Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain

Synthesis and structure–activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel

(2014) Nuno Rodrigues et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel

(2014) J. Kyle Bruner et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The LQLP Calcineurin Docking Site Is a Major Determinant of the Calcium-dependent Activation of Human TRESK Background K+Channel

(2014) Gábor Czirják et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons

(2014) Zhaohua Guo et al.   JOURNAL OF NEUROPHYSIOLOGY

TREK2 Expressed Selectively in IB4-Binding C-Fiber Nociceptors Hyperpolarizes Their Membrane Potentials and Limits Spontaneous Pain

(2014) C. Acosta et al.   JOURNAL OF NEUROSCIENCE

Regulating excitability of peripheral afferents: emerging ion channel targets

(2014) Stephen G Waxman et al.   NATURE NEUROSCIENCE

Over-Expression of TRESK K+ Channels Reduces the Excitability of Trigeminal Ganglion Nociceptors

(2014) Zhaohua Guo et al.   PLoS One

Opening paths to novel analgesics: the role of potassium channels in chronic pain

(2014) Christoforos Tsantoulas et al.   TRENDS IN NEUROSCIENCES

Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18

(2014) arslan sehgal et al.   Drug Design Development and Therapy

Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation

(2014) Cruz Morenilla-Palao et al.   Cell Reports

A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels

(2013) Sviatoslav N. Bagriantsev et al.   ACS Chemical Biology

Cloxyquin (5-chloroquinolin-8-ol) is an activator of the two-pore domain potassium channel TRESK

(2013) Paul D. Wright et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential

(2013) Xiaona Du et al.   Current Neuropharmacology

Analysis of 3 common polymorphisms in the KCNK18 gene in an Australian Migraine Case-control cohort

(2013) B.H. Maher et al.   GENE

Functional Analysis of a Migraine-Associated TRESK K+ Channel Mutation

(2013) P. Liu et al.   JOURNAL OF NEUROSCIENCE

A ‘toothache tree’ alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain

(2013) Makoto Tsunozaki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression of background potassium channels in rat DRG is cell-specific and down-regulated in a neuropathic pain model

(2013) Sarah L. Pollema-Mays et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Intrathecal TRESK gene recombinant adenovirus attenuates spared nerve injury-induced neuropathic pain in rats

(2013) Jun Zhou et al.   NEUROREPORT

SuperPain—a resource on pain-relieving compounds targeting ion channels

(2013) Björn O. Gohlke et al.   NUCLEIC ACIDS RESEARCH

Flufenamic acid as an ion channel modulator

(2013) Romain Guinamard et al.   PHARMACOLOGY & THERAPEUTICS

Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel

(2013) S. G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of TREK-1 by morphine results in analgesia without adverse side effects

(2013) Maïly Devilliers et al.   Nature Communications

Identification of blocker binding site in mouse TRESK by molecular modeling and mutational studies

(2012) Songmi Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1

(2012) Markus Rapedius et al.   Channels

Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains

(2012) Sviatoslav N Bagriantsev et al.   EMBO JOURNAL

Leak K+ channel mRNAs in dorsal root ganglia: Relation to inflammation and spontaneous pain behaviour

(2012) Barnaby Marsh et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Imiquimod Enhances Excitability of Dorsal Root Ganglion Neurons by Inhibiting Background (K2P) and Voltage-Gated (Kv1.1 and Kv1.2) Potassium Channels

(2012) Jaekwang Lee et al.   Molecular Pain

Optical Control of Endogenous Proteins with a Photoswitchable Conditional Subunit Reveals a Role for TREK1 in GABAB Signaling

(2012) Guillaume Sandoz et al.   NEURON

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1

(2012) A. N. Miller et al.   SCIENCE

Functional analysis of missense variants in the TRESK (KCNK18) K+ channel

(2012) Isabelle Andres-Enguix et al.   Scientific Reports

A Role for K2P Channels in the Operation of Somatosensory Nociceptors

(2012) Leigh D. Plant   Frontiers in Molecular Neuroscience

Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel

(2011) E-J Kim et al.   Acta Physiologica

Colitis decreases mechanosensitive K2P channel expression and function in mouse colon sensory neurons

(2011) Jun-Ho La et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

PKC-dependent activation of human K2P18.1 K+ channels

(2011) Ann-Kathrin Rahm et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular regulations governing TREK and TRAAK channel functions

(2011) Jacques Noël et al.   Channels

The pore structure and gating mechanism of K2P channels

(2011) Paula L Piechotta et al.   EMBO JOURNAL

Multiple modalities converge on a common gate to control K2Pchannel function

(2011) Sviatoslav N Bagriantsev et al.   EMBO JOURNAL

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors

(2011) Juliette Descoeur et al.   EMBO Molecular Medicine

External Ba2+Block of the Two-pore Domain Potassium Channel TREK-1 Defines Conformational Transition in Its Selectivity Filter

(2011) Xiao-Yun Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRESK Channel Contribution to Nociceptive Sensory Neurons Excitability: Modulation by Nerve Injury

(2011) Astrid Tulleuda et al.   Molecular Pain

TREK-1 isoforms generated by alternative translation initiation display different susceptibility to the antidepressant fluoxetine

(2011) Michaela Eckert et al.   NEUROPHARMACOLOGY

Chemoselective regulation of TREK2 channel: Activation by sulfonate chalcones and inhibition by sulfonamide chalcones

(2010) Eun-Jin Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dominant Negative Effects of a Non-conducting TREK1 Splice Variant Expressed in Brain

(2010) Emma L. Veale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Basis of Tingling Paresthesia Evokedby Hydroxy- -Sanshool

(2010) R. C. Lennertz et al.   JOURNAL OF NEUROSCIENCE

Ion channels as novel therapeutic targets in the treatment of pain

(2010) Alistair Mathie   JOURNAL OF PHARMACY AND PHARMACOLOGY

SYMPOSIUM REVIEW: Gating of two pore domain potassium channels

(2010) Alistair Mathie et al.   JOURNAL OF PHYSIOLOGY-LONDON

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura

(2010) Ronald G Lafrenière et al.   NATURE MEDICINE

Molecular Background of Leak K+ Currents: Two-Pore Domain Potassium Channels

(2010) Péter Enyedi et al.   PHYSIOLOGICAL REVIEWS

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Mammalian somatosensory mechanotransduction

(2009) Makoto Tsunozaki et al.   CURRENT OPINION IN NEUROBIOLOGY

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception

(2009) Jacques Noël et al.   EMBO JOURNAL

Gating the pore of potassium leak channels

(2009) Asi Cohen et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Activation of Lumbar Spinal Wide-Dynamic Range Neurons by a Sanshool Derivative

(2009) Carolyn M. Sawyer et al.   JOURNAL OF NEUROPHYSIOLOGY

Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system

(2009) SieHyeon Yoo et al.   NEUROSCIENCE LETTERS

Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells

(2009) Yoshio Yamamoto et al.   NEUROSCIENCE LETTERS

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue

(2009) G. Sandoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechano-gated K2P channel TREK-1

(2008) Alexandra Dedman et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Phosphorylation-dependent Binding of 14-3-3 Proteins Controls TRESK Regulation

(2008) Gábor Czirják et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pain-associated signals, acidosis and lysophosphatidic acid, modulate the neuronal K2P2.1 channel

(2008) Asi Cohen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

(2008) Diana M Bautista et al.   NATURE NEUROSCIENCE

Thrilling Moment of an Inhibitory Channel

(2008) Shi-Bing Yang et al.   NEURON

Alternative Translation Initiation in Rat Brain Yields K2P2.1 Potassium Channels Permeable to Sodium

(2008) Dierk Thomas et al.   NEURON

Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact

(2008) Douglas A. Bayliss et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Roles of TRESK, a novel two-pore domain K+ channel, in pain pathway and general anesthesia

(2008) Dong-Yue Huang et al.   Neuroscience Bulletin

mGlu4 potentiation of K2P2.1 is dependant on C-terminal dephosphorylation

(2007) Stuart M. Cain et al.   MOLECULAR AND CELLULAR NEUROSCIENCE