4.7 Article

Di-(2-ethyl hexyl) phthalate induces necroptosis in chicken cardiomyocytes by triggering calcium overload

期刊

JOURNAL OF HAZARDOUS MATERIALS
卷 387, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.jhazmat.2019.121696

关键词

Di-(2-ethyl hexyl)phthalate; Necroptosis; Calcium; Taxifolin; Cardiomyocytes

资金

  1. National Natural Science Foundation of China [31872531, 31702282]
  2. Earmarked Fund for China Agriculture Research System [CARS 35-04]
  3. Merit-based Funding for Returned Oversea Student of Heilongjiang Province [2018QD0005]
  4. State key laboratory of animal nutrition [2004DA125184F1725]
  5. Postdoctoral Scientific Research Developmental Fund of Heilongjiang Province [LBH-Q18018]
  6. Academic backbone Project of Northeast Agricultural University [17XG11]

向作者/读者索取更多资源

Di-(2-ethyl hexyl)phthalate (DEHP) is a kind of plasticizer that can cause cardiovascular disorders in animals, but its specific mechanism of action has not been determined. We aimed to investigate whether taxifolin (TAX) can antagonize the cytotoxicity of DEHP on cardiomyocytes. Chicken cardiomyocytes were treated with DEHP (500 mu M) and/or TAX (0.5 mu M) for 24 h. Ca2+ staining showed that the concentration of Ca2+ in the cytoplasm of cardiomyocytes was significantly increased under DEHP stimulation. However, in the DEHP + TAX group, the Ca2+ concentration was largely restored. In addition, the results of necroptosis-fluorescent and flow cytometry analysis showed that the DEHP group had severe necroptosis compared with the control group. The necrotic rate in the DEHP + TAX group was significantly lower than that in the DEHP group. At the mRNA and protein levels, the expression of the necrotic-calcium pathway genes RIPK1, RIPK3, MLKL, FAS, Caspase-8, CAMKII, and SERCA in the DEHP group increased to varying degrees relative to the control group. However, TAX improved this injury. Compared with the DEHP group, the expression of these genes was significantly decreased in the DEHP + TAX group. The present study indicate that DEHP could trigger cardiomyocyte necroptosis through Ca2+ overload, which could be alleviated by TAX.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Biochemistry & Molecular Biology

Melatonin ameliorates trimethyltin chloride-induced cardiotoxicity: The role of nuclear xenobiotic metabolism and Keap1-Nrf2/ARE axis-mediated pyroptosis

Jingzeng Cai, Jie Yang, Xiaoming Chen, Haoran Zhang, Yue Zhu, Qi Liu, Ziwei Zhang

Summary: TMT induces cardiac damage, inflammation, and oxidative stress, while MT mitigates these adverse changes.

BIOFACTORS (2022)

Article Biochemistry & Molecular Biology

Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis

Qi Liu, Pengyue Du, Yue Zhu, Xintong Zhang, Jingzeng Cai, Ziwei Zhang

Summary: Txnrd3 overexpression leads to intracellular calcium outflow and increased ROS, which eventually leads to necrosis and focal death of colon cancer cells, while causing Txnrd3-/- mice depth of the crypt deeper, weakened intestinal secretion and immune function and aggravate the occurrence of ulcerative colitis.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Article Environmental Sciences

Cadmium induces apoptosis and autophagy in swine small intestine by downregulating the PI3K/Akt pathway

Haoran Zhang, Jiaqiang Huang, Jie Yang, Jingzeng Cai, Qi Liu, Xintong Zhang, Jun Bao, Ziwei Zhang

Summary: Cadmium (Cd) is an environmental contaminant known for its potential toxicity, particularly in accumulating in the liver and kidney and causing serious damage. In this study, Cd-induced intestinal damage in swine was investigated through in vivo and in vitro models. The research found that Cd treatment induced ileal apoptosis and autophagy in cells, activating the PI3K/Akt pathway, and altering expression levels of apoptosis and autophagy-related proteins. Furthermore, the study showed that treatment with a PI3K activator could mitigate the effects of Cd-induced apoptosis and autophagy.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

Article Fisheries

Cadmium regulates FKBP5 through miR-9-5p and induces carp lymphocyte apoptosis

Peixian Luan, Haoran Zhang, Xiaofeng Zhang, Guo Hu, Ziwei Zhang

Summary: The study revealed that cadmium induces carp head kidney lymphocyte damage through the regulatory pathway involving miR-9-5p and its target gene FKBP5.

FISH & SHELLFISH IMMUNOLOGY (2022)

Article Engineering, Environmental

Cadmium exposure triggers oxidative stress, necroptosis, Th1/Th2 imbalance and promotes inflammation through the TNF-α/NF-ΚB pathway in swine small intestine

Xiaoming Chen, Mingyu Bi, Jie Yang, Jingzeng Cai, Haoran Zhang, Yue Zhu, Yingying Zheng, Qi Liu, Guangliang Shi, Ziwei Zhang

Summary: The study revealed that cadmium induced toxic effects in pig intestines primarily through activating necroptosis and inflammation pathways, resulting in damage. Additionally, cadmium caused an imbalance in Th1/Th2 immunity, exacerbating inflammatory responses.

JOURNAL OF HAZARDOUS MATERIALS (2022)

Article Environmental Sciences

Melatonin relieves 2,2,4,4-tetrabromodiphenyl ether (BDE-47)-induced apoptosis and mitochondrial dysfunction through the AMPK-Sirt1-PGC-1α axis in fish kidney cells (CIK)

Peixian Luan, Haoran Zhang, Xiaoming Chen, Yue Zhu, Guo Hu, Jingzeng Cai, Ziwei Zhang

Summary: According to the experiment, melatonin treatment can alleviate oxidative stress, mitochondrial dysfunction, and apoptosis in CIK cells poisoned by BDE-47. These findings provide new insights into the mechanisms of BDE-47 poisoning and suggest that melatonin treatment may be a potential strategy for addressing BDE-47 poisoning.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Fisheries

Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte*

Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhang

Summary: Cadmium is a common environmental pollutant that has toxic effects on fish head kidney lymphocytes. This study utilized an in vitro Cd exposure model and antioxidant treatment to demonstrate that Cd induced lymphocyte apoptosis, which could be alleviated by antioxidants.

FISH & SHELLFISH IMMUNOLOGY (2022)

Article Pharmacology & Pharmacy

Melatonin ameliorates nickel induced autophagy in mouse brain: Diminution of oxidative stress

Senqiu Qiao, Yue Sun, Yangyang Jiang, Xiaoming Chen, Jingzeng Cai, Qi Liu, Ziwei Zhang

Summary: This study found that oxidative stress is the main mechanism behind nickel neurotoxicity. Nickel induced oxidative stress damage and autophagy in the mouse brain, but melatonin was able to intervene and protect the nervous system.

TOXICOLOGY (2022)

Article Biochemistry & Molecular Biology

The protective effect of selenoprotein M on non-alcoholic fatty liver disease: the role of the AMPKα1-MFN2 pathway and Parkin mitophagy

Jingzeng Cai, Jiaqiang Huang, Jie Yang, Xiaoming Chen, Haoran Zhang, Yue Zhu, Qi Liu, Ziwei Zhang

Summary: This study reveals the role of selenoprotein M (SELENOM) in maintaining mitophagy in high-fat diet-induced non-alcoholic fatty liver disease (NAFLD). SELENOM downregulation aggravates hepatic steatosis, inflammation, and fibrosis, while reducing mitophagy and increasing mitochondrial apoptosis. SELENOM overexpression activates Parkin-mediated mitophagy, reducing mitochondrial apoptosis and removing damaged mitochondria.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Article Medicine, Research & Experimental

Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1/NF-kB/NLRP3 and PERK/TGF-β1 axis activation

Qi Liu, Yue Sun, Yue Zhu, Senqiu Qiao, Jingzeng Cai, Ziwei Zhang

Summary: Nickel exposure leads to liver dysfunction and fibrosis, which is exacerbated by Txnrd3 knockout. Melatonin, with its antioxidant effects, can mitigate oxidative damage caused by nickel exposure.

LIFE SCIENCES (2022)

Article Environmental Sciences

Role of Txnrd3 in NiCl2-induced kidney cell apoptosis in mice: Potential therapeutic effect of melatonin

Lihua Xu, Haoyue Guan, Xintong Zhang, Senqiu Qiao, Wenxue Ma, Pinnan Liu, Qiaohan Liu, Yue Sun, Yue Liu, Jingzeng Cai, Ziwei Zhang

Summary: This study investigates the roles of Melatonin (Mel) and Thioredoxin reductase 3 (Txnrd3) in the treatment of nickel-induced renal injury. The results suggest that Mel improves oxidative stress and apoptosis induced by nickel by regulating Txnrd3 expression, thus reducing kidney damage.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2023)

Article Fisheries

New insights into Microalgal astaxanthin's effect on Lambda-cyhalothrin-induced lymphocytes immunotoxicity in Cyprinus carpio: Involving miRNA-194-5p-FoxO1-mediated-mitophagy and pyroptosis

Jingzeng Cai, Haoyue Guan, Di Li, Bendong Shi, Yangyang Jiang, Senqiu Qiao, Qiaohan Liu, Cheng Fang, Ziwei Zhang

Summary: This study investigated the immunotoxicity of Lambda-cyhalothrin (LC), a widely used insecticide, on lymphocytes and the potential protective effect of Microalgal astaxanthin (MA). The results showed that MA attenuated LC-induced lymphocyte death and improved mitochondrial damage caused by LC exposure. MA also upregulated mitophagy-related factors and decreased pyroptosis-related gene expression. These findings suggest that MA can enhance damaged mitochondrial elimination, reduce mtROS accumulation, and alleviate pyroptosis in lymphocytes. Hence, the application of MA in aquaculture and the defense against agrobiological hazards are of great importance.

FISH & SHELLFISH IMMUNOLOGY (2023)

Article Food Science & Technology

Txnrd3 knockout enhancement of lung injury induced by Ni exposure via the VEGF-VEGFR-2 axis and alleviation of this effect by melatonin

Pinnan Liu, Yue Sun, Senqiu Qiao, Wenxue Ma, Lihua Xu, Yue Liu, Xiaoxue Gai, Qiaohan Liu, Jingzeng Cai, Ziwei Zhang

Summary: Exposure to nickel can cause respiratory diseases in mice. Melatonin has been shown to have a protective effect on lung tissue by regulating inflammation-related factors and activating the VEGF signaling pathway.

FOOD AND CHEMICAL TOXICOLOGY (2023)

Article Biochemistry & Molecular Biology

Cypermethrin induces apoptosis, autophagy and inflammation via ERS-ROS-NF-κB axis in hepatocytes of carp (Cyprinus carpio)

Di Li, Kaixuan Zhang, Chenchen Xu, Yangyang Jiang, Jianhua Shan, Ziwei Zhang, Jingzeng Cai

Summary: This study found that CYP exposure caused endoplasmic reticulum stress in carp hepatocytes, resulting in apoptosis, autophagy, and inflammation. The expression levels of related genes also showed dose-dependent changes.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2023)

Article Agriculture, Dairy & Animal Science

Exploring the Toxic Effects of ZEA on IPEC-J2 Cells from the Inflammatory Response and Apoptosis

Haoyue Guan, Wenxue Ma, Qiong Wu, Jingzeng Cai, Ziwei Zhang

Summary: This study constructed an in vitro model of zearalenone toxicity in porcine small intestinal epithelial cells and conducted various tests. The results showed that zearalenone can cause oxidative stress, inflammatory response, and apoptosis in porcine small intestinal cells, causing damage to the intestinal tissues. The study of zearalenone's effects on the intestinal tract of swine is of great significance for the prevention and treatment of zearalenone infection in swine.

ANIMALS (2023)

Article Engineering, Environmental

Temperature-modulated sensing characteristics of ultrafine Au nanoparticle-loaded porous ZnO nanobelts for identification and determination of BTEX

Shun-Shun Chen, Xu-Xiu Chen, Tian-Yu Yang, Li Chen, Zheng Guo, Xing-Jiu Huang

Summary: A temperature-modulated sensing strategy was proposed to identify and determine BTEX compounds. Highly effective identification of BTEX was achieved using linear discrimination and convolutional neural network analyses. Additionally, quantitative analysis of concentration was accomplished by establishing the relationship between concentration and response.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease

Myungkyung Noh, Jeong Yeon Sim, Jisung Kim, Jee Hwan Ahn, Hye-Young Min, Jong-Uk Lee, Jong-Sook Park, Ji Yun Jeong, Jae Young Lee, Shin Yup Lee, Hyo-Jong Lee, Choon-Sik Park, Ho-Young Lee

Summary: This study reveals that chronic exposure to PM induces chronic inflammation and development of COPD by dysregulating NAD+ metabolism and subsequent SIRT1 deficiency in pulmonary macrophages. Activation of SIRT1 by resveratrol effectively mitigates PM-induced inflammation and COPD development. Targeting metabolic and epigenetic reprogramming in macrophages induced by PM is a promising strategy for COPD treatment.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Electrocatalytic degradation of nitrogenous heterocycles on confined particle electrodes derived from ZIF-67

Yu Liu, Linlin Qin, Yiming Qin, Tong Yang, Haoran Lu, Yulong Liu, Qiqi Zhang, Wenyan Liang

Summary: Co/NC/PAC electrode was prepared by compounding ZIF-67 with powder-activated carbon for the electrocatalytic treatment of nitrogen-containing heterocyclic compounds. The degradation efficiency of the four compounds reached 90.2-93.7% under optimal conditions, and the degradation order was pyridazine < pyrimidine < pyrazine < pyridine.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Yttrium speciation variability in bauxite residues of various origins, ages and storage conditions

Julien Couturier, Pierre Tamba Oulare, Blanche Collin, Claire Lallemand, Isabelle Kieffer, Julien Longerey, Perrine Chaurand, Jerome Rose, Daniel Borschneck, Bernard Angeletti, Steven Criquet, Renaud Podor, Hamed Pourkhorsandi, Guilhem Arrachart, Clement Levard

Summary: This study analyzes the properties of bauxite residue samples and explores the influence of bauxite ore origin, storage conditions, and storage time. The results show that the speciation of yttrium is related to the origin of bauxite ore, while no significant variation was observed with storage conditions or aging of the residues.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Trophic transfer and their impact of microplastics on estuarine food chain model

Sakthinarenderan Saikumar, Ravi Mani, Mirunalini Ganesan, Inbakandan Dhinakarasamy, Thavamani Palanisami, Dharani Gopal

Summary: Microplastic contamination in marine ecosystems poses a growing concern due to its trophic transfer and negative effects on marine organisms. This study investigates the transfer and impacts of polystyrene microplastics in an estuarine food chain. The results show that microplastics can be transferred through the food chain, although the transfer rates are low. The exposed organisms exhibit stress responses, suggesting the potential risk of microplastics reaching humans through the food chain.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Review Engineering, Environmental

Antibiotic resistance genes and heavy metals in landfill: A review

Yan-Jiao Li, Ying Yuan, Wen-Bing Tan, Bei-Dou Xi, Hui Wang, Kun-Long Hui, Jia-Bao Chen, Yi-Fan Zhang, Lian-Feng Wang, Ren-Fei Li

Summary: This review investigated and analyzed the distribution, composition, and abundance of heavy metals and antibiotic resistance genes (ARGs) in landfill. The results showed that heavy metals have lasting effects on ARGs, and complexes of heavy metals and organic matter are common in landfill. This study provides a new basis to better understand the horizontal gene transfer (HGT) of ARGs in landfill.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

The effect of synthesis conditions on the in situ grown MIL-100(Fe)-chitosan beads: Interplay between structural properties and arsenic adsorption

Jessy Joseph, Ari Vaisanen, Ajay B. Patil, Manu Lahtinen

Summary: Efficient and environmentally friendly porous hybrid adsorbent beads have been developed for the removal of arsenic from drinking water. The structural tuning of the adsorbents has been shown to have a significant impact on their adsorption performance, with high crystallinity leading to increased adsorption capacity and selectivity towards As5+.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Phthalate metabolites in breast milk from mothers in Southern China: Occurrence, temporal trends, daily intake, and risk assessment

Yangyang Liu, Minhua Xiao, Kaiqin Huang, Juntao Cui, Hongli Liu, Yingxin Yu, Shengtao Ma, Xihong Liu, Meiqing Lin

Summary: This study measured the levels of phthalate metabolites in breast milk collected from mothers in southern China. The results showed that phthalates are still prevalent in the region, and breastfeeding contributes to phthalate intake in infants. However, the levels detected do not pose significant health risks to infants based on dietary exposure. The increasing exposure to certain phthalates calls for further research into their sources and potential risks.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Depth significantly affects plastisphere microbial evenness, assembly and co-occurrence pattern but not richness and composition

Zhiqiang Wu, Jianxing Sun, Liting Xu, Hongbo Zhou, Haina Cheng, Zhu Chen, Yuguang Wang, Jichao Yang

Summary: Ocean depth affects microbial diversity, composition, and co-occurrence patterns of microplastic microbial communities. Deterministic processes dominate the assembly of mesopelagic plastisphere microbial communities, while stochastic processes shape the assembly of bathypelagic microbial communities. The relationships between microorganisms in the mesopelagic layer are more complex and stable, with Proteobacteria and Actinobacteriota playing important roles.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Abatement of antibiotics and resistance genes during catalytic ozonation enhanced sludge dewatering process: Synchronized in volume and hazardousness reduction

Tingting Xiao, Renjie Chen, Chen Cai, Shijie Yuan, Xiaohu Dai, Bin Dong, Zuxin Xu

Summary: Based on the efficiency of catalytic ozonation techniques in enhancing sludge dewaterability, this study investigated its effectiveness in simultaneous reduction of antibiotics and antibiotic resistance genes. The results showed that catalytic ozonation conditioning changed the distribution of antibiotics and achieved high degradation rates. It also significantly reduced the abundance of ARGs, inhibited horizontal gene transfer, and decreased the signal transduction of typical ARGs host bacteria.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Unlocking the potential of ferrate(VI) in water treatment: Toward one-step multifunctional solutions

Yang Deng, Xiaohong Guan

Summary: This article discusses two different development approaches for ferrate(VI) technology in water treatment, arguing that process integration is a promising method that can drive technological innovation and revolution in water treatment, achieving higher treatment efficiency, reduced costs and energy consumption, and a smaller physical footprint.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Floating Catalytic Foam with prominent heat-induced convection for the effective photocatalytic removal of antibiotics

Zhe Zhang, Lu Zhang, Zhihao Huang, Yuxin Xu, Qingqing Zhao, Hongju Wang, Meiqing Shi, Xiangnan Li, Kai Jiang, Dapeng Wu

Summary: In this study, a floating catalytic foam was designed and prepared to enhance the mass transfer in immobilized photocatalysts for wastewater treatment. The floating catalytic foam could float on the water surface and establish a temperature gradient, effectively promoting the diffusion and adsorption of target molecules during the photocatalytic process.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Mechanism and synergistic effect of sulfadiazine (SDZ) and cadmium toxicity in spinach (Spinacia oleracea L.) and its alleviation through zinc fortification

Muhammad Nafees, Adiba Khan Sehrish, Sarah Owdah Alomrani, Linlin Qiu, Aasim Saeed, Shoaib Ahmad, Shafaqat Ali, Hongyan Guo

Summary: The accumulation of cadmium and antibiotics in edible plants and fertile soil is a worldwide problem. This study investigated the potential of zinc oxide nanoparticles to alleviate the toxicity of both cadmium and antibiotics and promote spinach growth.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Aminoalkyl organosilicon with dual chemical sites for SO2 absorption and analysis of site-specific absorption entropy and enthalpy

Lurui Wan, Kai Wang, Yuan Chen, Zhiyong Xu, Wenbo Zhao

Summary: In this study, a low viscosity and high thermal stability SO2 absorbent with dual interacting sites was successfully synthesized. The absorbent showed the highest absorption enthalpy change and entropy change values among reported SO2 absorbents, and exhibited lower viscosity and comparable thermal stability to ILs.

JOURNAL OF HAZARDOUS MATERIALS (2024)

Article Engineering, Environmental

Improvement of Fe(III)/percarbonate system by molybdenum powder and tripolyphosphate: Co-catalytic performance, low oxidant consumption, pH-dependent mechanism

Zhengwei Zhou, Guojie Ye, Yang Zong, Zhenyu Zhao, Deli Wu

Summary: This study utilized Mo powder and STPP to enhance the performance of the sodium percarbonate system in pollutant degradation. The presence of Mo and STPP resulted in a higher degradation rate of the model pollutant SMX, with low oxidant consumption. The system generated multiple active species through a series of chain reactions at different pH values, exhibiting excellent performance towards electron-rich pollutants. Furthermore, Mo demonstrated excellent stability and reusability.

JOURNAL OF HAZARDOUS MATERIALS (2024)