, Shail Kabrawala, Emily P. Fox, Clarissa J. Nobile, Alexander D. Johnson, Richard J. Bennett
Article
Microbiology
Yi-Kai Tseng, Yu-Chia Chen, Chien-Jui Hou, Fu-Sheng Deng, Shen-Huan Liang, Sin Yong Hoo, Chih-Chieh Hsu, Cai-Ling Ke, Ching-Hsuan Lin
Review
Genetics & Heredity
Shi Qian Lew, Ching-Hsuan Lin
Summary: Morphological transitions in Candida species, triggered by GlcNAc, exhibit significant differences in hyphal development response and signaling pathways between Candida albicans and Candida tropicalis. The diverse effects and pathways suggest distinct regulatory mechanisms in filamentous growth between these two species.
Article
Immunology
Cai-Ling Ke, Yu-Ting Liao, Ching-Hsuan Lin
Summary: The study demonstrates that chitosan inhibits mitochondrial function in Candida albicans by suppressing the expression of the MSS2 gene, leading to decreased virulence and invasive ability of the fungi. This indicates a potential strategy for antifungal drug development targeting fungal mitochondria.
Editorial Material
Microbiology
Ching-Hsuan Lin
Summary: Ching-Hsuan Lin is inspired by two papers to explore new bioactive antimicrobial compounds with his collaborators.
Review
Polymer Science
Cai-Ling Ke, Fu-Sheng Deng, Chih-Yu Chuang, Ching-Hsuan Lin
Summary: Chitosan, a naturally occurring product, has biocompatibility, biodegradability, and non-toxic properties, making it applicable in many areas. Its broad-spectrum antimicrobial activity provides great commercial potential, but varies depending on its physicochemical characteristics and type of microorganism. Understanding the fundamental properties and modes of antimicrobial action of chitosan, as well as how microorganisms genetically respond to it, can lead to better applications.
Article
Immunology
Cai-Ling Ke, Shi Qian Lew, Yi Hsieh, Szu-Cheng Chang, Ching-Hsuan Lin
Summary: This study investigates the role of SNF4 in Candida tropicalis and finds that it plays important roles in glucose derepression, cell wall integrity, and virulence. Additionally, the expression of both SNF1 and SNF4 is significantly induced under glucose limitation.
Article
Biochemistry & Molecular Biology
Wei-Hsuan Lo, Fu-Sheng Deng, Chih-Jung Chang, Ching-Hsuan Lin
Article
Biochemistry & Molecular Biology
Ching-Hsuan Lin, Hsiung-Fei Chien, Ming-Hsuan Lin, Chueh-Pin Chen, Mandy Shen, Chin-Tin Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Plant Sciences
Sreelekha Duruvasula, Ulaganathan Kandasamy, Sujatha Mulpuri
Summary: The study identified the MLO gene family in the sunflower genome using computational methods, analyzed their chromosomal distribution, gene structure, and phylogenetic relationship, providing a reference for future functional studies. Additionally, the analysis revealed 12 differentially expressed genes between powdery mildew resistant and susceptible sunflower varieties, further contributing to understanding genetic resistance mechanisms in sunflower.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2024)
Article
Plant Sciences
Zainul A. Khan, Damini Diksha, Pooja Thapa, Yazing S. Mailem, Susheel K. Sharma, Nitika Gupta, Gopi Kishan, Santosh Watpade, Virendra K. Baranwal
Summary: This study reported the presence of several viruses, including apple rubbery wood virus 1, apple necrotic mosaic virus, citrus virus A, apple stem grooving virus, apple stem pitting virus, apple chlorotic leaf spot virus, in pear trees in India for the first time. The genomes of these viruses were sequenced and analyzed, revealing the expansion of their host range in pear trees. These findings are of great importance for the biological study of pear viruses and virus indexing programs.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2024)
Article
Plant Sciences
Xueren Cao, Qiaohui Han, Jonathan S. West
Summary: Spraying double-stranded RNAs (dsRNA) targeting the genes of E. quercicola can effectively control rubber tree powdery mildew and reduce the expression of pathogen genes as well as the severity of the disease.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2024)