Review
Immunology
Thanh-Nhan Nguyen, Ghizal Siddiqui, Nicholas A. Veldhuis, Daniel P. Poole
Summary: Transient receptor potential vanilloid 4 (TRPV4) is a mechanosensitive ion channel that regulates macrophage activity and phenotype, influencing immune response and inflammatory diseases. While TRPV4 is generally considered pro-inflammatory, it may also have anti-inflammatory effects. However, the detailed mechanisms of TRPV4 in inflammatory diseases are still limited.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xueming Hu, Lixia Du, Shenbin Liu, Zhou Lan, Kaikai Zang, Jing Feng, Yonghui Zhao, Xingliang Yang, Zili Xie, Peter L. Wang, Aaron M. Ver Heul, Lvyi Chen, Vijay K. Samineni, Yan-Qing Wang, Kory J. Lavine, Robert W. Gereau Iv, Gregory F. Wu, Hongzhen Hu
Summary: The study found that genetic ablation or pharmacological blockade of TRPV4 significantly reduced neuropathic pain-like behaviors in a mouse model of nerve injury. It was discovered that microglia-expressed TRPV4 mediated microglial activation and proliferation, and promoted functional and structural plasticity of excitatory spinal neurons through the release of lipocalin-2. This identifies TRPV4 as a potential new target for the treatment of chronic pain.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Cell Biology
Trine L. Toft-Bertelsen, Nanna MacAulay
Summary: TRPV4 is a widely expressed ion channel that is activated by various stimuli and regulated by multiple post-translational modifications. Research has shown that TRPV4 plays important roles in both physiological functions and diseases.
Article
Medicine, Research & Experimental
Sabrina Qader Kudsi, Bruna Candia Piccoli, Daniel Ardisson-Araujo, Gabriela Trevisan
Summary: This article aims to analyze the baseline distribution of TRPA1, TRPV1, TRPV4, and TRPM8 channels in human systems at the transcriptional level. Using the RNA-seq dataset, the transcriptional levels of these channels were investigated and compared in 95 human subjects representing 33 different tissues, providing essential suggestions for further studies on these proteins.
Review
Cell Biology
Suhasini Rajan, Christian Schremmer, Jonas Weber, Philipp Alt, Fabienne Geiger, Alexander Dietrich
Summary: Members of the TRP superfamily, particularly TRPV4, play crucial roles in respiratory system physiology and pathology, serving as potential therapeutic targets for diseases like asthma, lung fibrosis, edema, and infections.
Article
Cell Biology
Tusar Kanta Acharya, Ashutosh Kumar, Rakesh Kumar Majhi, Shamit Kumar, Ranabir Chakraborty, Ankit Tiwari, Karl-Heinz Smalla, Xiao Liu, Young-Tae Chang, Eckart D. Gundelfinger, Chandan Goswami
Summary: TRPV4 is associated with various diseases, and mitochondrial abnormalities play a significant role in these diseases. Improper expression and function of TRPV4 lead to mitochondrial abnormalities, and TRPV4 also regulates mitochondrial numbers, Ca2+ levels, and temperature. Naturally occurring TRPV4 mutations affect mitochondrial morphology and distribution, which helps in understanding TRPV4-mediated channelopathies and classifying them as mitochondrial diseases.
Article
Multidisciplinary Sciences
Zdravka Daneva, Corina Marziano, Matteo Ottolini, Yen-Lin Chen, Thomas M. Baker, Maniselvan Kuppusamy, Aimee Zhang, Huy Q. Ta, Claire E. Reagan, Andrew D. Mihalek, Ramesh B. Kasetti, Yuanjun Shen, Brant E. Isakson, Richard D. Minshall, Gulab S. Zode, Elena A. Goncharova, Victor E. Laubach, Swapnil K. Sonkusare
Summary: Recent studies have found that the activity of TRPV4 channels in endothelial cell caveolae is impaired in patients with pulmonary hypertension and mouse models. Up-regulation of iNOS and NOX1 enzymes leads to the formation of the oxidant molecule peroxynitrite, which targets the structural protein caveolin-1 and reduces the activity of TRPV4 channels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Milena Duitama, Yurany Moreno, Sandra Paola Santander, Zulma Casas, Jhon Jairo Sutachan, Yolima P. Torres, Sonia L. Albarracin
Summary: Transient receptor potential (TRP) channels play a critical role in cancer-related pain. Substances released by the cancer microenvironment modulate the activity of TRP channels, affecting pain transmission. Secondary metabolites derived from plant extracts have the potential to serve as therapeutic agents for relieving cancer-induced pain.
Article
Physiology
David Manneck, Hannah-Sophie Braun, Katharina T. Schrapers, Friederike Stumpff
Summary: Analysis of samples from different parts of pig intestine revealed that TRPV3 and TRPV4 may play a role in the intestinal transport of ammonia, with TRPM6 and TRPM7 showing different expression levels in different locations. Pharmacological regulation of these channels may be possible for controlling ammonium transport in the gut.
Article
Neurosciences
Sarah N. Redmon, Oleg Yarishkin, Monika Lakk, Andrew Jo, Edin Mustafic, Petr Tvrdik, David Krizaj
Summary: The study found that TRPV4 plays a key role as a sensor for osmotic challenges in retinal microglia, with its activation modulating calcium signaling and cell structure. Inhibition of TRPV4 may be an effective strategy to suppress overactivation of swollen microglia in the central nervous system.
Review
Biochemistry & Molecular Biology
Christophe Simard, Margaux Aize, Sebastien Chaigne, Harlyne Mpweme Bangando, Romain Guinamard
Summary: The role of ion channels in cardiac activity, morphological remodeling, and valve development and remodeling is discussed. Mutation in ion channel genes is observed in patients with malformation, such as bicuspid aortic valve. Ion channels are also involved in the morphological remodeling of valves, leading to aortic stenosis. Understanding the role of ion channels in the progression of aortic stenosis is crucial for developing new therapeutic approaches to avoid valve replacement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Solene Barbeau, Alexandre Joushomme, Yann Chappe, Guillaume Cardouat, Isabelle Baudrimont, Veronique Freund-Michel, Christelle Guibert, Roger Marthan, Patrick Berger, Pierre Vacher, Yann Percherancier, Jean-Francois Quignard, Thomas Ducret
Summary: Cell density is a crucial parameter for the activity of the TRPV4 channel in response to hypoxia. At low density, TRPV4 response to hypoxia is increased, while at high density, TRPV4 response is strongly inhibited.
Article
Neurosciences
Barbara Barile, Maria Grazia Mola, Francesco Formaggio, Emanuela Saracino, Antonio Cibelli, Concetta Domenica Gargano, Guido Mogni, Antonio Frigeri, Marco Caprini, Valentina Benfenati, Grazia Paola Nicchia
Summary: Despite the prominent role of aquaporin (AQP) water channels in controlling transmembrane water fluxes, alternative ways of modulating water permeation have been proposed. This study aims to investigate the selective role of TRPV4 in regulating plasma membrane water permeability independently of AQP4. The results showed that TRPV4 activation can increase cell swelling rate and facilitate water transport, suggesting that TRPV4 can finely tune plasma membrane water permeability and serve as a protective mechanism against osmotic challenges.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Cell Biology
Goncalo Mesquita, Natalia Prevarskaya, Albrecht Schwab, V'yacheslav Lehen'kyi
Summary: TRP channels, a diverse superfamily of ion channels, have been implicated in various physiological processes and their potential role in cancer progression, particularly in pancreatic cancer, is being explored. This review analyzes existing knowledge on TRP channels in cancer, with a focus on potential therapeutic interventions for pancreatic ductal adenocarcinoma.
Article
Multidisciplinary Sciences
Quan Tian, Peiyu Wang, Chang Xie, Peiyuan Pang, Youjing Zhang, Yue Gao, Zhijian Cao, Yingliang Wu, Wenxin Li, Michael X. Zhu, Dongdong Li, Jing Yao
Summary: This study identified a channel in scorpions and fruit flies that senses natural repellents, providing insights into the mechanisms of arthropods' perception of these repellents. This knowledge is important for designing effective insect control strategies and conserving biodiversity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Makiko Kashio, Gao Wei-qi, Yasuyoshi Ohsaki, Mizuho A. Kido, Akiyuki Taruno
SCIENTIFIC REPORTS
(2019)
Article
Clinical Neurology
Takashi Matsusaki, Ryuji Kaku, Daisuke Ono, Arata Taniguchi, Hiroshi Morimatsu
JOURNAL OF PAIN RESEARCH
(2019)
Article
Anesthesiology
Tomoyuki Kanazawa, Kazuyoshi Shimizu, Tatsuo Iwasaki, Kenji Baba, Shinichi Otsuki, Yasuhiro Kotani, Shingo Kasahara, Hiroshi Morimatsu
Summary: The study indicated that milrinone infusion improves one-year survival in pediatric patients undergoing the Norwood-Sano procedure compared to routine epinephrine and dopamine infusion. Milrinone also reduces the occurrence of arrhythmias and improves systemic perfusion, potentially decreasing lethal cardiac events in the ICU.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Article
Multidisciplinary Sciences
Shinkichi Ohtani, Hiroko Shimizu, Masakazu Yamaoka, Toru Takahashi, Emiko Omori, Hiroshi Morimatsu
Summary: The study revealed that pretreatment with tin chloride can induce the expression of HO-1 in the kidneys, leading to the degradation of excess free heme and protecting rats from RM-AKI.
Article
Neurosciences
Makiko Kashio, Satoru Masubuchi, Makoto Tominaga
Summary: The temperature thresholds of TRPM2 channels can be regulated by cytosolic Ca2+ and TRPM2 phosphorylation, providing structural evidence for the determination and regulation of temperature thresholds in thermo-TRP channels.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Medicine, General & Internal
Jingwen Fu, Junko Kosaka, Hiroshi Morimatsu
Summary: This study analyzed the impact of using different KDIGO criteria on the incidence and clinical outcomes of AKI in patients after non-cardiac surgery. The results showed differences in the incidence of AKI and clinical outcomes when different criteria were used.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anesthesiology
Satoshi Kimura, Kazuyoshi Shimizu, Yoshikazu Matsuoka, Tatsuo Iwasaki, Tomoyuki Kanazawa, Hiroshi Morimatsu
Summary: This study investigated the management of neuromuscular blocking agents (NMBAs) for pediatric patients after cardiac surgery. The results showed that postoperative prophylactic neuromuscular blockade can be associated with prolonged mechanical ventilation, but has no association with major adverse events in pediatric patients with congenital heart disease.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Multidisciplinary Sciences
Naoya Kawanoue, Kosuke Kuroda, Hiroko Yasuda, Masahiko Oiwa, Satoshi Suzuki, Hidenori Wake, Hiroki Hosoi, Masahiro Nishibori, Hiroshi Morimatsu
Summary: This study analyzed the time course of histidine-rich glycoprotein (HRG) levels in sepsis patients and compared the differences between survivors and non-survivors. The results showed that first-day HRG levels were significantly lower in non-survivors and were associated with mortality risk. Additionally, HRG may have a superior predictive power for mortality compared to other biomarkers.
Article
Medicine, General & Internal
Zhangtian Shen, Kosuke Kuroda, Hiroshi Morimatsu
Summary: This study aimed to investigate the relationship between postinduction blood glucose levels and intraoperative hypothermia in patients undergoing laparoscopic surgery. The results showed that postinduction glucose levels were independently associated with hypothermia. For diabetic patients, postinduction glucose levels below 110 mg/dL may have an impact on the occurrence of hypothermia. Therefore, close monitoring of blood glucose levels during surgery is important to prevent hypothermia.
MEDICINA-LITHUANIA
(2023)
Article
Computer Science, Information Systems
Yoshitaka Kimori
Summary: Convolutional neural networks (CNNs) are important in medical imaging, but the quality of raw images in the dataset may not be sufficient for the CNN model to learn the target object's features. This paper proposes an image preprocessing method based on mathematical morphology, which efficiently solves this problem by utilizing prior knowledge about the lesion shape. Experimental results show that CNN models trained on the preprocessed dataset achieve remarkable performance improvements compared to models trained on the original dataset.
Article
Multidisciplinary Sciences
Wataru Ota, Yusuke Nakane, Makiko Kashio, Yoshiro Suzuki, Kazuhiro Nakamura, Yasuo Mori, Makoto Tominaga, Takashi Yoshimura
SCIENTIFIC REPORTS
(2019)