Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells

Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation

(2013) Ju Mei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tissue distribution profiles of three antiparkinsonian alkaloids from Piper longum L. in rats determined by liquid chromatography–tandem mass spectrometry

(2013) Haolong Liu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Targeting Cancer Cells With the Natural Compound Obtusaquinone

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Characterization of Adult Rat Astrocyte Cultures

(2013) Débora Guerini Souza et al.   PLoS One

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1

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Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

(2012) Dong Hoon Suh et al.   Annals of the New York Academy of Sciences

Pharmacological targeting of endoplasmic reticulum stress signaling in cancer

(2012) Axel H. Schönthal   BIOCHEMICAL PHARMACOLOGY

Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells

(2012) Reagan M. Jarvis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro

(2012) Seong-Su Han et al.   LEUKEMIA RESEARCH

Inactivation of a Peroxiredoxin by Hydrogen Peroxide Is Critical for Thioredoxin-Mediated Repair of Oxidized Proteins and Cell Survival

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Deregulated MYC expression induces dependence upon AMPK-related kinase 5

(2012) Lidan Liu et al.   NATURE

Suppression of Peroxiredoxin 4 in Glioblastoma Cells Increases Apoptosis and Reduces Tumor Growth

(2012) Tae Hyong Kim et al.   PLoS One

Inhibition of Endoplasmic Reticulum Stress Improves Mouse Embryo Development

(2012) Jin Yu Zhang et al.   PLoS One

Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas

(2011) Peeter Karihtala et al.   BMC CANCER

Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis

(2011) Dominique Ziech et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro

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Peroxiredoxin IV protects cells from oxidative stress by removing H2O2 produced during disulphide formation

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Oxidative Protein Folding by an Endoplasmic Reticulum-Localized Peroxiredoxin

(2010) Ester Zito et al.   MOLECULAR CELL

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

Comparative Proteomic Analysis of Osteosarcoma Cell and Human Primary Cultured Osteoblastic Cell

(2009) Xudong Liu et al.   CANCER INVESTIGATION

Conserved Gene Expression Programs Integrate Mammalian Prostate Development and Tumorigenesis

(2009) C. Pritchard et al.   CANCER RESEARCH

Peroxiredoxin 4knockout results in elevated spermatogenic cell death via oxidative stress

(2008) Yoshihito Iuchi et al.   BIOCHEMICAL JOURNAL

Pten Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas

(2008) C.-H. Kwon et al.   CANCER RESEARCH

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE