期刊
PHARMACEUTICAL BIOLOGY
卷 46, 期 10-11, 页码 700-703出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13880200802215859
关键词
Antiplasmodial; endophytic fungus; phomalactone; Plasmodium falciparum; Xylaria sp.
资金
- Smithsonian Tropical Research Institute
- International Cooperative Biodiversity Groups [1 UO1 TWO6634-01]
- Institute for Advanced Scientific Investigation and Technology Services
- NSF [DEB-0200413, DEB-0516564, DEB-0640956]
Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 mu g/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4H-pyran-2- one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1-3 against a chloroquine-resistant Plasmodium falciparum strain.
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