期刊
PHARMACEUTICAL BIOLOGY
卷 48, 期 2, 页码 195-200出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/13880200903078495
关键词
Affinin; analgesic action; Heliopsis longipes; Irwin's test
资金
- CONACYT (Consejo Nacional de Ciencia y Tecnologia) (Mexico) [172443]
Heliopsis longipes S. F. Blake (Asteraceae: Heliantheae) (chilcuague) is used in Mexican traditional medicine against parasites and to alleviate tooth and muscle pains. Its biocide effect has already been experimentally demonstrated; however, its analgesic action and its action on the nervous system (NS) have not been investigated yet. The objectives of this study were to evaluate the analgesic action of affinin and the H. longipes root ethanol extract, as well as their effects on the NS using an animal model. The ethanol extract was obtained by maceration, and affinin was purified from it through chromatographic techniques. Chemical and thermal analgesia were used to assess their analgesic proprieties. Irwin's test was used to evaluate their stimulating or depressing effects. The ethanol extract and affinin displayed analgesic action similar to ketorolac and stimulating effect comparable to caffeine on the nervous system of adult mice.
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