Editorial Material
Biochemistry & Molecular Biology
Elise Bornet, Alexander J. Westermann
Summary: This article discusses the increasing use of Bacteroides spp. as model gut commensals in cocolonization studies and their divergent roles in protecting against or promoting infection. It also explores the potential of cutting-edge transcriptomics in unraveling the molecular basis of these roles.
TRENDS IN MICROBIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Nayere Taebnia, Ute Romling, Volker M. Lauschke
Summary: Enteric bacterial infections are a major cause of disease and mortality worldwide, especially in developing countries. In vitro 2D monolayer cultures have provided valuable insights into the virulence mechanisms of various pathogens, leading to the discovery of potential targets for antimicrobial therapy and vaccines. More complex models, such as organoids, 3D bioengineered scaffolds, and microphysiological devices, have expanded our understanding of the effects of physiological and biological factors on infection. Advances in ex vivo cultures and intravital imaging have also allowed for the study of enteric pathogens on fluid secretion, barrier integrity, and immune cell surveillance. The combined use of these different methods promises to enhance our understanding of host-microbe interactions and their impact on intestinal health.
Article
Microbiology
Jasmin Koeffer, Melissa Kolb, Oceane Sorel, Camilla Ulekleiv, Jelena D. M. Feenstra, Ulrich Eigner
Summary: This study evaluated the clinical and analytical performance of the TAQPATH Enteric Bacterial Select Panel and found that it had 100% clinical sensitivity and specificity for Salmonella spp. and Shigella spp./Enteroinvasive Escherichia coli (EIEC). It also showed higher clinical sensitivity for Campylobacter compared to routine stool culture. Additionally, the TAQPATH panel provided faster time-to-result, required less hands-on time, and used less laboratory plastic compared to conventional stool culture.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Samantha K. Lindberg, Graham G. Willsey, Nicholas J. Mantis
Summary: Secretory IgA (SIgA) protects the intestinal epithelium from enteric pathogens such as Salmonella enterica serovar Typhimurium (STm) through immune exclusion, but the underlying mechanism of how SIgA mediates the transition from motile and invasive state to an avirulent sessile state in STm is unknown. In this report, the snow globe assay was developed to visualize and quantify STm agglutination by the mouse monoclonal IgA Sal4. The results showed that agglutination was influenced by bacterial motility and cell-cell collisions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Manikandan Srinivasan, Kulandaipalayam Natarajan Sindhu, Karthikeyan Ramanujam, Ranjith Kumar Ramasamy, Sathyapriya Subramaniam, Santhosh Kumar Ganesan, Swathi Vajja, Anita Shirley David, Pramitha Lankala, Winsley Rose, Prabhakar D. Moses, Nicholas C. Grassly, Gagandeep Kang, Jacob John
Summary: Blood culture is the gold standard for enteric fever diagnosis, and this study identified factors that predict positivity in blood cultures among children. Older children with higher fever temperatures, larger blood volume inoculated, and diagnoses of suspected typhoid or acute undifferentiated fever were more likely to have positive cultures. Refusals for blood cultures were more common among children from wealthier households or with milder illness.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Christopher Yuwono, Michael C. Wehrhahn, Fang Liu, Li Zhang
Summary: Aeromonas species were found to be the second most common bacterial enteric pathogens in patients with gastroenteritis. They exhibited a unique age-related three-peak infection pattern, especially in children younger than 18 months. The use of molecular detection methods (qPCR) enhanced the detection of Aeromonas species and other enteric pathogens, highlighting the importance of routine testing in diagnostic laboratories.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Jamieson B. McDonald, Nichollas E. Scott, Greg J. Underwood, Daniel M. Andrews, Thi Thu Hao Van, Robert J. Moore
Summary: Campylobacter hepaticus is a significant pathogen causing Spotty Liver Disease in layer chickens, leading to increased mortality and reduced egg production. This study confirms the functionality of the N-glycosylation system in C. hepaticus through glycoproteomic analysis, which showed the modification of over 35 proteins with an N-linked heptasaccharide glycan. C. hepaticus shares conserved glycoproteins with Campylobacter jejuni involved in host colonization and possesses unique glycoproteins that may contribute to its survival in challenging host environments.
SCIENTIFIC REPORTS
(2023)
Review
Biotechnology & Applied Microbiology
Angelene Richards, Danielle Baranova, Nicholas J. Mantis
Summary: This review examines preclinical studies on orally administered monoclonal secretory IgA antibodies targeting enteric bacterial pathogens. While highlighting the potential of SIgA as a prophylactic tool, the studies also underscore the challenges associated with using MAbs against enteric bacterial diseases.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Markus M. Heimesaat, Steffen Backert, Thomas Alter, Stefan Bereswill
Summary: Human campylobacteriosis is a foodborne infection caused by Campylobacter bacteria, which are responsible for bacterial gastroenteritis. Contaminated poultry meat is the main source of transmission to humans, causing abdominal pain and diarrhea. Prevention strategies focus on reducing pathogenic food contamination through hygiene measures.
Article
Microbiology
Christopher Yuwono, Michael C. Wehrhahn, Fang Liu, Stephen M. Riordan, Li Zhang
Summary: This study analyzed Aeromonas species infection in the Australian population and found that it is the third most common bacterial pathogen in gastroenteritis, correlated with age and gender, with the main species being veronii, caviae, and hydrophila.
Article
Immunology
Kwang Gon Kim, Jin Jung, Ji Hyun Shin, Hye Jung Park, Min Ji Kim, Jin Jong Seo, Young Ok Kim, Su-Ya Lee, Chang-Yee Cho, Tae Sun Kim
Summary: Due to differences in perspectives on human rights and laws in various social strata in Asian countries, the development of human rights laws in the Asian region has been relatively slow. In some countries in Asia, reform in the field of human rights laws has been hindered by government restrictions and pressures. The importance of human rights in Asian countries has gradually been recognized, but still faces many challenges.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Immunology
Dongmei Yan, Qisi Zhang, Qingping Fu, Mingzhong Sun, Xinxiang Huang
Summary: Persisters contribute to antibiotic treatment recalcitrance, and the deletion of the Fis gene regulating glutamate metabolism has been found to significantly reduce persister formation in S. Typhi.
MICROBIAL PATHOGENESIS
(2021)
Article
Public, Environmental & Occupational Health
Dehao Chen, Sarah L. McKune, Nitya Singh, Jemal Yousuf Hassen, Wondwossen Gebreyes, Mark J. Manary, Kevin Bardosh, Yang Yang, Nicholas Diaz, Abdulmuen Mohammed, Yitagele Terefe, Kedir Teji Roba, Mengistu Ketema, Negassi Ameha, Nega Assefa, Gireesh Rajashekara, Loic Deblais, Mostafa Ghanem, Getnet Yimer, Arie H. Havelaar
Summary: A study in rural eastern Ethiopia found that 50% of children had Environmental Enteric Dysfunction, 41% were stunted. Most households had access to an improved water source, but sanitation was poor with high levels of unimproved latrines and open defecation.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Immunology
Se-Hun Kim, Ramachandran Chelliah, Sudha Rani Ramakrishnan, Ayyappasamy Sudalaiyadum Perumal, Woo-Suk Bang, Momna Rubab, Eric Banan-Mwine Daliri, Kaliyan Barathikannan, Fazle Elahi, Eunji Park, Hyeon Yeong Jo, Su-Bin Hwang, Deog Hwan Oh
Summary: Campylobacter spp. are the leading cause of bacterial colon infections in humans globally, and their stress-adaptation mechanisms differ from other enteropathogenic bacteria, allowing them to survive in diverse environments and enhance their resistance mechanisms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Alberto Ignacio Olivares Olivares, Gabriel Azevedo Alves Leitao, Yan Cardoso Pimenta, Carina Pacheco Cantelli, Tulio Machado Fumian, Alexandre Madi Fialho, Sergio da Silva e Mouta Junior, Isabella Fernandes Delgado, Johan Nordgren, Lennart Svensson, Marize Pereira Miagostovich, Jose Paulo Gagliardi Leite, Marcia Terezinha Baroni de Moraes
Summary: The study confirmed that norovirus was the main etiological agent of acute gastroenteritis in children from the Amazon region. High frequencies of HAdV infection were observed in both AGE and ARI children, while RVA infection was the third most prevalent.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
W. Gu, A. R. Vieira, R. M. Hoekstra, P. M. Griffin, D. Cole
EPIDEMIOLOGY AND INFECTION
(2015)
Article
Food Science & Technology
Elaine Scallan, Stacy M. Crim, Arthur Runkle, Olga L. Henao, Barbara E. Mahon, Robert M. Hoekstra, Patricia M. Griffin
FOODBORNE PATHOGENS AND DISEASE
(2015)
Article
Pediatrics
Rajal K. Mody, Weidong Gu, Patricia M. Griffin, Timothy F. Jones, Josh Rounds, Beletshachew Shiferaw, Melissa Tobin-D'Angelo, Glenda Smith, Nancy Spina, Sharon Hurd, Sarah Lathrop, Amanda Palmer, Effie Boothe, Ruth E. Luna-Gierke, Robert M. Hoekstra
JOURNAL OF PEDIATRICS
(2015)
Article
Immunology
Kristina M. Angelo, Kelly A. Jackson, Karen K. Wong, Robert M. Hoekstra, Brendan R. Jackson
CLINICAL INFECTIOUS DISEASES
(2016)
Article
Immunology
Kristina M. Angelo, Jared Reynolds, Beth E. Karp, Robert Michael Hoekstra, Christina M. Scheel, Cindy Friedman
JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Ophthalmology
Allison C. Brown, Jonathan Ross, Daniel B. Jones, Sarah A. Collier, Tracy L. Ayers, Robert M. Hoekstra, Bryon Backensen, Sharon L. Roy, Michael J. Beach, Jonathan S. Yoder, David M. Dziewulski, Kenneth Soyemi, Charlotte E. Joslin, Elmer Tu, Monika Samper, William Mathers, Rupa Shah
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2018)
Article
Food Science & Technology
Marlene Tremblay, Stacy M. Crim, Dana J. Cole, Robert M. Hoekstra, Olga L. Henao, Dorte Dopfer
FOODBORNE PATHOGENS AND DISEASE
(2017)
Article
Food Science & Technology
Martha Iwamoto, Jared Reynolds, Beth E. Karp, Heather Tate, Paula J. Fedorka-Cray, Jodie R. Plumblee, Robert M. Hoekstra, Jean M. Whichard, Barbara E. Mahon
FOODBORNE PATHOGENS AND DISEASE
(2017)
Article
Public, Environmental & Occupational Health
M. R. Powell, S. M. Crim, R. M. Hoekstra, M. S. Williams, W. Gu
EPIDEMIOLOGY AND INFECTION
(2018)
Article
Public, Environmental & Occupational Health
A. Laufer Halpin, W. Gu, M. E. Wise, J. J. Sejvar, R. M. Hoekstra, B. E. Mahon
EPIDEMIOLOGY AND INFECTION
(2018)
Article
Food Science & Technology
Ulzii Orshikh Luvsansharav, Antonio Vieira, Sarah Bennett, Jennifer Huang, Jessica Meaghan Healy, Robert Michael Hoekstra, Beau Benjamin Bruce, Dana Cole
FOODBORNE PATHOGENS AND DISEASE
(2020)
Article
Public, Environmental & Occupational Health
M. C. Judd, R. M. Hoekstra, B. E. Mahon, P. Fields, K. K. Wong
EPIDEMIOLOGY AND INFECTION
(2019)
Article
Public, Environmental & Occupational Health
Weidong Gu, Felicita Medalla, Robert M. Hoekstra
SPATIAL AND SPATIO-TEMPORAL EPIDEMIOLOGY
(2018)
Article
Immunology
Eric D. Ebel, Michael S. Williams, Dana Cole, Curtis C. Travis, Karl C. Klontz, Neal J. Golden, Robert M. Hoekstra
EMERGING INFECTIOUS DISEASES
(2016)
Article
Immunology
Felicita Medalla, Weidong Gu, Barbara E. Mahon, Michael Judd, Jason Folster, Patricia M. Griffin, Robert M. Hoekstra
EMERGING INFECTIOUS DISEASES
(2017)