Article
Plant Sciences
Min Tang, Jialin Huang, Xiangli Ma, Juan Du, Yufen Bi, Peiwen Guo, Hao Lu, Lei Wang
Summary: This study presents a chromosome-level, near-complete genome assembly of Thalia dealbata, which is an emergent wetland plant with high ornamental and environmental value. The assembly was based on PacBio HiFi reads and Hi-C reads, resulting in a 255.05 Mb assembly with high contig N50 value and BUSCO recovery score. The genome provides valuable resources for further research on wetland plant adaptation and comparative genomics.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Engineering, Chemical
Vicente Vergara-Florez, Jorge Mieles-Galindo, Graciela Nani, Mayerlin Sandoval-Herazo, Luis Carlos Sandoval Herazo
Summary: This study evaluated the efficiency of a constructed wetland planted with Thalia geniculata for treating wastewater from the Arroyo Grande de la Sabana in Sucre, Colombia. The results showed that a 5-day hydraulic retention time was most effective in removing contaminants such as nitrates, nitrites, and phosphates.
Review
Biochemistry & Molecular Biology
Valery M. Dembitsky, Ekaterina Ermolenko, Nick Savidov, Tatyana A. Gloriozova, Vladimir V. Poroikov
Summary: Polycyclic endoperoxides are rare natural metabolites with antiprotozoal and antitumor properties, some of which are widely used in clinical medicine. These compounds can be divided into three groups based on their antiprotozoal activity, with the third group showing weak activity, the second group showing moderate activity, and the third group showing strong activity. Additionally, some polycyclic endoperoxides exhibit other strong activities such as antifungal and anti-inflammatory properties.
Article
Biochemistry & Molecular Biology
Clemens Hinteregger, Johanna Dolensky, Werner Seebacher, Robert Saf, Pascal Maeser, Marcel Kaiser, Robert Weis
Summary: 2,4-Diaminopyrimidines and (dialkylamino)azabicyclo-nonanes have activity against protozoan parasites. A series of fused hybrids were synthesized and tested in vitro against malaria tropica and sleeping sickness pathogens. The activities and selectivities of compounds strongly depended on the substitution pattern of both ring systems as well as the position of the nitrogen atom in the bicycles.
Article
Agricultural Engineering
Maryam Akaberi, Zahra Tayarani Najaran, Narjes Azizi, Seyed Ahmad Emami
Summary: Tropical diseases like leishmaniosis pose a major health concern in developing countries, with pathogens developing multiresistance to classic antibiotics, driving the urgent need for new antibiotics. The study focuses on the beneficial effects of Helichrysum spp., comparing their anti-protozoal activities and phytochemical components to tackle infectious diseases in an ongoing project.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Ozlem Sevik Kilicaslan, Sylvian Cretton, Luis Quiros-Guerrero, Merveilles A. Bella, Marcel Kaiser, Pascal Maeser, Joseph T. Ndongo, Muriel Cuendet
Summary: This study isolated and identified 16 compounds from P. bicarpellata extracts, including two previously unreported compounds. The absolute configurations of these compounds were determined through analysis of experimental and calculated data. The extracts and compounds were evaluated for their antiprotozoal activity, with tubotaiwine displaying the most significant antiplasmodial activity.
Article
Chemistry, Applied
Ahmed A. Zaki, Ahmed A. Ashour, Longxin Qiu
Summary: Chromatographic investigation of Calendula officinalis flowers led to the isolation of two sesquiterpenes, with a new compound showing antiprotozoal activity against Leishmania donovani Amastigote/THP1 and Trypanosoma brucei, while the previously reported compound exhibited no activity at the highest concentration tested.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Pedro G. Vasquez-Ocmin, Alice Gadea, Sandrine Cojean, Guillaume Marti, Sebastien Pomel, Anne-Cecile Van Baelen, Liliana Ruiz-Vasquez, Wilfredo Ruiz Mesia, Bruno Figadere, Lastenia Ruiz Mesia, Alexandre Maciuk
Summary: In the rural communities of the Alto Amazonas Province in Peru, the use of medicinal Piper species is common practice against parasitic infections. This ethnopharmacological study validated the traditional use of Piper species in Amazonian traditional medicine and identified several species with antiprotozoal activity, suggesting potential for further research. The metabolomic approach proved to be a useful method to identify active compounds in the medicinal plants.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Horticulture
Bruna Natalia Veloso dos Santos, Jessica Coutinho Silva, Wellington Ronildo Clarindo
Summary: In this study, the chromosome number and nuclear DNA content of Marantaceae plants were measured, revealing the genetic characteristics and evolutionary processes of this family. The results showed significant variation in chromosome number and nuclear DNA content among Marantaceae plants, and polyploidy plays an important role in this process.
SCIENTIA HORTICULTURAE
(2022)
Article
Agricultural Engineering
Fernanda Tomiotto-Pellissier, Bruna Taciane da Silva Bortoleti, Virginia Marcia Concato, Ana Flavia Marques Ganaza, Ana Carolina Quasne, Beatriz Ricci, Pedro Vinicius Dolce E Carvalho, Gustavo Henrique Della Colleta, Danielle Lazarin-Bidoia, Taylon Felipe Silva, Manoela Daiele Goncalves, Renata Katsuko Takayama Kobayashi, Gerson Nakazato, Idessania Nazareth Costa, Ivete Conchon-Costa, Milena Menegazzo Miranda-Sapla, Wander Rogerio Pavanelli
Summary: This study investigated the leishmanicidal and immunomodulatory effects of oregano essential oil (OEO) on experimental Leishmania amazonensis-model through in silico, in vitro, and in vivo approaches. The results demonstrated that OEO containing carvacrol, thymol, gamma-terpinene, p-cymene, and beta-caryophyllene as the main components showed potential as an oral and topical drug development for the treatment of L. amazonensis. OEO exhibited leishmanicidal activity by inducing a combination of autophagic, apoptotic, and necrotic events, and had immunomodulatory effects without triggering a pro-inflammatory response.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Plant Sciences
Barbara Verena Dias Galvao, Carlos Fernando Araujo-Lima, Monica Cristine Pereira dos Santos, Mariana Pulmar Seljan, Eduardo Kennedy Carrao-Dantas, Claudia Alessandra Fortes Aiub, Luiz Claudio Cameron, Mariana Simoes Larraz Ferreira, Edira Castello Branco de Andrade Goncalves, Israel Felzenszwalb
Summary: The study identified 14 phenolic compounds in Plinia cauliflora leaf extract, showing certain anti-Trypanosoma cruzi activity but also cytotoxic effects on liver cell lines.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jose Rodrigues do Carmo Neto, Rhanoica Oliveira Guerra, Juliana Reis Machado, Anielle Christine Almeida Silva, Marcos Vinicius da Silva
Summary: This review discusses the latest research on the effects of zinc oxide nanoparticles on parasites, focusing on the treatment of diseases harmful to human and animal health by disrupting the homeostasis of pathogens through the generation of ROS.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Johanna Dolensky, Clemens Hinteregger, Andreas Leitner, Werner Seebacher, Robert Saf, Ferdinand Belaj, Pascal Maser, Marcel Kaiser, Robert Weis
Summary: N-(Aminoalkyl)azabicyclo[3.2.2]nonanes with terminal tetrazole or sulfonamido partial structure were synthesized. The structures of these compounds were confirmed by various analyses. In vitro experiments showed that the sulfonamide and tetrazole derivatives exhibited significant activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense.
Article
Biochemistry & Molecular Biology
Samya S. Alenezi, Naif D. Alenezi, Godwin U. Ebiloma, Manal J. Natto, Marzuq A. Ungogo, John O. Igoli, Valerie A. Ferro, Alexander I. Gray, James Fearnley, Harry P. de Koning, David G. Watson
Summary: Profiling of a propolis sample from Papua New Guinea revealed the presence of several triterpenoids, which exhibited moderate to high activity against parasitic protozoa but low cytotoxicity against mammalian cells.
Article
Biochemistry & Molecular Biology
Anais Pannequin, Joelle Quetin-Leclercq, Jean Costa, Aura Tintaru, Alain Muselli
Summary: Chromatographic and spectroscopic methods were used to investigate the volatile metabolites of the liverwort Plagiochila porelloides harvested in Corsica. Three new compounds were isolated and their structures were determined. The essential oil and extract of P. porelloides showed moderate antiprotozoal and anticancer activities.
Article
Chemistry, Multidisciplinary
Che-Sheng Hsu, Carlos R. Goncalves, Veronica Tona, Amandine Pons, Marcel Kaiser, Nuno Maulide
Summary: The article presents a method of synthesizing amine compounds using highly electron-deficient iminium ions and highlights its broad applicability through a specific case study.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Medicinal
Sabina Beilstein, Radhia El Phil, Suzanne Sherihan Sahraoui, Leonardo Scapozza, Marcel Kaiser, Pascal Maser
Summary: This article discusses the experimental methods and strategies for selecting drug-resistant parasites, using African trypanosomes as an example. Researchers need to consider factors such as the environmental conditions, life stages, and pressure for selecting drug resistance, while taking into account the laboratory settings.
Article
Plant Sciences
Emeline Houel, Marine Ginouves, Nadine Azas, Eliane Bourreau, Veronique Eparvier, Sebastien Hutter, Adeline Knittel-Obrecht, Arnaud Jahn-Oyac, Ghislaine Prevot, Pascal Villa, Catherine Vonthron-Senecheau, Guillaume Odonne
Summary: This study investigated the effects of selected plant species from the Amazon region on Leishmania parasites and related pathophysiological aspects. The results showed that antiparasitic activity is not the only factor for antileishmanial evaluation. Furthermore, some species exhibited antifungal activity and immunomodulatory effects, while none of them had wound healing properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Basma Abdallah, Cendrine Seguin, Elora Aubert, Hassan Ait BenHassou, Laila Sbabou, Laurence Choulier, Catherine Vonthron, Isabelle J. Schalk, Gaetan L. A. Mislin, Sylvie Fournel, Veronique Pitchon, Pierre Fechter
Summary: This study explores the combination of metals and plants in ancient remedies and provides evidence for their potential therapeutic effects. By analyzing four medical formularies from the 9-12th century, the researchers discovered that these remedies contained a high proportion of metals and identified their specific roles in combating infections and promoting wound healing. The findings highlight the knowledge and skills of ancient physicians in manipulating metals for therapeutic purposes.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ozlem Sevik Kilicaslan, Sylvian Cretton, Luis Quiros-Guerrero, Merveilles A. Bella, Marcel Kaiser, Pascal Maeser, Joseph T. Ndongo, Muriel Cuendet
Summary: This study isolated and identified 16 compounds from P. bicarpellata extracts, including two previously unreported compounds. The absolute configurations of these compounds were determined through analysis of experimental and calculated data. The extracts and compounds were evaluated for their antiprotozoal activity, with tubotaiwine displaying the most significant antiplasmodial activity.
Article
Chemistry, Organic
Blaise Kimbadi Lombe, Lea Winand, Jan Diettrich, Melanie Tobermann, Wolf Hiller, Marcel Kaiser, Markus Nett
Summary: In this study, we report the discovery of massinidine, an aguanidine alkaloid with antiplasmodial activity, from bacteria of the genus Massilia. The biosynthetic genes of massinidine were identified and validated through heterologous expression. Bioinformatic analysis reveals the widespread potential for massinidine biosynthesis in various proteobacteria.
Article
Microbiology
Melissa L. Sykes, Emily K. Kennedy, Kevin D. Read, Marcel Kaiser, Vicky M. Avery
Summary: Chagas disease and Human African Trypanosomiasis (HAT) are parasitic diseases that pose a serious threat to human health. The existing treatment methods are not highly effective, thus there is a need for new therapeutic drugs. Through in vitro assays, compounds with selective activity against these parasites have been identified and evaluated for further research and development.
Article
Plant Sciences
J. Mcebisi Mabuza, Marcel Kaiser, M. Johanna Bapela
Summary: This study evaluated the antiplasmodial and cytotoxic activity of Pappea capensis extracts and fractions, and identified the major compounds responsible for the observed antiplasmodial activity. The results validated the traditional use of P. capensis for malaria treatment and demonstrated the potential for discovering novel antiplasmodial constituents.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Johanna Dolensky, Clemens Hinteregger, Andreas Leitner, Werner Seebacher, Robert Saf, Ferdinand Belaj, Pascal Maser, Marcel Kaiser, Robert Weis
Summary: N-(Aminoalkyl)azabicyclo[3.2.2]nonanes with terminal tetrazole or sulfonamido partial structure were synthesized. The structures of these compounds were confirmed by various analyses. In vitro experiments showed that the sulfonamide and tetrazole derivatives exhibited significant activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense.
Article
Biochemistry & Molecular Biology
Alireza Mousavi, Parham Foroumadi, Zahra Emamgholipour, Pascal Maser, Marcel Kaiser, Alireza Foroumadi
Summary: The nitro-containing compounds discovered in this study showed high activity against Trypanosoma brucei, making them potential candidates for treating sleeping sickness.
Article
Biochemistry & Molecular Biology
Nina Scheiber, Gregor Blaser, Eva-Maria Pferschy-Wenzig, Marcel Kaiser, Pascal Maser, Armin Presser
Summary: In this study, a series of cyclohexadienone and naphthoquinone derivatives were synthesized using different hypervalent iodine(III) reagents and evaluated for their in vitro antiprotozoal activity. It was found that benzyl naphthoquinone 5c was the most active and selective molecule against T. brucei rhodesiense.
Article
Biochemistry & Molecular Biology
Clemens Hinteregger, Johanna Dolensky, Werner Seebacher, Robert Saf, Pascal Maeser, Marcel Kaiser, Robert Weis
Summary: 2,4-Diaminopyrimidines and (dialkylamino)azabicyclo-nonanes have activity against protozoan parasites. A series of fused hybrids were synthesized and tested in vitro against malaria tropica and sleeping sickness pathogens. The activities and selectivities of compounds strongly depended on the substitution pattern of both ring systems as well as the position of the nitrogen atom in the bicycles.
Article
Chemistry, Multidisciplinary
Werner Seebacher, Marcel Kaiser, Pascal Maeser, Robert Saf, Eva-Maria Pferschy-Wenzig, Robert Weis
Summary: Several 1-benzyl and 1,3-dibenzyl derivatives of tetrahydropyridinylidene salts with varying electron withdrawing substituents at the aromatic residues have been synthesized and investigated for their biological activities and cytotoxicity. Characterization of these compounds was carried out using FT-IR, HRMS and NMR spectroscopy.
MONATSHEFTE FUR CHEMIE
(2023)
Article
Chemistry, Medicinal
Theresa Hermann, Robin Wallner, Johanna Dolensky, Werner Seebacher, Eva-Maria Pferschy-Wenzig, Marcel Kaiser, Pascal Maser, Robert Weis
Summary: The compound MMV030666 in MMV's Malaria Box exhibits multi-stage activity against various strains of Plasmodium falciparum without resistance development. By modifying the structure, a series of compounds were prepared and the relationship between the structure and activity was revealed. Furthermore, the pharmacokinetic and physicochemical parameters were improved.
Article
Multidisciplinary Sciences
Srinivasa P. S. Rao, Matthew K. Gould, Jonas Noeske, Manuel Saldivia, Rajiv S. Jumani, Pearly S. Ng, Olivier Rene, Yen-Liang Chen, Marcel Kaiser, Ryan Ritchie, Amanda Fortes Francisco, Nila Johnson, Debjani Patra, Harry Cheung, Colin Deniston, Andreas D. Schenk, Wilian A. Cortopassi, Remo S. Schmidt, Natalie Wiedemar, Bryanna Thomas, Rima Palkar, Nahdiyah A. Ghafar, Vanessa Manoharan, Catherine Luu, Jonathan E. Gable, Kah Fei Wan, Elmarie Myburgh, Jeremy C. Mottram, Whitney Barnes, John Walker, Charles Wartchow, Natasha Aziz, Colin Osborne, Juergen Wagner, Christopher Sarko, John M. Kelly, Ujjini H. Manjunatha, Pascal Maeser, Jan Jiricek, Suresh B. Lakshminarayana, Michael P. Barrett, Thierry T. Diagana
Summary: Millions of people in Latin America and sub-Saharan Africa are at risk of trypanosomatid infections. Researchers have identified a class of cyanotriazoles (CTs) that have potent trypanocidal activity and can potentially be used for the treatment of Chagas disease and human African trypanosomiasis. These CT compounds act by selectively and irreversibly inhibiting trypanosomal topoisomerase II and stabilizing DNA:enzyme cleavage complexes.
