Click Chemistry for Drug Delivery Nanosystems

Cooperative Binding of Bifunctionalized and Click-Synthesized Silver Nanoparticles for Colorimetric Co2+ Sensing

(2010) Yao Yao et al.   ACS Applied Materials & Interfaces

High-Frequency, Magnetic-Field-Responsive Drug Release from Magnetic Nanoparticle/Organic Hybrid Based on Hyperthermic Effect

(2010) Koichiro Hayashi et al.   ACS Applied Materials & Interfaces

Biodegradable Click Capsules with Engineered Drug-Loaded Multilayers

(2010) Christopher J. Ochs et al.   ACS Nano

Core−Shell Nanosized Assemblies Mediated by the α−β Cyclodextrin Dimer with a Tumor-Triggered Targeting Property

(2010) Chang-Yun Quan et al.   ACS Nano

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells

(2010) Jan Dommerholt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica

(2010) Axel Schlossbauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry

(2010) Vu Hong et al.   BIOCONJUGATE CHEMISTRY

Copper-Free Click Chemistry for Highly Luminescent Quantum Dot Conjugates: Application toin VivoMetabolic Imaging

(2010) Aude Bernardin et al.   BIOCONJUGATE CHEMISTRY

Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects

(2010) Hiroshi Maeda   BIOCONJUGATE CHEMISTRY

Tailoring the efficacy of nimodipine drug delivery using nanocarriers based on A2B miktoarm star polymers

(2010) Ghareb M. Soliman et al.   BIOMATERIALS

Multivalent Display and Receptor-Mediated Endocytosis of Transferrin on Virus-Like Particles

(2010) Deboshri Banerjee et al.   CHEMBIOCHEM

Azide: A Unique Dipole for Metal-Free Bioorthogonal Ligations

(2010) Marjoke F. Debets et al.   CHEMBIOCHEM

Sequential copper catalyzed alkyne–azide and thiol–ene click reactions for the multiple functionalization of fullerene hexaadducts

(2010) Julien Iehl et al.   CHEMICAL COMMUNICATIONS

“Clickable”, polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions

(2010) Amit Kumar et al.   CHEMICAL COMMUNICATIONS

“Clickable” polymer nanoparticles: a modular scaffold for surface functionalization

(2010) Sai Archana Krovi et al.   CHEMICAL COMMUNICATIONS

One-Pot Biofunctionalization of Magnetic Nanoparticles via Thiol−Ene Click Reaction for Magnetic Hyperthermia and Magnetic Resonance Imaging

(2010) Koichiro Hayashi et al.   CHEMISTRY OF MATERIALS

Chemoselective Attachment of Small Molecule Effector Functionality to Human Adenoviruses Facilitates Gene Delivery to Cancer Cells

(2010) Partha Sarathi Banerjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting of Cancer Cells Using Click-Functionalized Polymer Capsules

(2010) Marloes M. J. Kamphuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots Using Tetrazine−Norbornene Cycloaddition

(2010) Hee-Sun Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

(2010) John C. Jewett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Synthesis of Polymer Nanocapsules: Self-Assembly of Polymer Hollow Spheres through Irreversible Covalent Bond Formation

(2010) Dongwoo Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clickable Gold Nanoparticles as the Building Block of Nanobioprobes

(2010) Ming-Xi Zhang et al.   LANGMUIR

Thiol−Ene Induced Diphosphonic Acid Functionalization of Superparamagnetic Iron Oxide Nanoparticles

(2010) Ryan D. Rutledge et al.   LANGMUIR

Efficient Approaches for the Surface Modification of Platinum Nanoparticles via Click Chemistry

(2010) Eric Drockenmuller et al.   MACROMOLECULES

Polyvalent Oligonucleotide Iron Oxide Nanoparticle “Click” Conjugates

(2010) Joshua I. Cutler et al.   NANO LETTERS

Hybrid PET-optical imaging using targeted probes

(2010) Matthias Nahrendorf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Intein-Mediated Site-Specific Click Conjugation Strategy for Improved Tumor Targeting of Nanoparticle Systems

(2010) Drew R. Elias et al.   Small

Liposomes as ‘smart’ pharmaceutical nanocarriers

(2010) Rupa R. Sawant et al.   Soft Matter

Impact of Nanotechnology on Drug Delivery

(2009) Omid C. Farokhzad et al.   ACS Nano

Doxorubicin-Conjugated Immuno-Nanoparticles for Intracellular Anticancer Drug Delivery

(2009) Meng Shi et al.   ADVANCED FUNCTIONAL MATERIALS

Analysis and Optimization of Copper-Catalyzed Azide–Alkyne Cycloaddition for Bioconjugation

(2009) Vu Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

18F Labeled Nanoparticles forin VivoPET-CT Imaging

(2009) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

Synthesis and Applications of Biomedical and Pharmaceutical Polymers via Click Chemistry Methodologies

(2009) Maarten van Dijk et al.   BIOCONJUGATE CHEMISTRY

Macromolecular Cobalt Carbonyl Complexes Encapsulated in aClick-Cross-Linked Micelle Structure as a Nanoparticle To Deliver Cobalt Pharmaceuticals

(2009) Alexander B. J. Withey et al.   BIOMACROMOLECULES

Synthesis, Self-Assembly, and In Vitro Doxorubicin Release Behavior of Dendron-like/Linear/Dendron-like Poly(ε-caprolactone)-b-Poly(ethylene glycol)-b-Poly(ε-caprolactone) Triblock Copolymers

(2009) Yang Yang et al.   BIOMACROMOLECULES

Clickable, Biocompatible, and Fluorescent Hybrid Nanoparticles for Intracellular Delivery and Optical Imaging

(2009) Markus Müllner et al.   BIOMACROMOLECULES

Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers

(2009) Quan Shi et al.   BIOMATERIALS

Probing the Activity of Matrix Metalloproteinase II with a Sequentially Click-Labeled Silica Nanoparticle FRET Probe

(2009) Daniela E. Achatz et al.   CHEMBIOCHEM

Bioluminescent nanosensors for protease detection based upon gold nanoparticle–luciferase conjugates

(2009) Young-Pil Kim et al.   CHEMICAL COMMUNICATIONS

A click chemistry based coordination polymer inside small heat shock protein

(2009) Janice Lucon et al.   CHEMICAL COMMUNICATIONS

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

(2009) Marjoke F. Debets et al.   CHEMICAL COMMUNICATIONS

Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft Materials

(2009) Rhiannon K. Iha et al.   CHEMICAL REVIEWS

Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity

(2009) Elodie Boisselier et al.   CHEMICAL SOCIETY REVIEWS

Green Chemistry: Principles and Practice

(2009) Paul Anastas et al.   CHEMICAL SOCIETY REVIEWS

Stabilization and Functionalization of Polymer Multilayers and Capsules via Thiol−Ene Click Chemistry

(2009) Luke A. Connal et al.   CHEMISTRY OF MATERIALS

Bioconjugated Janus Particles Prepared by in Situ Click Chemistry

(2009) Jian Zhang et al.   CHEMISTRY OF MATERIALS

Chemoselective Synthesis of Folic Acid−Functionalized Magnetite Nanoparticles via Click Chemistry for Magnetic Hyperthermia

(2009) Koichiro Hayashi et al.   CHEMISTRY OF MATERIALS

A Click-Click Approach for the Preparation of Functionalized [5:1]-Hexaadducts of C60

(2009) Julien Iehl et al.   CHEMISTRY-A EUROPEAN JOURNAL

Polymersomes: nature inspired nanometer sized compartments

(2009) Caterina LoPresti et al.   JOURNAL OF MATERIALS CHEMISTRY

Synthesis of amphiphilic biodegradable glycocopolymers based on poly(ε-caprolactone) by ring-opening polymerization and click chemistry

(2009) Ning Xu et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Glaser coupling of polymers: Side-reaction in Huisgens “click” coupling reaction and opportunity for polymers with focal diacetylene units in combination with ATRP

(2009) Christopher J. Duxbury et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Buckyballs Meet Viral Nanoparticles: Candidates for Biomedicine

(2009) Nicole F. Steinmetz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of a Cross-Linked Branched Polymer Network in the Interior of a Protein Cage

(2009) Md Joynal Abedin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surpassing the Use of Copper in the Click Functionalization of Polymeric Nanostructures: A Strain-Promoted Approach

(2009) Enrique Lallana et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Functionalization of Carbon Nanotubes with Porphyrin Dendrons via Click Chemistry

(2009) Thomas Palacin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

“Clickable” Polymer-Caged Nanobins as a Modular Drug Delivery Platform

(2009) Sang-Min Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Labeling of Living Cells by a Photo-Triggered Click Reaction

(2009) Andrei A. Poloukhtine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surface Functionalization of Nanomaterials with Dendritic Groups: Toward Enhanced Binding to Biological Targets

(2009) Amanda L. Martin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalization of Polymer Microspheres Using Click Chemistry

(2009) Dana R. Breed et al.   LANGMUIR

Fabrication of Two Types of Shell-Cross-Linked Micelles with “Inverted” Structures in Aqueous Solution from Schizophrenic Water-Soluble ABC Triblock Copolymer via Click Chemistry

(2009) Xiaoze Jiang et al.   LANGMUIR

Surface Modification of Poly(divinylbenzene) Microspheres via Thiol−Ene Chemistry and Alkyne−Azide Click Reactions

(2009) Anja S. Goldmann et al.   MACROMOLECULES

Potato Virus X as a Novel Platform for Potential Biomedical Applications

(2009) Nicole F. Steinmetz et al.   NANO LETTERS

Research Highlights

(2009) R Banerjee   Nanomedicine

Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging

(2009) Santimukul Santra et al.   Small

Active targeting schemes for nanoparticle systems in cancer therapeutics

(2008) James D. Byrne et al.   ADVANCED DRUG DELIVERY REVIEWS

Biocompatible Carbon Nanotubes Generated by Functionalization with Glycodendrimers

(2008) Peng Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visualizing Metabolically Labeled Glycoconjugates of Living Cells by Copper-Free and Fast Huisgen Cycloadditions

(2008) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual Labeling of Biomolecules by Using Click Chemistry: A Sequential Approach

(2008) Péter Kele et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In VivoTumor Cell Targeting with “Click” Nanoparticles

(2008) Geoffrey von Maltzahn et al.   BIOCONJUGATE CHEMISTRY

Unnatural Amino Acid Incorporation into Virus-Like Particles

(2008) Erica Strable et al.   BIOCONJUGATE CHEMISTRY

Click Chemistry Functionalized Polymeric Nanoparticles Target Corneal Epithelial Cells through RGD-Cell Surface Receptors

(2008) Jiao Lu et al.   BIOCONJUGATE CHEMISTRY

Folate-Conjugated Thermoresponsive Block Copolymers: Highly Efficient Conjugation and Solution Self-Assembly

(2008) Priyadarsi De et al.   BIOMACROMOLECULES

Low-Fouling, Biofunctionalized, and Biodegradable Click Capsules

(2008) Christopher J. Ochs et al.   BIOMACROMOLECULES

Electrochemically Protected Copper(I)-Catalyzed Azide-Alkyne Cycloaddition

(2008) Vu Hong et al.   CHEMBIOCHEM

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Biological applications of gold nanoparticles

(2008) Ralph A. Sperling et al.   CHEMICAL SOCIETY REVIEWS

The origins and evolution of “controlled” drug delivery systems

(2008) Allan S. Hoffman   JOURNAL OF CONTROLLED RELEASE

Semiconductor to metal transition in SWNTs caused by interaction with gold and platinum nanoparticles

(2008) Rakesh Voggu et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry

(2008) Julian A. Codelli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioconjugation of Biotin to the Interfaces of Polymeric Micelles via In Situ Click Chemistry

(2008) Xiaojuan Wang et al.   LANGMUIR

Grafting BSA onto Poly[(L-lactide)-co-carbonate] Microspheres by Click Chemistry

(2008) Yadong Han et al.   MACROMOLECULAR BIOSCIENCE

Degradable Multilayer Films and Hollow Capsules via a ‘Click’ Strategy

(2008) Bruno G. De Geest et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Polyion Complex Micelles Possessing Thermoresponsive Coronas and Their Covalent Core Stabilization via “Click” Chemistry

(2008) Jingyan Zhang et al.   MACROMOLECULES

Synthesis and Characterization of Linear-Dendron-like Poly(ε-caprolactone)-b-poly(ethylene oxide) Copolymers via the Combination of Ring-Opening Polymerization and Click Chemistry

(2008) Chong Hua et al.   MACROMOLECULES

Clickable Macroinitiator Strategy to Build Amphiphilic Polymer Brushes on Carbon Nanotubes

(2008) Yu Zhang et al.   MACROMOLECULES

“Clicking” Fullerene with Polymers:  Synthesis of [60]Fullerene End-Capped Polystyrene

(2008) Wen-Bin Zhang et al.   MACROMOLECULES

Synthesis of Highly Functionalized Poly(alkyl cyanoacrylate) Nanoparticles by Means of Click Chemistry

(2008) Julien Nicolas et al.   MACROMOLECULES

Dendron-like Polypeptide/Linear Poly(ethylene oxide) Biohybrids with Both Asymmetrical and Symmetrical Topologies Synthesized via the Combination of Click Chemistry and Ring-Opening Polymerization

(2008) Song-Ming Peng et al.   MACROMOLECULES

Synthesis of poly(alkyl cyanoacrylate)-based colloidal nanomedicines

(2008) Julien Nicolas et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

The immobilization of proteins on biodegradable polymer fibers via click chemistry

(2007) Quan Shi et al.   BIOMATERIALS