Article
Biochemistry & Molecular Biology
Loretta Ferrera, Raffaella Barbieri, Cristiana Picco, Paolo Zuccolini, Alessia Remigante, Sara Bertelli, Maria Rita Fumagalli, Giovanni Zifarelli, Caterina A. M. La Porta, Paola Gavazzo, Michael Pusch
Summary: The response to oxidative stimulation in melanoma cells involves the activation of potassium currents and an increase in intracellular calcium levels, mediated by BK, KCa3.1, and TRPM2 channels. Differences in the expression levels of these channels in different cell lines may play a crucial role in melanoma progression. Targeting these ion channels pharmacologically could be a novel strategy to reduce the metastatic potential of melanoma cells alongside traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Karla M. Marquez-Nogueras, Ivana Y. Kuo
Summary: Calcium release from the endoplasmic reticulum is regulated by ion channel receptors InsP(3)R and RyR, with PC2 playing a less-studied role. PC2 is evolutionarily conserved and mutations in its gene are associated with polycystic kidney disease. However, the functional understanding of PC2 in different subcellular locations and extra-renal cells remains unclear. Recent studies have shed light on its structure and function, especially in the cardiovascular system.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Van den Eynde, Joris Vriens, Katrien De Clercq
Summary: Calcium ions play a critical role in cell function, with transient receptor potential (TRP) channels serving as a type of ion channel that can convey various stimuli and potentially participate in cellular responses to changing environments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Indyra Alencar Duarte Figueiredo, Sarah Rebeca Dantas Ferreira, Jayne Muniz Fernandes, Bagnolia Araujo da Silva, Luiz Henrique Cesar Vasconcelos, Fabiana de Andrade Cavalcante
Summary: Asthma, a common chronic disease, involves multiple pathophysiological mechanisms. Ion channels play a crucial role in the inflammatory response of asthma and serve as targets for the development of new drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Karla M. Marquez-Nogueras, Virdjinija Vuchkovska, Elisabeth DiNello, Sara Osorio-Valencia, Ivana Y. Kuo
Summary: Polycystin-2 (PC2) plays a crucial role in myogenesis by regulating intracellular Ca2+ signals and metabolic pathways, affecting the differentiation and mitochondrial remodeling of myoblasts.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leo C. T. Ng, Brandon J. Harris, Megan Larmore, My C. Ta, Thuy N. Vien, Valerie L. Tokars, Vladimir Yarov-Yarovoy, Paul G. DeCaen
Summary: In this study, computational prediction tools were used to model missing PKD2L1 structural motifs and evaluate over 150 mutations in the entire pore module. Results revealed an energetic landscape of the polycystin pore and identified critical structural regulators controlling the conductive and nonconductive states of the polycystin ion channel.
Review
Biochemistry & Molecular Biology
Dorina Zoephel, Chantal Hof, Annette Lis
Summary: Aging is an unstoppable process that affects every cell of the organism, especially the changes in Ca2+ signaling in immune cells which may profoundly impact the development of age-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Sung-Min Hwang, Ji Yeon Lee, Chul-Kyu Park, Yong Ho Kim
Summary: Neurodegenerative diseases (NDs) primarily affect neurons and glial cells in the brain, with risk factors and pathophysiological mechanisms not fully understood. Homeostasis of intracellular Ca2+ concentration and pH is crucial for cell function, with TRP channels and PMCA playing vital roles in modulating ionic homeostasis. Dysfunctions of TRP channels and PMCA disrupt neuronal homeostasis under pathological conditions, resulting in various NDs. This review highlights their potential as novel targets for treating NDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yusheng Liu, Yihan Lyu, Hongmei Wang
Summary: Transient receptor potential (TRP) channels, widely expressed on the plasma membrane of cells, play an essential role as sensors in the physiological and pathological processes of cells, regulating secretion, interfering with cell proliferation, and affecting neural activity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Anesthesiology
Mengmeng Zhao, Lei Liu, Zhenghao Chen, Ning Ding, Jiliang Wen, Jiaxin Liu, Nan Ge, Xiulin Zhang
Summary: TRPM3 channel plays an important role in the development of bladder pain in IC/PBS, and targeting TRPM3 may be a pharmacological strategy for treating bladder pain.
Review
Biochemistry & Molecular Biology
Milena Duitama, Yurany Moreno, Sandra Paola Santander, Zulma Casas, Jhon Jairo Sutachan, Yolima P. Torres, Sonia L. Albarracin
Summary: Transient receptor potential (TRP) channels play a critical role in cancer-related pain. Substances released by the cancer microenvironment modulate the activity of TRP channels, affecting pain transmission. Secondary metabolites derived from plant extracts have the potential to serve as therapeutic agents for relieving cancer-induced pain.
Review
Physiology
Eric A. Pereira da Silva, Miguel Martin-Aragon Baudel, Manuel F. Navedo, Madeline Nieves-Cintron
Summary: Ion channels, such as VGCC, TRP, K-V, and BK channels, regulate vascular smooth muscle excitability by influencing membrane potential and intracellular calcium concentration. These channels are regulated by various signaling molecules, including protein kinases and phosphatases, and form macromolecular complexes to target and compartmentalize signaling events.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Irina Shemarova
Summary: Chronic heart diseases, characterized by cardiac arrhythmias and dysfunction of Ca2+ channels, have a high mortality rate. The dysfunction of various types of calcium channels in humans and animals is closely related to the development of cardiac pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Wuping Sun, Yixuan Luo, Fei Zhang, Shuo Tang, Tao Zhu
Summary: Obesity is caused by an imbalance between energy intake and expenditure, and modulation of BAT thermogenesis may help in body weight control and obesity prevention. TRP channels play important roles in adipose tissue thermogenesis, energy metabolism, and body weight regulation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Rei Nishimoto, Sandra Derouiche, Kei Eto, Aykut Deveci, Makiko Kashio, Yoshitaka Kimori, Yoshikazu Matsuoka, Hiroshi Morimatsu, Junichi Nabekura, Makoto Tominaga
Summary: Microglia maintain central nervous system homeostasis by monitoring changes in their environment and taking protective actions, with their movement being modulated by temperature. This temperature-dependent movement may have potential clinical applications in preserving cell function.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)