Article
Environmental Sciences
Yuanxin Zhai, Dan Bai, Heyun Yang, Xiaoliang Li, Daiwen Zhu, Xin Cao, Hao Ma, Xiaolin Li, Xing Zheng
Summary: The E. coli whole-cell microarray assay was used to evaluate the impact of sucralose on 110 selected genes under different exposure concentrations. Sucralose at different concentrations induced varying levels of protein response and DNA damage in the study. Additionally, exposure to sucralose caused changes in gene expression, with DNA damage showing a concentration-dependent effect.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Lin-hui Zhai, Kai-feng Chen, Bing-bing Hao, Min-jia Tan
Summary: Protein post-translational modifications (PTMs) are crucial for protein activity regulation and are involved in diseases. PTM regulatory enzymes are important drug targets. Mass spectrometry-based proteomics enables systematic characterization of PTMs for drug target identification, mechanism elucidation and biomarker discovery in personalized therapy.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Chemistry, Medicinal
Aini Vuorinen, Isabel V. L. Wilkinson, Maria Chatzopoulou, Ben Edwards, Sarah E. Squire, Rebecca J. Fairclough, Noelia Araujo Bazan, Josh A. Milner, Daniel Conole, James R. Donald, Nandini Shah, Nicky J. Willis, R. Fernando Martinez, Francis X. Wilson, Graham M. Wynne, Stephen G. Davies, Kay E. Davies, Angela J. Russell
Summary: Duchenne muscular dystrophy is a fatal disease caused by lack of dystrophin, for which upregulation of utrophin offers a potential therapy independent of mutation type. The failure of the first-in-class utrophin modulator in clinical trials calls for the development of compounds with better efficacy. A novel class of utrophin modulators was discovered with a distinct mechanism of action, showing promising potential for treating the disease.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Brendan G. Dwyer, Chao Wang, Daniel Abegg, Brittney Racioppo, Nan Qiu, Zhensheng Zhao, Dany Pechalrieu, Anton Shuster, Dominic G. Hoch, Alexander Adibekian
Summary: This study introduces arylazopyrazole ureas and sulfones as a new class of photoswitchable serine hydrolase inhibitors and presents a chemoproteomic platform for rapid discovery of optically controlled serine hydrolase targets in complex proteomes. The research identifies highly potent and selective photoswitchable inhibitors for drug-metabolizing enzymes, and demonstrates their pharmacological application in optically controlling drug metabolism. The study suggests the potential for using photopharmacological tools to modulate drug metabolism by controlling the activity of metabolizing enzymes, and offers synthetically accessible scaffolds for expanding to other serine hydrolases.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Clinical Neurology
Brisa S. Fernandes, Yulin Dai, Peilin Jia, Zhongming Zhao
Summary: This study conducted proteomic analysis on schizophrenia, bipolar disorder, and major depressive disorder, identifying shared biological pathways between these disorders, particularly in immune system and signal transduction pathways.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Brisa S. Fernandes, Yulin Dai, Peilin Jia, Zhongming Zhao
Summary: This study systematically evaluated the peripheral blood proteome of individuals with schizophrenia (SZ), bipolar disorder (BD), or major depressive disorder (MDD), identifying a wide range of pathways related to immune system, signal transduction, and other biological themes shared among these disorders. These findings contribute to our understanding of protein variations and associations with these disorders, facilitating biomarker development and drug discovery.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kyle J. Mahoney, Jacob S. Bowie, Austin E. Ford, Neranjan Perera, Yasuki Sekiguchi, David M. Fothergill, Elaine C. Lee
Summary: The study aimed to identify proteins reflecting acute systemic response to prolonged hyperbaric stress and discover potential biomarker pathways for pulmonary O2 toxicity. Through a double-blind, randomized, crossover design, several proteins related to hemostasis, immune signaling and activation, and metabolism were identified.
Article
Environmental Sciences
Carly Colville, Alper James Alcaraz, Derek Green, Bradley Park, Jianguo Xia, Othman Soufan, Pavel Hruska, David Potesil, Zbynek Zdrahal, Doug Crump, Niladri Basu, Natacha Hogan, Markus Hecker
Summary: This study investigated the mechanistic toxicity of fluoxetine (FLX) in adult fathead minnows using new approach methodologies (NAMs). The results revealed that high concentrations of FLX caused molecular toxicity changes in the liver and brain, leading to lipid-type vacuolation in liver hepatocytes and alterations in serotonin-related signaling processes and reproductive behavior in the brain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemical Research Methods
Rebecca C. Poulos, Zhaoxiang Cai, Phillip J. Robinson, Roger R. Reddel, Qing Zhong
Summary: Proteomic data are valuable for drug response prediction and biomarker discovery due to the direct interaction between most drugs and proteins in target cells. This review highlights the opportunities of combining large-scale proteomic data with drug-related research, focusing on oncology. Successful applications of drug response prediction using molecular data are discussed, along with the technical advances in data-independent acquisition mass spectrometry (DIA-MS) for biomarker discovery. The potential of machine learning in pharmacoproteomics and the challenges of clinical validation are also explored.
Article
Chemistry, Medicinal
Junping Pei, Guan Wang, Lu Feng, Jifa Zhang, Tingting Jiang, Qiu Sun, Liang Ouyang
Summary: This article discusses strategies targeting lysosomal pathways and lysosome-based degradation techniques, as well as the advantages and challenges of lysosome-based degrading drugs. These tools can directly regulate protein levels in vivo and provide new strategies for treating diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yue Bai, Lu Chen, Pan-Pan Wang, Yu-Qiang Tang, Da-Chang Wu, Cui-Li Zhang, Qi Zhou, Ru Yan, Jie Hou
Summary: The study found that amentoflavone is an effective broad-spectrum inhibitor against bacterial GUS, which can be used as a promising lead compound for developing novel agents to alleviate GUS-associated intestinal toxicity.
Article
Biochemistry & Molecular Biology
Shih-Yi Hsu, Robert Morris, Feng Cheng
Summary: Silica nanoparticles have been shown to upregulate the common TNF and MAPK signaling pathways in different types of cells, potentially leading to toxic effects in the human body.
Article
Hematology
Bingqing Han, Chuanbao Li, Hexin Li, Ying Li, Xuanmei Luo, Ye Liu, Junhua Zhang, Zhu Zhang, Xiaobo Yu, Zhenguo Zhai, Xiaomao Xu, Fei Xiao
Summary: This study identified potential plasma biomarkers for the diagnosis and risk stratification of PE, including SAA1, S100A8, and TNC. These proteins are involved in thrombosis-associated biological processes and inflammation or injury repair, providing valuable insights for timely treatment options for high-risk PE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Biotechnology & Applied Microbiology
Ziqiu Lin, Shimei Pang, Zhe Zhou, Xiaozhen Wu, Pankaj Bhatt, Shaohua Chen
Summary: This paper discusses the toxic effects of the herbicide butachlor on aquatic and terrestrial animals, including humans, as well as the resistance developed in some organisms. It also explores the potential of using butachlor-resistant organisms for removing residues from the environment, focusing on microbial degradation methods. The study further investigates the biochemical pathways and molecular mechanisms of butachlor biodegradation for repairing contaminated environments.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Qianqian Qiu, Feng Zou, Huilan Li, Wei Shi, Daoguang Zhou, Ping Zhang, Teng Li, Ziyu Yin, Zilong Cai, Yuxuan Jiang, Wenlong Huang, Hai Qian
Summary: Compound 21 is a dual inhibitor that can block both P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), showing potential in overcoming multidrug resistance and improving the oral bioavailability of specific drugs.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)