Comparison of Polymeric siRNA Nanocarriers in a Murine LPS-Activated Macrophage Cell Line: Gene Silencing, Toxicity and Off-Target Gene Expression

Small Interfering RNAs Induce Macrophage Migration Inhibitory Factor Production and Proliferation in Breast Cancer Cells via a Double-Stranded RNA-Dependent Protein Kinase-Dependent Mechanism

(2014) M. E. Armstrong et al.   JOURNAL OF IMMUNOLOGY

Improving siRNA Bio-Distribution and Minimizing Side Effects

(2011) Bruna Scaggiante et al.   CURRENT DRUG METABOLISM

Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis

(2010) Maroun Khoury et al.   ARTHRITIS AND RHEUMATISM

Gene Silencing Activity of siRNA Polyplexes Based on ThiolatedN,N,N-Trimethylated Chitosan

(2010) Amir K. Varkouhi et al.   BIOCONJUGATE CHEMISTRY

Molecular Characterization of the Interaction between siRNA and PAMAM G7 Dendrimers by SAXS, ITC, and Molecular Dynamics Simulations

(2010) Linda B. Jensen et al.   BIOMACROMOLECULES

Tailorable Thiolated Trimethyl Chitosans for Covalently Stabilized Nanoparticles

(2010) Rolf J. Verheul et al.   BIOMACROMOLECULES

PEGylation of biodegradable dextran nanogels for siRNA delivery

(2010) B. Naeye et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Gene silencing activity of siRNA polyplexes based on biodegradable polymers

(2010) Amir K. Varkouhi et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: Quality by design optimization and characterization

(2010) Dongmei Cun et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Cationic nanosystems for the delivery of small interfering ribonucleic acid therapeutics: a focus on toxicogenomics

(2010) Saghir Akhtar   Expert Opinion on Drug Metabolism & Toxicology

Prolonged gene silencing by combining siRNA nanogels and photochemical internalization

(2010) K. Raemdonck et al.   JOURNAL OF CONTROLLED RELEASE

Structural and functional consequences of poly(ethylene glycol) inclusion on DNA condensation for gene delivery

(2010) Peter G. Millili et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Evaluating the Gene-Expression Profiles of HeLa Cancer Cells Treated with Activated and Nonactivated Poly(amidoamine) Dendrimers, and Their DNA Complexes

(2010) Jung-hua Steven Kuo et al.   MOLECULAR PHARMACEUTICS

Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery

(2009) Koen Raemdonck et al.   ADVANCED FUNCTIONAL MATERIALS

Silencing of proinflammatory genes targeted to peritoneal-residing macrophages using siRNA encapsulated in biodegradable microspheres

(2009) Tali Brunner et al.   BIOMATERIALS

Immunostimulatory Characteristics Induced by Linear Polyethyleneimine–Plasmid DNA Complexes in Cultured Macrophages

(2009) Yasunori Saito et al.   HUMAN GENE THERAPY

Ethylendiamine core PAMAM dendrimers/siRNA complexes as in vitro silencing agents

(2009) A.P. Perez et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging

(2009) Olivia M. Merkel et al.   JOURNAL OF CONTROLLED RELEASE

Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy

(2009) Kevin Buyens et al.   JOURNAL OF CONTROLLED RELEASE

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Treatment of rheumatoid arthritis: state of the art 2009

(2009) Ronald F. van Vollenhoven   Nature Reviews Rheumatology

siRNA and Innate Immunity

(2009) Marjorie Robbins et al.   OLIGONUCLEOTIDES

Dextran Microgels for Time-Controlled Delivery of siRNA

(2008) Koen Raemdonck et al.   ADVANCED FUNCTIONAL MATERIALS

Overcoming the Innate Immune Response to Small Interfering RNA

(2008) Adam Judge et al.   HUMAN GENE THERAPY

Polymeric Nanocarriers for siRNA Delivery: Challenges and Future Prospects

(2008) Dongmei Cun et al.   Journal of Biomedical Nanotechnology

Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

(2008) Kenneth A Howard et al.   MOLECULAR THERAPY

Changes in Gene Expression Pattern of Human Primary Macrophages Induced by Carbosilane Dendrimer 2G-NN16

(2008) Rafael Gras et al.   PHARMACEUTICAL RESEARCH

Advanced nanogel engineering for drug delivery

(2008) Koen Raemdonck et al.   Soft Matter

Microarray Analysis of the Toxicogenomics and the Genotoxic Potential of a Cationic Lipid-Based Gene Delivery Nanosystem in Human Alveolar Epithelial A549 Cells

(2008) Yadollah Omidi et al.   TOXICOLOGY MECHANISMS AND METHODS

Delivery of siRNA from lyophilized polymeric surfaces

(2007) Morten Ø. Andersen et al.   BIOMATERIALS

Biodegradable polymers as non-viral carriers for plasmid DNA delivery

(2007) Jordy Luten et al.   JOURNAL OF CONTROLLED RELEASE