Article
Environmental Sciences
Carolina Olguin-Jacobson, Kylie A. Pitt, Anthony R. Carroll, Steven D. Melvin
Summary: This study investigated the carry-over effects on Aurelia coerulea jellyfish, detecting subtle effects in two metabolites. Although these carry-over effects were not immediately reflected in other response variables, they could potentially have negative physiological consequences on the jellyfish in the long-term.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Jiawen Cui, Zhiyu Hao, Qin Zhou, Minna Qiu, Yuhang Liu, Yuhao Liu, Xiaohua Teng, Lu Kang
Summary: Water pollution caused by the widely used agricultural pesticide chlorpyrifos has led to public concern. This study investigates the effect of chlorpyrifos on the livers of common carp, revealing that it induces liver injury and mitochondrial dysfunction through the activation of autophagy and mitophagy. Additionally, chlorpyrifos disrupts energy metabolism, activates oxidative stress, and causes time-dependent hepatotoxicity. These findings provide insights into the molecular mechanism of chlorpyrifos-induced hepatotoxicity and contribute to the evaluation of pesticide toxicity in aquatic organisms.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Dongfang Zhang, Weikai Ding, Wei Liu, Liuying Li, Gongming Zhu, Junguo Ma
Summary: Chlorpyrifos (CPF) and glyphosate (GLY) are widely used organophosphate insecticide and herbicide, respectively. This study found that exposure to CPF and GLY, alone or in combination, had toxic effects on the brain of carp, including inhibition of acetylcholinesterase and Na+/K+-ATPase activities, alterations in monoamine oxidase levels, decreased antioxidant enzyme activities, and accumulation of malondialdehyde. RNA-seq analysis revealed that exposure to CPF and GLY induced transcriptomic changes in the fish brain, with the combined exposure showing a greater impact than single exposure. These findings provide new insights into the molecular mechanisms of CPF and GLY in fish brains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Tong Xu, Qiaohan Liu, Dan Chen, Yanyan Liu
Summary: This study reveals that Atrazine exposure induces necroptosis and inflammation in the gills of common carp through the P450/ROS pathway. The findings provide valuable insights into the mechanism of Atrazine-induced injury in common carp.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jianqing Chen, Bing Shao, Jinliang Wang, Zhiqiang Shen, Honggui Liu, Shu Li
Summary: Chlorpyrifos exposure in common carp gills activated the MAPK/NF-kappa B/TNF-alpha pathway, leading to inflammatory injury and necroptosis with concentration dependency. This study provides valuable data for aquaculture and toxicological research on the toxic effects of CPF.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Fisheries
Meichen Gao, Huijun Zhu, Jinming Guo, Yutian Lei, Wenying Sun, Hongjin Lin
Summary: Atrazine, a commonly used herbicide, poses a threat to organisms and future generations by remaining in water sources, soil, and biological tissue. Tannic acid, found in gallnuts, has been shown to counteract heavy metal toxicity, antioxidant activity, and inflammation. This study investigates whether tannic acid can alleviate Atrazine-induced cytotoxicity and immune dysfunction in Grass carp hepatocytes. The results show that Atrazine exposure induces apoptosis, inflammation, and oxidative stress in the cells, but tannic acid treatment alleviates the toxic effects through the ROS/TNF-alpha/TNFR 1 pathway.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Meichen Gao, Naixi Yang, Yutian Lei, Wenyue Zhang, Huanyi Liu, Hongjin Lin
Summary: This study demonstrated that ATR exposure induced DNA damage and autophagy in grass carp hepatocytes through the NO/iNOS/NF-kappa B axis, resulting in immunotoxic effects and cell death.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Environmental Sciences
Mahdi Banaee, Antoni Sureda, Caterina Faggio
Summary: The study showed that Protexin supplementation has a protective effect against chlorpyrifos-induced oxidative stress and immunotoxicity in Cyprinus carpio.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Fisheries
Radek Machat, Lubomir Pojezdal, Jan Gebauer, Jan Matiasovic, Radek Tesarik, Hana Minarova, Nikola Hodkovicova, Martin Faldyna
Summary: The economic importance of common carp is increasing, but viral diseases pose a significant threat and cause economic losses in carp aquaculture. This study focuses on confirming the differences in early immune response to Koi herpesvirus (KHV) depending on resistance level. The differences in immune response were mainly detected at the protein expression level between highly resistant amur wild carp (AS) and highly susceptible koi carp (KOI).
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Environmental Sciences
Corentin Mit, Cleo Tebby, Tristan Gueganno, Anne Bado-Nilles, Remy Beaudouin
Summary: This study investigated the interactions of atrazine and chlorpyrifos mixtures on aquatic organisms using mechanistic mathematical models. The modeling focused on the inhibition of acetylcholinesterase by the chemicals, but synergistic effects could not be demonstrated in adult fish despite predictions from the model.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Fisheries
Linyi Bai, Guanliu Yu, Yujie Liu, Muhammad Aizaz, Guiwen Yang, Lei Chen
Summary: In this study, cITLN3 was cloned from common carp and found to play an important role in infection and bacterial stimulation, including bacterial aggregation, inhibition of bacterial proliferation, and potential involvement in intestinal integrity and Toll-like receptors signaling pathway activation.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Immunology
Zhiying Jia, Nan Wu, Xiaona Jiang, Heng Li, Jiaxin Sun, Mijuan Shi, Chitao Li, Yanlong Ge, Xuesong Hu, Weidong Ye, Ying Tang, Junwei Shan, Yingyin Cheng, Xiao-Qin Xia, Lianyu Shi
Summary: It was found that a breeding strain of common carp developed resistance to CyHV-3 infection through specific immune mechanisms. The study revealed the biological processes related to infection resistance and possible susceptible factors for CyHV-3.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Ning Suo, Zhi-Xiong Zhou, Jian Xu, Ding-Chen Cao, Bi-Yin Wu, Han-Yuan Zhang, Peng Xu, Zi-Xia Zhao
Summary: Hypoxia is an urgent problem in the aquaculture fish breeding industry that affects the economic benefits. This study tested the hypoxia tolerance of different strains of common carp and identified key factors for hypoxia tolerance through transcriptome sequencing analysis. The findings provide insights into the genetic mechanism for breeding high hypoxia tolerance in common carp.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Physical
Manviri Rani, Jyoti Yadav, Keshu, Uma Shanker
Summary: The synthesis of ZnO@CdS nanocomposite using a green method showed enhanced photocatalytic activity, efficient removal of pesticides, and potential for environmental applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Environmental Sciences
Jingbo Liu, Guangcheng Yang, Yanxia Gao, Xinran Li, Yuting Long, Shuling Wei, Yuxin Zhao, Shanshan Sun, Shujuan Gao
Summary: In this study, the effects of high-dose atrazine (ATZ) exposure on the liver transcriptome of juvenile common carp were analyzed. The results showed that ATZ exposure at different concentrations caused liver damage in juvenile carp, as indicated by changes in biochemical parameters and histopathological alterations. Comparative transcriptomics revealed alterations in the expression of lipid metabolism-related genes following high-dose ATZ exposure. Furthermore, a network analysis highlighted the complex relationship between high-dose ATZ-induced liver damage and key differentially expressed genes. These findings suggest that impaired lipid metabolism is the primary molecular mechanism underlying ATZ-triggered hepatotoxicity in juvenile carp.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jianwen Xu, Yafan Gong, Yue Sun, Jingzeng Cai, Qi Liu, Jun Bao, Jie Yang, Ziwei Zhang
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Article
Engineering, Environmental
Yingying Zheng, Guangliang Shi, Jingzeng Cai, Jie Yang, Yuan Zhang, Yafan Gong, Qi Liu, Dahai Yu, Ziwei Zhang
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Fisheries
Shuting Wang, Yirong Cao, Shengchen Wang, Jingzeng Cai, Ziwei Zhang
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Engineering, Environmental
Shufang Zheng, Shengchen Wang, Qiaojian Zhang, Ziwei Zhang, Shiwen Xu
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Marine & Freshwater Biology
Jianqing Chen, Dechun Chen, Jingxin Li, Yuanlong Liu, Xianhong Gu, Xiaohua Teng
Summary: Cadmium-induced damage in carp gills is associated with apoptosis, mainly involving oxidative stress, immunosuppression, and apoptosis-related genes. Cadmium exposure resulted in cadmium accumulation and apoptotic injury caused by mitochondrion, along with oxidative stress and immunosuppression mediated through the JNK-FoxO3a-PUMA pathway.
AQUATIC TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dechun Chen, Jiatian Liang, Chunyu Jiang, Di Wu, Bin Huang, Xiaohua Teng, You Tang
Summary: The study found that manganese (Mn) poisoning in chickens suppressed the expression levels of heat shock protein 40 and 60 genes, while increasing the expression levels of heat shock protein 27, 70, and 90 genes. In addition, Mn poisoning also damaged the myoid cells, spermatocytes, and Sertoli cells in chicken testes, and caused abnormal shapes and extensive vacuolation of mitochondria. This study provides new insights into the identification of manganese toxicity in chicken testes.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Engineering, Biomedical
Yuanhang Kong, Xin Zhang, Xinnan Ma, Leilei Wu, Dechun Chen, Bo Su, Daqian Liu, Xintao Wang
Summary: This study elucidates the role of the TLR4/PI3K/AKT signaling axis in Si-CaP-mediated osteogenic-angiogenic coupling. Si-CaP treatment upregulates TLR4 expression and AKT phosphorylation, activating the PI3K/AKT signaling pathway and promoting the expression of osteogenic and angiogenic-related genes. These findings provide new molecular mechanism support for the application of Si-CaP in bone tissue engineering.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Yuanhang Kong, Xinnan Ma, Xin Zhang, Leilei Wu, Dechun Chen, Bo Su, Daqian Liu, Xintao Wang
Summary: This study investigates the mechanism of Fructus Ligustri Lucidi (FLL) in promoting the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). By combining network pharmacological predictions and in vitro experiments, it is confirmed that FLL promotes BMSCs osteogenic differentiation by activating the PI3K/AKT signaling pathway. This research provides theoretical support for the clinical application of FLL in the treatment of bone formation deficiency.
Article
Biotechnology & Applied Microbiology
Dechun Chen, Guanghua Chen, Xin Zhang, Jingtao Chen, Jinmeng Li, Kunlong Kang, Weitao He, Yuanhang Kong, Leilei Wu, Bo Su, Kui Zhao, Daiwei Si, Xintao Wang
Summary: The study used digital light processing (DLP) printing technology to fabricate a novel porous 3D printed Si-CaP scaffold, which exhibited a uniform spatial structure, appropriate mechanical properties, and effective interior permeability. Compared to conventional Si-CaP ceramics, the 3D printed Si-CaP scaffold showed sustained release of ions and enhanced osteogenic effects, improving the adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Jiangying Lei, Xuan Ran, Minghao Guo, Jiahao Liu, Falong Yang, Dechun Chen
Summary: The aim of this study was to isolate Bacillus species with good probiotic properties from yak feces. Various tests were conducted on the isolated Bacillus, which included identification, antibacterial activity, tolerance, hydrophobicity, auto-aggregation, sensitivity, growth performance, antioxidants, and immune indexes. A safe and harmless Bacillus pumilus strain with high survival rate, hydrophobicity, auto-aggregation, and antibacterial activity was identified. Feeding mice with this strain promoted weight gain, improved gut health, and enhanced immune response. This study confirms the probiotic effects of Bacillus pumilus isolated from yak feces and provides a theoretical basis for clinical application and development of new feed additives.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Engineering, Chemical
Ruichao Zhang, Dechun Chen, Nu Lu, Bo Zhang, Yanjie Yang
Summary: This paper proposes a diagnosis model of working conditions based on feature recognition, which solves the problems of the lack of an electric power diagram atlas under different working conditions and the difficulty in intelligent diagnosis of variable torqued pumping unit wells. The mathematical relationship model between the polished rod load and motor output power is derived, and the electric power diagram can be calculated based on a dynamometer card. The electric power diagram atlas is created, and feature analysis is carried out to realize the direct diagnosis of the working conditions in the variable torque pumping unit wells.
Article
Chemistry, Multidisciplinary
Ruichao Zhang, Dechun Chen, Liangfei Xiao
Summary: A mathematical simulation model is established to study the effect of real-time frequency variation on a beam pumping system. Deep reinforcement learning theory is used to define key elements and construct an intelligent model for frequency modulation optimization. The results show that the model can significantly reduce fluctuations in various parameters and improve the stability and energy efficiency of the system. It also enables independent learning and control of parameters, enhancing the information and intelligent management of oil wells.
Article
Agriculture, Dairy & Animal Science
Haoyue Guan, Wenxue Ma, Qiong Wu, Jingzeng Cai, Ziwei Zhang
Summary: This study constructed an in vitro model of zearalenone toxicity in porcine small intestinal epithelial cells and conducted various tests. The results showed that zearalenone can cause oxidative stress, inflammatory response, and apoptosis in porcine small intestinal cells, causing damage to the intestinal tissues. The study of zearalenone's effects on the intestinal tract of swine is of great significance for the prevention and treatment of zearalenone infection in swine.
Article
Biochemistry & Molecular Biology
Haifeng Liu, Xinmiao Wang, Hongchuan Deng, Haocheng Huang, Yifan Liu, Zhijun Zhong, Liuhong Shen, Suizhong Cao, Xiaoping Ma, Ziyao Zhou, Dechun Chen, Guangneng Peng
Summary: Adipose-derived mesenchymal stem cells (ADMSCs) have shown significant therapeutic potential in treating liver fibrosis, reducing liver damage markers and improving liver lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Daiwei Si, Bo Su, Jingwei Zhang, Kui Zhao, JinMeng Li, DeChun Chen, ShiQi Hu, Xintao Wang
Summary: This study investigated the effects of low-level laser therapy (LLLT) using three different irradiation methods on the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in vitro. The results indicated that covering irradiation was the most favorable method for promoting BMSCs proliferation and osteogenic differentiation.
LASERS IN MEDICAL SCIENCE
(2022)
