Article
Multidisciplinary Sciences
Xiangli Zhao, Yi Lin, Benjamin Liou, Wenyu Fu, Jinlong Jian, Venette Fannin, Wujuan Zhang, Kenneth D. R. Setchell, Gregory A. Grabowski, Ying Sun, Chuan-ju Liu
Summary: PGRN plays a crucial role in the pathologies associated with GBA1/Gba1 mutations, as demonstrated by in vivo and ex vivo evidence in this study. Additionally, a PGRN-derived biologic that can penetrate the blood-brain barrier has been developed for the treatment of nGD and PD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Cristina Barale, Elena Melchionda, Giulia Tempesta, Alessandro Morotti, Isabella Russo
Summary: Chronic disorders closely relate to cardiovascular diseases, and regular exercise training is widely recognized as a key tool for improving cardiovascular risk factors. Platelet function is affected by metabolic disorders, and the correction of hyperglycemia, lipid profile, and body weight is associated with the amelioration of platelet function. Physical exercise triggers important mechanisms for health improvement and protects against cardiovascular events, but it may interfere with platelet function depending on the type and intensity of the exercise.
Article
Nutrition & Dietetics
Sara DiLauro, Jonathan P. Wong, Tanveer Collins, Nita Chahal, Brian W. McCrindle
Summary: The traditional dietary assessment tools for determining achievement of cholesterol-lowering targets are time consuming. This study found that the Healthy Eating Assessment Tool (HEAT), a simplified dietary assessment tool, is associated with markers of adiposity and lipid variables. The HEAT may be a more useful and simplified way of assessing and tracking broader dietary goals in clinical practice.
Article
Medicine, Research & Experimental
Pintu Miah, Surovi Binte Sharmin Mohona, Md Mizanur Rahman, Nusrat Subhan, Ferdous Khan, Hemayet Hossain, Shazid Md Sharker, Md Ashraful Alam
Summary: The study found that supplementation with cumin powder significantly improved glucose intolerance, fat weights, and lipid parameters induced by a high-fat diet, reducing oxidative stress biomarkers and hepatic damage. Additionally, cumin supplementation restored antioxidant enzyme activities and normalized liver histology in rats fed a high-fat diet.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Felix J. Meigel, Thomas Darwent, Leonie Bastin, Lucas Goehring, Karen Alim
Summary: This study investigates dispersive transport through complex media and reveals the nonlinear dependence between microscopic morphology and macroscopic transport characteristics by studying the statistics of pore-junction units. It is of great significance for understanding and controlling transport in complex media.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Masakazu Hori, Teruhiko Imamura, Nikhil Narang, Hiroshi Onoda, Shuhei Tanaka, Ryuichi Ushijima, Mitsuo Sobajima, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa
Summary: In patients with acute coronary syndrome, there is a positive correlation between small dense LDL-cholesterol and triglyceride levels, with triglyceride being a major determinant of small dense LDL-cholesterol. Together with body mass index, triglyceride level can serve as a useful and practical biomarker for risk stratification in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Filip Morys, Alain Dagher
Summary: Prior studies have linked obesity and components of metabolic health like hypertension or inflammation to increased hospitalizations and mortality in COVID-19 patients. Investigating over 1,000 individuals from the UK Biobank, researchers found that individuals with worse metabolic health are at increased risk of COVID-19-related death, with factors such as increased serum glucose levels, systolic blood pressure, and waist circumference contributing to this increased mortality.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Eryvelton S. Franco, Elizabeth Nascimento, Diogo AA. Vasconcelos, Priscila AA. Silva, Taciana L. Novaes, Maria GS. Feitosa, Amanda AM. Silva, Maria BS. Maia
Summary: The study showed that the polar fraction obtained from Parkinsonia aculeata can significantly reduce total cholesterol, LDL, and triglyceride levels in animals, which helps control dyslipidemia and reduce the risk of cardiovascular diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Food Science & Technology
Ana Maria Garcia-Munoz, Ana I. Garcia-Guillen, Desiree Victoria-Montesinos, Maria Salud Abellan-Ruiz, Begona Alburquerque-Gonzalez, Fernando Canovas
Summary: Metabolic syndrome is linked to increased risks of cardiovascular disease and type 2 diabetes, further exacerbated by a sedentary lifestyle and situations like the COVID-19 pandemic. Recent studies suggest that consumption of polyphenol-rich fruits and vegetables has a protective effect in reducing cardiovascular risk. Hibiscus sabdariffa (HS) in combination with other plant extracts has been gaining attention for its potential in treating metabolic syndrome. A systematic review and meta-analysis of randomized clinical trials were conducted to examine the effects of HS with other plant extracts on metabolic syndrome prevention, revealing improvements in anthropometric parameters, blood pressure, and lipid profile.
Article
Biochemistry & Molecular Biology
Chindiana Khutami, Sri Adi Sumiwi, Nur Kusaira Khairul Ikram, Muchtaridi Muchtaridi
Summary: This review discusses the activity of antioxidant compounds against obesity, dyslipidemia, and diabetes, along with their molecular signaling mechanisms. These antioxidant compounds exhibit activity against the three metabolic disorders through various molecular signaling pathways, and further research may help in predicting drug targets for optimal effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Junjie Zhu, Yue Zhang, Yiling Wu, Yu Xiang, Xin Tong, Yuting Yu, Yun Qiu, Shuheng Cui, Qi Zhao, Na Wang, Yonggen Jiang, Genming Zhao
Summary: This study examined the association between obesity and dyslipidemia among Chinese adults in Shanghai. The study found that participants with obesity had a higher risk of high cholesterol, high triglycerides, high LDL-C, and low HDL-C. Gender, age, hypertension, and diabetes were found to potentially modify this association.
Article
Immunology
Xiaolong Wang, Lin Li, Mingjian Bai, Jiaxin Zhao, Xiaojie Sun, Yu Gao, Haitao Yu, Xia Chen, Chunjing Zhang
Summary: The results demonstrate that Tolypocladium sinense mycelium (TSP) can effectively prevent obesity and dyslipidemia by altering the gut microbiota, alleviating inflammatory response, and regulating gene expression of liver lipid metabolism.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Chaojun Yang, Xiaocan Jia, Yuping Wang, Jingwen Fan, Chenyu Zhao, Yongli Yang, Xuezhong Shi
Summary: This study examines the prevalence, intervention, and control of metabolic syndrome (MetS) among US adults from 1999 to 2018, finding a significant increase in MetS prevalence during this time period. Factors such as smoking and vigorous activity were found to influence MetS prevalence. Elevated blood glucose and obesity were identified as the main causes of MetS burden. The study suggests that targeting specific populations for treatment and lifestyle modification could improve the control of blood glucose and obesity.
Review
Medicine, General & Internal
Michal Wicinski, Anna Fajkiel-Madajczyk, Zuzanna Kurant, Karol Gryczka, Dominik Kurant, Monika Szambelan, Bartosz Malinowski, Michal Falkowski, Jan Zabrzynski, Maciej Slupski
Summary: Cannabis-derived therapies, particularly cannabidiol (CBD), have shown potential in the treatment of metabolic syndrome components such as obesity, impaired glucose and lipid metabolism, high blood pressure, and NAFLD. CBD has been found to have positive effects on glucose homeostasis, lipid disorders, and hypertension, but more research is needed. Limited data on CBD and NAFLD in human studies make it unclear whether CBD is beneficial for this condition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Liang-Yu Liu, Xiyidan Aimaiti, Ying-Ying Zheng, Xiao-Yu Zhi, Zhi-Long Wang, Xin Yin, Ying Pan, Ting-Ting Wu, Xiang Xie
Summary: An observational cross-sectional study on 22,379 college students at Xinjiang Medical University revealed a high prevalence of dyslipidemia among Chinese youth, with higher rates in men than in women, and increasing with age. The study also found a significantly higher rate of obesity in men compared to women. These findings provide valuable insights for the prevention and control of atherosclerotic cardiovascular disease events.
LIPIDS IN HEALTH AND DISEASE
(2023)