Systems pharmacology assessment of the 5-fluorouracil pathway

Two cases of 5-fluorouracil toxicity linked with gene variants in the DPYD gene

(2009) Anna Öfverholm et al.   CLINICAL BIOCHEMISTRY

Impacts of fluorouracil-metabolizing enzymes on the outcomes of patients treated with S-1 alone or S-1 plus cisplatin for first-line treatment of advanced gastric cancer

(2009) Wasaburo Koizumi et al.   INTERNATIONAL JOURNAL OF CANCER

Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studies

(2009) James Cassidy et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Chemotherapy, Bevacizumab, and Cetuximab in Metastatic Colorectal Cancer

(2009) Jolien Tol et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy

(2008) R. Soong et al.   ANNALS OF ONCOLOGY

Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy

(2008) Masashi Ishikawa et al.   BMC CANCER

Genetic regulation of ??-ureidopropionase and its possible implication in altered uracil catabolism

(2008) Holly R. Thomas et al.   Pharmacogenetics and Genomics

β-Ureidopropionase deficiency presenting with congenital anomalies of the urogenital and colorectal systems

(2007) J. Yaplito-Lee et al.   MOLECULAR GENETICS AND METABOLISM