标题
The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update
作者
关键词
Bcl-2, Apoptosis, BH3, Mitochondria, Cancer, Neurodegenerative disorders, Extrinsic pathway
出版物
ARCHIVES OF TOXICOLOGY
Volume 89, Issue 3, Pages 289-317
出版商
Springer Nature
发表日期
2015-01-24
DOI
10.1007/s00204-014-1448-7
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Lack of Association Between the CYP1A1 Ile462Val Polymorphism and Endometrial Cancer Risk: a Meta-analysis
- (2013) Xi-Wen Wang et al. Asian Pacific Journal of Cancer Prevention
- Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer
- (2013) François Vaillant et al. CANCER CELL
- Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis
- (2013) Peter E. Czabotar et al. CELL
- Intracellular localization of the BCL-2 family member BOK and functional implications
- (2013) N Echeverry et al. CELL DEATH AND DIFFERENTIATION
- Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins
- (2013) Brian J. Smith et al. CHEMBIOCHEM
- A Potent and Highly Efficacious Bcl-2/Bcl-xL Inhibitor
- (2013) Angelo Aguilar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming
- (2013) Barbara Schellenberg et al. MOLECULAR CELL
- Structure-guided design of a selective BCL-XL inhibitor
- (2013) Guillaume Lessene et al. Nature Chemical Biology
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
- (2013) Andrew J Souers et al. NATURE MEDICINE
- BID-induced structural changes in BAK promote apoptosis
- (2013) Tudor Moldoveanu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Direct activation of full-length proapoptotic BAK
- (2013) Elizaveta S. Leshchiner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease
- (2013) K. D. Mason et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms of Action of Bcl-2 Family Proteins
- (2013) A. Shamas-Din et al. Cold Spring Harbor Perspectives in Biology
- The Role of the Acidity of N-Heteroaryl Sulfonamides as Inhibitors of Bcl-2 Family Protein–Protein Interactions
- (2013) B. Barry Touré et al. ACS Medicinal Chemistry Letters
- A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer
- (2012) A A Chiappori et al. BRITISH JOURNAL OF CANCER
- BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax
- (2012) F Wilfling et al. CELL DEATH AND DIFFERENTIATION
- The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria
- (2012) F Todt et al. CELL DEATH AND DIFFERENTIATION
- Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer
- (2012) C. M. Rudin et al. CLINICAL CANCER RESEARCH
- Mediation of the Antiapoptotic Activity of Bcl-xL Protein upon Interaction with VDAC1 Protein
- (2012) Nir Arbel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers
- (2012) James L. LaBelle et al. JOURNAL OF CLINICAL INVESTIGATION
- Structure-Based Discovery of BM-957 as a Potent Small-Molecule Inhibitor of Bcl-2 and Bcl-xL Capable of Achieving Complete Tumor Regression
- (2012) Jianfang Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Differences in the Mechanisms of Proapoptotic BH3 Proteins Binding to Bcl-XL and Bcl-2 Quantified in Live MCF-7 Cells
- (2012) Alexander Aranovich et al. MOLECULAR CELL
- Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
- (2012) Rhonda M. Perciavalle et al. NATURE CELL BIOLOGY
- Inflammasomes in carcinogenesis and anticancer immune responses
- (2012) Laurence Zitvogel et al. NATURE IMMUNOLOGY
- N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death
- (2012) Dimitry Ofengeim et al. NATURE NEUROSCIENCE
- Mitochondria: master regulators of danger signalling
- (2012) Lorenzo Galluzzi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
- (2012) G J P Rautureau et al. Cell Death & Disease
- c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells
- (2011) J. C. Allen et al. BLOOD
- Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol
- (2011) Frank Edlich et al. CELL
- Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival
- (2011) Caroline H. Yi et al. CELL
- Autophagy: Renovation of Cells and Tissues
- (2011) Noboru Mizushima et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: Role in Ca2+ signaling and disease
- (2011) Clark W. Distelhorst et al. CELL CALCIUM
- Cell death by autophagy: facts and apparent artefacts
- (2011) D Denton et al. CELL DEATH AND DIFFERENTIATION
- Bax dimerizes via a symmetric BH3:groove interface during apoptosis
- (2011) G Dewson et al. CELL DEATH AND DIFFERENTIATION
- The Beclin 1 network regulates autophagy and apoptosis
- (2011) R Kang et al. CELL DEATH AND DIFFERENTIATION
- Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis
- (2011) Peter E. Czabotar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease
- (2011) Andrew W. Roberts et al. JOURNAL OF CLINICAL ONCOLOGY
- Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity
- (2011) Brad E. Sleebs et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction
- (2011) Steven A. Kawamoto et al. JOURNAL OF MEDICINAL CHEMISTRY
- Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain
- (2011) Melissa D. Boersma et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Role of Bcl-2 family proteins and caspases in the regulation of apoptosis
- (2011) Mohammad Shamsul Ola et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria
- (2011) Fabien Llambi et al. MOLECULAR CELL
- Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase
- (2011) Kambiz N. Alavian et al. NATURE CELL BIOLOGY
- Regulation of Neutrophil Survival/Apoptosis by Mcl-1
- (2011) Eric Milot et al. TheScientificWorldJOURNAL
- Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance
- (2010) Russell S. Whelan et al. Annual Review of Physiology
- Molecular biology of Bax and Bak activation and action
- (2010) Dana Westphal et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat
- (2010) Diego Rodriguez et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Anti-apoptosis and cell survival: A review
- (2010) Liam Portt et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Bcl-2 Family Proteins as Therapeutic Targets
- (2010) Peter E. Czabotar et al. CURRENT PHARMACEUTICAL DESIGN
- MicroRNA regulation of core apoptosis pathways in cancer
- (2010) Raquel T. Lima et al. EUROPEAN JOURNAL OF CANCER
- Regulation of the Apaf-1-caspase-9 apoptosome
- (2010) S. B. Bratton et al. JOURNAL OF CELL SCIENCE
- BI-97C1, an Optically Pure Apogossypol Derivative as Pan-Active Inhibitor of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins
- (2010) Jun Wei et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phase I/II Study of AT-101 with Topotecan in Relapsed and Refractory Small Cell Lung Cancer
- (2010) Rebecca Suk Heist et al. Journal of Thoracic Oncology
- Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
- (2010) Wyndham H Wilson et al. LANCET ONCOLOGY
- VDAC, a multi-functional mitochondrial protein regulating cell life and death
- (2010) Varda Shoshan-Barmatz et al. MOLECULAR ASPECTS OF MEDICINE
- BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX
- (2010) Evripidis Gavathiotis et al. MOLECULAR CELL
- “Where, O Death, Is Thy Sting?” A Brief Review of Apoptosis Biology
- (2010) Andrew H. Wyllie MOLECULAR NEUROBIOLOGY
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria
- (2010) Yehudit Zaltsman et al. NATURE CELL BIOLOGY
- The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
- (2010) Michelle L Stewart et al. Nature Chemical Biology
- Mitochondria and cell death: outer membrane permeabilization and beyond
- (2010) Stephen W. G. Tait et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Still embedded together binding to membranes regulates Bcl-2 protein interactions
- (2010) B Leber et al. ONCOGENE
- BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs
- (2010) E. M. Carrington et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bcl-2 family on guard at the ER
- (2009) Eva Szegezdi et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The Role of Mitochondria in Apoptosis
- (2009) Chunxin Wang et al. Annual Review of Genetics
- The Bax carboxy-terminal hydrophobic helix does not determine organelle-specific targeting but is essential for maintaining Bax in an inactive state and for stable mitochondrial membrane insertion
- (2009) Stephanie E. Brock et al. APOPTOSIS
- Multifaceted deaths orchestrated by mitochondria in neurones
- (2009) Phillip Nagley et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Blinded by the Light: The Growing Complexity of p53
- (2009) Karen H. Vousden et al. CELL
- Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2
- (2009) Z X Chen et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial cell death effectors
- (2009) Dirk Brenner et al. CURRENT OPINION IN CELL BIOLOGY
- Structural and functional link between the mitochondrial network and the endoplasmic reticulum
- (2009) Carlotta Giorgi et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Control of mitochondrial apoptosis by the Bcl-2 family
- (2009) J. K. Brunelle et al. JOURNAL OF CELL SCIENCE
- The mitochondrial death pathway: a promising therapeutic target in diseases
- (2009) Sanjeev Gupta et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation
- (2009) L. A. O'Reilly et al. JOURNAL OF IMMUNOLOGY
- Major cell death pathways at a glance
- (2009) Linde Duprez et al. MICROBES AND INFECTION
- Mitochondrial gateways to cancer
- (2009) Lorenzo Galluzzi et al. MOLECULAR ASPECTS OF MEDICINE
- Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation
- (2009) Blanca Schafer et al. MOLECULAR BIOLOGY OF THE CELL
- The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex
- (2009) Frédéric Mille et al. NATURE CELL BIOLOGY
- BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions
- (2009) G Chinnadurai et al. ONCOGENE
- The autophagy effector Beclin 1: a novel BH3-only protein
- (2009) S Sinha et al. ONCOGENE
- Bid: a Bax-like BH3 protein
- (2009) L P Billen et al. ONCOGENE
- Mechanism of Bcl-2 and Bcl-XL inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization
- (2009) B. Faustin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntington’s disease patients
- (2008) Sandra Almeida et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Targeting post-mitochondrial effectors of apoptosis for neuroprotection
- (2008) Lorenzo Galluzzi et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Targets for neuroprotection in Parkinson's disease
- (2008) Talene A. Yacoubian et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mitochondrial death pathways in yeast and mammalian cells
- (2008) Wen-Chih Cheng et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
- (2008) C. Tse et al. CANCER RESEARCH
- Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax
- (2008) Jonathan F. Lovell et al. CELL
- Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters
- (2008) Andrea Ventura et al. CELL
- Cell death in the host response to infection
- (2008) K Labbé et al. CELL DEATH AND DIFFERENTIATION
- No death without life: vital functions of apoptotic effectors
- (2008) L Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
- (2008) M Kvansakul et al. CELL DEATH AND DIFFERENTIATION
- Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane
- (2008) S Lucken-Ardjomande et al. CELL DEATH AND DIFFERENTIATION
- Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
- (2008) G Kroemer et al. CELL DEATH AND DIFFERENTIATION
- Regulation of Bcl-2 Family Proteins by Posttranslational Modifications
- (2008) Anthony Letai et al. CURRENT MOLECULAR MEDICINE
- Anti-Apoptosis Mechanisms in Malignant Gliomas
- (2008) David S. Ziegler et al. JOURNAL OF CLINICAL ONCOLOGY
- Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
- (2008) Catherine L. Day et al. JOURNAL OF MOLECULAR BIOLOGY
- BAX activation is initiated at a novel interaction site
- (2008) Evripidis Gavathiotis et al. NATURE
- Mitofusin 2 tethers endoplasmic reticulum to mitochondria
- (2008) Olga Martins de Brito et al. NATURE
- Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
- (2008) Allyson E. Vaughn et al. NATURE CELL BIOLOGY
- Regulation of autophagy by cytoplasmic p53
- (2008) Ezgi Tasdemir et al. NATURE CELL BIOLOGY
- Dual role of proapoptotic BAD in insulin secretion and beta cell survival
- (2008) Nika N Danial et al. NATURE MEDICINE
- Structure of transmembrane pore induced by Bax-derived peptide: Evidence for lipidic pores
- (2008) S. Qian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
- (2008) Jerry E. Chipuk et al. TRENDS IN CELL BIOLOGY
- Bcl-2 Protein Family Members: Versatile Regulators of Calcium Signaling in Cell Survival and Apoptosis
- (2007) Yiping Rong et al. Annual Review of Physiology
- The BCL-2 protein family: opposing activities that mediate cell death
- (2007) Richard J. Youle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Apoptosis: controlled demolition at the cellular level
- (2007) Rebecca C. Taylor et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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