Review
Immunology
Caroline Dudreuilh, Sumoyee Basu, Cristiano Scotta, Anthony Dorling, Giovanna Lombardi
Summary: Regulatory T cells like Tregs play a crucial role in maintaining immune balance and preventing autoimmune diseases. Specifically, Tfr cells regulate interactions between B cells and Tfh cells, and their potential applications in transplantation and immunosuppression warrant further exploration.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Angus W. Thomson, Kazuki Sasaki, Mohamed B. Ezzelarab
Summary: Non-human primates (NHP) are crucial for studying Treg immunobiology and their potential in adoptive therapy. NHP Treg have been successfully isolated and expanded ex vivo, showing promise in organ transplantation. Studies have provided insights into the fate and stability of adoptively transferred Treg in NHP.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Gabriel Orozco, Meera Gupta, Roberto Gedaly, Francesc Marti
Summary: This review discusses the major challenges that Treg cell transplant investigators currently face, including Treg cell diversity, manufacturing process, administration route, and lack of effective monitoring and biomarkers.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Claudia Selck, Margarita Dominguez-Villar
Summary: Regulatory T (Treg) cells are a diverse population of immunosuppressive T cells with therapeutic potential for treating autoimmune diseases and graft rejection. Antigen-specific Treg cells have shown to be more effective in disease-specific regulation, but face challenges such as the identification of disease-relevant antigens and the stability of cells post-transfer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiaopei Cui, Chun-Guang Li, Haiqing Gao, Mei Cheng, Fan Jiang
Summary: Regulatory T cells (Tregs) play critical roles in immune balance and anti-inflammatory responses. Recent studies have shown that CX-5461 can promote Treg differentiation and prevent allogeneic acute rejection through a unique molecular mechanism. These findings suggest a potential role of p53 in mediating Treg differentiation and regulating Treg function through various mechanisms. Pharmacological p53 activators may offer new possibilities for enhancing Treg-mediated immune tolerance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Marta Fortunato, Konstantina Morali, Laura Passeri, Silvia Gregori
Summary: Enhancing regulatory cells to promote immune tolerance is a solution to improve long-term allograft survival in organ transplantation. Cell populations like regulatory T cells and regulatory myeloid cells show promise in restoring tolerance. Efforts in applying regulatory cell-based therapy have shown progress in clinical applications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Roberto Gedaly, Gabriel Orozco, Alexandre P. Ancheta, Mackenzie Donoho, Siddharth N. Desai, Fanny Chapelin, Aman Khurana, Lillie J. Lewis, Cuiping Zhang, Francesc Marti
Summary: This study aimed to compare the effects of AZD8055 and RAPA on the manufacturing of clinically competent Treg cells. The results showed that AZD8055 had a stronger inhibition on the mTORC2 signaling pathway and IL2-receptor downstream events compared to RAPA, but it also disrupted the long-term expansion and suppressive function of Tregs, and affected cellular metabolism and stress response pathways.
Review
Pharmacology & Pharmacy
Sergio G. Garcia, Noelia Sandoval-Hellin, Marcella Franquesa
Summary: Bregs are gaining attention in the context of kidney injury, as their restoration and balance could serve as potential therapeutic tools. Efforts are being made to identify specific markers defining Bregs as a unique cell subset, while exploring induction mechanisms for further research and applications in kidney disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Eleni Gavriilaki, Panagiotis Dolgyras, Sotiria Dimou-Mpesikli, Aikaterini Poulopoulou, Paschalis Evangelidis, Nikolaos Evangelidis, Christos Demosthenous, Evangelia Zachrou, Panagiotis Siasios, Despina Mallouri, Anna Vardi, Zoi Bousiou, Alkistis Panteliadou, Ioannis Batsis, Marianna Masmanidou, Chrysavgi Lalayanni, Evangelia Yannaki, Damianos Sotiropoulos, Achilles Anagnostopoulos, Timoleon-Achilleas Vyzantiadis, Ioanna Sakellari
Summary: This retrospective study investigated the prevalence and outcome of invasive fungal infections (IFD) in patients who received cellular therapies. It was found that CAR T cell and gene therapy recipients did not develop IFD, while autologous HCT recipients with primary refractory/relapsed lymphomas had probable IFD. Among allogeneic HCT recipients, 11 experienced probable IFD, 31 had possible IFD, and 10 had proven IFD. These findings suggest that IFD is associated with poor outcomes in allogeneic HCT recipients.
Article
Biochemical Research Methods
James R. Byrnes, Amy M. Weeks, Eric Shifrut, Julia Carnevale, Lisa Kirkemo, Alan Ashworth, Alexander Marson, James A. Wells
Summary: Immunosuppressive factors in the tumor microenvironment impair T cell function. This study examines how regulatory T cells (Tregs) and hypoxia affect the surface proteome of primary human T cells. The results show that Tregs have only a modest effect on the surface proteome, while hypoxia drastically alters it, inducing an immunosuppressed state.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Immunology
Mark Mensink, Thi Ngoc Minh Tran, Esther A. Zaal, Ellen Schrama, Celia R. Berkers, Jannie Borst, Sander de Kivit
Summary: CD4(+) T cells play a role in immune responses depending on the environment and stage, with nutrient availability also impacting their functionality. TNFR2 has been identified as key in regulating T cells, particularly Tregs. This study provides new evidence for the role of TNFR2 in metabolic regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Magis Mandapathil, Miroslaw J. Szczepanski, Edwin K. Jackson, Stephan Lang, Theresa L. Whiteside
Summary: The study suggests that breast cancer cells producing ADO are conducive to the induction of Tr1 cells, which exhibit higher immunosuppressive activity. Inhibiting ectonucleotidases and A2A receptors can reduce the proliferative suppression mediated by Tr1 cells.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yi-Qi Li, Chun-Ling Luo, Jia-Xin Jiang, Shuai He, Yang Liu, Wen-Xin Yan, Yi Xia, Qian Cui, Ying Huang, Jing Quan Lim, Dachuan Huang, Izzah Nabilah Hussein, Yan Gao, Guo-Wang Lin, Yi-Hong Ling, Dong Ma, Yue-Tong Zhang, Jason Yongsheng Chan, Pan-Pan Wei, Xiao-Xiao Wang, Chee Leong Cheng, Jie Xiong, Wei-Li Zhao, Choon Kiat Ong, Soon Thye Lim, Hui-Qiang Huang, Rou-Jun Peng, Jin-Xin Bei
Summary: This study utilizes single-cell RNA sequencing and in vitro and in vivo models to explore the heterogeneity of extranodal natural killer/T-cell lymphoma (NKTCL). They identify a subset of malignant NK cells with EBV-encoded LMP1 that contribute to tumorigenesis and interact with immunocytes, impairing chemotaxis and exhibiting an immunosuppressive effect on T cells. High transcription of EBV-encoded genes and low infiltration of tumor-associated macrophages (TAMs) are favorable prognostic indicators for NKTCL. This study provides insights into the pathogenic mechanisms of NKTCL and potential therapeutic strategies.
Article
Engineering, Biomedical
Yingmei Luo, Ze Chen, Mingjian Sun, Baohong Li, Fan Pan, Aiqing Ma, Jianhong Liao, Ting Yin, Xiaofan Tang, Guojun Huang, Baozhen Zhang, Hong Pan, Mingbin Zheng, Lintao Cai
Summary: This study developed IL-12 nanostimulant-engineered CAR T cell (INS-CAR T) biohybrids for boosting antitumor immunity, which showed promising effects in eliminating solid tumors and minimizing side effects.
Review
Immunology
Angus Hann, Ye H. Oo, M. Thamara P. R. Perera
Summary: The liver possesses unique immunological characteristics but is susceptible to immune mediated injury. Regulatory T cells play a crucial role in preventing tissue damage, and therapies aiming to increase their function have shown efficacy in autoimmune diseases and organ transplantations. Research on the hepatic microenvironment and the role of Tregs in liver diseases is crucial for maintaining immunological balance.
FRONTIERS IN IMMUNOLOGY
(2021)