Article
Pharmacology & Pharmacy
Palak P. Oza, Khosrow Kashfi
Summary: Cancer is a global burden that affects premature mortality, productivity loss, healthcare expenditures, and mental health. Recent research has revealed a new role for cholesterol-lowering PCSK9 inhibitors in cancer treatment. PCSK9 is an enzyme that degrades LDL receptors, responsible for cholesterol clearance. By inhibiting PCSK9, LDL receptors are upregulated, leading to cholesterol reduction. The cholesterol-lowering effects of PCSK9 inhibitors have potential in combating cancer growth and enhancing existing anticancer therapies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Patrice Marques, Elena Domingo, Arantxa Rubio, Sergio Martinez-Hervas, Juan F. Ascaso, Laura Piqueras, Jose T. Real, Maria-Jesus Sanz
Summary: Inhibiting PCSK9 function can impact systemic inflammation and endothelial dysfunction by constraining leukocyte-endothelium interactions, enhancing T-regulatory cell activation, and reducing inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Hayato Tada, Kan Yamagami, Nobuko Kojima, Junichi Shibayama, Tetsuo Nishikawa, Hirofumi Okada, Akihiro Nomura, Soichiro Usui, Kenji Sakata, Masayuki Takamura, Masa-aki Kawashiri
Summary: The study revealed that the prevalence of APOE7 mutant among patients clinically diagnosed with FH was higher than expected, especially among those without other causative mutations. This suggests that APOE7 mutant may be one of the causes of FH, particularly in individuals without FH mutations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Mikko Karpale, Janne Hukkanen, Jukka Hakkola
Summary: Atherosclerosis is a global health concern with high total and LDL cholesterol as the main risk factors. Understanding the factors influencing an individual's cholesterol levels during the formation of arteriosclerotic plaques is crucial. Activation of pregnane X receptor (PXR) has been shown to induce hypercholesterolemia and may play a role in drug-induced high cholesterol levels.
Article
Biochemistry & Molecular Biology
Alessandro Di Minno, Roberta Clara Orsini, Mattia Chiesa, Viviana Cavalca, Ilenia Calcaterra, Maria Tripaldella, Andrea Anesi, Susanna Fiorelli, Sonia Eligini, Gualtiero Colombo, Elena Tremoli, Benedetta Porro, Matteo Nicola Dario Di Minno
Summary: Utilizing untargeted metabolomics, our study demonstrated a significant reduction in LDL-cholesterol levels in FH patients after 12 weeks of treatment with PCSK9i, along with concomitant decreases in inflammation and platelet activation metabolites.
Article
Pharmacology & Pharmacy
Kjell-Erik Arnesen, Ann Vinh Phung, Karoline Randsborg, Irene Mork, Marlene Thorvall, Gisle Langslet, Arne Svilaas, Cecilie Wium, Leiv Ose, Kjetil Retterstol
Summary: The study aimed to investigate the long-term treatment effects of intensive lipid lowering medication and optimized lifestyle in patients with familial hypercholesterolemia. Results showed that under intensive treatment, the average LDL-C in FH patients was reduced to 3.0 mmol/L, with women having higher LDL-C levels than men. The majority of patients with established ASCVD at enrollment experienced new events during the study period, while FH patients in primary prevention had a low cardiovascular risk of 13% in ten years.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arianna Toscano, Maria Cinquegrani, Michele Scuruchi, Antonino Di Pino, Salvatore Piro, Viviana Ferrara, Carmela Morace, Alberto Lo Gullo, Egidio Imbalzano, Francesco Purrello, Giovanni Squadrito, Roberto Scicali, Giuseppe Mandraffino
Summary: This study evaluated the impact of PCSK9 plasma levels on pulse wave velocity (PWV) and the effect of PCSK9 inhibitors (PCSK9-i) on circulating PCSK9 and PWV in HeFH subjects. The results showed that PCSK9 levels were associated with baseline PWV values in HeFH subjects, and the variations in PCSK9 levels seemed to be correlated with PWV changes on LLT.
Article
Genetics & Heredity
Alexey Meshkov, Alexandra Ershova, Anna Kiseleva, Evgenia Zotova, Evgeniia Sotnikova, Anna Petukhova, Anastasia Zharikova, Pavel Malyshev, Tatyana Rozhkova, Anastasia Blokhina, Alena Limonova, Vasily Ramensky, Mikhail Divashuk, Zukhra Khasanova, Anna Bukaeva, Olga Kurilova, Olga Skirko, Maria Pokrovskaya, Valeriya Mikova, Ekaterina Snigir, Alexsandra Akinshina, Sergey Mitrofanov, Daria Kashtanova, Valentin Makarov, Valeriy Kukharchuk, Sergey Boytsov, Sergey Yudin, Oxana Drapkina
Summary: This study examined LDLR, APOB, and PCSK9 gene variants in 595 index Russian patients with FH, identifying 224 variants, 36.1% of which were specific to the Russian population. The findings significantly expand knowledge of FH genetics in Russia and may enhance genetic diagnostics for FH patients in the country.
Article
Medicine, General & Internal
Marcin Basiak, Marcin Hachula, Michal Kosowski, Boguslaw Okopien
Summary: The study aimed to determine the efficacy of PCSK9 inhibitors in patients with isolated hypercholesterolemia. The results showed that PCSK9 inhibitors reduced plasma levels/activity of fibrinogen, factor VII, and plasminogen activator inhibitor-1, suggesting potential benefits for patients who cannot tolerate or are contraindicated for statin use.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Enchen Zhou, Zhuang Li, Hiroyuki Nakashima, Ahlam Choukoud, Sander Kooijman, Jimmy F. P. Berbee, Patrick C. N. Rensen, Yanan Wang
Summary: Accelerating lipolytic processing of VLDL by brown fat activation can further lower (V)LDL levels and reduce the risk of atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Marcello Arca, Simone Celant, Pier Paolo Olimpieri, Antonietta Colatrella, Luca Tomassini, Laura D'Erasmo, Maurizio Averna, Alberto Zambon, Alberico Luigi Catapano, Pierluigi Russo
Summary: This study evaluated the prescription patterns and long-term efficacy of alirocumab and evolocumab in treating familial hypercholesterolemia in clinical practice. The findings showed that these two drugs had comparable LDL-C-lowering efficacy to controlled trials, but a low proportion of patients achieved the recommended LDL-C goals.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Takahito Doi, Mika Hori, Mariko Harada-Shiba, Yu Kataoka, Daisuke Onozuka, Kunihiro Nishimura, Ryo Nishikawa, Kosuke Tsuda, Masatsune Ogura, Cheol Son, Yoshihiro Miyamoto, Teruo Noguchi, Hiroaki Shimokawa, Satoshi Yasuda
Summary: Patients with both LDLR and PCSK9 gene variants have higher levels of LDL cholesterol and increased risk of cardiovascular events, particularly nonfatal myocardial infarction. These patients require more intensive antiatherosclerotic management.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Gregory G. Schwartz, Michael Szarek, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, J. Wouter Jukema, Ulf Landmesser, Patricio Lopez-Jaramillo, Garen Manvelian, Robert Pordy, Michel Scemama, Peter R. Sinnaeve, Harvey D. White, Ph Gabriel Steg
Summary: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Marianne Zeller, Gilles Lambert, Michel Farnier, Maud Maza, Brice Nativel, Luc Rochette, Catherine Vergely, Yves Cottin
Summary: The study found an association between serum PCSK9 levels, metabolic parameters, and certain biomarkers in patients with acute myocardial infarction. However, PCSK9 levels were not predictive of the severity of coronary artery disease or the risk of cardiovascular events in this population.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Urology & Nephrology
Elias Jatem, Joan Lima, Bruno Montoro, Francisco Torres-Bondia, Alfons Segarra
Summary: In patients with refractory nephrotic syndrome and uncontrolled hypercholesterolemia despite treatment with statins, PCSK9 inhibitors led to a significant decrease in total cholesterol and LDL-C levels. Plasma PCSK9 levels were also significantly reduced after six months of treatment, indicating that PCSK9 inhibitors may be an effective and safe alternative for this patient population.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Eri T. Kato, Michael G. Silverman, Ofri Mosenzon, Thomas A. Zelniker, Avivit Cahn, Remo H. M. Furtado, Julia Kuder, Sabina A. Murphy, Deepak L. Bhatt, Lawrence A. Leiter, Darren K. McGuire, John P. H. Wilding, Marc P. Bonaca, Christian T. Ruff, Akshay S. Desai, Shinya Goto, Peter A. Johansson, Ingrid Gause-Nilsson, Per Johanson, Anna Maria Langkilde, Itamar Raz, Marc S. Sabatine, Stephen D. Wiviott
Article
Cardiac & Cardiovascular Systems
Remo H. M. Furtado, Marc P. Bonaca, Itamar Raz, Thomas A. Zelniker, Ofri Mosenzon, Avivit Cahn, Julia Kuder, Sabina A. Murphy, Deepak L. Bhatt, Lawrence A. Leiter, Darren K. McGuire, John P. H. Wilding, Christian T. Ruff, Jose C. Nicolau, Ingrid A. M. Gause-Nilsson, Martin Fredriksson, Anna Maria Langkilde, Marc S. Sabatine, Stephen D. Wiviott
Article
Cardiac & Cardiovascular Systems
Jemma C. Hopewell, Maysson Ibrahim, Michael Hill, Peter M. Shaw, Eugene Braunwald, Robert O. Blaustein, Louise Bowman, Martin J. Landray, Marc S. Sabatine, Rory Collins, M. J. Landray, L. Bowman, R. Collins, E. Braunwald, J. C. Hopewell, L. Jiang, C. P. Cannon, S. D. Wiviott, J. Armitage, R. Haynes, A. P. Maggioni, C. E. Angermann, G. Ertl, C. Wanner, T. Pedersen, S. Goto, T. Teramoto, C. Baigent, P. Barter, Y. Chen, Z. Chen, A. Gray, B. Mihaylova, P. Sleight, J. Tobert, R. Blaustein, P. DeLucca, Y. Mitchel, G. van Leijenhorst
Article
Cardiac & Cardiovascular Systems
Francois Mach, Colin Baigent, Alberico L. Catapano, Konstantinos C. Koskinas, Manuela Casula, Lina Badimon, M. John Chapman, Guy G. De Backer, Victoria Delgado, Brian A. Ference, Ian M. Graham, Alison Halliday, Ulf Landmesser, Borislava Mihaylova, Terje R. Pedersen, Gabriele Riccardi, Dimitrios J. Richter, Marc S. Sabatine, Marja-Riitta Taskinen, Lale Tokgozoglu, Olov Wiklund, Christian Mueller, Heinz Drexel, Victor Aboyans, Alberto Corsini, Wolfram Doehner, Michel Farnier, Bruna Gigante, Meral Kayikcioglu, Goran Krstacic, Ekaterini Lambrinou, Basil S. Lewis, Josep Masip, Philippe Moulin, Steffen Petersen, Anna Sonia Petronio, Massimo Francesco Piepoli, Xavier Pinto, Lorenz Raber, Kausik K. Ray, Zeljko Reiner, Walter F. Riesen, Marco Roffi, Jean-Paul Schmid, Evgeny Shlyakhto, Iain A. Simpson, Erik Stroes, Isabella Sudano, Alexandros D. Tselepis, Margus Viigimaa, Cecile Vindis, Alexander Vonbank, Michal Vrablik, Mislav Vrsalovic, Jose Luis Zamorano Gomez, Jean-Philippe Collet
EUROPEAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Mikhail N. Kosiborod, Pardeep S. Jhund, Kieran F. Docherty, Mirta Diez, Mark C. Petrie, Subodh Verma, Jose C. Nicolau, Bela Merkely, Masafumi Kitakaze, David L. DeMets, Silvio E. Inzucchi, Lars Kober, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, Scott D. Solomon, Olof Bengtsson, Daniel Lindholm, Anna Niklasson, Mikaela Sjoestrand, Anna Maria Langkilde, John J. V. McMurray
Letter
Cardiac & Cardiovascular Systems
Eri T. Kato, Marc S. Sabatine, Stephen D. Wiviott
Article
Cardiac & Cardiovascular Systems
Felipe A. Martinez, Matteo Serenelli, Jose C. Nicolau, Mark C. Petrie, Chern-En Chiang, Sergey Tereshchenko, Scott D. Solomon, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Piotr Ponikowski, Marc S. Sabatine, David L. DeMets, Monika Dutkiewicz-Piasecka, Olof Bengtsson, Mikaela Sjostrand, Anna Maria Langkilde, Pardeep S. Jhund, John J. V. McMurray
Correction
Cardiac & Cardiovascular Systems
Francois Mach, Colin Baigent, Alberico L. Catapano, Konstantinos C. Koskinas, Manuela Casula, Lina Badimon, M. John Chapman, Guy G. De Backer, Victoria Delgado, Brian A. Ference, Ian M. Graham, Alison Halliday, Ulf Landmesser, Borislava Mihaylova, Terje R. Pedersen, Gabriele Riccardi, Dimitrios J. Richter, Marc S. Sabatine, Marja-Riitta Taskinen, Lale Tokgozoglu, Olov Wiklund, Djamaleddine Nibouche, Parounak H. Zelveian, Peter Siostrzonek, Ruslan Najafov, Philippe van de Borne, Belma Pojskic, Arman Postadzhiyan, Lambros Kypris, Jindrich Spinar, Mogens Lytken Larsen, Hesham Salah Eldin, Margus Viigimaa, Timo E. Strandberg, Jean Ferrieres, Rusudan Agladze, Ulrich Laufs, Loukianos Rallidis, Laszlo Bajnok, Thorbjorn Gudjonsson, Vincent Maher, Yaakov Henkin, Michele Massimo Gulizia, Aisulu Mussagaliyeva, Gani Bajraktari, Alina Kerimkulova, Gustavs Latkovskis, Omar Hamoui, Rimvydas Slapikas, Laurent Visser, Philip Dingli, Victoria Ivanov, Aneta Boskovic, Mbarek Nazzi, Frank Visseren, Irena Mitevska, Kjetil Retterstol, Piotr Jankowski, Ricardo Fontes-Carvalho, Dan Gaita, Marat Ezhov, Marina Foscoli, Vojislav Giga, Daniel Pella, Zlatko Fras, Leopoldo Perez de Isla, Emil Hagstrom, Roger Lehmann, Leila Abid, Oner Ozdogan, Olena Mitchenko, Riyaz S. Patel, Stephan Windecker, Victor Aboyans, Colin Baigent, Jean-Philippe Collet, Veronica Dean, Victoria Delgado, Donna Fitzsimons, Chris P. Gale, Diederick Grobbee, Sigrun Halvorsen, Gerhard Hindricks, Bernard Iung, Peter Juni, Hugo A. Katus, Ulf Landmesser, Christophe Leclercq, Maddalena Lettino, Basil S. Lewis, Bela Merkely, Christian Mueller, Steffen Petersen, Anna Sonia Petronio, Dimitrios J. Richter, Marco Roffi, Evgeny Shlyakhto, Iain A. Simpson, Miguel Sousa-Uva, Rhian M. Touyz
Correction
Cardiac & Cardiovascular Systems
Francois Mach, Colin Baigent, Alberico L. Catapano, Konstantinos C. Koskinas, Manuela Casula, Lina Badimon, M. John Chapman, Guy G. De Backer, Victoria Delgado, Brian A. Ference, Ian M. Graham, Alison Halliday, Ulf Landmesser, Borislava Mihaylova, Terje R. Pedersen, Gabriele Riccardi, Dimitrios J. Richter, Marc S. Sabatine, Marja-Riitta Taskinen, Lale Tokgozoglu, Olov Wiklund, Djamaleddine Nibouche, Parounak H. Zelveian, Peter Siostrzonek, Ruslan Najafov, Philippe van de Borne, Belma Pojskic, Arman Postadzhiyan, Lambros Kypris, Jindrich Spinar, Mogens Lytken Larsen, Hesham Salah Eldin, Margus Viigimaa, Timo E. Strandberg, Jean Ferrieres, Rusudan Agladze, Ulrich Laufs, Loukianos Rallidis, Laszlo Bajnok, Thorbjorn Gudjonsson, Vincent Maher, Yaakov Henkin, Michele Massimo Gulizia, Aisulu Mussagaliyeva, Gani Bajraktari, Alina Kerimkulova, Gustays Latkovskis, Omar Hamoui, Rimvydas Slapikas, Laurent Visser, Philip Dingli, Victoria Ivanov, Aneta Boskovic, Mbarek Nazzi, Frank Visseren, Irena Mitevska, Kjetil Retterstol, Piotr Jankowski, Ricardo Fontes-Carvalho, Dan Gaita, Marat Ezhov, Marina Foscoli, Vojislav Giga, Daniel Pella, Zlatko Fras, Leopoldo Perez de Isla, Emil Hagstrom, Roger Lehmann, Leila Abid, Oner Ozdogan, Olena Mitchenko, Riyaz S. Patel, Stephan Windecker, Victor Aboyans, Colin Baigent, Jean -Philippe Collet, Veronica Dean, Victoria Delgado, Donna Fitzsimons, Chris P. Gale, Diederick Grobbee, Sigrun Halvorsen, Gerhard Hindricks, Bernard Iung, Peter Juni, Hugo A. Katus, Ulf Landmesser, Christophe Leclercq, Maddalena Lettino, Basil S. Lewis, Bela Merkely, Christian Mueller, Steffen Petersen, Anna Sonia Petronio, Dimitrios J. Richter, Marco Roffi, Evgeny Shlyakhto, Lain A. Simpson, Miguel Sousa-Uva, Rhian M. Touyz
Article
Endocrinology & Metabolism
Avivit Cahn, Ofri Mosenzon, Stephen D. Wiviott, Aliza Rozenberg, Ilan Yanuv, Erica L. Goodrich, Sabina A. Murphy, Deepak L. Bhatt, Lawrence A. Leiter, Darren K. McGuire, John P. H. Wilding, Ingrid A. M. Gause-Nilsson, Martin Fredriksson, Peter A. Johansson, Anna Maria Langkilde, Marc S. Sabatine, Itamar Raz
Article
Endocrinology & Metabolism
Harpreet S. Bajaj, Itamar Raz, Ofri Mosenzon, Sabina A. Murphy, Aliza Rozenberg, Ilan Yanuv, Deepak L. Bhatt, Lawrence A. Leiter, Darren K. McGuire, John P. H. Wilding, Ingrid A. M. Gause-Nilsson, Marc S. Sabatine, Stephen D. Wiviott, Avivit Cahn
DIABETES OBESITY & METABOLISM
(2020)
Article
Cardiac & Cardiovascular Systems
Remo H. M. Furtado, Jose C. Nicolau, Jianping Guo, Kyungah Im, Jennifer A. White, Marc S. Sabatine, L. Kristin Newby, Robert P. Giugliano
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Peter Sever, Ioanna Gouni-Berthold, Anthony Keech, Robert Giugliano, Terje R. Pedersen, KyungAh Im, Huei Wang, Beat Knusel, Marc S. Sabatine, Michelle L. O'Donoghue
Summary: Evolocumab demonstrated consistent efficacy and safety across a wide range of ages and in both men and women in the FOURIER trial.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Meeting Abstract
Endocrinology & Metabolism
I. Raz, S. D. Wiviott, A. Rozenberg, T. A. Zelniker, A. Cahn, H. J. L. Heerspink, J. P. Dwyer, D. K. McGuire, E. L. Goodrich, J. P. H. Wilding, I. A. M. Gause-Nilsson, P. A. Johansson, A. Langkilde, M. S. Sabatine, O. Mosenzon
Meeting Abstract
Endocrinology & Metabolism
O. Mosenzon, S. D. Wiviott, I. Yanuv, A. Cahn, H. J. L. Heerspink, J. P. Dwyer, E. T. Kato, E. L. Goodrich, L. A. Leiter, D. L. Bhatt, A. Langkilde, M. Fredriksson, I. A. M. Gause-Nilsson, M. S. Sabatine, I. Raz