Article
Medicine, Research & Experimental
Min Wei, Anxiang Chen, Jian Zhang, Yuhong Ren
Summary: This study developed an engineered immunotoxin by fusing the oxygen-dependent degradation domain (ODDD) with an immunotoxin, which showed selective killing effect on cancer cells under hypoxia and reduced nonspecific toxicity to normal cells under normoxic conditions.
MOLECULAR PHARMACEUTICS
(2023)
Review
Cell Biology
Elena V. Mitroshina, Maria O. Savyuk, Evgeni Ponimaskin, Maria V. Vedunova
Summary: Hypoxia is a common pathological condition induced by various events, with the body's adaptation to it being crucial for health and disease. HIFs, a family of transcription factors, play a key role in cellular responses to hypoxia and are increasingly viewed as potential targets for treating a range of hypoxia-associated diseases. The role of HIFs in adaptation to hypoxia is universal across tissue types, including the CNS, where they are involved in regulating neurogenesis, nerve cell differentiation, and neuronal apoptosis, potentially offering new therapeutic opportunities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biology
Li Li, Susan Shen, Philip Bickler, Matthew P. Jacobson, Lani F. Wu, Steven J. Altschuler
Summary: The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms. This review summarizes known and potential hypoxia sensors among human O-2-dependent enzymes and highlights their possible roles in hypoxia-related adaptation and diseases.
Review
Biochemistry & Molecular Biology
Bang-Hao Zhao, Amanguli Ruze, Ling Zhao, Qiu-Lin Li, Jing Tang, Nilupaer Xiefukaiti, Min-Tao Gai, An-Xia Deng, Xue-Feng Shan, Xiao-Ming Gao
Summary: Myocardial ischemia/reperfusion (I/R) injury involves myocardial stunning, microvascular damage (MVD), reperfusion arrhythmia, and lethal reperfusion injury. MVD, which is often neglected, is strongly associated with the development of heart failure. Understanding and addressing MVD are crucial for improving patient prognosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Biology
Michael Ohh, Cassandra C. Taber, Fraser G. Ferens, Daniel Tarade
Summary: von Hippel-Lindau (VHL) disease is a rare hereditary cancer syndrome caused by mutations in pVHL and disruption of HIF alpha degradation, and the understanding of its genotype-phenotype relationship is crucial for future management of VHL patients.
Article
Biotechnology & Applied Microbiology
Shinya Masumoto, Akihiko Ono, Akira Ito, Yoshinori Kawabe, Masamichi Kamihira
Summary: Researchers developed a hypoxia-responsive gene expression system to introduce the angiogenic factor VEGF into artificial 3D tissues, aiming to improve hypoxia and nutrition deficiencies. Experimental results demonstrated the effectiveness of this system in both in vitro and in vivo settings, providing valuable insights for preparing artificial 3D tissues in regenerative medicine.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Lingchun Kong, Jingjing Li, Yuqin Yang, Huixin Tang, Hong Zou
Summary: This study found that Paeoniflorin (PF) can alleviate the progression of retinal vein occlusion (RVO) by inhibiting the HIF-1 alpha/VEGF/STAT3 pathway. The results of this study may provide theoretical knowledge for exploring novel treatments for RVO patients.
Review
Engineering, Biomedical
Kelsey G. DeFrates, Daniela Franco, Ellen Heber-Katz, Phillip B. Messersmith
Summary: Traditional approaches in regenerative medicine face limitations in translation and commercialization, prompting the development of therapies that stimulate endogenous processes for regeneration. Recent studies highlight the potential of oxygen-sensing pathways, with upregulation of HIF-1α showing promise in modulating cell metabolism and plasticity for tissue regeneration.
Review
Immunology
Qianyan He, Yinzhong Ma, Jie Liu, Dianhui Zhang, Jiaxin Ren, Ruoyu Zhao, JunLei Chang, Zhen-Ni Guo, Yi Yang
Summary: Ischemic stroke, caused by inadequate cerebrovascular blood and oxygen supply, poses a significant global health burden. HIF-1α, a key regulator of oxygen homeostasis, plays a critical role in various aspects of stroke pathophysiology and is an important target for potential therapeutic interventions. Further research into the differential regulation of HIF-1α in different cell types during ischemic stroke is crucial for understanding the disease mechanism and identifying novel treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Qiuyue Qin, Yiping Liu, Zhen Yang, Maierhaba Aimaijiang, Rui Ma, Yixin Yang, Yidi Zhang, Yanmin Zhou
Summary: Sufficient oxygen is crucial for normal cellular and physiological function, and both pathological hypoxia and environmental hypoxia can impact bone health. Adaptation to hypoxia is a key event in cellular development and differentiation, and hypoxia-inducible transcription factors (HIFs) are essential for regulating bone development and repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sujin Ju, Leejin Lim, Kwanhwan Wi, Changwon Park, Young-Jae Ki, Dong-Hyun Choi, Heesang Song
Summary: LRP5 may act as a negative regulator of ischemic heart injury through interacting with PHD2 to degrade HIF-1α in hypoxic myocardium, Overexpression of LRP5 promotes cell apoptosis, while silencing LRP5 protects cardiomyocytes from hypoxia. Additionally, specific phosphorylation of LRP5 enhances PHD2 activity, resulting in HIF-1α degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Yingjia Guo, Junpeng Zhou, Xianglong Li, Ying Xiao, Jingyao Zhang, Yutao Yang, Li Feng, Y. James Kang
Summary: Elderly rats show defective recovery from ischemic stroke possibly due to suppressed HIF-1 transcription activity. Overexpression of COMMD1 in aged rats leads to impaired HIF-1 transactivation and affects cerebral recovery.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Cardiac & Cardiovascular Systems
Emilio Y. Lucero Garcia Rojas, Cleva Villanueva, Richard A. Bond
Summary: Cardiovascular diseases are the leading cause of death in industrialized countries, with hypoxia playing a central role in their pathogenesis. The review highlights the importance of HIFs and derived factors in the development and perpetuation of hypoxia in these diseases, categorizing them into acute and chronic hypoxic states to better understand the temporal relevance of HIFs in disease progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biology
Xiaowei Zheng, Sampath Narayanan, Cheng Xu, Sofie Eliasson Angelstig, Jacob Grunler, Allan Zhao, Alessandro Di Toro, Luciano Bernardi, Massimiliano Mazzone, Peter Carmeliet, Marianna Del Sole, Giancarlo Solaini, Elisabete A. Forsberg, Ao Zhang, Kerstin Brismar, Tomas A. Schiffer, Neda Rajamand Ekberg, Ileana Ruxandra Botusan, Fredrik Palm, Sergiu-Bogdan Catrina
Summary: Excessive production of mitochondrial reactive oxygen species (ROS) in diabetes complications is mainly caused by impaired responses to hypoxia due to the inhibition of hypoxia-inducible factor-1 (HIF-1) by hyperglycemia. Restoring HIF-1 function can attenuate ROS overproduction, protect cells against apoptosis and renal injury in diabetes. These findings suggest that targeting HIF-1 repression could be a potential therapeutic strategy for diabetic complications.
Review
Physiology
Karim Ullah, Rongxue Wu
Summary: Endothelial cells play a crucial role in maintaining cardiovascular homeostasis, tissue growth, and repair, relying on glycolysis to resist hypoxic damage and promote angiogenesis in ischemic regions. Hypoxia-inducible factors (HIFs) are key regulators of endothelial cell metabolism and angiogenesis, with varying effects on cardiovascular dysfunction in different disease settings.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yong-Joon Lee, Jae Young Cho, Seng Chan You, Yong-Ho Lee, Kyeong Ho Yun, Yun-Hyeong Cho, Won-Yong Shin, Sang Wook Im, Woong Chol Kang, Yongwhi Park, Sung Yoon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: This study evaluated the effect of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy among patients with diabetes mellitus and atherosclerotic cardiovascular disease. The study found that the combination therapy had similar outcomes in terms of cardiovascular events compared to the monotherapy, but had a higher rate of intolerance-related discontinuation or dose reduction. However, the combination therapy was more effective in achieving lower LDL cholesterol levels.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jung-Joon Cha, Ngoc-Luu Nguyen, Cong Tran, Won-Yong Shin, Seul-Gee Lee, Yong-Joon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jinyong Ha, Jung-Sun Kim
Summary: This study aimed to evaluate and compare the diagnostic accuracy of machine learning fractional flow reserve (ML-FFR) based on optical coherence tomography (OCT) with wire-based FFR. OCT and FFR data were obtained for 356 individual coronary lesions in 130 patients. The ML-FFR showed good diagnostic performance in predicting FFR irrespective of the coronary territory, highlighting its potential in clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Gunnar Tepe, Marianne Brodmann, Antonio Micari, Dierk Scheinert, Donghoon Choi, Jeremiah Menk, Thomas Zeller
Summary: This study evaluated the safety and effectiveness of drug-coated balloon (DCB) treatment in three different types of atherosclerotic lesions over a 5-year period. The results demonstrated long-term safety and efficacy of DCB in all three patient cohorts.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Medicine, General & Internal
Sung-Jin Hong, Yong-Joon Lee, Seung-Jun Lee, Bum-Kee Hong, Woong Chol Kang, Jong-Young Lee, Jin-Bae Lee, Tae-Hyun Yang, Junghan Yoon, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong-Ki Hong
Summary: This study compared the effectiveness of initial statin treatment with high-intensity statins versus a treat-to-target strategy in patients with coronary artery disease. The results showed that the treat-to-target strategy of achieving an LDL-C level between 50 and 70 mg/dL was noninferior to high-intensity statin therapy in terms of clinical outcomes over a 3-year period.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Sang-Hyup Lee, Yong -Joon Lee, Jung Ho Heo, Seung-Ho Hur, Hyun Hee Choi, Kyung-Jin Kim, Ju Han Kim, Keun-Ho Park, Jung Hee Lee, Yu Jeong Choi, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: This study compared the cardiovascular effects and tolerability of combination therapy with moderate-intensity statins and ezetimibe versus high-intensity statin monotherapy in elderly patients. The results showed no significant difference in the occurrence of cardiovascular events between the two treatment groups among patients aged ≥75 years and <75 years, but the combination therapy group had lower rates of adverse reactions. Therefore, combination therapy with moderate-intensity statins and ezetimibe has similar cardiovascular effects and greater tolerability in elderly patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Bom Lee, Teklay Gebrehaweria Baraki, Byung Gyu Kim, Yong-Joon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Dong-Ho Shin, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: This study evaluated the impact of various stent expansion indices on clinical outcomes and identified optimal stent implantation criteria using optical coherence tomography (OCT). It found that minimal stent area (MSA) was negatively correlated with the risk of adverse events, while overall volumetric stent expansion was associated with greater risk. Categorical criteria, such as MSA<5.0 mm(2), MSA/distal reference lumen area<90%, and stent expansion by linear model>= 65.0%, were independently associated with adverse events.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Oh-Hyun Lee, Ji Woong Roh, Yongcheol Kim, Nak-Hoon Son, Jay Yi Cho, Daesek Jang, Eui Im, Deok-Kyu Cho, Donghoon Choi
Summary: This study aimed to compare the effectiveness of different medication regimens in preventing radial artery spasm (RAS) during coronary catheterization. The results showed that intra-arterial injection of nitroglycerin (NTG) as a single agent was effective and safe in preventing RAS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Byung Gyu Kim, Sung-Jin Hong, Byeong-Keuk Kim, Yong-Joon Lee, Seung-Jun Lee, Chul-Min Ahn, Dong-Ho Shin, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: This study aimed to evaluate the BMI-dependent effect of ticagrelor monotherapy after 3-month DAPT compared with 12-month DAPT on clinical outcomes in patients with ACS. The results showed consistent effects of ticagrelor monotherapy after 3-month DAPT on major clinical outcomes, regardless of BMI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Oncology
Soo Yeon Baek, Woo Chul Noh, Sei-Hyun Ahn, Hyun-Ah Kim, Jai Min Ryu, Seung Il Kim, Eun-Gyeong Lee, Seock-Ah Im, Yongsik Jung, Min Ho Park, Kyong Hwa Park, Su Hwan Kang, Joon Jeong, Eunhwa Park, Sung Yong Kim, Min Hyuk Lee, Lee Su Kim, Woosung Lim, Seonok Kim, Hee Jeong Kim
Summary: The purpose of the study was to determine the long-term outcomes of adding ovarian suppression to tamoxifen in young women with hormone-sensitive breast cancer. The study involved 1,483 premenopausal women under 45 years old who were randomly assigned to receive tamoxifen alone or with ovarian function suppression. Results showed a consistent reduction in disease-free survival events with the addition of ovarian suppression, suggesting its consideration for premenopausal patients or those who resume ovarian function after chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Seung-Jun Lee, Jae Hong Joo, Sohee Park, Choongki Kim, Dong-Woo Choi, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Chung-Mo Nam, Myeong-Ki Hong
Summary: This observational study evaluated the effects of high-intensity statin monotherapy compared with combination therapy (statin plus ezetimibe) in patients after drug-eluting stent implantation. The results showed that combination therapy was associated with lower occurrence of adverse events and better drug compliance.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Seung-Jun Lee, Woong Chol Kang, Jong-Young Lee, Jin-Bae Lee, Tae-Hyun Yang, Junghan Yoon, Yong-Joon Lee, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Bum-Kee Hong, Yangsoo Jang, Myeong-Ki Hong, LODESTAR Investigators
Summary: For patients with coronary artery disease and diabetes mellitus, achieving target LDL-C levels is comparable to high-intensity statin therapy in terms of 3-year clinical efficacy and safety outcomes.
Article
Endocrinology & Metabolism
Yong-Joon Lee, Sang-Hyup Lee, Seng Chan You, Yong-ho Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: The study evaluated the safety and efficacy of a moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with metabolic syndrome (MetS) and atherosclerotic cardiovascular disease. The combination therapy showed comparable cardiovascular benefits with lower drug intolerance and low-density lipoprotein cholesterol levels compared to monotherapy, but no significant difference in new-onset diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Seung-Jun Lee, Jung-Joon Cha, Woong Gil Choi, Wang-Soo Lee, Jin-Ok Jeong, Seonghoon Choi, Yoon-Haeng Cho, Woojung Park, Chang-Hwan Yoon, Yong-Joon Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Soon Jun Hong, Jung-Sun Kim
Summary: The study aimed to evaluate the outcomes of a moderate-intensity statin with ezetimibe combination in patients with very high risk (VHR) and non-VHR of atherosclerotic cardiovascular disease (ASCVD). The results showed no significant difference in the primary end point between combination therapy and high-intensity statin monotherapy in both VHR and non-VHR patients. Additionally, the combination therapy group had significantly lower levels of low-density lipoprotein cholesterol (LDL-C) compared to the high-intensity statin group, and was associated with greater changes in LDL-C levels and a higher proportion of patients with LDL-C levels below 70 mg/dL. The discontinuation or dose reduction of lipid-lowering drugs due to intolerance occurred less frequently in the combination therapy group.
Article
Surgery
Hyung Jin Kim, Juhyeon Lee, In-Chul Park, Yireh Han, Min-Ki Seong, Woo Chul Noh, Hye Jin Kang, Hyun-Ah Kim, Chan Sub Park
Summary: The overall survival of breast cancer survivors varies depending on the sites of second primary malignancies. The prognoses of patients with second primary hematologic malignancies were not significantly different from those with metastatic breast cancer.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2023)
Article
Surgery
Juhyeon Lee, Chan Sub Park, Jeong Hun Oh, In-Chul Park, Min-Ki Seong, Woo Chul Noh, Hyun-Ah Kim
Summary: This study compared the outcomes of patients with hormone receptor-positive, HER2-negative breast cancer who received chemotherapy followed by tamoxifen plus a GnRH agonist to those who received tamoxifen plus a GnRH agonist alone. The results showed that there was no significant survival benefit from undergoing chemotherapy before receiving tamoxifen and GnRH agonist therapy.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2023)