Review
Pediatrics
Rebecca Alison Fabricius, Camilla Birgitte Sorensen, Liselotte Skov, Nanette Mol Debes
Summary: Cytokines play an important role in pediatric OCD and/or movement disorder symptoms, with significant changes in the immune system of patients with these symptoms. Many cytokines show significant alterations in children with these symptoms, particularly TNF-alpha, IL-1 beta, and IL-17.
FRONTIERS IN PEDIATRICS
(2022)
Article
Clinical Neurology
Isabella Rea, Cristiana Alessia Guido, Alberto Spalice
Summary: The study revealed clinical differences between PANDAS and PANS patients in terms of symptoms and laboratory findings, with PANS patients exhibiting more irritability, aggressivity, and food restriction, while PANDAS patients had higher levels of anti-streptolysin O and anti-DNAse B.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Antonella Gagliano, Alessandra Carta, Marcello G. Tanca, Stefano Sotgiu
Summary: Pediatric acute-onset neuropsychiatric syndrome (PANS) is characterized by a constellation of acute symptoms followed by a chronic course. Recent research has focused on clinical and pathophysiological aspects of PANS, as well as strategies for disease management. The importance of a comprehensive approach to treatment and the role of neuro-inflammation in psychiatric disorders are highlighted. This article is rated 7 out of 10 in terms of importance.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Review
Biochemistry & Molecular Biology
Nicolas Lamanna-Rama, Diego Romero-Miguel, Manuel Desco, Maria Luisa Soto-Montenegro
Summary: Curcumin, a therapeutic compound with antioxidant, anti-inflammatory, and neuroprotective properties, has been studied in preclinical and clinical trials for psychiatric disorders. While there are some positive results reported, the limited number of trials and protocol heterogeneity make it difficult to draw solid conclusions about the real efficacy of curcumin in psychiatric disorders.
Article
Immunology
Hannah F. Jones, Velda X. Han, Shrujna Patel, Brian S. Gloss, Nicolette Soler, Alvin Ho, Suvasini Sharma, Kavitha Kothur, Margherita Nosadini, Louise Wienholt, Chris Hardwick, Elizabeth H. Barnes, Jacqueline R. Lim, Sarah Alshammery, Timothy C. Nielsen, Melanie Wong, Markus J. Hofer, Natasha Nassar, Wendy Gold, Fabienne Brilot, Shekeeb S. Mohammad, Russell C. Dale
Summary: Genetic variation is a major risk factor for neurodevelopmental disorders, but environmental factors during pregnancy and early life also play a significant role. Studies show that mothers and families of children with tic disorders and OCD have higher rates of autoimmune diseases and other pro-inflammatory states, implying a potential link between maternal inflammation and childhood neurodevelopmental disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Clinical Neurology
Natalia Szejko, Kirsten R. Muller-Vahl
Summary: Tourette syndrome (TS) is characterized by vocal and motor tics, often accompanied by psychiatric comorbidities. Differential diagnosis between tics and OCD-related phenomena can be challenging, as some symptoms may overlap. "Just right" phenomena are common in patients with TS, showing similarities with both tics and OCD. Treatment strategies for tics and OCD in TS patients should take into consideration these complexities.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Psychiatry
Giuseppe Fanelli, Barbara Franke, Ward De Witte, I. Hyun Ruisch, Jan Haavik, Veerle van Gils, Willemijn J. Jansen, Stephanie J. B. Vos, Lars Lind, Jan K. Buitelaar, Tobias Banaschewski, Soren Dalsgaard, Alessandro Serretti, Nina Roth Mota, Geert Poelmans, Janita Bralten
Summary: The prevalence of somatic insulinopathies, such as metabolic syndrome, obesity, and type 2 diabetes mellitus, is higher in Alzheimer's disease, autism spectrum disorder, and obsessive-compulsive disorder. There is a genetic overlap between these neuropsychiatric disorders and insulin-related diseases/traits, indicating a potential shared genetic mechanism.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: This study revealed a bidirectional longitudinal relationship between eating disorders and obsessive-compulsive disorder, particularly in terms of cognitive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: The study found a bidirectional, longitudinal relationship between symptoms of eating disorders (ED) and obsessive-compulsive disorder (OCD), particularly in terms of cognitive symptoms. However, this longitudinal association was only present at certain time points.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medicine, Research & Experimental
Dalia Dop, Iulia Rahela Marcu, Rodica Padureanu, Carmen Elena Niculescu, Vlad Padureanu
Summary: PANDAS is clinically characterized by sudden onset of obsessive-compulsive manifestations, motor and verbal tics, and other behavioral symptoms in children with streptococcal infection. It is considered an autoimmune disease with molecular mimicry as the most frequent physiopathological mechanism. Diagnosis relies on clinical presentation and detailed medical history, while treatment options are complex.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Psychology, Developmental
Kira Panzer, Alexis Harmon, Reginald Lerebours, Linmarie Sikich, Samuel Pullen, Heather Van Mater
Summary: This study aimed to explore the differences in autoimmune encephalitis (AE) features between neurodevelopmental disorder (NDD) patients and typically developing (TD) children. The results showed that NDD children with AE had similar clinical domains and treatment response compared to TD children.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Behavioral Sciences
Jon E. Grant, Samuel R. Chamberlain
Summary: This study examined the presence of autistic traits in adults with trichotillomania and found a higher rate of probable ASD. The results highlight the importance of screening for autistic traits in individuals with trichotillomania.
BRAIN AND BEHAVIOR
(2022)
Article
Pediatrics
Sarah L. L. O'Dor, Saffron Homayoun, Olivia M. M. Downer, Mary A. A. Hamel, Julia S. S. Zagaroli, Kyle A. A. Williams
Summary: This study describes the comorbid medical and psychiatric conditions in a self-referred cohort of pediatric patients with PANS/PANDAS, along with the high prevalence of autoimmune and psychiatric conditions in family members. The caregivers of these patients experience elevated levels of burden, stress, anxiety, and depression.
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2022)
Article
Biology
Razieh Avan, Adeleh Sahebnasagh, Javad Hashemi, Mahila Monajati, Fatemeh Faramarzi, Neil C. Henney, Fabrizio Montecucco, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Statins are widely accepted as first-line agents for preventing lipid-related cardiovascular diseases. They have shown potential protective effects against major depressive disorder and schizophrenia, as well as significant positive effects in anxiety disorders. However, further research is needed to confirm their effectiveness in other neuropsychiatric disorders.
Article
Clinical Neurology
Jose Fidel Baizabal-Carvallo, Marlene Alonso-Juarez, Joseph Jankovic
Summary: This study found that dystonic tics are present in about a third of patients with Tourette syndrome (TS) and are associated with increased severity of TS.
JOURNAL OF NEUROLOGY
(2022)
Article
Orthopedics
Noam Ben-Eliezer, Jose G. Raya, James S. Babb, Thomas Youm, Daniel K. Sodickson, Riccardo Lattanzi
Summary: A new study proposed a normalized T2-index method to evaluate cartilage in FAI patients, showing high accuracy in detecting cartilage lesions. Normalizing T2 values was found to be important to address interpatient variability, and the T2-index may be a promising biomarker for cartilage lesion detection in FAI. Further research is needed to explore the combination of T2-index with morphologic MRI and other quantitative biomarkers to improve cartilage assessment in FAI.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sahar Semaan, Naik Vietti Violi, Sara Lewis, Manjil Chatterji, Christopher Song, Cecilia Besa, James S. Babb, M. Isabel Fiel, Myron Schwartz, Swan Thung, Claude B. Sirlin, Bachir Taouli
EUROPEAN RADIOLOGY
(2020)
Article
Neurosciences
Faye McKenna, James Babb, Laura Miles, Donald Goff, Mariana Lazar
Article
Geriatrics & Gerontology
Jian W. Dong, Ileana O. Jelescu, Benjamin Ades-Aron, Dmitry S. Novikov, Kent Friedman, James S. Babb, Ricardo S. Osorio, James E. Galvin, Timothy M. Shepherd, Els Fieremans
NEUROBIOLOGY OF AGING
(2020)
Article
Oncology
Sushma Gaddam, Samantha L. Heller, James S. Babb, Yiming Gao
Summary: Breast cancer screening recommendations vary widely among high-risk men, with most undergoing clinical breast examination and only a minority undergoing mammography screening.
CLINICAL BREAST CANCER
(2021)
Article
Clinical Neurology
Simona Schiavi, Maria Petracca, Peng Sun, Lazar Fleysher, Sirio Cocozza, Mohamed Mounir El Mendili, Alessio Signori, James S. Babb, Kornelius Podranski, Sheng-Kwei Song, Matilde Inglese
Summary: This study investigated the feasibility of diffusion basis spectrum imaging in multiple sclerosis at 7 T, identifying significant differences in various diffusion metrics between different types of lesions and normal appearing white matter. The study also found associations between certain diffusion metrics and clinical measures, suggesting the potential clinical relevance of diffusion basis spectrum imaging in monitoring disease progression and treatment response in multiple sclerosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher J. Burke, Mohammad Samim, Hamza Alizai, Julien Sanchez, Dallas Kingsbury, James S. Babb, William R. Walter
Summary: This study evaluated the utility of a 2D dynamic HASTE sequence in assessing cervical spine flexion-extension, specifically comparing dynamic spondylolisthesis to radiographs and assessing dynamic contact or deformity of the cord. The results showed good agreement in evaluating dynamic spondylolisthesis and cord deformity using the dynamic HASTE sequence.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lea Azour, William H. Moore, Thomas O'Donnell, Mylene T. Truong, James Babb, Bowen Niu, Andreas Wimmer, Saman Kiumehr, Jane P. Ko
Summary: This study evaluated the inter-observer consistency of radiomic features for subsolid pulmonary nodules. The results showed that some features had high consistency among observers, and nodule morphology influenced both feature consistency and segmentation accuracy.
ACADEMIC RADIOLOGY
(2022)
Article
Geriatrics & Gerontology
Ivan I. Kirov, Marc Sollberger, Matthew S. Davitz, Lidia Glodzik, Brian J. Soher, James S. Babb, Andreas U. Monsch, Achim Gass, Oded Gonen
Summary: In a study involving older and younger adults, MRI scans showed that while brain tissue atrophy was present with age, neuronal integrity, as reflected by WBNAA, did not remain preserved in normal aging. Women showed less brain atrophy compared to men across all age groups.
NEUROBIOLOGY OF AGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anastasia Plaunova, Samantha L. Heller, James S. Babb, Cathleen C. Heffernan
Summary: The COVID-19 pandemic has disproportionately affected female academic radiologists by increasing their household responsibilities and reducing their work productivity.
Female academic radiologists with young children reported a significant decrease in productivity, while male counterparts reported having more time for productivity.
ACADEMIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lea Azour, Sharon Steinberger, Danielle Toussie, Ruwanthi Titano, Nina Kukar, James Babb, Adam Jacobi
Summary: In this study, the distribution of Agatston score severity categories differed in codominant versus right- or left-dominant patients, but there was no significant difference in Agatston score based on coronary dominance pattern in the cohort.
Article
Clinical Neurology
Teresa Gerhalter, Anna M. Chen, Seena Dehkharghani, Rosemary Peralta, Fatemeh Adlparvar, James S. Babb, Tamara Bushnik, Jonathan M. Silver, Brian S. Im, Stephen P. Wall, Ryan Brown, Steven H. Baete, Ivan I. Kirov, Guillaume Madelin
Summary: The study found that while there were significant differences in sodium concentration and anisotropy in specific regions, overall patients had lower sodium concentrations compared to controls. Linear regression analysis showed significantly lower global sodium concentrations in patients, with the strongest correlation found between global grey matter sodium concentration and patient outcomes. This suggests that sodium imaging may be a non-invasive and sensitive method for assessing outcomes in mild traumatic brain injury.
BRAIN COMMUNICATIONS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samantha L. Heller, Melanie Wegener, James S. Babb, Yiming Gao
Summary: The study evaluated the impact of an artificial intelligence support system on breast ultrasound diagnostic accuracy. Artificial intelligence was found to be more accurate in assessing irregular shape lesions and improved diagnostic accuracy for low-confidence lesions rated by readers.
ULTRASOUND QUARTERLY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laura Heacock, Alana Lewin, Abimbola Ayoola, Melanie Moccaldi, James S. Babb, Sungheon G. Kim, Linda Moy
ACADEMIC RADIOLOGY
(2020)
Article
Computer Science, Artificial Intelligence
Tatiane Cantarelli Rodrigues, Cem M. Deniz, Erin F. Alaia, Natalia Gorelik, James S. Babb, Jared Dublin, Soterios Gyftopoulos
RADIOLOGY-ARTIFICIAL INTELLIGENCE
(2020)