Article
Chemistry, Medicinal
Bin Zhou, Beilei Wang, Fengming Zou, Husheng Mei, Qingwang Liu, Shuang Qi, Wenliang Wang, Rui Jin, Aoli Wang, Yongfei Chen, Feiyang Liu, Wenchao Wang, Jing Liu, Qingsong Liu
Summary: A novel covalent EZH2 degrader was discovered, which can reduce the expression of EZH2 in multiple types of cancer and exhibit antiproliferation activity. This study provides an opportunity for the development of new drug candidates.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Mahshid Deldar Abad Paskeh, Atefeh Mehrabi, Mohammad Hossein Gholami, Amirhossein Zabolian, Ehsan Ranjbar, Hossein Saleki, Adnan Ranjbar, Mehrdad Hashemi, Yavuz Nuri Ertas, Kiavash Hushmandi, Sepideh Mirzaei, Milad Ashrafizadeh, Ali Zarrabi, Saeed Samarghandian
Summary: EZH2 plays a crucial role in brain tumors, promoting the proliferation and invasion of cancer cells while demonstrating tumor-suppressor activity in medulloblastoma. In addition to regulating gene expression, EZH2 can also influence the response of brain tumors to chemotherapy and radiotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Deborah Mannino, Sarah Adriana Scuderi, Giovanna Casili, Valentina Bova, Laura Cucinotta, Marika Lanza, Alessia Filippone, Emanuela Esposito, Irene Paterniti
Summary: Parkinson's disease is characterized by degeneration of dopaminergic neurons and can cause motor disorders. The upregulation of EZH2 in the brains of PD patients suggests its possible role in PD pathogenesis. In this study, the neuroprotective effects of the EZH2 inhibitor GSK-343 were evaluated in an in vivo model of MPTP-induced dopaminergic degeneration. The results showed that GSK-343 treatment improved behavioral deficits and reduced PD hallmarks.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Chengmei He, Yanlei Yang, Zhilei Chen, Suying Liu, Taibiao Lyu, Liuting Zeng, Li Wang, Yongzhe Li, Mu Wang, Hua Chen, Fengchun Zhang
Summary: EZH2 is upregulated in CD4(+) T cells of pSS patients, promoting Tfh differentiation by enhancing STAT3 phosphorylation. EZH2 promotes Tfh differentiation and may be implicated in the pathogenesis of pSS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Ye Shang, Shujuan Wu, SaiJiao Li, Xiaolin Qin, Jiao Chen, Jinli Ding, Jing Yang
Summary: The study found a significant decrease in the expression of EZH2 in villi tissue from RSA patients compared to healthy controls. Inhibition of EZH2 expression or function in trophoblasts promoted M1 macrophage polarization, potentially contributing to the pathogenesis of RSA. Additionally, EZH2 suppression affected the secretion of immune and inflammatory cytokines in trophoblasts.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dina Hany, Marloes Zoetemelk, Kaushik Bhattacharya, Patrycja Nowak-Sliwinska, Didier Picard
Summary: Breast cancer is a persistent threat to women worldwide, and current monotherapies often face issues of drug resistance and toxicity. By mining data and constructing a network, we identified two multidrug combinations with high therapeutic relevance for ER alpha positive/HER2-/PI3K alpha mutant subtype of breast cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Oncology
Kiyoshi Tone, Sachiyo Ohno, Masatake Honda, Akifumi Notsu, Keiko Sasaki, Takashi Sugino
Summary: The study evaluated the utility of EZH2 immunocytochemistry in bile cytology for diagnosing pancreatobiliary adenocarcinoma. EZH2 ICC significantly improved sensitivity in indeterminate cytology samples and may be useful as an initial assessment to ensure no cancer cells are missed.
CANCER CYTOPATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Johanna Barth, Ivonne Loeffler, Tzvetanka Bondeva, Marita Liebisch, Gunter Wolf
Summary: This study analyzed the impact of hypoxia and HIFs on epigenetic changes in podocytes, specifically affecting NIPP1, EZH2, and H3K27me3. It was found that hypoxic conditions and pharmacological HIFs activation significantly reduced the expression of NIPP1 and EZH2, and diminished H3K27 trimethylation.
Article
Cell Biology
Mayank Maheshwari, Nisha Yadav, Mohammad Hasanain, Praveen Pandey, Rohit Sahai, Kuldeep Choyal, Akhilesh Singh, Mushtaq A. Nengroo, Krishan K. Saini, Deepak Kumar, Kalyan Mitra, Dipak Datta, Jayanta Sarkar
Summary: The article discusses the dual function of p21 in cancer, with both inhibitory and oncogenic effects. Specifically, p21 negatively regulates basal autophagy and has oncogenic activity during early tumor development, while its inhibition promotes survival and growth of established tumors.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Wuhan Yu, Ning Liu, Xiaogang Song, Lang Chen, Mancai Wang, Guohui Xiao, Tengfei Li, Zheyuan Wang, Youcheng Zhang
Summary: This article focuses on the value of EZH2 research in gastric cancer by examining its crucial involvement in gastric cancer progression. The article first introduces the two main functions of EZH2: histone methylation modification and DNA methylation. It then provides a detailed description of the mechanisms of EZH2 in gastric cancer-related events, and concludes with a summary of the progress in the development of EZH2 inhibitors. This review article provides researchers studying the epigenetics of gastric cancer with new research ideas to find new targets for studying the pathogenesis of gastric cancer.
Article
Cell & Tissue Engineering
Li Wang, Yanyan He, Wanchen Ning
Summary: The study demonstrated that EZH2 knockdown inhibited OC formation by elevating miR-101 expression through VCAM-1 suppression, ultimately attenuating periodontitis. Silencing of EZH2 or VCAM-1 also reduced the severity of periodontitis in vivo.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Teng Ma, Jie Gu, Ye Zhao, Su Li, Duowu Zou, Di Ge
Summary: This study investigated the attenuated tight junction in PPI-refractory gastroesophageal reflux disease (RGERD) and revealed a potential mechanism by which EZH2-mediated H3K27me3 impairs esophageal epithelial barrier function through suppressing the transcription of CLDN1.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Lin Xu, Jiandong Gao, Di Huang, Pinglan Lin, Dongsheng Yao, Feng Yang, Yaheng Zhang, Xuejun Yang, Ming Wu, Chaoyang Ye
Summary: Emodin delays the progression of chronic renal failure and inhibits renal tubulointerstitial fibrosis by reducing extracellular collagen deposition and inhibiting pro-fibrotic signaling pathways, through down-regulation of EZH2.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Qi Zhang, Yangchen Guo, Moorim Kang, Wei-Hsiang Lin, Jian-Cheng Wu, Ying Yu, Long-Cheng Li, Aimin Sang
Summary: The study suggests that p21 saRNA can be a potential therapeutic approach for PVR by inhibiting cell proliferation and migration of RPE cells, leading to the prevention of PVR progression and reducing postoperative failure rates.
Article
Oncology
Shaomin Shi, Chongyang Li, Yanli Zhang, Chaowei Deng, Mengqin Tan, Guangzhao Pan, Juan Du, Yacong Ji, Qian Li, Hanghua Liang, Wei Liu, Leiyang Guo, Gaichao Zhao, Yaling Liu, Hongjuan Cui
Summary: The active ingredient Lycorine hydrochloride sourced from the medicinal herb Lycoris radiata has been shown to possess tumor suppression activity in various human cancers. In melanoma, an increased expression of p21(Cip1/WAF1) was found in tumor tissues and correlated with tumor invasion depth. Functional experiments demonstrated that LH effectively inhibited the proliferation, migration, and invasion ability of melanoma cells by inducing S phase cell cycle arrest and regulating epithelial-mesenchymal transition (EMT).
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Meeting Abstract
Surgery
Ramesh B. Batchu, Aamer M. Qazi, Oksana V. Gruzdyn, Jaskiran Kaur, Ebrahem M. Mahmud, Donald W. Weaver, Scott A. Gruber
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2015)
Article
Surgery
Ramesh B. Batchu, Oksana V. Gruzdyn, Aamer M. Qazi, Jaskiran Raur, Ebrahem M. Mahmud, Donald W. Weaver, Scott A. Gruber
Review
Oncology
Arif Malik, Misbah Sultana, Aamer Qazi, Mahmood Husain Qazi, Gulshan Parveen, Sulayman Waquar, Abdul Basit Ashraf, Mahmood Rasool
ANALYTICAL CELLULAR PATHOLOGY
(2016)
Letter
Surgery
Ramesh B. Batchu, Oksana V. Gruzdyn, Aamer M. Qazi, Ebrahem M. Mahmud, Gamal Mostafa, Donald W. Weaver, Scott A. Gruber
Article
Surgery
Ramesh B. Batchu, Oksana V. Gruzdyn, Ebrahem M. Mahmud, Fatme Chukr, Rajesh Dachepalli, Santosh K. Manmari, Gamal Mostafa, Donald W. Weaver, Scott A. Gruber
Article
Oncology
Mahmood Rasool, Arif Malik, Ahmad Ashar Ghuman, Muhammad Abdul Basit Ashraf, Mahwish Arooj, Sulayman Waquar, Sara Zahid, Sumera Shaheen, Aamer Qazi, Muhammad Imran Naseer, Mazin A. Zamzami, Ayat Al-Ghafari, Othman A. Baothman, Mustafa Zeyadi, Nawal Helmi, Hani Choudhry, Mohammad Sarwar Jamal, Mohammed Hussein Al-Qahtani
FRONTIERS IN ONCOLOGY
(2018)
Article
Immunology
Ramesh B. Batchu, Oksana V. Gruzdyn, AMberly M. Moreno-Bost, Susann Szmania, Giridhararao Jayandharan, Arun Srivastava, Bala K. Kolli, Donald W. Weaver, Frits van Rhee, Scott A. Gruber
Article
Surgery
Ramesh B. Batchu, Oksana Gruzdyn, Ravindra B. Potti, Donald W. Weaver, Scott A. Gruber
Article
Surgery
Ramesh B. Batchu, Oksana V. Gruzdyn, Pavan S. Tavva, Bala K. Kolli, Rajesh Dachealli, Donald W. Weaver, Scott A. Gruber
Article
Biochemistry & Molecular Biology
Fatima Ali, Nadia Wajid, Maryam Ghulam Sarwar, Aamer Mahmood Qazi
Summary: The study found that oral administration of Aloe vera promotes early healing of excisional wounds in Sprague Dawley rats, with gradual improvement in wound areas and collagen content. Aloe vera also increased the expression of IGF-1 and VEGF in skin and bone marrow, indicating enhanced angiogenesis. RT-PCR analysis showed upregulation of genes related to chemotaxis in skin and bone marrow.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Nadia Wajid, Muhammad Azam, Seemab Khalid, Fatima Ali, Aamer Qazi, M. H. Qazi
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2017)
Review
Nanoscience & Nanotechnology
Arif Malik, Tariq Tahir Butt, Sara Zahid, Fatima Zahid, Sulayman Waquar, Mahmood Rasool, Mahmood Husain Qazi, Aamer Mahmood Qazi
JOURNAL OF NANOTECHNOLOGY
(2017)
Article
Chemistry, Medicinal
Ramesh B. Batchu, Oksana Gruzdyn, Christopher S. Bryant, Aamer M. Qazi, Sanjeev Kumar, Sreedhar Chamala, Shu T. Kung, Ramana S. Sanka, Udaya S. Puttagunta, Donald W. Weaver, Scott A. Gruber