Article
Oncology
Ru-Tsun Mai, Chi-Hong Chao, Yao-Wen Chang, Yu-Ching Kao, Yi Cheng, Hsiang -Yu Hsu, Yi-Yuan Su, Chen-Yun Wang, Bo-Ying Lai
Summary: Numerous reports indicate that enhanced expression of Y-box binding protein-1 (YB-1) is strongly associated with tumorigenesis, aggressiveness, drug resistance, as well as poor prognosis in several types of cancers. This study reveals the sumoylation of YB-1 and its crucial role in DNA mismatch repair deficiency and alkylator tolerance.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Eva L. Morozko, Charlene Smith-Geater, Alejandro Mas Monteys, Subrata Pradhan, Ryan G. Lim, Peter Langfelder, Marketta Kachemov, Austin Hill, Jennifer T. Stocksdale, Pieter R. Cullis, Jie Wu, Joseph Ochaba, Ricardo Miramontes, Anirban Chakraborty, Tapas K. Hazra, Alice Lau, Sophie St-Cyr, Iliana Orellana, Lexi Kopan, Keona Q. Wang, Sylvia Yeung, Blair R. Leavitt, Jack C. Reidling, X. William Yang, Joan S. Steffan, Beverly L. Davidson, Partha S. Sarkar, Leslie M. Thompson
Summary: This study reveals the involvement of PIAS1 in DNA damage repair pathways and its connection with transcriptional modulation in neurodegenerative diseases. Knockdown of PIAS1 in HD mice normalizes transcriptional dysregulation and DNA damage repair mechanisms, impacting genomic integrity in neurons. The findings highlight the role of SUMO modifying machinery in DNA damage repair responses and transcriptional modulation in the context of neurodegenerative disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Pattarasiri Rangsrikitphoti, Diana C. Marquez-Garban, Richard J. Pietras, Eileen McGowan, Viroj Boonyaratanakornkit
Summary: Sex steroid hormones (SSHs) play a crucial role in modulating the sensitivity of cancer cytotoxic treatment. The dysregulation of these hormones can lead to abnormal DNA repair, promoting cancer progression and resistance to cancer treatment. Different SSHs interact with DNA repair components and impact DNA repair regulation and response to genotoxic therapies.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Engineering, Environmental
Hongrui Guo, Yujuan Ouyang, Jiaqi Wang, Hengmin Cui, Huidan Deng, Xinyue Zhong, Zhijie Jian, Huan Liu, Jing Fang, Zhicai Zuo, Xun Wang, Ling Zhao, Yi Geng, Ping Ouyang, Huaqiao Tang
Summary: Copper is essential but over-exposure can lead to adverse health effects. CuSO4 was found to induce spermatogenesis disorder through oxidative stress-mediated DNA damage and apoptosis, impairing male reproductive function.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Zhong-Xuan Wang, Yao-Lin Li, Jia-Li Pu, Bao-Rong Zhang
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, and the role of DNA damage and repair deficiency in its pathogenesis has been increasingly recognized. This review provides an overview of the current understanding of DNA damage and repair in PD, including the evidence and causes of DNA damage, the potential pathways linking DNA damage to neurotoxicity, and possible interventions targeting DNA damage and repair. Future research should focus on addressing key issues to further elucidate the role of DNA damage in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Sneh M. Toprani, Dimitrios Bitounis, Qiansheng Huang, Nathalia Oliveira, Kee Woei Ng, Chor Yong Tay, Zachary D. Nagel, Philip Demokritou
Summary: The potential genotoxic effects of engineered nanomaterials (ENMs) on DNA repair pathways have been investigated using a fluorescence multiplex-host-cell reactivation (FM-HCR) assay. Results showed that some ENMs may enhance DNA repair capacity while others suppress it. This method can be a valuable part of a multitier, in vitro hazard assessment of ENMs, providing insights into the interplay between ENM properties, DNA repair efficiency, and genomic stability.
Review
Cell Biology
Lin Fu, Kun Lu, Qian Jiao, Xi Chen, Fengju Jia
Summary: OTUD5 is a cysteine protease belonging to the OTU family, which functions as a deubiquitinase. It plays a crucial role in the deubiquitination of key proteins in various cellular signaling pathways, contributing to normal human development and physiological functions. Dysregulation of OTUD5 can result in physiological dysfunctions, including immunity and DNA damage repair, as well as the development of tumors, inflammatory diseases, and genetic disorders. Therefore, understanding and controlling the activity and expression of OTUD5 is of great significance for disease research and therapeutic interventions.
Editorial Material
Microbiology
Jacob L. Steenwyk
Summary: Cell cycle checkpoints and DNA repair pathways are crucial for maintaining genome integrity, but recent studies have revealed evolutionary diversity in eukaryotic DNA damage responses, with some fungi showing reduced activation of key kinases and downregulation of genome maintenance genes in response to DNA damage.
Article
Gastroenterology & Hepatology
Man Hsin Hung, Ching Wen Chang, Kathy Cheng Wang, Jittiporn Chaisaingmongkol, Mathuros Ruchirawat, Tim F. Greten, Xin Wei Wang
Summary: In this study, the researchers analyzed the purine metabolism pathways in tumor and non-tumor liver tissues of patients with hepatocellular carcinoma (HCC), one of the most lethal cancers globally. The findings showed that purine synthesis genes are upregulated and purine degradation genes are inhibited in HCC tumors. High purine anabolism is associated with specific somatic mutational signatures and leads to dysregulation of DNA damage repairing machinery. Furthermore, high purine anabolism determines the sensitivity of HCC to DDR-targeting agents and correlates with clinical outcomes.
Review
Oncology
Caroline Molinaro, Alain Martoriati, Katia Cailliau
Summary: Cells respond to genotoxic stress through complex protein pathways called DNA damage response (DDR), ensuring genomic integrity and activating processes like DNA repair, cell cycle regulation, and programmed cell death. Alterations in DDR network proteins can lead to various diseases, including cancer. Recent technological advancements have allowed for the exploitation of DDR vulnerabilities to improve cancer treatments through DNA damage strategies and combination therapies.
Article
Biochemistry & Molecular Biology
Julio C. Y. Liu, Ulrike Kuhbacher, Nicolai B. Larsen, Nikoline Borgermann, Dimitriya H. Garvanska, Ivo A. Hendriks, Leena Ackermann, Peter Haahr, Irene Gallina, Claire Guerillon, Emma Branigan, Ronald T. Hay, Yoshiaki Azuma, Michael Lund Nielsen, Julien P. Duxin, Niels Mailand
Summary: The study reveals that the SUMO-targeted ubiquitin ligase RNF4 plays a major role in ubiquitylation and proteasomal clearance of SUMOylated DPCs in the absence of DNA replication. SUMO modifications of DPCs do not affect their rapid degradation during DNA replication, but provide a critical salvage mechanism to remove DPCs formed after replication. The absence of the SUMO-RNF4 pathway leads to accumulation of unresolved DPCs, causing defective chromosome segregation and cell death during mitosis.
Article
Chemistry, Multidisciplinary
Yong Woong Jun, Eddy Albarran, David L. Wilson, Jun Ding, Eric T. Kool
Summary: Mitochondrial function declines with aging and neurodegeneration, largely due to accumulated mutations in mtDNA from deficient DNA repair. A fluorescent probe, UBER, was used to visualize mitochondrial BER activity, showing increased repair under oxidative stress and time delay between stress onset and BER initiation. Cells lacking MTH1 exhibited elevated demand for BER activity during extended stress, while absence of OGG1 limited glycosylation capacity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Qiuling Huang, Dajiang Qin, Duanqing Pei, Michiel Vermeulen, Xiaofei Zhang
Summary: A study revealed that UBE2O interacts with RECQL4, causing its multi-monoubiquitinylation and subsequent degradation, leading to the inhibition of homologous recombination-mediated DSBs repair. Additionally, UBE2O also attenuates the interaction between RECQL4 and DNA damage repair proteins, affecting the repair process.
Article
Biotechnology & Applied Microbiology
Martina Fiumara, Samuele Ferrari, Attya Omer-Javed, Stefano Beretta, Luisa Albano, Daniele Canarutto, Angelica Varesi, Chiara Gaddoni, Chiara Brombin, Federica Cugnata, Erika Zonari, Matteo Maria Naldini, Matteo Barcella, Bernhard Gentner, Ivan Merelli, Luigi Naldini
Summary: Base and prime editors have shown potential for precise genetic engineering, but their cellular responses and genotoxicity are not well understood. This study compared the efficiency, toxicity, and genotoxicity between base and prime editors and Cas9 in human hematopoietic cells. The findings suggest that these editors can induce harmful effects and genotoxicity, raising concerns for their clinical applications.
NATURE BIOTECHNOLOGY
(2023)
Article
Oncology
Sophie Gilbert, Benjamin Peant, Anne-Marie Mes-Masson, Fred Saad
Summary: Inhibition of IKK-epsilon expression or using IKK-epsilon inhibitors can decrease proliferation and tumor volume of castrate resistant prostate cancer cells. Moreover, these inhibitors can induce senescence, DNA damage, and genomic instability. Combining Amlexanox and Olaparib can enhance the anti-cancer effects.
Review
Cell Biology
Bingbing Wan, Lisa E. Hang, Xiaolan Zhao
Article
Genetics & Heredity
Sonia Silva, Veronika Altmannova, Nadine Eckert-Boulet, Peter Kolesar, Irene Gallina, Lisa Hang, Inn Chun, Milica Arneric, Xiaolan Zhao, Line Due Buron, Uffe H. Mortensen, Lumir Krejci, Michael Lisby
Article
Cell Biology
Xiaoyu Xue, Alma Papusha, Koyi Choi, Jacob N. Bonner, Sandeep Kumar, Hengyao Niu, Hardeep Kaur, Xiao-Feng Zheng, Roberto A. Donnianni, Lucy Lu, Michael Lichten, Xiaolan Zhao, Grzegorz Ira, Patrick Sung
GENES & DEVELOPMENT
(2016)
Article
Biochemistry & Molecular Biology
Lei Wei, Xiaolan Zhao
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Lei Wei, Xiaolan Zhao
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2016)
Article
Cell Biology
Jacob N. Bonner, Koyi Choi, Xiaoyu Xue, Nikko P. Torres, Barnabas Szakal, Lei Wei, Bingbing Wan, Meret Arter, Joao Matos, Patrick Sung, Grant W. Brown, Dana Branzei, Xiaolan Zhao
Article
Genetics & Heredity
Antoinette M. Dummer, Zhangli Su, Rachel Cherney, Koyi Choi, John Denu, Xiaolan Zhao, Catherine A. Fox
Article
Cell Biology
Lisa Hang, Xiaolan Zhao
Review
Genetics & Heredity
Jacob N. Bonner, Xiaolan Zhao
Editorial Material
Cell Biology
Nalini Dhingra, Xiaolan Zhao
GENES & DEVELOPMENT
(2017)
Editorial Material
Biochemistry & Molecular Biology
Nalini Dhingra, Xiaolan Zhao
Article
Genetics & Heredity
Xiao P. Peng, Shelly Lim, Shibai Li, Lisette Marjavaara, Andrei Chabes, Xiaolan Zhao
Review
Biochemistry & Molecular Biology
Xiaolan Zhao
Article
Biochemistry & Molecular Biology
Nalini Dhingra, Lei Wei, Xiaolan Zhao
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Review
Biotechnology & Applied Microbiology
Xiangzhou Meng, Xiaolan Zhao
FEMS YEAST RESEARCH
(2017)