Article
Dentistry, Oral Surgery & Medicine
Y. Zhang, S. Lin, J. Liu, Q. Chen, J. Kang, J. Zhong, M. Hu, M. S. Basabrain, Y. Liang, C. Yuan, C. Zhang
Summary: This study found that dental pulp stem cells can increase the lifespan and perfusion of blood vessels. The results revealed that dental pulp stem cells inhibit endothelial cell sprouting by activating the TEK tyrosine kinase (Tie2) signaling and regulating the expression levels of vascular endothelial (VE)-cadherin and vascular endothelial growth factor receptor 2 (VEGFR2).
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yan Wang, Jiahui Ni, Aiyu Wang, Run Zhang, Linjie Wang
Summary: This study found that VEGFA regulates glycolipid metabolism in Schizothorax prenanti through AMPK alpha, contributing to a better understanding of the functions of VEGFA in fish glycolipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ni Yang, Yucong Zhang, Yi Huang, Jinhua Yan, Zonghao Qian, Han Li, Pengcheng Luo, Zhen Yang, Mandi Luo, Xiuxian Wei, Hao Nie, Lei Ruan, Yi Hao, Shangbang Gao, Kai Zheng, Cuntai Zhang, Le Zhang
Summary: This study explored the effects of serum FGF21 on vascular endothelial cells and found that FGF21 within the physiological concentration range has a beneficial effect on the cells, potentially through the regulation of SIRT1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Multidisciplinary Sciences
Christina M. Termini, Amara Pang, Tiancheng Fang, Martina Roos, Vivian Y. Chang, Yurun Zhang, Nicollette J. Setiawan, Lia Signaevskaia, Michelle Li, Mindy M. Kim, Orel Tabibi, Paulina K. Lin, Joshua P. Sasine, Avradip Chatterjee, Ramachandran Murali, Heather A. Himburg, John P. Chute
Summary: Ionizing radiation and chemotherapy deplete hematopoietic stem cells and damage the vascular niche, leading to the secretion of SEMA3A from bone marrow endothelial cells. Inhibition of NRP1 promotes vascular and hematopoietic regeneration through increased expression of R spondin 2, suggesting a potential therapeutic target for improving hematopoietic recovery after myeloablation.
NATURE COMMUNICATIONS
(2021)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Yolanda Fernandez-Cladera, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Agustin F. Gonzalez-Rivero, Antonia De Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the relationship between VEGF and sVEGFR with SLE disease-related features and found that serum levels of VEGF and sVEGFR in SLE patients were associated with disease damage, with musculoskeletal manifestations being the most commonly associated feature.
Article
Multidisciplinary Sciences
Marta Braga, Chee Hau Leow, Javier Hernandez Gil, Jin H. Teh, Laurence Carroll, Nicholas J. Long, Meng-Xing Tang, Eric O. Aboagye
Summary: This study successfully developed a T140-MB for imaging CXCR4 expression in the tumor vasculature, showing specificity and high sensitivity in cells and animal models. PET imaging demonstrated marked differences in CXCR4 expression between high and low expressing tumors, while microvessel density and CXCR4 expression in the vasculature were relatively consistent.
Article
Pharmacology & Pharmacy
Jun-Hei Chang, Chen-Chuan Cheng, Yen-Yu Lu, Cheng-Chih Chung, Yung-Hsin Yeh, Yao-Chang Chen, Satoshi Higa, Shih-Ann Chen, Yi-Jen Chen
Summary: VEGF reduces PV arrhythmogenesis by modulating sodium/calcium homeostasis through VEGFR-1/NOS signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Xiao-yu Dai, Li-jun Ren, Lang Yan, Ji-qian-zhu Zhang, Yi-fan Dong, Tao-lin Qing, Wen-jing Shi, Jin-feng Li, Fang-yuan Gao, Xiao-fang Zhang, Yi-jun Tian, Yu-ping Zhu, Jiang-bo Zhu, Ji-kuai Chen
Summary: This study demonstrated that MWCNTs can affect endothelial cell activity, disrupt tube formation and cell migration ability, subsequently affecting angiogenesis. Furthermore, the VEGF-Akt-eNOS axis plays a crucial role in MWCNT-induced endothelial cell injury.
Article
Biotechnology & Applied Microbiology
Yumiko Yamada, Shih-Te Chuang, Ching-Yu Tseng, Guan-Ru Liao, Shin-Wu Liu, Yeu-Yang Tseng, Fong-Yuan Lin, Wei-Li Hsu
Summary: This study compared Taiwanese ORFV isolates and found that deletion mutants of VEGF and CBP genes both lost virulence in cell and goat models, with the VEGF-deletion mutant showing a greater loss of virulence.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Hematology
Kathryn N. Phoenix, Zhichao Yue, Lixia Yue, Chunxia G. Cronin, Bruce T. Liang, Luke H. Hoeppner, Kevin P. Claffey
Summary: This study identifies PLC beta 2 as a key regulator of vascular permeability induced by VEGF, functioning through regulation of calcium flux and phosphatidylinositol 4,5-bisphosphate levels. Targeting PLC beta 2 could provide a novel approach to regulate vascular permeability in patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Prashant Jain, Chethan D. Shanthamurthy, Shani Leviatan Ben-Arye, Sharon Yehuda, Sharvani S. Nandikol, Hirekodathakallu Thulasiram, Vered Padler-Karavani, Raghavendra Kikkeri
Summary: A potential heparan sulfate (HS) ligand was discovered to target several growth factors using specific HS tetrasaccharide ligands. One tetrasaccharide ligand showed strong binding with the VEGF(165) growth factor, and in vitro experiments demonstrated the therapeutic potential of these synthetic HS ligands by inhibiting vascular endothelial cell proliferation, migration, and angiogenesis in the presence of VEGF(165) and the specific tetrasaccharides.
CHEMICAL COMMUNICATIONS
(2021)
Article
Clinical Neurology
Il-doo Kim, John W. Cave, Sunghee Cho
Summary: Obese mice with acute stroke showed increased mortality, infarct volume, swelling, and blood-brain barrier disruption, along with elevated VEGF-A and VEGFR2 expression. Aflibercept could reduce brain edema and vascular permeability, improving stroke outcomes in obese subjects.
Meeting Abstract
Surgery
Sarwat Ahmad, Yanbao Xiong, Charles C. Brinkman, Jonathan S. Bromberg
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2015)
Editorial Material
Immunology
C. Colin Brinkman, Jonathan S. Bromberg
Review
Urology & Nephrology
Jonathan S. Bromberg, W. Florian Fricke, C. Colin Brinkman, Thomas Simon, Emmanuel F. Mongodin
NATURE REVIEWS NEPHROLOGY
(2015)
Article
Immunology
Girdhari Lal, Yumi Nakayama, Apoorva Sethi, Amit K. Singh, Bryna E. Burrell, Neeraja Kulkarni, C. Colin Brinkman, Daiki Iwami, Tianshu Zhang, Jonathan S. Bromberg
Article
Immunology
Bryna E. Burrell, Kristi J. Warren, Yumi Nakayama, Daiki Iwami, C. Colin Brinkman, Jonathan S. Bromberg
Article
Immunology
Yumi Nakayama, C. Colin Brinkman, Jonathan S. Bromberg
Article
Immunology
Girdhari Lal, Neeraja Kulkarni, Yumi Nakayama, Amit K. Singh, Apoorva Sethi, Bryna E. Burrell, C. Colin Brinkman, Daiki Iwami, Tianshu Zhang, Thomas Hehlgans, Jonathan S. Bromberg
IMMUNOLOGY LETTERS
(2016)
Article
Immunology
Yanbao Xiong, Sarwat Ahmad, Daiki Iwami, C. Colin Brinkman, Jonathan S. Bromberg
JOURNAL OF IMMUNOLOGY
(2016)
Article
Multidisciplinary Sciences
C. Colin Brinkman, Daiki Iwami, Molly K. Hritzo, Yanbao Xiong, Sarwat Ahmad, Thomas Simon, Keli L. Hippen, Bruce R. Blazar, Jonathan S. Bromberg
NATURE COMMUNICATIONS
(2016)
Meeting Abstract
Immunology
Yanbao Xiong, C. Colin Brinkman, Lauren E. Hittle, W. Florian Fricke, Emmanuel F. Mongodin, Jonathan S. Bromberg
Article
Multidisciplinary Sciences
Wenji Piao, Yanbao Xiong, Konrad Famulski, C. Colin Brinkman, Lushen Li, Nicholas Toney, Chelsea Wagner, Vikas Saxena, Thomas Simon, Jonathan S. Bromberg
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Yanbao Xiong, C. Colin Brinkman, Konrad S. Famulski, Emmanuel F. Mongodin, Colin J. Lord, Keli L. Hippen, Bruce R. Blazar, Jonathan S. Bromberg
SCIENTIFIC REPORTS
(2017)
Article
Microbiology
Emmanuel F. Mongodin, Lauren L. Hittle, Suvarna Nadendla, C. Colin Brinkman, Yanbao Xiong, Jonathan S. Bromberg
GENOME ANNOUNCEMENTS
(2017)
Meeting Abstract
Surgery
Y. Xiong, D. Iwami, C. Brinkman, S. Ahmad, J. Bromberg
AMERICAN JOURNAL OF TRANSPLANTATION
(2014)