Article
Materials Science, Multidisciplinary
Subhasish Sahoo, Bibhas Hazra, Pradip K. Tarafdar, Priyadarsi De
Summary: Accessing the interior of cells is crucial for drug delivery, and cholic acid-based copolymers have shown potential in destabilizing cellular membranes. In this study, cholate-containing amphiphilic copolymers were synthesized and self-organized into nanoaggregates. These copolymers efficiently destabilized liposomes and showed promise in delivering therapeutic drugs.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Christian C. M. Sproncken, Berta Gumi-Audenis, Sanam Foroutanparsa, Jose Rodrigo Magana, Ilja K. Voets
Summary: By modulating the pH, weak polyelectrolytes can be complexed to achieve temporal control over their coassembly. In this study, oppositely charged poly(allylamine hydrochloride) and poly(sodium methacrylate) were mixed in a (bi)sulfite buffer, resulting in the formation of nanoscopic complex coacervates. The addition of formaldehyde triggered the formaldehyde-sulfite clock reaction, which affected the polyelectrolyte assembly by changing their charge density and inducing chemical modifications on the polymer. Interestingly, core-shell polymeric nanoparticles were produced, which remained colloidally stable for months.
Article
Pharmacology & Pharmacy
Dan-Li Hao, Ya-Jie Wang, Jia-Ying Yang, Ran Xie, Ling-Yu Jia, Jin-Tang Cheng, Hai Ma, Ji-Xiang Tian, Shan-Shan Guo, Ting Liu, Feng Sui, Yu Zhao, Yan-Jun Chen, Qing-He Zhao
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common clinical syndromes that can lead to severe respiratory failure and high mortality. Nanotechnology-mediated anti-inflammatory therapy is a promising approach for ALI treatment. This study demonstrated that the artesunate prodrugs can effectively attenuate LPS-induced ALI, suggesting a novel strategy for treating inflammation-induced lung injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Lina Zhao, Meina Ren, Yanjiao Wang, Hailong An, Fude Sun
Summary: Exploiting PEG-DPPE micelles as drug delivery carriers has great potential in improving therapeutic targeting and half-lives of drugs. However, the kinetics of carrier-membrane interactions and the contributions of micelle hydrophobic/hydrophilic components need further investigation. In this study, we used MARTINI coarse-grain molecular dynamics simulations to explore the fusion dynamics of PEG-DPPE micelles with different PEG repetitions in delivering doxorubicin (DOX). Our results provide new insights into the mechanism of PEG-DPPE micelles in delivering drugs through membranes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Materials Science, Biomaterials
Anne Nguyen, Elham Rouhollahi, Roland Bottger, Chun Yat Ong, Po-Han Chao, Jiamin Wu, Yao Chen, Shyh-Dar Li
Summary: Conjugating poorly water-soluble small hydrophobic compounds with hydrophilic polymers can improve their aqueous solubility and circulation time. This study investigates the influence of polymer molecular weight and linker on the toxicity and drug release of conjugates. Using a click chemistry platform, mPEG of different molecular weights were conjugated to an anti-tumor drug, resulting in nanoparticles with optimal anti-tumor efficacy for mPEG(5000) and an ester linker.
BIOMATERIALS SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Xiangjie Su, Mercedes Ramirez-Escudero, Feilong Sun, Joep B. van den Dikkenberg, Mies J. van Steenbergen, Roland J. Pieters, Bert J. C. Janssen, Peter M. van Hasselt, Wim E. Hennink, Cornelus F. van Nostrum
Summary: This study aimed to investigate the internalization and transport of PEGylated mixed micelles loaded with vitamin K, mediated by SR-B1. Inhibition of SR-B1 reduced endocytosis and transport of the micelles, and PEGylation was found to play a key role in the interaction with SR-B1, independent of vitamin K content. Additionally, molecular docking calculations supported the dual binding of both vitamin K and PEG with the binding domain of SR-B1.
Article
Chemistry, Physical
Omid Shafiee, Samantha G. Jenkins, Takashi Ito, Daniel A. Higgins
Summary: Solute diffusion within lyotropic liquid crystal gels was studied using fluorescence correlation spectroscopy. The gels were prepared from water and C12EO10 mixtures, and small angle X-ray scattering revealed hexagonal mesophases of cylindrical micelles. Different Nile red dyes were used as model solutes, and their diffusion coefficients were measured. The results provide insights into molecular mass transport in soft nanomaterials for drug delivery and chemical separations.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Prachi Sharma, Neeraj Sohal, Banibrata Maity
Summary: The entrapment of non-fluorescent dye Crystal Violet (CV) in bile-salt aggregates led to a significant enhancement of its fluorescence properties. The addition of KCl salt caused the release of CV molecules from the aggregates to the aqueous medium, resulting in a reduction of various photophysical properties.
Article
Materials Science, Multidisciplinary
Dipankar Ghosh, Libby J. Marshall, Giuseppe Ciccone, Wanli Liu, Adam Squires, Annela Seddon, Massimo Vassalli, Dave J. Adams
Summary: Supramolecular assembly can be used to fabricate complex functional materials, but controlling hierarchical assembly across multiple length scales is difficult. This study investigates the correlation between a supramolecular gel network and a pre-gelling aggregate using a functional dipeptide 2NapFF. By varying the counterions, different micellar structures can be formed at high pH. Replacing the counterions with a divalent calcium salt results in a cross-linked gel network or an analog gel noodles.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Food Science & Technology
Yeonmi Lee, Yasutake Tanaka, Wakana Iwasaki, Fumika Yokoyama, Ga-Hyun Joe, Misaki Tsuji, Takuma Nose, Koji Tada, Taketo Hanai, Shota Hori, Hidehisa Shimizu, Kimiko Minamida, Kazunori Miwa, Satoshi Ishizuka
Summary: Dietary supplementation with a synbiotic containing okara and Bacillus coagulans lilac-01 can improve hepatic lipid accumulation induced by cholic acid, by reducing de novo lipogenesis and enhancing fecal triglyceride excretion.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Physical
Mamta Rani, Manoj Sehrawat, Rashmi Rani, Bhasker Gahtori, Bhanu Pratap Singh
Summary: Increasing the interfaces of carbon nanotube buckypaper improves its mechanical load transfer ability, but also increases contact resistance and retards the increase in electrical conductivity. Chemical functionalization, doping, and densifying have shown positive results but still fall short of the physical attributes of individual nanotubes. In this study, the amount of surfactant was controlled during the preparation of buckypaper to manipulate its mechanical and electrical properties. The prepared buckypapers exhibited high crystallinity and lower defects, and the interplay between surfactant and physical parameters affected the dispersion forces and interface contact among nanotubes. The buckypaper with the lowest surfactant content had the highest electrical conductivity (91.74 S/cm), which was twice that of the buckypaper with the highest surfactant content. Moreover, the tensile strength of the buckypaper showed a 104% improvement with the control of surfactant concentration, indicating the viability and importance of this study for further buckypaper development.
SURFACES AND INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Deniz Yildiz, Robert Goestl, Andreas Herrmann
Summary: Active pharmaceutical ingredients (APIs) are widely used in medicine, but they have limitations such as off-target activity and toxicity. To address these issues, researchers are developing stimuli-responsive controlled delivery and release strategies. Recently, new molecular technologies using ultrasound as a stimulus have emerged in the field of polymer mechanochemistry. This review focuses on the use of ultrasound to control drug activation, monitoring, and release, while highlighting the challenges and limitations for future developments.
Article
Polymer Science
Franka Gruschwitz, Tobias Klein, Maren T. Kuchenbrod, Naoto Moriyama, Shota Fujii, Ivo Nischang, Stephanie Hoeppener, Kazuo Sakurai, Ulrich S. Schubert, Johannes C. Brendel
Summary: Strong directional hydrogen bonds drive the one-dimensional aqueous self-assembly of polymeric amphiphiles, with obtained morphologies strongly dependent on the pathway. Controlled transfer from organic solvents to aqueous environments enables the formation of stable nanostructures, ranging from small objects to remarkably large fibers. A detailed analysis of the assembly mechanism reveals a cooperative nature, opening a new pathway to control the length of 1D polymer nanostructures.
Article
Chemistry, Applied
A. S. Eremina, Yu Kargina, A. Yu Kharin, D. Petukhov, V. Yu Timoshenko
Summary: A one-step procedure using polyethylene glycol (PEG) coating during grinding in a planetary ball mill has been proposed to stabilize mesoporous silicon nanoparticles in aqueous solutions. The nanoparticles were found to have a size of 50-100 nm, preserved nanocrystallinity and mesopores, and remained stable in aqueous solution for at least 24 hours. This PEGylation method offers a way to control the physical properties and stability of mesoporous silicon nanoparticles for biomedical applications.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Chemistry, Medicinal
Fazlin Pheiffer, Yannik K. -H. Schneider, Espen Holst Hansen, Jeanette Hammer Andersen, Johan Isaksson, Tobias Busche, Christian Rueckert, Joern Kalinowski, Leonardo van Zyl, Marla Trindade
Summary: This study investigates the bioactive potential of the marine invertebrate symbiont Thalassomonas actiniarum, identifying its antibacterial and cytotoxic activities, as well as their ability to produce cholic acid and 3-oxo cholic acid through hydrolysis of conjugated bile acids. The findings provide a foundation for further research on the bioactivities and ecological role of Thalassomonas sp. in the marine environment.
Article
Biochemistry & Molecular Biology
Ting Wang, Christoph Oppawsky, Yong Duan, Joerg Tittor, Dieter Oesterhelt, Marc T. Facciotti
Article
Neurosciences
Jiya Sun, Xuemei Feng, Dapeng Liang, Yong Duan, Hongxing Lei
JOURNAL OF ALZHEIMERS DISEASE
(2012)
Article
Neurosciences
Jiajia Wang, Xuemei Feng, Zhouxian Bai, Lee-Way Jin, Yong Duan, Hongxing Lei
JOURNAL OF ALZHEIMERS DISEASE
(2014)
Article
Neurosciences
Guangchun Han, Jiajia Wang, Fan Zeng, Xuemei Feng, Jun Yu, Hong-Yuan Cao, Xu Yi, Huadong Zhou, Lee-Way Jin, Yong Duan, Yan-Jiang Wang, Hongxing Lei
JOURNAL OF ALZHEIMERS DISEASE
(2013)
Article
Neurosciences
Xuemei Feng, Zhouxian Bai, Jiajia Wang, Bin Xie, Jiya Sun, Guangchun Han, Fuhai Song, Peter J. Crack, Yong Duan, Hongxing Lei
JOURNAL OF ALZHEIMERS DISEASE
(2014)
Article
Neurosciences
Jiya Sun, Fuhai Song, Jiajia Wang, Guangchun Han, Zhouxian Bai, Bin Xie, Xuemei Feng, Jianping Jia, Yong Duan, Hongxing Lei
JOURNAL OF ALZHEIMERS DISEASE
(2014)
Article
Biophysics
Xiaochuan Tang, Yong Duan
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2013)
Article
Chemistry, Physical
Junmei Wang, Piotr Cieplak, Jie Li, Qin Cai, Meng-Juei Hsieh, Ray Luo, Yong Duan
JOURNAL OF PHYSICAL CHEMISTRY B
(2012)
Article
Chemistry, Physical
Jun Wang, Piotr Cieplak, Qin Cai, Meng-Juei Hsieh, Junmei Wang, Yong Duan, Ray Luo
JOURNAL OF PHYSICAL CHEMISTRY B
(2012)
Article
Multidisciplinary Sciences
Dapeng Liang, Guangchun Han, Xuemei Feng, Jiya Sun, Yong Duan, Hongxing Lei
Article
Multidisciplinary Sciences
Ting Wang, Marc T. Facciotti, Yong Duan
Article
Multidisciplinary Sciences
Bin Xie, Dapeng Wang, Yong Duan, Jun Yu, Hongxing Lei
Article
Multidisciplinary Sciences
Zhou Gong, Yunjie Zhao, Changjun Chen, Yong Duan, Yi Xiao
Article
Biochemistry & Molecular Biology
Ting Wang, Ayla O. Sessions, Christopher S. Lunde, Shahab Rouhani, Robert M. Glaeser, Yong Duan, Marc T. Facciotti
Meeting Abstract
Chemistry, Multidisciplinary
Yong Duan, Qin Cai, Piotr Cieplak, Junmei Wang, MengJuei Hsieh, Ray Luo
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
Article
Chemistry, Physical
Sergey Yu. Ketkov, Sheng-Yuan Tzeng, Elena A. Rychagova, Anton N. Lukoyanov, Wen-Bih Tzeng
Summary: Metallocenes, including methylcobaltocene, play important roles in various fields of chemistry. The ionization energy and vibrational structure of (Cp ')(Cp)Co can be influenced by introducing methyl substituents. The mass-analyzed threshold ionization spectrum and DFT calculations provide accurate information about the properties and transformations of (Cp ')(Cp)Co.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Review
Chemistry, Physical
Qifeng Mu, Jian Hu
Summary: Polymer mechanochemistry has experienced a renaissance due to the rapid development of mechanophores and principles governing mechanochemical transduction or material strengthening. It has not only provided fundamental guidelines for converting mechanical energy into chemical output, but also found applications in engineering and smart devices.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Da Hye Yang, Francesco Ricci, Fredrik L. Nordstrom, Na Li
Summary: Through systematic evaluation of the oiling-out behavior of procaine, we identified both stable and metastable liquid-liquid phase separation, and established phase diagrams to assist in rational selection of crystallization strategies.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Vikki Anand Varma, Simmie Jaglan, Mohd Yasir Khan, Sujin B. Babu
Summary: Designing engineering structures like nanocages, shells, and containers through self-assembly of colloids is a challenging problem. This work proposes a simple model for the subunit, which leads to the formation of monodispersed spherical cages or containers. The model with only one control parameter can be used to design cages with the desired radius.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Hainan Jiang, Yaolong He, Xiaolin Li, Zhiyao Jin, Huijie Yu, Dawei Li
Summary: The cycling lifespan and coulombic efficiency of lithium-ion batteries are crucial for high C-rate applications. The Li-ion concentration plays a crucial role in determining the mechanical integrity and structural stability of electrodes. This study focuses on graphite as the working electrode and establishes an experimental system to investigate the mechanical properties of composite graphite electrode at different C-rates. Considering the effect of Li-ion concentration in stress analysis is found to be significant.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Zhiye Wang, Yunchuan Li, Mingjun Sun
Summary: This study investigates the influence of intramolecular pi-pi interactions on the electronic transport capabilities of molecules. By designing and analyzing three pi-conjugated molecules, the researchers observe that different pi-conjugated structures have varying effects on electron transport. The findings provide a theoretical foundation for designing single-molecule electronic devices with multiple electron channels based on intramolecular pi-pi interactions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Yuandong Xu, Haoyang Feng, Chaoyang Dong, Yuqing Yang, Meng Zhou, Yajun Wei, Hui Guo, Yaqing Wei, Jishan Su, Yingying Ben, Xia Zhang
Summary: Hollow MoS2 cubes and spheres were successfully synthesized using a one-step hydrothermal method with the hard template method. The hollow MoS2 cubes exhibited higher specific capacitance and energy density compared to the hollow MoS2 spheres. The symmetrical supercapacitors assembled with these hollow structures showed good performance and high capacity retention after multiple cycles. These findings suggest that controlling the pore structure and surface characteristics of MoS2 is crucial for enhancing its electrochemical properties.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Ainhoa Oliden-Sanchez, Rebeca Sola-Llano, Joaquin Perez-Pariente, Luis Gomez-Hortiguela, Virginia Martinez-Martinez
Summary: The combination of photoactive molecules and inorganic structures is important for the development of advanced materials in optics. In this study, bulky dyes were successfully encapsulated in a zeolitic framework, resulting in emission throughout the visible spectrum.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Miaomiao Zhang, Cunyuan Pei, Qiqi Xiang, Lintao Liu, Zhongxu Dai, Huijuan Ma, Shibing Ni
Summary: The design of a solid electrolyte interphase (SEI) plays a crucial role in improving the electrochemical performance of anode materials. In this study, lithium difluoro(oxalate)borate (LiDFOB) is used as an electrolyte additive to form a protective SEI film on Li3VO4 (LVO) anodes. The addition of LiDFOB results in a dense, uniform, stable, and LiF-richer SEI, which enhances the Li-ion storage kinetics. The generated SEI also prevents further decomposition of the electrolyte and maintains the morphology of LVO anodes during charge/discharge processes. This work demonstrates the effectiveness of LiDFOB as a multi-functional additive for LiPF6 electrolytes and provides insights into SEI construction for high-performance LVO anodes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
B. V. Andryushechkin, T. V. Pavlova, V. M. Shevlyuga
Summary: The atomic structure of the Ag(111)-p(4 x 4)-O phase was reexamined and two phases with the same periodicity were discovered. It was demonstrated that the accepted Ag6 model is incompatible with high-resolution oxygen-sensitive STM images.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
S. L. Romo-Avila, D. Marquez-Ruiz, R. A. Guirado-Lopez
Summary: In this study, we used density functional theory (DFT) calculations to investigate the interaction between model graphene oxide (GO) nanostructures and chlorine monoxide ClO. We aimed to understand the role of this highly oxidizing species in breaking C-C bonds and forming significant holes on GO sheets. Our results showed that C-C bonds in a single graphene oxide sheet can be broken through a simple mechanism involving the dissociation of two chemically attached ClO molecules. The formation of carbonyl groups and holes on the GO surface was also observed. This study provides important insights into the degradation of carbon nanotubes and the stability of GO during the myeloperoxidase (MPO) catalytic cycle.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Alberto Garcia-Fernandez, Birgit Kammlander, Stefania Riva, Hakan Rensmo, Ute B. Cappel
Summary: In this study, the X-ray stability of five different lead halide perovskite compositions (MAPbI3, MAPbCl3, MAPbBr3, FAPbBr3, CsPbBr3) was investigated using photoelectron spectroscopy. Different degradation mechanisms and resistance to X-ray were observed depending on the crystal composition. Overall, perovskite compositions based on the MA+ cation were found to be less stable than those based on FA+ or Cs+. Metallic lead formation was most easily observed in the chloride perovskite, followed by bromide, and very little in MAPbI3. Multiple degradation processes were identified for the bromide compositions, including ion migration, formation of volatile and solid products, as well as metallic lead. CsBr was formed as a solid degradation product on the surface of CsPbBr3.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Timofei Rostilov, Vadim Ziborov, Alexander Dolgoborodov, Mikhail Kuskov
Summary: The shock-loading behavior of nanomaterials is investigated in this study. It is found that shock compaction waves exhibit a distinct two-step structure, with the formation of faster precursor waves that travel ahead of the main compaction waves. The complexity of the shock Hugoniot curve of the tested nanomaterial is described, and the effect of initial porosity on the compressed states is demonstrated.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Sergey S. Nikitin, Alexander D. Koryakov, Elizaveta A. Antipinskaya, Alexey A. Markov, Mikhail V. Patrakeev
Summary: The stability of La1/3Sr2/3Fe1-xMnxO3-delta, a perovskite-type oxide, under reducing conditions is dependent on the manganese content. Increasing the manganese content leads to a decrease in stability. The behavior of iron and manganese in the oxide shows distinct differences, which can be attributed to the difference in the enthalpy of oxidation reactions. Additionally, the change in the La/Sr ratio affects the concentration of iron and manganese ions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Mosayeb Naseri, Shirin Amirian, Mehrdad Faraji, Mohammad Abdur Rashid, Maicon Pierre Lourenco, Venkataraman Thangadurai, D. R. Salahub
Summary: Inspired by the successful transfer of freestanding ultrathin films of SrTiO3 and BiFeO3, this study assessed the structural stability and investigated the electronic, optical, and thermoelectric properties of a group of two-dimensional perovskite-type materials called perovskenes. The findings revealed that these materials are wide bandgap semiconductors with potential application in UV shielding. Moreover, they exhibit better electrical and thermal conductivity at high temperatures, enabling efficient power generation in thermoelectric devices.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)