Article
Medicine, Research & Experimental
Yan Li, Lin Teng, Xuebin Xu, Xiaomeng Li, Xianqi Peng, Xiao Zhou, Jiaxin Du, Yanting Tang, Zhijie Jiang, Zining Wang, Chenghao Jia, Anja Mueller, Corinna Kehrenberg, Haoqiu Wang, Beibei Wu, Francois-Xavier Weill, Min Yue
Summary: The study investigates the emergence of invasive nontyphoidal Salmonella in China and identifies the international animal feed trade as a likely vehicle for its introduction. The results highlight the importance of genomics in uncovering international transmission and the emergence of hypervirulent strains with increased antibiotic resistance.
EMBO MOLECULAR MEDICINE
(2022)
Article
Microbiology
Kamonporn Poramathikul, Mariusz Wojnarski, Somethy Sok, Vannara Sokh, Sivhour Chiek, Heng Seng, Sidonn Krang, Sovann Ly, Samon Nou, Soklyda Chann, Siriporn Sornsakrin, Woradee Lurchachaiwong, Worachet Kuntawunginn, Paphavee Lertsethtakarn, Aaron Farmer, Brett Swierczewski, Norman Waters, Samandra Demons, Brian Vesely, Satharath Prom, Chanthap Lon, Ladaporn Bodhidatta
Summary: This study found an increasing trend of multidrug resistance among Shigella and nontyphoidal Salmonella isolates collected in Cambodia, highlighting a major challenge for the selection of treatment options for acute infectious diarrhea in the country. It is crucial for treatment practices to be updated and guided by local antimicrobial resistance data for the identified pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Chien-Shun Chiou, Yu-Ping Hong, You-Wun Wang, Bo-Han Chen, Ru-Hsiou Teng, Hui-Yung Song, Ying-Shu Liao
Summary: This study investigated antimicrobial resistance in non-typhoidal Salmonella isolates from humans in Taiwan and identified the genetic determinants of azithromycin resistance. The study revealed that nearly half of the isolates were multidrug-resistant and 20% were resistant to third-generation cephalosporins. The rate of azithromycin resistance in Taiwan's NTS isolates was higher than that in the United States and Europe. The study also found that azithromycin resistance was primarily mediated by mph(A), erm(42), erm(B), and ramAp, which are frequently carried on mobile genetic elements, indicating a potential dissemination of these resistance determinants among different bacterial pathogens.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Jade L. L. Teng, Elaine Chan, Asher C. H. Dai, Gillian Ng, Tsz Tuen Li, Christopher Lai, Alan K. L. Wu, Susanna K. P. Lau, Patrick C. Y. Woo
Summary: Ceftolozane/tazobactam showed high activity against most strains of both typhoidal and nontyphoidal salmonellae, including those producing ESBL.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Erin Frey, G. Sean Stapleton, Megin C. Nichols, Lauren M. Gollarza, Meseret Birhane, Jessica C. Chen, Andre Mccullough, Heather A. Carleton, Eija Trees, Kelley B. Hise, Beth Tolar, Louise Francois Watkins
Summary: Animal contact is a risk factor for non-typhoidal Salmonella infections and outbreaks. Whole-genome sequencing can enhance the characterization of outbreaks by identifying subtypes and antimicrobial resistance profiles.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Immunology
Sophia Inbaraj, Ravi Kant Agrawal, Prasad Thomas, Chandra Mohan, S. R. K. Agarwal, Med Ram Verma, Pallab Chaudhuri
Summary: The study conducted a retrospective analysis of antimicrobial resistance in non-typhoidal Salmonella enterica isolates from India between 1990 and 2017. Results showed that nearly half of the isolates (49.08%) were resistant to at least one antimicrobial drug, with almost a third (29.89%) being multidrug resistant. Typhimurium serovars demonstrated higher susceptibility compared to Kentucky serovars. The susceptibility to most antibiotics decreased over time, except for cephalosporins and carbapenems. Statistical analysis showed a significant association between time period and antimicrobial resistance. Genetic determinants associated with antimicrobial resistance were detected in resistant isolates, including genes like class I integrons, sul1, sul2, catIII, cmlA, dfrA, bla(TEM), bla(AmpC), as well as plasmid mediated quinolone resistant determinants qnrD and qnrS.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2022)
Article
Microbiology
Yi-Jung Chang, Yi-Ching Chen, Nai-Wen Chen, Ying-Jie Hsu, Hsiao-Han Chu, Chyi-Liang Chen, Cheng-Hsun Chiu
Summary: The antimicrobial resistance of NTS in children has increased progressively in the past decade in Taiwan, with different serogroups exhibiting different resistance patterns. Infants showed the highest risk of acquiring a third-generation cephalosporin-resistant NTS infection, highlighting the need for continual surveillance among children with NTS in Taiwan.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Reem A. Youssef, Ahmad M. Abbas, Ahmed M. El-Shehawi, Mona I. Mabrouk, Khaled M. Aboshanab
Summary: The study found that human and poultry-derived nontyphoidal Salmonella serovars shared similarities in terms of antimicrobial resistance, virulence genes, and genotypes. Enterobacterial repetitive intergenic consensus PCR analysis also showed clustering together of human and poultry serovars, indicating similarity.
Article
Immunology
John A. Crump, Kate M. Thomas, Jackie Benschop, Matthew A. Knox, David A. Wilkinson, Anne C. Midwinter, Peninah Munyua, John B. Ochieng, Godfrey M. Bigogo, Jennifer R. Verani, Marc-Alain Widdowson, Gerard Prinsen, Sarah Cleaveland, Esron D. Karimuribo, Rudovick R. Kazwala, Blandina T. Mmbaga, Emanuel S. Swai, Nigel P. French, Ruth N. Zadoks
Summary: The study found that some clades of Salmonella Enteritidis ST11 in East Africa may be an important source of human infection through the meat pathway, while human infection by Salmonella Typhimurium ST313 does not occur through the meat pathway. Further research on other sources of nontyphoidal Salmonella disease in East Africa is needed.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Joao Pires, Jana S. Huisman, Sebastian Bonhoeffer, Thomas P. Van Boeckel
Summary: The rapid growth of bacterial genomes in public databases presents opportunities to track antimicrobial resistance (AMR) trends. Using genomic data, it was found that resistance in nontyphoidal Salmonella varied among food animals in the United States, showing a decline in bovines and swine but an increase in poultry. Results from genomic surveillance were consistent with national surveillance data, indicating the potential for using genomes to monitor AMR trends in expanding sequencing capacities.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Wei Zhao, Xin Li, Xuening Shi, Kewei Li, Ben Shi, Jingyu Sun, Chao Zhao, Juan Wang
Summary: This study characterized 260 strains of human Salmonella isolated from Jilin, China through serotyping and antimicrobial resistance analysis using whole genome sequencing. The most common serotype was Salmonella enteritidis, followed by S. I 4,[5],12:i:- and Salmonella Typhimurium. The presence of resistance genes and their corresponding phenotypes were confirmed, as well as the presence of specific mutations related to quinolone resistance. The combination of multilocus sequence typing (MLST) and core genome multilocus sequence typing (cgMLST) proved to be effective in molecular traceability. Comprehensive surveillance of Salmonella infections in children was recommended to monitor antimicrobial-resistant trends and prevent outbreaks of foodborne diseases, thus protecting public health.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Fang-Ching Liu, Yi-Jung Chang, Chyi-Liang Chen, Hsin-Ping Yang, Chien-Chung Lee, Cheng-Hsun Chiu
Summary: This study investigated the characteristics and antimicrobial resistance of nontyphoidal Salmonella (NTS) infections in young infants. The results showed that invasive NTS infections were not common among young infants, but the antimicrobial resistance had increased. The study suggested reconsidering routine antibiotic treatment for infants aged 1 to 3 months with NTS infections.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Medicine, General & Internal
Chieh-Ming Lee, Min-Sheng Lee, Te-Liang Yang, Kuan-Lin Lee, Ting-Yu Yen, Chun-Yi Lu, Po-Ren Hsueh, Ping-Ing Lee, Jong-Min Chen, Li-Min Huang, Luan-Yin Chang
Summary: This study investigated the clinical features and antimicrobial susceptibility of inpatient children with nontyphoidal salmonellosis from 2010 to 2018 in Taiwan. The results showed an increase in resistance to third-generation cephalosporin and a decrease in resistance to ciprofloxacin over this period. Bacteremia patients with nontyphoidal salmonellosis had longer fever and diarrhea durations and a higher rate of anemia compared to non-bacteremia patients.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Veterinary Sciences
Chia-Chi Wang, Yu-Ting Hung, Che-Yu Chou, Shih-Ling Hsuan, Zeng-Weng Chen, Pei-Yu Chang, Tong-Rong Jan, Chun-Wei Tung
Summary: Antimicrobial resistance is a global health issue and surveillance of AMR can provide valuable insights. Salmonella, widely found in food-producing animals, is prioritized in the AMR surveillance program by WHO. The study aims to develop WGS-based random forest models for predicting MIC values of 24 drugs using data from labs in Taiwan.
VETERINARY RESEARCH
(2023)
Article
Infectious Diseases
Li-juan Wu, Yan Luo, Guo-lu Shi, Zhong-yue Li
Summary: This study retrospectively analyzed the prevalence, clinical features, serotypes, and antibiotic resistance changes of NTS infections in children in Chongqing from 2009 to 2018. The results showed that NTS infections mainly occurred in children under three years old, with the majority cases happening between July and October. Despite a slight decrease in resistance rates to some antibiotics, overall antibiotic resistance rates remained high in Chongqing.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Ophthalmology
Allison C. Brown, Jonathan Ross, Daniel B. Jones, Sarah A. Collier, Tracy L. Ayers, Robert M. Hoekstra, Bryon Backensen, Sharon L. Roy, Michael J. Beach, Jonathan S. Yoder, David M. Dziewulski, Kenneth Soyemi, Charlotte E. Joslin, Elmer Tu, Monika Samper, William Mathers, Rupa Shah
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2018)
Article
Microbiology
D. Campbell, K. Tagg, A. Bicknese, A. McCullough, J. Chen, B. E. Karp, J. P. Folster
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Public, Environmental & Occupational Health
M. R. Powell, S. M. Crim, R. M. Hoekstra, M. S. Williams, W. Gu
EPIDEMIOLOGY AND INFECTION
(2018)
Article
Public, Environmental & Occupational Health
A. Laufer Halpin, W. Gu, M. E. Wise, J. J. Sejvar, R. M. Hoekstra, B. E. Mahon
EPIDEMIOLOGY AND INFECTION
(2018)
Article
Public, Environmental & Occupational Health
Beth E. Karp, Davina Campbell, Jessica C. Chen, Jason P. Folster, Cindy R. Friedman
ZOONOSES AND PUBLIC HEALTH
(2018)
Article
Food Science & Technology
Stacy M. Crim, Shua J. Chai, Beth E. Karp, Michael C. Judd, Jared Reynolds, Krista C. Swanson, Amie Nisler, Andre McCullough, L. Hannah Gould
FOODBORNE PATHOGENS AND DISEASE
(2018)
Letter
Microbiology
Hattie E. Webb, Kaitlin A. Tagg, Jessica C. Chen, Justin Kim, Rebecca Lindsey, Louise K. Francois Watkins, Beth E. Karp, Yo Sugawara, Jason P. Folster
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Food Science & Technology
Ulzii Orshikh Luvsansharav, Antonio Vieira, Sarah Bennett, Jennifer Huang, Jessica Meaghan Healy, Robert Michael Hoekstra, Beau Benjamin Bruce, Dana Cole
FOODBORNE PATHOGENS AND DISEASE
(2020)
Article
Immunology
Jennifer P. Collins, Cindy R. Friedman, Meseret G. Birhane, Beth E. Karp, Anthony Osinski, Mary W. Montgomery, Deepam Thomas, Jonathan Barkley, Martha C. Sanchez, Samir Hanna, Azizat A. Adediran, Jessica C. Chen, Hayat Caidi, Louise Francois Watkins
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Public, Environmental & Occupational Health
Michelle A. Waltenburg, Ariana Perez, Zainab Salah, Beth E. Karp, Jean Whichard, Beth Tolar, Lauren Gollarza, Lia Koski, Anna Blackstock, Colin Basler, Megin Nichols
Summary: Non-typhoidal Salmonella infections, particularly those linked to reptiles and amphibians, have caused a significant number of illnesses and hospitalizations in the United States. Young children are particularly vulnerable to these outbreaks. This study analyzes multistate outbreaks to understand the nature of the illnesses and inform prevention strategies.
ZOONOSES AND PUBLIC HEALTH
(2022)
Letter
Immunology
Beth E. Karp, Molly M. Leeper, Jessica C. Chen, Kaitlin A. Tagg, Louise K. Francois Watkins, Cindy R. Friedman
EMERGING INFECTIOUS DISEASES
(2020)
Article
Public, Environmental & Occupational Health
Walter O. Ochieng, Tun Ye, Christina Scheel, Aun Lor, John Saindon, Sue Lin Yee, Martin I. Meltzer, Vikas Kapil, Kevin Karem
LANCET GLOBAL HEALTH
(2020)
Article
Public, Environmental & Occupational Health
M. C. Judd, R. M. Hoekstra, B. E. Mahon, P. Fields, K. K. Wong
EPIDEMIOLOGY AND INFECTION
(2019)
Article
Public, Environmental & Occupational Health
Weidong Gu, Felicita Medalla, Robert M. Hoekstra
SPATIAL AND SPATIO-TEMPORAL EPIDEMIOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Blanca Samayoa, Monika Roy, Angela Ahlquist Cleveland, Narda Medina, Dalia Lau-Bonilla, Christina M. Scheel, Beatriz L. Gomez, Tom Chiller, Eduardo Arathoon
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2017)