Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives

From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource

(2011) Ellen M McDonagh et al.   Biomarkers in Medicine

Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses

(2011) Stella Trompet et al.   BMC Medical Genetics

A systematic review on pharmacogenetics in cardiovascular disease: is it ready for clinical application?

(2011) Jeffrey J.W. Verschuren et al.   EUROPEAN HEART JOURNAL

No Impact of KIF6 Genotype on Vascular Risk and Statin Response Among 18,348 Randomized Patients in the Heart Protection Study

(2011) Jemma C. Hopewell et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

KIF6 Polymorphism as a Predictor of Risk of Coronary Events and of Clinical Event Reduction by Statin Therapy

(2010) Yonghong Li et al.   AMERICAN JOURNAL OF CARDIOLOGY

Clinical Implications of Pharmacogenetic Variation on the Effects of Statins

(2010) Simran D.S. Maggo et al.   DRUG SAFETY

KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study

(2010) Olga A. Iakoubova et al.   EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies

(2010) Themistocles L. Assimes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pharmacogenetic interactions betweenABCB1andSLCO1B1tagging SNPs and the effectiveness of statins in the prevention of myocardial infarction

(2010) Bas JM Peters et al.   PHARMACOGENOMICS

High-density lipoprotein (HDL) cholesterol: leveraging practice-based biobank cohorts to characterize clinical and genetic predictors of treatment outcome

(2010) R A Wilke   PHARMACOGENOMICS JOURNAL

Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations

(2010) Mathew J. Barber et al.   PLoS One

Comprehensive Whole-Genome and Candidate Gene Analysis for Response to Statin Therapy in the Treating to New Targets (TNT) Cohort

(2009) John F. Thompson et al.   Circulation-Cardiovascular Genetics

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

(2009) Bruce M. Psaty et al.   Circulation-Cardiovascular Genetics

APOE gene polymorphisms and response to statin therapy

(2009) E Zintzaras et al.   PHARMACOGENOMICS JOURNAL

The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy

(2009) S P R Romaine et al.   PHARMACOGENOMICS JOURNAL

Variation in the 3-Hydroxyl-3-Methylglutaryl Coenzyme A Reductase Gene Is Associated With Racial Differences in Low-Density Lipoprotein Cholesterol Response to Simvastatin Treatment

(2008) Ronald M. Krauss et al.   CIRCULATION

ABCB1 Haplotypes Differentially Affect the Pharmacokinetics of the Acid and Lactone Forms of Simvastatin and Atorvastatin

(2008) JE Keskitalo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction

(2008) J. J. Regieli et al.   EUROPEAN HEART JOURNAL

Surprises of the Genome and “Personalized” Medicine⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.

(2008) Ali J. Marian   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Kinesin Family Member 6 Variant Is Associated With Coronary Heart Disease in the Women’s Health Study

(2008) Dov Shiffman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Association of the Trp719Arg Polymorphism in Kinesin-Like Protein 6 With Myocardial Infarction and Coronary Heart Disease in 2 Prospective Trials

(2008) Olga A. Iakoubova et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Polymorphism in KIF6 Gene and Benefit From Statins After Acute Coronary Syndromes

(2008) Olga A. Iakoubova et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenetics of apolipoprotein E gene during lipid-lowering therapy: lipid levels and prevention of coronary heart disease

(2008) Tuomo Nieminen et al.   PHARMACOGENOMICS

Association of Gene Variants With Incident Myocardial Infarction in the Cardiovascular Health Study

(2007) Dov Shiffman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY